PTEN in cancer, metabolism, and aging.

The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma. Cancers (Basel) (2014) 1.10

Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis (2014) 1.03

Metabolic regulation by protein tyrosine phosphatases. J Biomed Res (2014) 0.95

Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging. Aging (Albany NY) (2014) 0.92

Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. Microbes Infect (2013) 0.91

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells. Autophagy (2015) 0.87

Pten regulates development and lactation in the mammary glands of dairy cows. PLoS One (2014) 0.87

Upregulation of micro-ribonucleic acid-128 cooperating with downregulation of PTEN confers metastatic potential and unfavorable prognosis in patients with primary osteosarcoma. Onco Targets Ther (2014) 0.86

Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN. Sci Rep (2015) 0.85

Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes? Int Neurourol J (2016) 0.84

Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol (2015) 0.83

IL-1β, RAGE and FABP4: targeting the dynamic trio in metabolic inflammation and related pathologies. Future Med Chem (2013) 0.81

Tau deletion promotes brain insulin resistance. J Exp Med (2017) 0.78

Impact of acetylation on tumor metabolism. Mol Cell Oncol (2014) 0.78

PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. Oncol Rep (2016) 0.77

Maf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab (2016) 0.77

NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene (2015) 0.77

Brain patterning perturbations following PTEN loss. Front Mol Neurosci (2014) 0.77

Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas. Neuroradiology (2014) 0.76

PTEN gene mutations correlate to poor prognosis in glioma patients: a meta-analysis. Onco Targets Ther (2016) 0.76

Reduced expression levels of PTEN are associated with decreased sensitivity of HCC827 cells to icotinib. Oncol Lett (2017) 0.75

Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification. Front Vet Sci (2017) 0.75

PI3Kα inhibition reduces obesity in mice. Aging (Albany NY) (2016) 0.75

Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxid Redox Signal (2017) 0.75

DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue. Cell Discov (2017) 0.75

Energy, the driving force behind good and ill health. Front Cell Dev Biol (2014) 0.75

Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome. J Proteome Res (2016) 0.75

Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells. Oncotarget (2016) 0.75

Association between PTEN Gene IVS4 polymorphism and risk of cancer: a meta-analysis. PLoS One (2014) 0.75

Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis. PLoS One (2017) 0.75

Hallmarks of cancer: the next generation. Cell (2011) 140.01

AKT/PKB signaling: navigating downstream. Cell (2007) 31.26

Brown adipose tissue: function and physiological significance. Physiol Rev (2004) 23.00

mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 17.36

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature (2009) 13.28

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36

Extending healthy life span--from yeast to humans. Science (2010) 12.12

The genetics of ageing. Nature (2010) 12.08

TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A (1999) 11.38

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80

The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol (2012) 7.32

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (2012) 6.69

Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46

Thermogenic mechanisms in brown fat. Physiol Rev (1984) 5.34

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A (2010) 4.99

PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol (2009) 4.83

Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science (2007) 4.80

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell (2011) 4.49

The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene (2008) 4.39

PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer (2011) 4.37

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab (2008) 4.36

Subtle variations in Pten dose determine cancer susceptibility. Nat Genet (2010) 4.19

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A (2010) 4.18

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol (2011) 4.12

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J (2007) 3.83

PTEN: life as a tumor suppressor. Exp Cell Res (2001) 3.41

PTEN mutations as a cause of constitutive insulin sensitivity and obesity. N Engl J Med (2012) 3.39

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science (2010) 2.93

Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab (2010) 2.90

The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab (2010) 2.80

Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell (2012) 2.39

Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab (2008) 1.83

Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab (2012) 1.81

Interplay between FOXO, TOR, and Akt. Biochim Biophys Acta (2011) 1.47

Three years with adult human brown adipose tissue. Ann N Y Acad Sci (2010) 1.36

Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J Gerontol (1991) 1.33

Forkhead box o as a sensor, mediator, and regulator of redox signaling. Antioxid Redox Signal (2010) 1.26

UCP1: its involvement and utility in obesity. Int J Obes (Lond) (2008) 1.22

Control of glycolysis through regulation of PFK1: old friends and recent additions. Cold Spring Harb Symp Quant Biol (2011) 1.20

PI3 kinase inhibitors in the clinic: an update. Anticancer Res (2012) 1.19

Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure. Curr Opin Clin Nutr Metab Care (2011) 1.11

Perspective: Does brown fat protect against diseases of aging? Ageing Res Rev (2009) 1.07

The role of genetic variants in human longevity. Ageing Res Rev (2010) 1.00

Metabolic control by S6 kinases depends on dietary lipids. PLoS One (2012) 0.82

The hallmarks of aging. Cell (2013) 14.29

Tumour biology: senescence in premalignant tumours. Nature (2005) 10.15

Cellular senescence in cancer and aging. Cell (2007) 9.04

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature (2009) 7.96

The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature (2009) 7.39

Senescence in tumours: evidence from mice and humans. Nat Rev Cancer (2010) 6.34

Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell (2003) 5.17

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev (2007) 5.07

Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell (2009) 4.59

The common biology of cancer and ageing. Nature (2007) 4.28

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17

Delayed ageing through damage protection by the Arf/p53 pathway. Nature (2007) 3.87

