Published in PLoS Genet on May 13, 2010
Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging. Cell Stem Cell (2015) 1.42
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28
The influence of skeletal muscle on systemic aging and lifespan. Aging Cell (2013) 1.13
No evidence of elevated germline mutation accumulation under oxidative stress in Caenorhabditis elegans. Genetics (2011) 0.95
Myc-dependent genome instability and lifespan in Drosophila. PLoS One (2013) 0.92
Epigenetics and aging. Sci Adv (2016) 0.84
Measuring genome instability in aging - a mini-review. Gerontology (2011) 0.83
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila. Genome Biol (2011) 0.83
Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae. Aging Cell (2015) 0.83
A hormone receptor-based transactivator bridges different binary systems to precisely control spatial-temporal gene expression in Drosophila. PLoS One (2012) 0.83
Evolution of a higher intracellular oxidizing environment in Caenorhabditis elegans under relaxed selection. PLoS One (2013) 0.80
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes. Sci Rep (2015) 0.79
Effect of prolonged coldness on survival and fertility of Drosophila melanogaster. PLoS One (2014) 0.78
A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat. Front Genet (2011) 0.78
Effect of temperature on the rate of ageing: an experimental study of the blowfly Calliphora stygia. PLoS One (2013) 0.77
Support for the evolutionary speed hypothesis from intraspecific population genetic data in the non-biting midge Chironomus riparius. Proc Biol Sci (2016) 0.75
Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations. BMC Genet (2016) 0.75
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span. NPJ Aging Mech Dis (2017) 0.75
Overview of caloric restriction and ageing. Mech Ageing Dev (2005) 6.68
Rates of DNA sequence evolution differ between taxonomic groups. Science (1986) 6.46
Test of synergistic interactions among deleterious mutations in bacteria. Nature (1997) 6.40
Demography of dietary restriction and death in Drosophila. Science (2003) 4.82
Gene regulatory networks for development. Proc Natl Acad Sci U S A (2005) 4.45
ON THE NATURE OF THE AGING PROCESS. Proc Natl Acad Sci U S A (1959) 3.98
The high spontaneous mutation rate: is it a health risk? Proc Natl Acad Sci U S A (1997) 3.85
Mutation rate variation in multicellular eukaryotes: causes and consequences. Nat Rev Genet (2007) 3.48
Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines. Genome Res (2009) 3.47
Puzzles, promises and a cure for ageing. Nature (2008) 3.23
Dietary restriction in Drosophila: delayed aging or experimental artefact? PLoS Genet (2007) 2.51
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc Natl Acad Sci U S A (2000) 1.81
Large genome rearrangements as a primary cause of aging. Mech Ageing Dev (2002) 1.56
Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion. Proc Natl Acad Sci U S A (2004) 1.48
Plasmid-based transgenic mouse model for studying in vivo mutations. Nature (1995) 1.46
Temperature-dependence of mitochondrial function and production of reactive oxygen species in the intertidal mud clam Mya arenaria. J Exp Biol (2002) 1.37
The mitochondrial free radical theory of ageing--where do we stand? Front Biosci (2008) 1.29
Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mech Ageing Dev (2008) 1.24
Genome dynamics in aging mice. Genome Res (2002) 1.20
The aging process and cancerogenesis. Ann N Y Acad Sci (1958) 1.15
Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One (2007) 1.11
Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster. Methods Mol Biol (2007) 1.11
A model system for analyzing somatic mutations in Drosophila melanogaster. Nat Methods (2007) 1.02
Mutagenicity of metabolic oxygen radicals in mammalian cell cultures. Carcinogenesis (1994) 0.97
Characterization of color mutants in lacZ plasmid-based transgenic mice, as detected by positive selection. Mutagenesis (1999) 0.96
Use of the mouse spot test in chemical mutagenesis: interpretation of past data and recommendations for future work. Mutat Res (1981) 0.95
Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell (2009) 0.93
Evaluation of the genotoxicity of four herbicides in the wing spot test of Drosophila melanogaster using two different strains. Mutat Res (2004) 0.93
High somatic mutation frequencies in a LacZ transgene integrated on the mouse X-chromosome. Mutat Res (1991) 0.90
Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences. Nucleic Acids Res (2008) 0.86
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell (2009) 4.20
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell (2007) 3.78
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
Allocrine modulation of feeding behavior by the Sex Peptide of Drosophila. Curr Biol (2006) 3.01
Compensatory ingestion upon dietary restriction in Drosophila melanogaster. Nat Methods (2005) 2.80
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet (2009) 2.60
DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell (2004) 2.11
Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol (2011) 1.98
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med (2010) 1.86
Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell (2007) 1.75
Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants. Mutat Res (2011) 1.75
A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster. Curr Biol (2010) 1.63
Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell (2013) 1.60
