Published in Nat Med on December 01, 2003
Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model. PLoS One (2015) 0.81
Immune-mediated and autoimmune myocarditis: clinical presentation, diagnosis and management. Heart Fail Rev (2013) 0.80
Agonist-like autoantibodies against calcium channel in patients with dilated cardiomyopathy. Heart Vessels (2011) 0.80
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med (2004) 4.06
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA (2008) 3.64
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev (2007) 3.41
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res (2008) 3.26
Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23
Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science (2002) 3.13
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab (2013) 3.01
Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol (2002) 2.97
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol (2006) 2.90
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet (2004) 2.86
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res (2004) 2.72
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res (2002) 2.69
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics (2005) 2.61
Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A (2002) 2.56
Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC Syst Biol (2008) 2.51
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology (2002) 2.45
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest (2011) 2.37
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res (2002) 2.28
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood (2009) 2.26
A treasure trove for lipoprotein biology. Nat Genet (2008) 2.25
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest (2007) 2.24
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab (2013) 2.17
Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A (2007) 2.13
Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J (2008) 2.09
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07
The allelic structure of common disease. Hum Mol Genet (2002) 2.03
Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. J Neurochem (2006) 2.00
Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation (2002) 1.96
Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation (2003) 1.90
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells (2008) 1.83
Positional cloning of the combined hyperlipidemia gene Hyplip1. Nat Genet (2001) 1.82
Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol (2008) 1.81
Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Circ Res (2007) 1.81
Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett (2005) 1.81
Genomic analysis of metabolic pathway gene expression in mice. Genome Biol (2005) 1.79
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. Circ Cardiovasc Genet (2011) 1.78
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes (2012) 1.78
Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res (2010) 1.75
Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A (2010) 1.74
Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol (2009) 1.72
High-resolution mapping of gene expression using association in an outbred mouse stock. PLoS Genet (2008) 1.72
CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. J Immunol (2009) 1.70
Systems genetics analysis of gene-by-environment interactions in human cells. Am J Hum Genet (2010) 1.69
Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice. Mamm Genome (2003) 1.68
Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet (2011) 1.68
Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals. J Biol Chem (2004) 1.66
Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation (2012) 1.60
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition. J Lipid Res (2004) 1.58
Regulation of the mammalian cell cycle: a model of the G1-to-S transition. Am J Physiol Cell Physiol (2002) 1.58
Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell (2012) 1.57
Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics (2010) 1.55
Understanding the sexome: measuring and reporting sex differences in gene systems. Endocrinology (2012) 1.55
Dynamics of the cell cycle: checkpoints, sizers, and timers. Biophys J (2003) 1.47
Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome Biol (2007) 1.46
Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1. Arterioscler Thromb Vasc Biol (2005) 1.46
Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. Am J Physiol Lung Cell Mol Physiol (2006) 1.45
Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia. Circ Res (2003) 1.44
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol (2008) 1.44
Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome (2012) 1.43
Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. Proc Natl Acad Sci U S A (2004) 1.42
Regulation of RNA polymerase III transcription during hypertrophic growth. EMBO J (2006) 1.42
Copy number variation influences gene expression and metabolic traits in mice. Hum Mol Genet (2009) 1.42
Role of phospholipid oxidation products in atherosclerosis. Circ Res (2012) 1.41
Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nat Genet (2008) 1.41
Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure. J Am Coll Cardiol (2004) 1.41
Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway. EMBO J (2006) 1.41
Expression of human paraoxonase (PON1) during development. Pharmacogenetics (2003) 1.40
Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions. Arterioscler Thromb Vasc Biol (2006) 1.39
Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice. Arterioscler Thromb Vasc Biol (2002) 1.39
Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol (2013) 1.38
Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. J Neurosci (2011) 1.36
Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. Circ Res (2011) 1.36
FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol (2006) 1.35
Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res (2007) 1.34
An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. J Bone Miner Res (2009) 1.33
Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice. Mamm Genome (2006) 1.33
Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2. J Biol Chem (2006) 1.32
Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up. Circulation (2005) 1.32
NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arterioscler Thromb Vasc Biol (2010) 1.32
Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Syst Biol (2011) 1.30