Published in Nucleic Acids Res on November 03, 2008
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
PARP inhibition: PARP1 and beyond. Nat Rev Cancer (2010) 6.70
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol (2012) 3.45
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat Struct Mol Biol (2009) 3.26
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci U S A (2011) 2.47
Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol Cell (2011) 2.33
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J (2010) 2.25
Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol (2009) 2.24
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal (2011) 1.73
The role of PARP in DNA repair and its therapeutic exploitation. Br J Cancer (2011) 1.71
Dual roles of PARP-1 promote cancer growth and progression. Cancer Discov (2012) 1.63
Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity. J Biol Chem (2011) 1.60
Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. Cell Cycle (2012) 1.50
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Proc Natl Acad Sci U S A (2011) 1.42
Poly (ADP-ribose) polymerase inhibitors: recent advances and future development. J Clin Oncol (2015) 1.41
PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR. Nat Commun (2017) 1.38
Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal (2011) 1.37
Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. Nat Med (2011) 1.36
Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. Genes Dev (2012) 1.33
Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes. J Biol Chem (2011) 1.29
PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks. Nucleic Acids Res (2012) 1.28
Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress. Nucleic Acids Res (2012) 1.25
Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. Cancer Res (2010) 1.22
Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell (2009) 1.20
PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1. J Cell Biol (2012) 1.18
Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases. J Am Chem Soc (2010) 1.18
Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells. FASEB J (2009) 1.17
Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry. Proteome Sci (2010) 1.14
Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response. Proc Natl Acad Sci U S A (2010) 1.14
Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair. J Biol Chem (2012) 1.13
Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol (2014) 1.12
New functions for an ancient domain. Nat Struct Mol Biol (2009) 1.12
Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Mol Aspects Med (2012) 1.11
The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells. Front Oncol (2013) 1.10
The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. J Biol Chem (2013) 1.07
Poly-ADP-ribose polymerase: machinery for nuclear processes. Mol Aspects Med (2013) 1.06
Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer. Cancer Discov (2015) 1.06
Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation. Nat Rev Mol Cell Biol (2013) 1.02
ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion. Cell Rep (2014) 1.00
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. Aging (Albany NY) (2010) 0.98
The Promise of Proteomics for the Study of ADP-Ribosylation. Mol Cell (2015) 0.98
Targeting poly(ADP-ribose) polymerase activity for cancer therapy. Cell Mol Life Sci (2010) 0.96
PARPs and ADP-Ribosylation: 50 Years … and Counting. Mol Cell (2015) 0.95
Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm. RNA Biol (2012) 0.94
Poly(ADP-ribose): an organizer of cellular architecture. J Cell Biol (2014) 0.93
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol Reprod (2011) 0.93
Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. PLoS One (2012) 0.92
PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining. Mol Cell (2016) 0.91
Functional Aspects of PARP1 in DNA Repair and Transcription. Biomolecules (2012) 0.91
High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. Biochemistry (2010) 0.90
PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent. PLoS One (2012) 0.90
Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation. Oxid Med Cell Longev (2012) 0.90
The emerging role of lysine demethylases in DNA damage response: dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites. Cell Cycle (2015) 0.89
ATM alters the otherwise robust chromatin mobility at sites of DNA double-strand breaks (DSBs) in human cells. PLoS One (2014) 0.89
A wheat SIMILAR TO RCD-ONE gene enhances seedling growth and abiotic stress resistance by modulating redox homeostasis and maintaining genomic integrity. Plant Cell (2014) 0.88
Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation. PLoS One (2012) 0.87
Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res (2015) 0.87
Molecular Insights into Poly(ADP-ribose) Recognition and Processing. Biomolecules (2012) 0.86
Regulation of myofibroblast differentiation by poly(ADP-ribose) polymerase 1. Am J Pathol (2013) 0.86
A Functional Proteomics Perspective of DBC1 as a Regulator of Transcription. J Proteomics Bioinform (2013) 0.86
Perinatal asphyxia: CNS development and deficits with delayed onset. Front Neurosci (2014) 0.85
Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins. Int J Mol Sci (2013) 0.85
Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking. Front Pharmacol (2012) 0.85
Site-specific noncovalent interaction of the biopolymer poly(ADP-ribose) with the Werner syndrome protein regulates protein functions. ACS Chem Biol (2012) 0.85
ARTD1 (PARP1) activation and NAD(+) in DNA repair and cell death. DNA Repair (Amst) (2014) 0.84
Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function. FEBS J (2014) 0.84
Inhibition of DNA damage repair by artificial activation of PARP with siDNA. Nucleic Acids Res (2013) 0.84
Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase. Cell Adh Migr (2012) 0.84
A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase. J Biol Chem (2014) 0.82
Proteomics approaches to identify mono-(ADP-ribosyl)ated and poly(ADP-ribosyl)ated proteins. Proteomics (2014) 0.82
Enzymatic synthesis and structural characterization of 13C, 15N-poly(ADP-ribose). J Am Chem Soc (2009) 0.81
RNA Regulation by Poly(ADP-Ribose) Polymerases. Mol Cell (2015) 0.81
Role of Biomarkers in the Development of PARP Inhibitors. Biomark Cancer (2016) 0.80
X-ray repair cross complementing protein 1 in base excision repair. Int J Mol Sci (2012) 0.80
Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins. Methods Mol Biol (2011) 0.80
Helicobacter pylori activation of PARP-1: usurping a versatile regulator of host cellular health. Gut Microbes (2011) 0.79
Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress. Nat Chem Biol (2017) 0.79
The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation. Cell Mol Life Sci (2011) 0.79
PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Rep (2016) 0.79
Single cell resolution in vivo imaging of DNA damage following PARP inhibition. Sci Rep (2015) 0.79
Arabidopsis PARG1 is the key factor promoting cell survival among the enzymes regulating post-translational poly(ADP-ribosyl)ation. Sci Rep (2015) 0.79
Trial watch - inhibiting PARP enzymes for anticancer therapy. Mol Cell Oncol (2015) 0.79
Ovarian Cancers Harbour Defects in Non-Homologous End Joining Resulting in Resistance to Rucaparib. Clin Cancer Res (2016) 0.78
Zinc finger transcription factor CASZ1 interacts with histones, DNA repair proteins and recruits NuRD complex to regulate gene transcription. Oncotarget (2015) 0.78
Chemical reporters for exploring ADP-ribosylation and AMPylation at the host-pathogen interface. Curr Opin Chem Biol (2014) 0.78
ADP-ribosylation: activation, recognition, and removal. Mol Cells (2014) 0.78
Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation. Elife (2016) 0.78
Poly(ADP-ribose) Polymerase 1 Modulates Interaction of the Nucleotide Excision Repair Factor XPC-RAD23B with DNA via Poly(ADP-ribosyl)ation. J Biol Chem (2015) 0.78
A Novel Role of Chromodomain Protein CBX8 in DNA Damage Response. J Biol Chem (2016) 0.78
Poly (ADP-ribose) in the pathogenesis of Parkinson's disease. BMB Rep (2014) 0.77
Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. DNA Repair (Amst) (2015) 0.77
Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. PLoS Biol (2016) 0.77
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1. Oncotarget (2015) 0.77
Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clin Exp Gastroenterol (2011) 0.77
Application of proteomics to cerebrovascular disease. Electrophoresis (2012) 0.77
Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers. J Exp Clin Cancer Res (2014) 0.76
Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells. Anat Cell Biol (2016) 0.76
High resolution two-dimensional electrophoresis of proteins. J Biol Chem (1975) 133.45
Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76
Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal Chem (2002) 35.30
Pfam: clans, web tools and services. Nucleic Acids Res (2006) 34.83
A statistical model for identifying proteins by tandem mass spectrometry. Anal Chem (2003) 29.58
BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics (2005) 24.04
GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol (2003) 22.63
Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol (2005) 14.42
New developments in the InterPro database. Nucleic Acids Res (2007) 12.49
NPS@: network protein sequence analysis. Trends Biochem Sci (2000) 9.68
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Regulation of DNA double-strand break repair pathway choice. Cell Res (2008) 6.19
At the heart of the chromosome: SMC proteins in action. Nat Rev Mol Cell Biol (2006) 5.45
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev (2008) 4.69
The macro domain is an ADP-ribose binding module. EMBO J (2005) 4.07
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res (2003) 3.85
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A (2006) 3.47
Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. EMBO J (2000) 3.46
Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A (2006) 3.41
Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J Biol Chem (2000) 3.30
Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res (2007) 3.20
PARP goes transcription. Cell (2003) 3.16
