Published in Nat Rev Mol Cell Biol on March 01, 2011
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab (2012) 3.64
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J Clin Invest (2012) 2.98
Intrinsically disordered proteins in cellular signalling and regulation. Nat Rev Mol Cell Biol (2015) 2.69
Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest (2012) 1.92
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Molecular mechanism of action of metformin: old or new insights? Diabetologia (2013) 1.71
Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell (2015) 1.65
The myriad roles of cyclic AMP in microbial pathogens: from signal to sword. Nat Rev Microbiol (2011) 1.58
Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation. Cell (2013) 1.55
Signal integration by Ca(2+) regulates intestinal stem-cell activity. Nature (2015) 1.52
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A (2012) 1.52
Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature (2012) 1.42
Knock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity. PLoS One (2016) 1.40
Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction. J Exp Med (2017) 1.39
IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell (2014) 1.34
Dissociating fatty liver and diabetes. Trends Endocrinol Metab (2012) 1.29
AMPK at the nexus of energetics and aging. Cell Metab (2014) 1.28
Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nat Chem Biol (2012) 1.20
PTEN in cancer, metabolism, and aging. Trends Endocrinol Metab (2012) 1.18
Cellular basis of memory for addiction. Dialogues Clin Neurosci (2013) 1.15
mTOR links incretin signaling to HIF induction in pancreatic beta cells. Proc Natl Acad Sci U S A (2011) 1.14
Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab (2014) 1.13
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature (2015) 1.11
MicroRNA-433 inhibits liver cancer cell migration by repressing the protein expression and function of cAMP response element-binding protein. J Biol Chem (2013) 1.11
Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2. Proc Natl Acad Sci U S A (2012) 1.08
CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis. BMB Rep (2013) 1.07
A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Res (2013) 1.05
Multi-tasking: nuclear transcription factors with novel roles in the mitochondria. Trends Cell Biol (2012) 1.05
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci U S A (2011) 1.05
Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest (2013) 1.04
Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment. Proc Natl Acad Sci U S A (2012) 1.04
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nat Commun (2014) 1.04
A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes. J Cell Sci (2013) 1.03
cAMP signaling in subcellular compartments. Pharmacol Ther (2014) 1.02
The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis. Sci Signal (2013) 1.01
Crosstalk between Mycobacterium tuberculosis and the host cell. Semin Immunol (2014) 1.00
Involvement of SIK3 in glucose and lipid homeostasis in mice. PLoS One (2012) 0.99
The paradox of mitochondrial dysfunction and extended longevity. Exp Gerontol (2014) 0.99
PRMT5 modulates the metabolic response to fasting signals. Proc Natl Acad Sci U S A (2013) 0.98
Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver. Mol Cell Endocrinol (2012) 0.97
Regulation of glucose homeostasis by GLP-1. Prog Mol Biol Transl Sci (2014) 0.97
Nocturnin: at the crossroads of clocks and metabolism. Trends Endocrinol Metab (2012) 0.97
Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. BMC Genomics (2013) 0.97
The CRTC1-SIK1 pathway regulates entrainment of the circadian clock. Cell (2013) 0.97
Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways. Genes Dev (2014) 0.97
Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides. Diabetes (2012) 0.96
Sirt1: def-eating senescence? Cell Cycle (2012) 0.94
The AKTion in non-canonical insulin signaling. Nat Med (2012) 0.94
Are BDNF and glucocorticoid activities calibrated? Neuroscience (2012) 0.92
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα). J Biol Chem (2013) 0.92
Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate. J Lipid Res (2012) 0.92
The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases. Biochem J (2015) 0.91
CREB and leukemogenesis. Crit Rev Oncog (2011) 0.91
Creb coactivators direct anabolic responses and enhance performance of skeletal muscle. EMBO J (2014) 0.91
Renal proximal tubule Na,K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1. Cell Signal (2015) 0.91
The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss. Cancer Res (2012) 0.91
Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels. J Mol Cell Cardiol (2013) 0.91
Glucagon secretion and signaling in the development of diabetes. Front Physiol (2012) 0.90
Combinatorial regulation of photoreceptor differentiation factor, neural retina leucine zipper gene NRL, revealed by in vivo promoter analysis. J Biol Chem (2011) 0.90
SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes. J Cell Sci (2015) 0.90
Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis. PLoS Genet (2016) 0.89
ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Mol Cell Biol (2014) 0.89
Adipocyte iron regulates leptin and food intake. J Clin Invest (2015) 0.89
Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase. Nat Commun (2013) 0.89
Biophysical techniques for detection of cAMP and cGMP in living cells. Int J Mol Sci (2013) 0.88
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. Retrovirology (2013) 0.88
CREB pathway links PGE2 signaling with macrophage polarization. Proc Natl Acad Sci U S A (2015) 0.88
Signaling from the cytoplasm to the nucleus in striatal medium-sized spiny neurons. Front Neuroanat (2011) 0.88
Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals. PLoS Genet (2014) 0.88
Impact of nutrients on circadian rhythmicity. Am J Physiol Regul Integr Comp Physiol (2014) 0.87
The role of circadian clocks in metabolic disease. Yale J Biol Med (2012) 0.87
Interconnected network motifs control podocyte morphology and kidney function. Sci Signal (2014) 0.87
Splicing regulator SLU7 is essential for maintaining liver homeostasis. J Clin Invest (2014) 0.86
