Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol (2017) 2.02

The regulation of immune tolerance by FOXP3. Nat Rev Immunol (2017) 0.76

Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42

An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol (2003) 19.16

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol (2006) 14.33

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 14.15

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet (2001) 10.92

FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell (2003) 7.43

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39

Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell (2003) 6.48

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol (2003) 5.50

A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell (2006) 5.36

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature (2007) 5.14

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A (2005) 3.33

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A (2007) 3.32

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet (1999) 2.60

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood (2009) 2.49

The phenotype of human STK4 deficiency. Blood (2012) 1.84

Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology (2009) 1.81

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival. Blood (2011) 1.76

Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci Signal (2012) 1.71

TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A (2008) 1.65

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J (2009) 1.58

Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol (2011) 1.53

A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses. J Immunol Methods (2007) 1.38

A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol (2009) 1.35

Rapid temporal control of Foxp3 protein degradation by sirtuin-1. PLoS One (2011) 1.31

FOXP3 and scurfy: how it all began. Nat Rev Immunol (2014) 1.25

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med (2012) 1.25

Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Exp Mol Pathol (2009) 1.22

Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease. J Exp Med (2011) 1.13

Canonical Wnt signaling negatively modulates regulatory T cell function. Immunity (2013) 1.13

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus. Nat Commun (2012) 1.11

MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation. J Biol Chem (2011) 0.96

Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma. DNA Cell Biol (2000) 0.95

Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. J Immunol (2014) 0.94

Post-translational modification networks regulating FOXP3 function. Trends Immunol (2014) 0.92

Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers. Exp Mol Pathol (2013) 0.83

Hippo and its mission for growth control. Nat Cell Biol (2003) 0.83

Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLoS One (2014) 0.78