Published in Nat Rev Genet on March 09, 2011
Expand and regularize federal funding for human pluripotent stem cell research. J Policy Anal Manage (2012) 2.37
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol Med (2012) 1.93
Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol (2013) 1.91
Revolutionizing medicine in the 21st century through systems approaches. Biotechnol J (2012) 1.60
Diseases in a dish: modeling human genetic disorders using induced pluripotent cells. Nat Med (2011) 1.50
Genetic and epigenetic stability of human pluripotent stem cells. Nat Rev Genet (2012) 1.38
Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. Sci Rep (2017) 1.38
Human pluripotent stem cells: applications and challenges in neurological diseases. Front Physiol (2012) 1.31
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23
Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles. Mol Ther (2012) 1.07
Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol (2015) 1.04
Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination. PLoS One (2011) 1.00
X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. Front Psychiatry (2012) 0.97
Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol (2013) 0.96
Discovery of functional gene variants associated with human longevity: opportunities and challenges. J Gerontol A Biol Sci Med Sci (2011) 0.96
Human amniotic fluid stem cells as a model for functional studies of genes involved in human genetic diseases or oncogenesis. Oncotarget (2011) 0.92
Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models. PLoS One (2013) 0.90
Concise review: modeling central nervous system diseases using induced pluripotent stem cells. Stem Cells Transl Med (2014) 0.87
Patient-derived stem cells: pathways to drug discovery for brain diseases. Front Cell Neurosci (2013) 0.87
Derivation of Ethnically Diverse Human Induced Pluripotent Stem Cell Lines. Sci Rep (2015) 0.86
Modeling physiological and pathological human neurogenesis in the dish. Front Neurosci (2014) 0.86
Evolution of iPSC disease models. Protein Cell (2012) 0.85
Generating human hematopoietic stem cells in vitro -exploring endothelial to hematopoietic transition as a portal for stemness acquisition. FEBS Lett (2016) 0.84
The decision on the "optimal" human pluripotent stem cell. Stem Cells Transl Med (2014) 0.83
A gutsy task: generating intestinal tissue from human pluripotent stem cells. Dig Dis Sci (2013) 0.83
A platform for rapid generation of single and multiplexed reporters in human iPSC lines. Sci Rep (2015) 0.82
The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells. Hum Mol Genet (2013) 0.82
Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges. Genome Med (2011) 0.82
Friedreich ataxia: new pathways. J Child Neurol (2012) 0.82
Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients. EMBO Mol Med (2015) 0.82
Recent technological updates and clinical applications of induced pluripotent stem cells. Korean J Intern Med (2014) 0.81
Dynamic status of REST in the mouse ESC pluripotency network. PLoS One (2012) 0.80
Induced pluripotency and direct reprogramming: a new window for treatment of neurodegenerative diseases. Protein Cell (2013) 0.80
Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Transl Med (2013) 0.80
Transcriptomic analysis of pluripotent stem cells: insights into health and disease. Genome Med (2011) 0.78
Cellular reprogramming for understanding and treating human disease. Front Cell Dev Biol (2014) 0.78
Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes. Brain Res (2015) 0.78
Amniotic fluid stem cell-based models to study the effects of gene mutations and toxicants on male germ cell formation. Asian J Androl (2012) 0.78
Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. Dis Model Mech (2017) 0.77
Amniotic fluid stem cells: future perspectives. Stem Cells Int (2012) 0.76
Genetics of resistant hypertension: a novel pharmacogenomics phenotype. Curr Hypertens Rep (2015) 0.76
Vascular Smooth Muscle Cells From Hypertensive Patient-Derived Induced Pluripotent Stem Cells to Advance Hypertension Pharmacogenomics. Stem Cells Transl Med (2015) 0.76
Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem Cells. J Clin Med (2015) 0.76
Distinct and Shared Determinants of Cardiomyocyte Contractility in Multi-Lineage Competent Ethnically Diverse Human iPSCs. Sci Rep (2016) 0.75
Amniotic Fluid Stem Cells: A Novel Source for Modeling of Human Genetic Diseases. Int J Mol Sci (2016) 0.75
Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development. Biol Sex Differ (2016) 0.75
Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells. Front Cell Dev Biol (2017) 0.75
Amniotic fluid stem cells to study mTOR signaling in differentiation. Organogenesis (2012) 0.75
Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell (2017) 0.75
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell (2009) 8.97
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell (2005) 7.99
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol (2009) 6.76
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell (2002) 5.71
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell (2003) 5.71
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet (2010) 5.37
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
Generation of induced pluripotent stem cells from human blood. Blood (2009) 4.92
Generation of human-induced pluripotent stem cells. Nat Protoc (2008) 4.85
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc (2015) 4.70
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature (2003) 4.56
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
Chromatin-modifying enzymes as modulators of reprogramming. Nature (2012) 4.22
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature (2009) 4.14
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature (2009) 3.93
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Lin28: A microRNA regulator with a macro role. Cell (2010) 3.39
Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (2010) 3.36
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25
A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet (2006) 3.24
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell (2010) 3.08
Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell (2013) 3.08
The terminology of teratocarcinomas and teratomas. Nat Biotechnol (2007) 3.03
Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell (2009) 3.03
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (2012) 2.98
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98
Reprogramming of T cells from human peripheral blood. Cell Stem Cell (2010) 2.93
A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature (2009) 2.88
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One (2011) 2.86
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. PLoS Genet (2009) 2.78
High-efficiency RNA interference in human embryonic stem cells. Stem Cells (2005) 2.76
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet (2010) 2.72
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells (2009) 2.59
Induced pluripotent stem cells--opportunities for disease modelling and drug discovery. Nat Rev Drug Discov (2011) 2.58
Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell (2007) 2.56
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med (2010) 2.50
LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells (2004) 2.37
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature (2012) 2.32
Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci U S A (2005) 2.28
Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell (2013) 2.27
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell (2008) 2.17
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature (2003) 2.16
Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer. Cell Stem Cell (2007) 2.14
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14
Overcoming reprogramming resistance of Fanconi anemia cells. Blood (2012) 2.07
Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res (2011) 2.05
Stem cell metabolism in tissue development and aging. Development (2013) 2.01
The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell (2012) 1.96
Therapeutic potential of embryonic stem cells. Blood Rev (2005) 1.96
Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol (2013) 1.91
Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell (2012) 1.89
Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood (2010) 1.88
Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev (2014) 1.87
Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems. Biotechnol Bioeng (2002) 1.85
Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol (2004) 1.83
Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Rev (2010) 1.77
Altered nuclear transfer in stem-cell research - a flawed proposal. N Engl J Med (2004) 1.77
Upping the ante: recent advances in direct reprogramming. Mol Ther (2009) 1.73
Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood (2002) 1.72
Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients. Ann Neurol (2011) 1.72
Reprogramming cellular identity for regenerative medicine. Cell (2012) 1.71
Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes. Blood (2008) 1.71