Published in Biochemistry on January 28, 2011
The potential and challenges of nanopore sequencing. Nat Biotechnol (2008) 14.24
Continuous base identification for single-molecule nanopore DNA sequencing. Nat Nanotechnol (2009) 8.09
Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore. Proc Natl Acad Sci U S A (2009) 3.74
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors. Mol Ther (2008) 2.93
Recognizing a single base in an individual DNA strand: a step toward DNA sequencing in nanopores. Angew Chem Int Ed Engl (2005) 2.83
Toward single molecule DNA sequencing: direct identification of ribonucleoside and deoxyribonucleoside 5'-monophosphates by using an engineered protein nanopore equipped with a molecular adapter. J Am Chem Soc (2006) 2.68
Restoration of cone vision in a mouse model of achromatopsia. Nat Med (2007) 2.44
Gene therapy for red-green colour blindness in adult primates. Nature (2009) 2.44
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis. Mol Ther (2005) 2.27
Enhanced translocation of single DNA molecules through alpha-hemolysin nanopores by manipulation of internal charge. Proc Natl Acad Sci U S A (2008) 2.11
Brain microglial cytokines in neurogenic hypertension. Hypertension (2010) 1.97
Identification of epigenetic DNA modifications with a protein nanopore. Chem Commun (Camb) (2010) 1.93
Functional bionetworks from nanoliter water droplets. J Am Chem Soc (2007) 1.81
Interactions of peptides with a protein pore. Biophys J (2005) 1.79
Formation of droplet networks that function in aqueous environments. Nat Nanotechnol (2011) 1.78
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina. Mol Ther (2010) 1.77
Direct transfer of membrane proteins from bacteria to planar bilayers for rapid screening by single-channel recording. Nat Chem Biol (2006) 1.77
Single-molecule observation of the catalytic subunit of cAMP-dependent protein kinase binding to an inhibitor peptide. Chem Biol (2005) 1.74
Subunit composition of a bicomponent toxin: staphylococcal leukocidin forms an octameric transmembrane pore. Protein Sci (2002) 1.73
Stochastic sensing of nanomolar inositol 1,4,5-trisphosphate with an engineered pore. Chem Biol (2002) 1.69
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation. Invest Ophthalmol Vis Sci (2008) 1.68
A tissue-like printed material. Science (2013) 1.66
Hybrid pore formation by directed insertion of α-haemolysin into solid-state nanopores. Nat Nanotechnol (2010) 1.65
Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore. Proc Natl Acad Sci U S A (2003) 1.62
Droplet networks with incorporated protein diodes show collective properties. Nat Nanotechnol (2009) 1.61
Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury. Exp Physiol (2011) 1.61
A primary hydrogen-deuterium isotope effect observed at the single-molecule level. Nat Chem (2010) 1.58
Protein detection by nanopores equipped with aptamers. J Am Chem Soc (2012) 1.55
Protein nanopores with covalently attached molecular adapters. J Am Chem Soc (2007) 1.55
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc Natl Acad Sci U S A (2013) 1.54
Real-time stochastic detection of multiple neurotransmitters with a protein nanopore. ACS Nano (2012) 1.52
Nucleobase recognition in ssDNA at the central constriction of the alpha-hemolysin pore. Nano Lett (2010) 1.51
Outer membrane protein G: Engineering a quiet pore for biosensing. Proc Natl Acad Sci U S A (2008) 1.48
Single DNA rotaxanes of a transmembrane pore protein. Angew Chem Int Ed Engl (2004) 1.48
Partitioning of individual flexible polymers into a nanoscopic protein pore. Biophys J (2003) 1.45
Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis. FEBS Lett (2008) 1.44
Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol (2010) 1.43
Controlled translocation of individual DNA molecules through protein nanopores with engineered molecular brakes. Nano Lett (2011) 1.42
Multiple base-recognition sites in a biological nanopore: two heads are better than one. Angew Chem Int Ed Engl (2010) 1.41
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores. Proc Natl Acad Sci U S A (2010) 1.41