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab (2006) 3.22

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun (2010) 2.97

The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer (2006) 2.85

Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell (2008) 2.85

Programmed cell senescence during mammalian embryonic development. Cell (2013) 2.78

The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell (2004) 2.65

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell (2011) 2.56

Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature (2006) 2.51

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet (2011) 2.47

Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature (2013) 2.47

Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells. Cell Cycle (2011) 2.45

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43

Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway. Cell Cycle (2010) 2.41

p53: guardian of the genome and policeman of the oncogenes. Cell Cycle (2007) 2.23

A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity. Cell Cycle (2011) 2.13

SIRT1: recent lessons from mouse models. Nat Rev Cancer (2010) 2.07

Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. Cancer Res (2007) 1.97

miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal. Cell Cycle (2010) 1.95

Tumour biology: Policing of oncogene activity by p53. Nature (2006) 1.86

Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab (2012) 1.81

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev (2004) 1.71

IgA antibodies against β2 glycoprotein I in hemodialysis patients are an independent risk factor for mortality. Kidney Int (2012) 1.59

Nephrin deficiency activates NF-kappaB and promotes glomerular injury. J Am Soc Nephrol (2009) 1.57

Oncogenicity of the developmental transcription factor Sox9. Cancer Res (2012) 1.55

Usefulness of plasma cardiotrophin-1 in assessment of left ventricular hypertrophy regression in hypertensive patients. J Hypertens (2005) 1.53

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 1.51

Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs. Cell Cycle (2008) 1.50

Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci U S A (2010) 1.48

Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence. PLoS One (2009) 1.48

SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol (2010) 1.48

Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Cancer Res (2007) 1.45

WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res (2009) 1.39

The Arf/p53 pathway in cancer and aging. Cancer Res (2008) 1.37

Tumour-suppression activity of the proapoptotic regulator Par4. EMBO Rep (2005) 1.36

Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 1.31

Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep (2006) 1.30

Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO J (2008) 1.25

Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38. EMBO Rep (2003) 1.24

p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation. Cell Stem Cell (2012) 1.23

Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS One (2009) 1.22

Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation. Mol Cell Biol (2009) 1.20

p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis. J Am Coll Cardiol (2010) 1.18

The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine. Oncogene (2004) 1.18

Resistance to viral infection of super p53 mice. Oncogene (2005) 1.17

Dietary restriction: standing up for sirtuins. Science (2010) 1.17

Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1). Oncogene (2002) 1.15

Impact of Sirt1 on mammalian aging. Aging (Albany NY) (2010) 1.13

Anti-aging activity of the Ink4/Arf locus. Aging Cell (2009) 1.13

Cellular senescence limits regenerative capacity and allograft survival. J Am Soc Nephrol (2012) 1.11

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours. Sci Rep (2012) 1.10

The senescent side of tumor suppression. Cell Cycle (2005) 1.08

Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. EMBO J (2004) 1.07

In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities. PLoS One (2012) 1.06

Dissecting the role of mTOR complexes in cellular senescence. Cell Cycle (2012) 1.05

Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer. Cancer Res (2013) 1.04

Inactivation of imprinted genes induced by cellular stress and tumorigenesis. Cancer Res (2005) 1.04

Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma. Proc Natl Acad Sci U S A (2009) 1.02

A high-throughput loss-of-function screening identifies novel p53 regulators. Cell Cycle (2006) 1.02

Antiviral action of the tumor suppressor ARF. EMBO J (2006) 1.02

Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J (2003) 0.99

Genomic instability in iPS: time for a break. EMBO J (2011) 0.99

A new mechanism of inactivation of the INK4/ARF locus. Cell Cycle (2006) 0.98

p73beta-Mediated apoptosis requires p57kip2 induction and IEX-1 inhibition. Cancer Res (2005) 0.96

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling. Hepatology (2014) 0.96

Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. Exp Cell Res (2002) 0.95

NOTCH pathway inactivation promotes bladder cancer progression. J Clin Invest (2015) 0.95

Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency. Aging Cell (2011) 0.95

Shifting senescence into quiescence by turning up p53. Cell Cycle (2010) 0.93

Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis. Cardiovasc Res (2007) 0.92

Regulation of the INK4a/ARF locus by histone deacetylase inhibitors. J Biol Chem (2005) 0.92

Is plasma cardiotrophin-1 a marker of hypertensive heart disease? J Hypertens (2005) 0.91

Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells. Cell Cycle (2012) 0.91

The PTEN/NRF2 axis promotes human carcinogenesis. Antioxid Redox Signal (2014) 0.90

Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A. J Biol Chem (2002) 0.90

Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1). Eur J Immunol (2009) 0.90

SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PLoS One (2010) 0.89

Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge. Brain (2013) 0.89

Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89

Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. Mol Cell Biol (2005) 0.88

Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2. Oncogene (2002) 0.88

Specific contribution of p19(ARF) to nitric oxide-dependent apoptosis. J Immunol (2006) 0.88

A strategy to study tyrosinase transgenes in mouse melanocytes. BMC Cell Biol (2005) 0.88

Genomic profiling of circulating plasma RNA for the analysis of cancer. Clin Chem (2007) 0.88

The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers. Hepatology (2002) 0.88

MSK2 inhibits p53 activity in the absence of stress. Sci Signal (2009) 0.87

Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice. Oncogene (2004) 0.86

Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress. J Biol Chem (2007) 0.86