Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.

PubWeight™: 7.21‹?› | Rank: Top 1%

🔗 View Article (PMID 17123592)

Published in Cell on November 22, 2006

Authors

Alessandra Moretti1, Leslie Caron, Atsushi Nakano, Jason T Lam, Alexandra Bernshausen, Yinhong Chen, Yibing Qyang, Lei Bu, Mika Sasaki, Silvia Martin-Puig, Yunfu Sun, Sylvia M Evans, Karl-Ludwig Laugwitz, Kenneth R Chien

Author Affiliations

1: Massachusetts General Hospital - Cardiovascular Research Center, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA.

Articles citing this

(truncated to the top 100)

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature (2009) 10.26

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03

Heart regeneration. Nature (2011) 5.91

Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res (2010) 5.47

De novo cardiomyocytes from within the activated adult heart after injury. Nature (2011) 5.17

Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68

Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood (2008) 3.13

Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology. Circ Res (2011) 2.76

Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (2009) 2.60

Origins and fates of cardiovascular progenitor cells. Cell (2008) 2.55

Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview. Circ Res (2012) 2.51

Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell (2008) 2.46

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci (2008) 2.36

c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci U S A (2012) 2.35

Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol (2008) 2.34

Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation. J Mol Cell Cardiol (2008) 2.16

Vessel and blood specification override cardiac potential in anterior mesoderm. Dev Cell (2007) 2.16

Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J Cell Mol Med (2009) 2.15

Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest (2007) 2.12

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol (2013) 2.11

Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol (2008) 2.08

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest (2010) 2.06

c-kit expression identifies cardiovascular precursors in the neonatal heart. Proc Natl Acad Sci U S A (2009) 2.06

Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell (2012) 2.06

Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS One (2008) 1.99

Assessment and optimization of cell engraftment after transplantation into the heart. Circ Res (2010) 1.90

Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol (2008) 1.88

Distinct origins and genetic programs of head muscle satellite cells. Dev Cell (2009) 1.86

Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell (2013) 1.86

Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells (2008) 1.83

Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. J Clin Invest (2008) 1.80

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.80

Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. J Am Coll Cardiol (2014) 1.77

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol (2009) 1.73

Controlled differentiation of stem cells. Adv Drug Deliv Rev (2007) 1.72

Induced pluripotent stem cells: developmental biology to regenerative medicine. Nat Rev Cardiol (2010) 1.71

Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. Proc Natl Acad Sci U S A (2009) 1.68

Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity (2013) 1.62

Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57

Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. J Cell Biol (2011) 1.56

FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circ Res (2011) 1.52

An emerging consensus on cardiac regeneration. Nat Med (2014) 1.50

Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest (2009) 1.50

Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. Science (2014) 1.49

Vascular smooth muscle progenitor cells: building and repairing blood vessels. Circ Res (2011) 1.46

Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A (2007) 1.46

CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res (2012) 1.46

Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell (2012) 1.43

Transcriptional pathways in second heart field development. Semin Cell Dev Biol (2007) 1.43

Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochem Biophys Res Commun (2008) 1.40

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest (2011) 1.39

Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway. Dev Dyn (2008) 1.38

Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol (2013) 1.38

Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res (2009) 1.37

Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun (2013) 1.36

Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One (2011) 1.33

Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell function. Exp Hematol (2010) 1.33

Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function. Biomaterials (2011) 1.30

"String theory" of c-kit(pos) cardiac cells: a new paradigm regarding the nature of these cells that may reconcile apparently discrepant results. Circ Res (2015) 1.29

Cardiogenic small molecules that enhance myocardial repair by stem cells. Proc Natl Acad Sci U S A (2008) 1.28

Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res (2013) 1.26

Bioengineering heart muscle: a paradigm for regenerative medicine. Annu Rev Biomed Eng (2011) 1.26

Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Nat Biotechnol (2015) 1.22

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors. Cell Stem Cell (2016) 1.20

Notch signaling respecifies the hemangioblast to a cardiac fate. Nat Biotechnol (2008) 1.19

Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest (2009) 1.19

Islet1 derivatives in the heart are of both neural crest and second heart field origin. Circ Res (2012) 1.18

ER71 directs mesodermal fate decisions during embryogenesis. Development (2011) 1.18

From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration. J Cell Biol (2009) 1.17

Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function. Development (2011) 1.17

Stem cells and the vasculature. Nat Med (2011) 1.17

Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ Res (2011) 1.16

A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nat Cell Biol (2013) 1.16

Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech (2009) 1.16

Human embryonic stem cells and cardiac repair. Transplant Rev (Orlando) (2008) 1.15

High-throughput analysis of signals regulating stem cell fate and function. Curr Opin Chem Biol (2007) 1.15

Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. PLoS One (2010) 1.15

Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. Development (2008) 1.14

Inhibition of the SDF-1/CXCR4 axis attenuates neonatal hypoxia-induced pulmonary hypertension. Circ Res (2009) 1.14

ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood (2012) 1.14

The heart endocardium is derived from vascular endothelial progenitors. Development (2011) 1.13

Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Transl Med (2013) 1.13

Stem cells in the heart: what's the buzz all about?--Part 1: preclinical considerations. Heart Rhythm (2008) 1.11

Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife (2014) 1.11

Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue. Proc Natl Acad Sci U S A (2009) 1.10

Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges. Circ Res (2014) 1.09

Identification and characterization of a novel multipotent sub-population of Sca-1⁺ cardiac progenitor cells for myocardial regeneration. PLoS One (2011) 1.09

HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science (2015) 1.09

Cardiac differentiation of pluripotent stem cells. Stem Cells Int (2011) 1.09

Gene regulatory networks in cardiac conduction system development. Circ Res (2012) 1.09

Concise review: heart regeneration and the role of cardiac stem cells. Stem Cells Transl Med (2013) 1.08

Understanding diabetic teratogenesis: where are we now and where are we going? Birth Defects Res A Clin Mol Teratol (2010) 1.08

BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway. J Cell Biochem (2010) 1.08

Functional cardiac tissue engineering. Regen Med (2012) 1.07

Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol (2013) 1.07

Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development (2010) 1.07

Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis. Cardiovasc Res (2011) 1.06

THY-1 receptor expression differentiates cardiosphere-derived cells with divergent cardiogenic differentiation potential. Stem Cell Reports (2014) 1.06

Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. Cell Cycle (2008) 1.05

Development of the endocardium. Pediatr Cardiol (2010) 1.04

Articles by these authors

Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol (2007) 14.48

Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44

Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med (2010) 9.19

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet (2011) 6.89

Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19

A myocardial lineage derives from Tbx18 epicardial cells. Nature (2008) 6.15

Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72

Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68

Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature (2006) 4.35

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A (2012) 3.90

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol (2010) 3.70

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med (2004) 3.63

Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature (2002) 3.60

The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54

ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med (2002) 3.36

Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A (2005) 3.13

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A (2002) 3.13

Paclitaxel-eluting balloons, paclitaxel-eluting stents, and balloon angioplasty in patients with restenosis after implantation of a drug-eluting stent (ISAR-DESIRE 3): a randomised, open-label trial. Lancet (2012) 3.12

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J (2003) 3.02

Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol (2006) 2.81

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development (2002) 2.71

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nat Cell Biol (2003) 2.71

Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell (2008) 2.68

A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells. Cell Stem Cell (2010) 2.65

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell (2004) 2.64

Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (2009) 2.60

Origins and fates of cardiovascular progenitor cells. Cell (2008) 2.55

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50

Identification of cardiac-specific myosin light chain kinase. Circ Res (2008) 2.45

Islet1 cardiovascular progenitors: a single source for heart lineages? Development (2008) 2.39

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell (2013) 2.38

Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med (2002) 2.37

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci (2008) 2.36

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A (2002) 2.32

Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention. Circulation (2012) 2.32

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol (2004) 2.12

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol (2013) 2.11

Drug-eluting versus bare-metal stents in saphenous vein graft lesions (ISAR-CABG): a randomised controlled superiority trial. Lancet (2011) 2.10

The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol (2006) 2.06

Isl1Cre reveals a common Bmp pathway in heart and limb development. Development (2006) 2.04

The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes (2005) 1.96

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol (2004) 1.95

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol Med (2012) 1.93

Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J Mol Cell Cardiol (2011) 1.93

Randomized trial of paclitaxel- versus sirolimus-eluting stents for treatment of coronary restenosis in sirolimus-eluting stents: the ISAR-DESIRE 2 (Intracoronary Stenting and Angiographic Results: Drug Eluting Stents for In-Stent Restenosis 2) study. J Am Coll Cardiol (2010) 1.93

Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell (2009) 1.92

T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development (2005) 1.92

Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Dev Dyn (2002) 1.87

Distinct origins and genetic programs of head muscle satellite cells. Dev Cell (2009) 1.86

Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res (2010) 1.85

Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82

Randomized, non-inferiority trial of three limus agent-eluting stents with different polymer coatings: the Intracoronary Stenting and Angiographic Results: Test Efficacy of 3 Limus-Eluting Stents (ISAR-TEST-4) Trial. Eur Heart J (2009) 1.81

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.80

Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol (2004) 1.79

Stem cells: lost in translation. Nature (2004) 1.79

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest (2004) 1.79

Towards regenerative therapy for cardiac disease. Lancet (2012) 1.75

Paclitaxel- versus sirolimus-eluting stents for unprotected left main coronary artery disease. J Am Coll Cardiol (2009) 1.73

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol (2009) 1.72

Prognostic value of sensitive troponin T in patients with stable and unstable angina and undetectable conventional troponin. Am Heart J (2011) 1.70

Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun (2004) 1.69

Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation (2012) 1.69

Antagonism between retinoic acid and fibroblast growth factor signaling during limb development. Cell Rep (2013) 1.65

Development of the cardiac conduction system as delineated by minK-lacZ. J Cardiovasc Electrophysiol (2003) 1.65

Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity (2013) 1.62

Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol (2007) 1.60

Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet (2007) 1.59

Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng (2003) 1.58

Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation (2007) 1.57

ISAR-REACT 3A: a study of reduced dose of unfractionated heparin in biomarker negative patients undergoing percutaneous coronary intervention. Eur Heart J (2010) 1.56

Targeted conditional gene knockout in human embryonic stem cells. Cell Res (2010) 1.53

The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J Biol Chem (2003) 1.50

Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. EMBO J (2007) 1.48

One-year outcomes with abciximab and unfractionated heparin versus bivalirudin during percutaneous coronary interventions in patients with non-ST-segment elevation myocardial infarction: updated results from the ISAR-REACT 4 trial. EuroIntervention (2013) 1.47

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest (2011) 1.46

Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46