Asymmetric droplet interface bilayers. J Am Chem Soc (2008) 1.41
Single protein pores containing molecular adapters at high temperatures. Angew Chem Int Ed Engl (2005) 1.39
Screening blockers against a potassium channel with a droplet interface bilayer array. J Am Chem Soc (2008) 1.35
Membrane protein stoichiometry determined from the step-wise photobleaching of dye-labelled subunits. Chembiochem (2007) 1.33
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Mol Ther (2011) 1.32
Multistep protein unfolding during nanopore translocation. Nat Nanotechnol (2013) 1.29
Analysis of single nucleic acid molecules with protein nanopores. Methods Enzymol (2010) 1.29
Probing distance and electrical potential within a protein pore with tethered DNA. Biophys J (2002) 1.29
A storable encapsulated bilayer chip containing a single protein nanopore. J Am Chem Soc (2007) 1.28
Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model. Mol Ther (2002) 1.26
Comparative analysis of in vivo and in vitro AAV vector transduction in the neonatal mouse retina: effects of serotype and site of administration. Vision Res (2007) 1.24
Stochastic detection of motor protein-RNA complexes by single-channel current recording. Chemphyschem (2007) 1.24
Kinetics of a reversible covalent-bond-forming reaction observed at the single-molecule level. Angew Chem Int Ed Engl (2002) 1.21
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice. Am J Pathol (2009) 1.19
Stochastic detection of enantiomers. J Am Chem Soc (2006) 1.17
DNA strands from denatured duplexes are translocated through engineered protein nanopores at alkaline pH. Nano Lett (2009) 1.17
Catalyzing the translocation of polypeptides through attractive interactions. J Am Chem Soc (2007) 1.17
Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye. Mol Vis (2009) 1.16
Electrical behavior of droplet interface bilayer networks: experimental analysis and modeling. J Am Chem Soc (2007) 1.15
Involvement of the brain (pro)renin receptor in cardiovascular homeostasis. Circ Res (2010) 1.14
Folding of a monomeric porin, OmpG, in detergent solution. Biochemistry (2003) 1.14
Simultaneous measurement of ionic current and fluorescence from single protein pores. J Am Chem Soc (2009) 1.14
An engineered ClyA nanopore detects folded target proteins by selective external association and pore entry. Nano Lett (2012) 1.13
The leukocidin pore: evidence for an octamer with four LukF subunits and four LukS subunits alternating around a central axis. Protein Sci (2005) 1.13
Intrinsically disordered protein threads through the bacterial outer-membrane porin OmpF. Science (2013) 1.13
Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept. Hum Gene Ther (2012) 1.12
Temperature-responsive protein pores. J Am Chem Soc (2006) 1.10
Properties of Bacillus cereus hemolysin II: a heptameric transmembrane pore. Protein Sci (2002) 1.09
Urea facilitates the translocation of single-stranded DNA and RNA through the alpha-hemolysin nanopore. Biophys J (2010) 1.08
Single-molecule covalent chemistry with spatially separated reactants. Angew Chem Int Ed Engl (2003) 1.08
Direct introduction of single protein channels and pores into lipid bilayers. J Am Chem Soc (2005) 1.07
Membrane-protein structure: Piercing insights. Nature (2009) 1.07
Catalytic subunit of protein kinase A caged at the activating phosphothreonine. J Am Chem Soc (2002) 1.06
Achromatopsia as a potential candidate for gene therapy. Adv Exp Med Biol (2010) 1.06
Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells. Invest Ophthalmol Vis Sci (2011) 1.06
Individual RNA base recognition in immobilized oligonucleotides using a protein nanopore. Nano Lett (2012) 1.06
The diversity of the liquid ordered (Lo) phase of phosphatidylcholine/cholesterol membranes: a variable temperature multinuclear solid-state NMR and x-ray diffraction study. Biophys J (2006) 1.05
Nanopore-based identification of individual nucleotides for direct RNA sequencing. Nano Lett (2013) 1.04
A genetically encoded pore for the stochastic detection of a protein kinase. Chembiochem (2006) 1.04