Published in Mol Cell on December 23, 2011
Transcriptional regulation and its misregulation in disease. Cell (2013) 2.92
A day in the life of the spliceosome. Nat Rev Mol Cell Biol (2014) 2.18
Getting up to speed with transcription elongation by RNA polymerase II. Nat Rev Mol Cell Biol (2015) 1.97
The super elongation complex (SEC) family in transcriptional control. Nat Rev Mol Cell Biol (2012) 1.78
P-TEFb, the super elongation complex and mediator regulate a subset of non-paused genes during early Drosophila embryo development. PLoS Genet (2015) 1.45
RNA polymerase II transcription elongation control. Chem Rev (2013) 1.27
The Mediator complex and transcription elongation. Biochim Biophys Acta (2012) 1.24
Large-scale quality analysis of published ChIP-seq data. G3 (Bethesda) (2014) 1.23
Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing. Mol Cell (2013) 1.19
Genomic study of RNA polymerase II and III SNAPc-bound promoters reveals a gene transcribed by both enzymes and a broad use of common activators. PLoS Genet (2012) 1.06
Chromatin landscapes of retroviral and transposon integration profiles. PLoS Genet (2014) 1.02
Transcriptional elongation checkpoint control in development and disease. Genes Dev (2013) 0.98
An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation. RNA (2012) 0.98
The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell (2013) 0.86
ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair. Proc Natl Acad Sci U S A (2013) 0.85
Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis. Cancers (Basel) (2012) 0.83
A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. J Cell Sci (2014) 0.82
Vicinal: a method for the determination of ncRNA ends using chimeric reads from RNA-seq experiments. Nucleic Acids Res (2014) 0.79
Developmental analysis of spliceosomal snRNA isoform expression. G3 (Bethesda) (2014) 0.78
ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of histone deacetylase 1. Mol Cell Biol (2013) 0.77
Epigenetics of hematopoiesis and hematological malignancies. Genes Dev (2016) 0.77
Role of Ser7 phosphorylation of the CTD during transcription of snRNA genes. RNA Biol (2012) 0.76
ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nat Commun (2016) 0.76
MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. Nat Commun (2015) 0.76
Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults. BMC Genomics (2017) 0.75
The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression. EMBO J (2017) 0.75
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
The human genome browser at UCSC. Genome Res (2002) 168.23
TopHat: discovering splice junctions with RNA-Seq. Bioinformatics (2009) 81.13
Differential expression analysis for sequence count data. Genome Biol (2010) 64.56
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
affy--analysis of Affymetrix GeneChip data at the probe level. Bioinformatics (2004) 32.08
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Defining the human deubiquitinating enzyme interaction landscape. Cell (2009) 11.39
Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics (2005) 10.64
Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17
Pre-mRNA processing reaches back to transcription and ahead to translation. Cell (2009) 7.45
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell (1999) 6.34
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol (1994) 5.01
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99
Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science (2007) 4.18
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. Mol Cell (2010) 3.49
An RNA polymerase II elongation factor encoded by the human ELL gene. Science (1996) 3.46
Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression. Science (2007) 3.36
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26
Refinements to label free proteome quantitation: how to deal with peptides shared by multiple proteins. Anal Chem (2010) 3.07
Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science (1995) 3.03
Cajal bodies: a long history of discovery. Annu Rev Cell Dev Biol (2005) 2.92
HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol Cell (2010) 2.91
The RNA polymerase II elongation complex. Annu Rev Biochem (2003) 2.76
The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63
Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription. J Biol Chem (2001) 2.57
Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell (2011) 2.53
Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci U S A (1994) 2.44
Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis. EMBO J (1998) 2.34
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34
Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). Genes Dev (2011) 1.77
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77
The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science (2011) 1.72
A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood (2000) 1.71
P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes. EMBO J (2005) 1.66
ELL2, a new member of an ELL family of RNA polymerase II elongation factors. Proc Natl Acad Sci U S A (1997) 1.62
RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs. Nucleic Acids Res (2003) 1.61
RNA-mediated interaction of Cajal bodies and U2 snRNA genes. J Cell Biol (2001) 1.41
Rescue of arrested RNA polymerase II complexes. J Cell Sci (2003) 1.41
Drosophila melanogaster genes for U1 snRNA variants and their expression during development. Nucleic Acids Res (1990) 1.41
