Functional dynamics in the voltage-dependent anion channel.

Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis. Liver Int (2014) 1.40

Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. Am J Physiol Heart Circ Physiol (2012) 1.23

Affixing N-terminal α-helix to the wall of the voltage-dependent anion channel does not prevent its voltage gating. J Biol Chem (2012) 1.13

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes. Structure (2015) 1.08

β-Barrel mobility underlies closure of the voltage-dependent anion channel. Structure (2012) 1.04

Computational analysis of local membrane properties. J Comput Aided Mol Des (2013) 0.94

Viruses as modulators of mitochondrial functions. Adv Virol (2013) 0.85

An outer membrane protein undergoes enthalpy- and entropy-driven transitions. Biochemistry (2012) 0.85

Nucleotide interactions of the human voltage-dependent anion channel. J Biol Chem (2014) 0.85

Acidification asymmetrically affects voltage-dependent anion channel implicating the involvement of salt bridges. J Biol Chem (2014) 0.84

Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations. Structure (2015) 0.82

Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. J Biomol NMR (2014) 0.82

Flexibility of the N-terminal mVDAC1 segment controls the channel's gating behavior. PLoS One (2012) 0.82

Charged residues distribution modulates selectivity of the open state of human isoforms of the voltage dependent anion-selective channel. PLoS One (2014) 0.81

Concentration dependent ion selectivity in VDAC: a molecular dynamics simulation study. PLoS One (2011) 0.80

Current state of theoretical and experimental studies of the voltage-dependent anion channel (VDAC). Biochim Biophys Acta (2016) 0.79

Global redesign of a native β-barrel scaffold. Biochim Biophys Acta (2015) 0.79

Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold. ACS Chem Biol (2015) 0.78

Magic angle spinning nuclear magnetic resonance characterization of voltage-dependent anion channel gating in two-dimensional lipid crystalline bilayers. Biochemistry (2015) 0.78

Computational investigation of cholesterol binding sites on mitochondrial VDAC. J Phys Chem B (2014) 0.78

Exploring the Membrane Potential of Simple Dual-Membrane Systems as Models for Gap-Junction Channels. Biophys J (2016) 0.77

Characterization of the ground state dynamics of proteorhodopsin by NMR and optical spectroscopies. J Biomol NMR (2012) 0.77

Does the voltage dependent anion channel modulate cardiac ischemia-reperfusion injury? Biochim Biophys Acta (2011) 0.77

A role for loop G in the β1 strand in GABAA receptor activation. J Physiol (2016) 0.77

High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins. Angew Chem Int Ed Engl (2016) 0.75

Mapping membrane protein backbone dynamics: a comparison of site-directed spin labeling with NMR 15N-relaxation measurements. Biophys J (2014) 0.75

NMR-based detection of hydrogen/deuterium exchange in liposome-embedded membrane proteins. PLoS One (2014) 0.75

Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins. Anal Chem (2017) 0.75

Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1. Biophys J (2016) 0.75

Extension of the Highly Mobile Membrane Mimetic to Transmembrane Systems through Customized in Silico Solvents. J Phys Chem B (2017) 0.75

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target. Front Physiol (2017) 0.75

Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential. Fold Des (1997) 11.73

Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. Phys Rev Lett (1996) 9.75

Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondria. J Membr Biol (1976) 5.01

Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel. Nature (1986) 3.89

Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science (2008) 3.38

Structure of outer membrane protein A transmembrane domain by NMR spectroscopy. Nat Struct Biol (2001) 2.99

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A (2008) 2.82

Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69

Voltage-dependent anion channel (VDAC) as mitochondrial governator--thinking outside the box. Biochim Biophys Acta (2005) 2.57

VDAC, a multi-functional mitochondrial protein regulating cell life and death. Mol Aspects Med (2010) 2.36

Electrostatic couplings in OmpA ion-channel gating suggest a mechanism for pore opening. Nat Chem Biol (2006) 2.29

A TROSY CPMG sequence for characterizing chemical exchange in large proteins. J Biomol NMR (1999) 2.25

Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins. Biochim Biophys Acta (1994) 2.20

Protein dynamics measurements by TROSY-based NMR experiments. J Magn Reson (2000) 2.12

The voltage-dependent anion channel (VDAC): function in intracellular signalling, cell life and cell death. Curr Pharm Des (2006) 1.78

On the role of VDAC in apoptosis: fact and fiction. J Bioenerg Biomembr (2005) 1.68

Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding. J Biol Chem (2008) 1.65

The voltage-dependent anion channel-1 modulates apoptotic cell death. Cell Death Differ (2005) 1.63

A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol (2008) 1.61

oGNM: online computation of structural dynamics using the Gaussian Network Model. Nucleic Acids Res (2006) 1.60

VDAC regulation: role of cytosolic proteins and mitochondrial lipids. J Bioenerg Biomembr (2008) 1.60

Structure of the monomeric outer-membrane porin OmpG in the open and closed conformation. EMBO J (2006) 1.58

Lipids and membrane protein structures. Curr Opin Struct Biol (2008) 1.58

Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel. Proc Natl Acad Sci U S A (1993) 1.52

How protein transmembrane segments sense the lipid environment. Biochemistry (2007) 1.50

Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC. Biochemistry (1986) 1.49

VDAC channels. IUBMB Life (2002) 1.48

Gradient and sensitivity enhancement of 2D TROSY with water flip-back, 3D NOESY-TROSY and TOCSY-TROSY experiments. J Biomol NMR (1999) 1.45

Concordance of residual dipolar couplings, backbone order parameters and crystallographic B-factors for a small alpha/beta protein: a unified picture of high probability, fast atomic motions in proteins. J Mol Biol (2006) 1.45

Study of protein dynamics by X-ray diffraction. Methods Enzymol (1986) 1.43

Mapping chemical exchange in proteins with MW > 50 kD. J Am Chem Soc (2003) 1.36

Uncovering the role of VDAC in the regulation of cell life and death. J Bioenerg Biomembr (2008) 1.34

Dynamics of reassembled thioredoxin studied by magic angle spinning NMR: snapshots from different time scales. J Am Chem Soc (2009) 1.32

Phospholipid composition of highly purified mitochondrial outer membranes of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane? Biochim Biophys Acta (1997) 1.28

Interaction and conformational dynamics of membrane-spanning protein helices. Protein Sci (2009) 1.19

Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. Proc Natl Acad Sci U S A (2010) 1.17

Predicting weakly stable regions, oligomerization state, and protein-protein interfaces in transmembrane domains of outer membrane proteins. Proc Natl Acad Sci U S A (2009) 1.10

TROSY NMR with partially deuterated proteins. J Biomol NMR (2001) 1.06

The native conformation of the human VDAC1 N terminus. Angew Chem Int Ed Engl (2010) 1.05

The mitochondrial channel VDAC has a cation-selective open state. Biochim Biophys Acta (2005) 1.01

The role of solution NMR in the structure determinations of VDAC-1 and other membrane proteins. Curr Opin Struct Biol (2009) 1.00

Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides. FEBS J (2009) 0.99

Probing excited states and activation energy for the integral membrane protein phospholamban by NMR CPMG relaxation dispersion experiments. Biochim Biophys Acta (2009) 0.97

Solution structure and dynamics of integral membrane proteins by NMR: a case study involving the enzyme PagP. Methods Enzymol (2005) 0.96

Solid-state (2)H and (15)N NMR studies of side-chain and backbone dynamics of phospholamban in lipid bilayers: investigation of the N27A mutation. Biochim Biophys Acta (2009) 0.96

beta-Barrel membrane bacterial proteins: structure, function, assembly and interaction with lipids. Curr Protein Pept Sci (2007) 0.95

Amyloid peptide pores and the beta sheet conformation. Adv Exp Med Biol (2010) 0.95

Solution state NMR structure and dynamics of KpOmpA, a 210 residue transmembrane domain possessing a high potential for immunological applications. J Mol Biol (2008) 0.94

Fast-time scale dynamics of outer membrane protein A by extended model-free analysis of NMR relaxation data. Biochim Biophys Acta (2009) 0.92

Conformational change in the mitochondrial channel, VDAC, detected by electron cryo-microscopy. Biophys J (1993) 0.92

pH dependent inactivation of solubilized F1F0 ATP synthase by dicyclohexylcarbodiimide: pK(a) of detergent unmasked aspartyl-61 in Escherichia coli subunit c. Biochim Biophys Acta (2002) 0.90

Location of the dicyclohexylcarbodiimide-reactive glutamate residue in the bovine heart mitochondrial porin. J Biol Chem (1993) 0.89

Solid-state NMR approaches to measure topological equilibria and dynamics of membrane polypeptides. Biochim Biophys Acta (2009) 0.85