Mendelian disorders of the epigenetic machinery: tipping the balance of chromatin states. Annu Rev Genomics Hum Genet (2014) 0.86
GLP-1 improves neuropathology after murine cold lesion brain trauma. Ann Clin Transl Neurol (2014) 0.86
Impact of various exercise modalities on hepatic mitochondrial function. Med Sci Sports Exerc (2014) 0.85
Optogenetic modulation of an adenylate cyclase in Toxoplasma gondii demonstrates a requirement of the parasite cAMP for host-cell invasion and stage differentiation. J Biol Chem (2013) 0.85
The short isoform of the ubiquitin ligase NEDD4L is a CREB target gene in hepatocytes. PLoS One (2013) 0.85
Nuclear receptors in neurodegenerative diseases. Neurobiol Dis (2014) 0.85
Identification of O-linked N-acetylglucosamine (O-GlcNAc)-modified osteoblast proteins by electron transfer dissociation tandem mass spectrometry reveals proteins critical for bone formation. Mol Cell Proteomics (2013) 0.85
CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease. Nucleic Acids Res (2013) 0.85
Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation. Cold Spring Harb Perspect Med (2013) 0.85
Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death Dis (2011) 0.84
Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription. PLoS One (2012) 0.84
CREB regulates spine density of lateral amygdala neurons: implications for memory allocation. Front Behav Neurosci (2013) 0.84
Cyclic AMP dynamics in the pancreatic β-cell. Ups J Med Sci (2012) 0.84
Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes. Proc Natl Acad Sci U S A (2014) 0.84
Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism. Nutr Metab (Lond) (2014) 0.84
The Aging Epigenome. Mol Cell (2016) 0.84
Molecular pathophysiology of hepatic glucose production. Mol Aspects Med (2015) 0.84
Defects in pancreatic development and glucose metabolism in SMN-depleted mice independent of canonical spinal muscular atrophy neuromuscular pathology. Hum Mol Genet (2014) 0.83
Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade. J Biol Chem (2012) 0.83
Transcriptional and Chromatin Regulation during Fasting - The Genomic Era. Trends Endocrinol Metab (2015) 0.83
Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer. J Natl Cancer Inst (2014) 0.83
The distribution of messenger RNAs encoding the three isoforms of the transducer of regulated cAMP responsive element binding protein activity in the rat forebrain. J Neuroendocrinol (2011) 0.83
Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours. Proc Natl Acad Sci U S A (2015) 0.83
Exploring the emerging complexity in transcriptional regulation of energy homeostasis. Nat Rev Genet (2015) 0.83
Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice. Immunology (2015) 0.83
Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock. J Neurosci (2013) 0.83
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (2005) 12.35
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature (2005) 7.14
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science (2003) 5.25
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med (2004) 4.64
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature (2007) 4.54
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
TORCs: transducers of regulated CREB activity. Mol Cell (2003) 4.42
Hepatic glucose sensing via the CREB coactivator CRTC2. Science (2008) 4.05
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem (2006) 3.35
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature (2011) 3.32
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev (2003) 3.32
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science (2006) 3.26
Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol Cell (2003) 3.23
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med (2010) 2.65
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity (2005) 2.56
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest (2004) 2.56
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature (2009) 2.48
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nat Struct Biol (2003) 2.32
A hormone-dependent module regulating energy balance. Cell (2011) 2.30
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med (2007) 2.17
The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab (2008) 2.09
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J (2007) 2.07
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature (2003) 1.98
The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med (2008) 1.87
Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci U S A (2004) 1.77
Adipocyte CREB promotes insulin resistance in obesity. Cell Metab (2009) 1.72
CREB: the unindicted cancer co-conspirator. Trends Cell Biol (2005) 1.70
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A (2010) 1.60
CRTC3 links catecholamine signalling to energy balance. Nature (2010) 1.55
Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab (2005) 1.43
Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature (2012) 1.42
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab (2009) 1.31
Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol (2002) 1.31
Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metab (2006) 1.15
mTOR links incretin signaling to HIF induction in pancreatic beta cells. Proc Natl Acad Sci U S A (2011) 1.14
In vino veritas: a tale of two sirt1s? Cell (2006) 1.10
Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2. Proc Natl Acad Sci U S A (2012) 1.08
Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest (2013) 1.04
PRMT5 modulates the metabolic response to fasting signals. Proc Natl Acad Sci U S A (2013) 0.98
CREB is activated by muscle injury and promotes muscle regeneration. PLoS One (2011) 0.96
Can you hear me now? Regulating transcriptional activators by phosphorylation. Sci STKE (2005) 0.89
Glutamine rich and basic region/leucine zipper (bZIP) domains stabilize cAMP-response element-binding protein (CREB) binding to chromatin. J Biol Chem (2005) 0.88
Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem (2012) 0.83
Diabetes: outfoxing insulin resistance? Nature (2004) 0.82
Fatty acids and insulin resistance: a perfect storm. Mol Cell (2006) 0.82
CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5. Cell Metab (2006) 0.77