The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. Mol Cell Biol (2001) 1.40
Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo. EMBO J (2001) 1.39
Expression of human snRNA genes from beginning to end. Biochem Soc Trans (2008) 1.39
dELL is an essential RNA polymerase II elongation factor with a general role in development. Proc Natl Acad Sci U S A (2002) 1.34
The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain. J Biol Chem (2010) 1.33
Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3. J Biol Chem (2000) 1.32
Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL. Proc Natl Acad Sci U S A (2008) 1.30
Transcriptional regulation of human small nuclear RNA genes. Biochim Biophys Acta (2008) 1.25
Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes. Mol Cell Biol (2009) 1.23
A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation. Mol Cell Biol (2010) 1.13
ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia. Mol Biol Cell (2003) 1.05
COMA server for protein distant homology search. Bioinformatics (2010) 0.95
N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. J Biol Chem (2001) 0.92
Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster. Mol Cell Biol (2005) 0.90
Splicing therapeutics in SMN2 and APOB. Curr Opin Mol Ther (2009) 0.89
Control of mouse U1a and U1b snRNA gene expression by differential transcription. Nucleic Acids Res (1992) 0.81
Fire exit is a potential four transmembrane protein expressed in developing Drosophila glia. Genesis (2003) 0.78
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Prepublication data sharing. Nature (2009) 12.24
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell (2005) 10.68
A proteomic view of the Plasmodium falciparum life cycle. Nature (2002) 10.65
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature (2011) 7.92
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae. J Proteome Res (2006) 6.43
A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science (2005) 5.99
The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. Nucleic Acids Res (2005) 5.59
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science (2004) 4.97
The European Bioinformatics Institute's data resources: towards systems biology. Nucleic Acids Res (2005) 4.90
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem (2002) 4.75
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49
Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell (2007) 4.49
An operational definition of epigenetics. Genes Dev (2009) 4.26
Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol (2007) 4.17
Correlation of relative abundance ratios derived from peptide ion chromatograms and spectrum counting for quantitative proteomic analysis using stable isotope labeling. Anal Chem (2005) 4.16
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem (2003) 3.81
Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature (2010) 3.72
Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors. Proc Natl Acad Sci U S A (2006) 3.71
Shotgun identification of protein modifications from protein complexes and lens tissue. Proc Natl Acad Sci U S A (2002) 3.70
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66
Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science (2003) 3.64
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res (2004) 3.63
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54
Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors. Methods (2006) 3.37
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol Cell (2004) 3.34
Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. PLoS Pathog (2008) 3.27
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26
Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. Proc Natl Acad Sci U S A (2008) 3.23
The language of histone crosstalk. Cell (2010) 3.18
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
Refinements to label free proteome quantitation: how to deal with peptides shared by multiple proteins. Anal Chem (2010) 3.07
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc Natl Acad Sci U S A (2009) 3.02
Extending CATH: increasing coverage of the protein structure universe and linking structure with function. Nucleic Acids Res (2010) 2.93
The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies. Nucleic Acids Res (2008) 2.92
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell (2009) 2.91
Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell (2005) 2.89
Histone modification: cause or cog? Trends Genet (2011) 2.85
Scm3 is essential to recruit the histone h3 variant cse4 to centromeres and to maintain a functional kinetochore. Mol Cell (2007) 2.82
Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem (2003) 2.76
Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol Cell (2007) 2.74
GutenTag: high-throughput sequence tagging via an empirically derived fragmentation model. Anal Chem (2003) 2.74
Construction, visualisation, and clustering of transcription networks from microarray expression data. PLoS Comput Biol (2007) 2.73
Proteomic analysis by multidimensional protein identification technology. Methods Mol Biol (2006) 2.69
Quantifying the similarities within fold space. J Mol Biol (2002) 2.65
Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle. Proc Natl Acad Sci U S A (2007) 2.64
The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63
The European Bioinformatics Institute's data resources. Nucleic Acids Res (2009) 2.55