Large genome rearrangements as a primary cause of aging. Mech Ageing Dev (2002) 1.56
Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res (2011) 1.56
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A (2002) 1.54
Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Aging Cell (2002) 1.49
Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab (2010) 1.46
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Hum Mutat (2002) 1.44
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res (2006) 1.43
SNP discovery in associating genetic variation with human disease phenotypes. Mutat Res (2005) 1.42
Genome instability, cancer and aging. Biochim Biophys Acta (2009) 1.40
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab (2011) 1.39
Aging and genome maintenance. Ann N Y Acad Sci (2005) 1.39
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair (Amst) (2005) 1.38
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J Neurosci (2008) 1.36
Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab (2012) 1.34
Mitochondrial DNA mutations and aging: devils in the details? Trends Genet (2008) 1.30
A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genet (2009) 1.29
Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mech Ageing Dev (2008) 1.24
Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol (2008) 1.23
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis. Antimicrob Agents Chemother (2005) 1.22
Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Exp Gerontol (2010) 1.21
Genome dynamics in aging mice. Genome Res (2002) 1.20
Aging alters the apoptotic response to genotoxic stress. Nat Med (2002) 1.18
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mech Ageing Dev (2003) 1.18
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis (2011) 1.17
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. Antioxid Redox Signal (2006) 1.16
Does damage to DNA and other macromolecules play a role in aging? If so, how? J Gerontol A Biol Sci Med Sci (2009) 1.16
Epigenetic factors in aging and longevity. Pflugers Arch (2009) 1.15
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Res (2008) 1.15
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res (2005) 1.12
Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One (2007) 1.11
Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster. Methods Mol Biol (2007) 1.11
Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res (2010) 1.10
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. J Lipid Res (2008) 1.09
Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study. Atherosclerosis (2010) 1.09
Mutational fingerprints of aging. Nucleic Acids Res (2002) 1.08
The demographic and biomedical case for late-life interventions in aging. Sci Transl Med (2010) 1.08
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell (2012) 1.08
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Res (2006) 1.08
TOR signaling never gets old: aging, longevity and TORC1 activity. Ageing Res Rev (2010) 1.07
DNA structure-induced genomic instability in vivo. J Natl Cancer Inst (2008) 1.06
Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One (2011) 1.06
Catalase transgenic mice: characterization and sensitivity to oxidative stress. Arch Biochem Biophys (2004) 1.04
Dietary restriction and aging, 2009. Aging Cell (2010) 1.03
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03
A model system for analyzing somatic mutations in Drosophila melanogaster. Nat Methods (2007) 1.02
High carbohydrate-low protein consumption maximizes Drosophila lifespan. Exp Gerontol (2013) 1.02
The Wasp System: an open source environment for managing and analyzing genomic data. Genomics (2012) 1.01
Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study. Circ Cardiovasc Genet (2012) 1.01
Chromosome-specific accumulation of aneuploidy in the aging mouse brain. Hum Mol Genet (2012) 1.00
The hypoxic response and aging. Cell Cycle (2009) 1.00
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics (2012) 0.99
Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair (Amst) (2005) 0.98
Attenuation of leukocyte-endothelium interaction by antioxidant enzymes. Free Radic Biol Med (2003) 0.98
Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. PLoS One (2012) 0.98
Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging? Aging Cell (2006) 0.97
Chromosomal aneuploidy in the aging brain. Mech Ageing Dev (2011) 0.95
Metabolic syndrome model definitions predicting type 2 diabetes and cardiovascular disease. Diabetes Care (2012) 0.94
Detection by denaturing gradient gel electrophoresis of pncA mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis isolates from the United States-Mexico border region. Antimicrob Agents Chemother (2005) 0.94
Cell signaling. Aging is RSKy business. Science (2009) 0.94
Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes. Aging (Albany NY) (2013) 0.94
Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell (2009) 0.93
Mitochondrial DNA mutations and aging: a case closed? Nat Genet (2007) 0.93
Identification of TUB as a novel candidate gene influencing body weight in humans. Diabetes (2006) 0.93
Myc-dependent genome instability and lifespan in Drosophila. PLoS One (2013) 0.92
Drosophila melanogaster as an emerging translational model of human nephrolithiasis. J Urol (2013) 0.91
RAD51 mutants cause replication defects and chromosomal instability. Mol Cell Biol (2012) 0.91
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res (2008) 0.90