Poly(ADP-ribose) is required for spindle assembly and structure. Nature (2004) 3.11
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol (2005) 2.70
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem (2007) 2.62
Improved silver staining protocols for high sensitivity protein identification using matrix-assisted laser desorption/ionization-time of flight analysis. Proteomics (2001) 2.60
In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J (2004) 2.30
The DEAD-box protein Dbp5 controls mRNA export by triggering specific RNA:protein remodeling events. Mol Cell (2007) 2.17
The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression. Biochim Biophys Acta (2005) 2.15
The role of poly(ADP-ribose) in the DNA damage signaling network. Biochem Cell Biol (2005) 2.14
PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol (2003) 2.08
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell (2008) 1.99
DNA mismatch repair and mutation avoidance pathways. J Cell Physiol (2002) 1.96
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93
Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. J Biol Chem (2000) 1.93
Purification, identification, and characterization of an osmotic response element binding protein. Biochem Biophys Res Commun (2000) 1.84
The Prohibitins: emerging roles in diverse functions. J Cell Mol Med (2006) 1.81
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J Biol Chem (2007) 1.80
Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J (2002) 1.79
Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc Natl Acad Sci U S A (2002) 1.76
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length. Nucleic Acids Res (2007) 1.73
Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains. J Virol (2006) 1.70
Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase. J Biol Chem (1998) 1.67
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Curr Opin Cell Biol (2003) 1.65
Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair. Mol Cell (2006) 1.54
Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling. Oncogene (2005) 1.51
Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor. J Biol Chem (2004) 1.46
A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins. Biochem J (2003) 1.45
Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei. J Biol Chem (1968) 1.45
Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res (2002) 1.43
Poly(ADP-ribosyl)ated chromatin domains: access granted. J Cell Sci (2004) 1.42
APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. Mol Cell Biol (2008) 1.41
DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. Mol Cell Biol (2008) 1.40
B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. J Biol Chem (2005) 1.38
DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Res (2004) 1.31
Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo. Anal Biochem (1995) 1.28
Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated. J Biol Chem (2002) 1.27
Bid-induced release of AIF from mitochondria causes immediate neuronal cell death. Cell Death Differ (2008) 1.27
Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury. J Neurochem (2007) 1.25
Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase. Biochem J (2007) 1.21
Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation. Nucleic Acids Res (2006) 1.18
Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc. Hum Mol Genet (2002) 1.17
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation. Int J Biochem Cell Biol (2008) 1.16
DDB complexities. DNA Repair (Amst) (2003) 1.16
Mode of action of poly(ADP-ribose) glycohydrolase. Biochim Biophys Acta (1994) 1.11
Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1. BMC Mol Biol (2007) 1.10
Regulation of the expression or recruitment of components of the DNA synthesome by poly(ADP-ribose) polymerase. Biochemistry (1998) 1.10
Poly(ADP-ribose) polymerase is a zinc metalloenzyme. Eur J Biochem (1984) 1.10
Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1. Am J Physiol Renal Physiol (2006) 1.09
The MCM helicase: linking checkpoints to the replication fork. Biochem Soc Trans (2008) 1.08
Poly(ADP-ribose) binds to the splicing factor ASF/SF2 and regulates its phosphorylation by DNA topoisomerase I. J Biol Chem (2008) 1.08
Rapid assay of poly(ADP-ribose) glycohydrolase. Biochem Cell Biol (1987) 1.07
Targeting of histone tails by poly(ADP-ribose). J Biol Chem (1993) 1.06
Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1. J Virol (2005) 1.06
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage. Proc Natl Acad Sci U S A (2005) 1.05
The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death. Cell Mol Life Sci (2008) 1.02
The modulation of inter-organelle cross-talk to control apoptosis. Med Chem (2006) 0.95
Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-ribose) polymerase-1: possible targets for drug-based therapies. Subcell Biochem (2007) 0.94
Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles. Biochem J (2005) 0.89
Haploinsufficiency of poly(ADP-ribose) polymerase-1-mediated poly(ADP-ribosyl)ation for centrosome duplication. Biochem Biophys Res Commun (2007) 0.89