Dicyclohexylcarbodiimide interaction with the voltage-dependent anion channel from sarcoplasmic reticulum. Eur J Biochem (1998) 0.78

Special issue on "membrane protein dynamics: correlating structure to function". Biochim Biophys Acta (2010) 0.77

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science (2008) 8.04

Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core. Science (2008) 5.55

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci U S A (2005) 3.48

Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc Natl Acad Sci U S A (2005) 3.37

Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69

Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J Comput Aided Mol Des (2010) 2.67

VDAC, a multi-functional mitochondrial protein regulating cell life and death. Mol Aspects Med (2010) 2.36

Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR. Nature (2006) 2.34

Mars -- robust automatic backbone assignment of proteins. J Biomol NMR (2004) 2.22

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Nat Struct Biol (2002) 2.21

Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles. EMBO J (2006) 2.19

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Ann Neurol (2013) 2.10

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J (2009) 2.09

NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. Proc Natl Acad Sci U S A (2006) 2.05

Atomic model of the type III secretion system needle. Nature (2012) 2.02

Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy. J Am Chem Soc (2005) 2.02

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. J Biol Chem (2008) 1.94

Predicting free energy changes using structural ensembles. Nat Methods (2009) 1.93

Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. J Am Chem Soc (2005) 1.75

Scrutinizing molecular mechanics force fields on the submicrosecond timescale with NMR data. Biophys J (2010) 1.75

Atomic-resolution three-dimensional structure of HET-s(218-289) amyloid fibrils by solid-state NMR spectroscopy. J Am Chem Soc (2010) 1.69

Mechanism of selectivity in aquaporins and aquaglyceroporins. Proc Natl Acad Sci U S A (2008) 1.67

Model-free analysis of protein backbone motion from residual dipolar couplings. J Am Chem Soc (2002) 1.65

A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol (2008) 1.61

Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61

Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem (2009) 1.57

Structure and function of water channels. Curr Opin Struct Biol (2002) 1.55

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem (2005) 1.54

A concept for rapid protein-structure determination by solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2005) 1.53

Dissociation of amyloid fibrils of alpha-synuclein in supercooled water. Angew Chem Int Ed Engl (2008) 1.51

Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 1.50

A designed inhibitor of a CLC antiporter blocks function through a unique binding mode. Chem Biol (2012) 1.49

Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. J Am Chem Soc (2007) 1.49

The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem (2003) 1.48

Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action. J Biol Chem (2006) 1.46

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci (2010) 1.46

Weak long-range correlated motions in a surface patch of ubiquitin involved in molecular recognition. J Am Chem Soc (2011) 1.45

Kinetics, statistics, and energetics of lipid membrane electroporation studied by molecular dynamics simulations. Biophys J (2008) 1.43

NMR characterization of long-range order in intrinsically disordered proteins. J Am Chem Soc (2010) 1.43

Crystal structure of a yeast aquaporin at 1.15 angstrom reveals a novel gating mechanism. PLoS Biol (2009) 1.41

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO J (2004) 1.41

Crystallographic ab initio protein structure solution below atomic resolution. Nat Methods (2009) 1.38

Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin. Angew Chem Int Ed Engl (2009) 1.38

Structural properties of pore-forming oligomers of alpha-synuclein. J Am Chem Soc (2009) 1.36

A structural link between inactivation and block of a K+ channel. Nat Struct Mol Biol (2008) 1.36

Protein refolding is required for assembly of the type three secretion needle. Nat Struct Mol Biol (2010) 1.36

A thorough dynamic interpretation of residual dipolar couplings in ubiquitin. J Biomol NMR (2006) 1.34

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol (2013) 1.34

Protein thermostability calculations using alchemical free energy simulations. Biophys J (2010) 1.33

Self-consistent residual dipolar coupling based model-free analysis for the robust determination of nanosecond to microsecond protein dynamics. J Biomol NMR (2008) 1.33

Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings. Structure (2009) 1.33

Structure of the unphosphorylated STAT5a dimer. J Biol Chem (2005) 1.32

Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation. J Biol Chem (2005) 1.30

Computational electrophysiology: the molecular dynamics of ion channel permeation and selectivity in atomistic detail. Biophys J (2011) 1.30

Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science (2014) 1.29

Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement. J Am Chem Soc (2006) 1.28

Does CO2 permeate through aquaporin-1? Biophys J (2006) 1.28

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J Biol Chem (2005) 1.27

A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family. PLoS Comput Biol (2009) 1.27