Adenosine diphosphate ribosyltransferase and protein acceptors associated with cytoplasmic free messenger ribonucleoprotein particles. Biochimie (1984) 0.89
Immunoelectron microscopical distribution of poly(ADP-ribose)polymerase in the mammalian cell nucleus. Exp Cell Res (1988) 0.89
Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression. Infect Agent Cancer (2007) 0.86
Purification and characterization of an (ADP-ribose)n glycohydrolase from human erythrocytes. Eur J Biochem (1990) 0.86
Endogenous polymers of ADP-ribose are associated with the nuclear matrix. J Biol Chem (1987) 0.85
Chromatin architecture and functions: the role(s) of poly(ADP-RIBOSE) polymerase and poly(ADPribosyl)ation of nuclear proteins. Biochem Cell Biol (2005) 0.85
Cytoplasmic poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase in AEV-transformed chicken erythroblasts. Mol Biol Rep (1988) 0.81
Cytoplasmic poly(ADP-ribose)polymerase from mouse plasmacytoma free messenger ribonucleoprotein particles: purification and characterization. Biochem Biophys Res Commun (1993) 0.79
Cytoplasmic poly(ADP-ribose) polymerase associated with free messenger ribonucleoprotein particles in rat brain. J Neurochem (1988) 0.78
[Phosphorylation of cytoplasmic poly (ADP-ribose) polymerase linked to free ribonucleoprotein particles by an associated protein kinase C]. C R Acad Sci III (1989) 0.77
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (2002) 8.41
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
Molecular pathways of neurodegeneration in Parkinson's disease. Science (2003) 7.55
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A (2005) 6.98
PARP inhibition: PARP1 and beyond. Nat Rev Cancer (2010) 6.70
Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci (2005) 5.93
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet (2011) 5.58
Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci (2006) 5.32
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum Mol Genet (2007) 4.99
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science (2004) 4.97
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med (2010) 4.45
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell (2011) 4.00
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. J Neurosci (2005) 3.92
Genetic animal models of Parkinson's disease. Neuron (2010) 3.86
Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann Neurol (2006) 3.72
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A (2006) 3.47
Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A (2006) 3.41
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A (2002) 3.33
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet (2004) 3.12
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A (2005) 3.00
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A (2007) 2.87
Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest (2006) 2.86
A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron (2007) 2.83
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum Mol Genet (2005) 2.72
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem (2007) 2.62
Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J Biol Chem (2002) 2.56
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol (2008) 2.56
Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene (2004) 2.52
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. J Neurosci (2009) 2.47
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci U S A (2005) 2.45
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum Mol Genet (2007) 2.44
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J (2012) 2.34
Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet (2011) 2.29
Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. J Biol Chem (2003) 2.26
Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol (2009) 2.24
Understanding microRNAs in neurodegeneration. Nat Rev Neurosci (2009) 2.22
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol (2012) 2.20
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proc Natl Acad Sci U S A (2004) 2.20
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci (2004) 2.17
Using FRAP and mathematical modeling to determine the in vivo kinetics of nuclear proteins. Methods (2003) 2.15
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells. Mol Biol Cell (2005) 2.13
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin. Hum Mol Genet (2005) 2.11
PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol (2003) 2.08
Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J Neurosci (2005) 2.06
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Hum Mol Genet (2004) 2.02
Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci U S A (2004) 1.99
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med (2012) 1.99
Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. J Biol Chem (2008) 1.99
Nucleoplasmic beta-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations. J Cell Biol (2006) 1.98
Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases? Neurobiol Aging (2005) 1.96
Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol Sci (2004) 1.95
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (2011) 1.93
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet (2005) 1.92