Published in Lab Invest on January 01, 1987
Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am J Pathol (1989) 2.21
Tumour progression and the nature of cancer. Br J Cancer (1991) 1.69
Relationships between hepatic neoplasms and related lesions and exposure to toxic chemicals in marine fish from the U.S. West Coast. Environ Health Perspect (1991) 1.67
Evidence for the progressive and adaptive nature of spontaneous transformation in the NIH 3T3 cell line. Proc Natl Acad Sci U S A (1989) 1.61
Experimental models of hepatocellular carcinoma. J Hepatol (2008) 1.61
Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol (1987) 1.53
Molecular biology of hepatitis B virus infection. Virology (2015) 1.47
Relation of spontaneous transformation in cell culture to adaptive growth and clonal heterogeneity. Proc Natl Acad Sci U S A (1990) 1.39
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc Natl Acad Sci U S A (1987) 1.21
MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches. Cell Death Differ (2014) 1.17
High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances. Environ Health Perspect (1987) 1.10
Glutathione S-transferase expression in benign and malignant ovarian tumours. Br J Cancer (1993) 1.09
Alpha-fetoprotein, stem cells and cancer: how study of the production of alpha-fetoprotein during chemical hepatocarcinogenesis led to reaffirmation of the stem cell theory of cancer. Tumour Biol (2008) 1.08
Hepatitis B virus infection and primary hepatocellular carcinoma. Clin Microbiol Rev (1992) 1.04
Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. Carcinogenesis (2011) 0.97
Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis. Proc Natl Acad Sci U S A (2002) 0.96
Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysis. Proc Natl Acad Sci U S A (2005) 0.94
Relationships between toxicopathic hepatic lesions and exposure to chemical contaminants in English sole (Pleuronectes vetulus), starry flounder (Platichthys stellatus), and white croaker (Genyonemus lineatus) from selected marine sites on the Pacific Coast, USA. Environ Health Perspect (1994) 0.91
Differential growth: from carcinogenesis to liver repopulation. Am J Pathol (2000) 0.90
Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia. Am J Pathol (1995) 0.88
Gene expression profile related to the progression of preneoplastic nodules toward hepatocellular carcinoma in rats. Neoplasia (2006) 0.87
Effects of formaldehyde gas on the respiratory tract of rhesus monkeys. Pathology and cell proliferation. Am J Pathol (1989) 0.85
Tamoxifen prevents induction of hepatic neoplasia by zeranol, an estrogenic food contaminant. Proc Natl Acad Sci U S A (1992) 0.84
Possible etiologic mechanisms in chemical carcinogenesis. Environ Health Perspect (1987) 0.84
An approach to the determination of the relative potencies of chemical agents during the stages of initiation and promotion in multistage hepatocarcinogenesis in the rat. Environ Health Perspect (1987) 0.83
Neoplasms and nonneoplastic liver lesions in winter flounder, Pseudopleuronectes americanus, from Boston Harbor, Massachusetts. Environ Health Perspect (1991) 0.83
Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma. Invest New Drugs (2009) 0.82
Alterations of pancreatic hepatocytes in rats exposed to carcinogens. Am J Pathol (1991) 0.81
Models for analyzing data in initiation-promotion studies. Environ Health Perspect (1991) 0.81
Correlation between Bcl-2 expression and histopathology in diethylnitrosamine-induced mouse hepatocellular tumors. Am J Pathol (1997) 0.80
Multistage models for carcinogenesis. Environ Health Perspect (1989) 0.79
Chromatin changes in cell transformation: progressive unfolding of the higher-order structure during the evolution of rat hepatocyte nodules. A differential scanning calorimetry study. Biophys J (1993) 0.79
The effects of continuous exposure to epidermal growth factor on the spontaneous transformation of cultured rat liver epithelial cells. Am J Pathol (1992) 0.77
Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis. World J Gastroenterol (2008) 0.77
Cell population kinetics and ploidy rate of early focal lesions during hepatocarcinogenesis in the rat. Br J Cancer (1989) 0.77
From Reductionism to Holism: Systems-oriented Approaches in Cancer Research. Glob Adv Health Med (2012) 0.76
An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells. Exp Mol Med (2008) 0.75
Comfrey (Symphytum Officinale. l.) and Experimental Hepatic Carcinogenesis: A Short-term Carcinogenesis Model Study. Evid Based Complement Alternat Med (2007) 0.75
Association between alpha-fetoprotein and metabolic syndrome in a Chinese asymptomatic population: a cross-sectional study. Lipids Health Dis (2016) 0.75
Dietary guidelines for prevention of cancer: are they justified? Can Fam Physician (1990) 0.75
Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis. J Mol Histol (2008) 0.75
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol (1977) 2.45
The sequential analysis of cancer development. Adv Cancer Res (1980) 2.28
Cell proliferation is not a major risk factor for cancer. Mod Pathol (1996) 2.05
The multistep nature of cancer development. Cancer Res (1984) 1.93
Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture. Cancer Res (1984) 1.70
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens. Cancer Res (1976) 1.58
Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy. Am J Pathol (1984) 1.48
The sequential analysis of liver cancer induction. Biochim Biophys Acta (1980) 1.46
Studies on DNA repair in human lymphocytes treated with proximate carcinogens and alkylating agents. Cancer Res (1971) 1.44
Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res (1980) 1.42
Chemical carcinogenesis. N Engl J Med (1981) 1.41
Carcinogenesis--cellular evolution as a unifying thread: Presidential address. Cancer Res (1973) 1.30
The inhibition of liver ribonucleic acid synthesis by ethionine. J Biol Chem (1966) 1.30
Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study. J Hepatol (1999) 1.28
Patterns of transfer RNA in normal rat liver and during hepatic carcinogenesis. Proc Natl Acad Sci U S A (1967) 1.27
Chemical carcinogenesis: a biologic perspective. Am J Pathol (1982) 1.26
A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. Cancer Res (1976) 1.26
Ethionine fatty liver. Adv Lipid Res (1967) 1.26
Liver tumour promotion by chemicals: models and mechanisms. Cancer Surv (1986) 1.25
Initiation of chemical carcinogenesis requires cell proliferation. Nature (1978) 1.25
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis. Cancer Res (1978) 1.24
The rapid acceleration of hepatic nuclear ribonucleic acid breakdown by actinomycin but not by ethionine. J Biol Chem (1968) 1.21
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc Natl Acad Sci U S A (1987) 1.21
Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad. Am J Pathol (1977) 1.20
Effect of dietary tryptophan on hepatic polyribosomes and protein synthesis in fasted mice. J Biol Chem (1968) 1.19
On the mechanism of induction of hepatic adenosine triphosphate deficiency by ethionine. J Biol Chem (1966) 1.19
On the molecular pathology of ischemic renal cell death. Reversible and irreversible cellular and mitochondrial metabolic alterations. Am J Pathol (1968) 1.19
Reversal by adenine of the ethionine-induced lipid accumulation in the endoplasmic reticulum of the rat liver. A preliminary report. J Cell Biol (1965) 1.19
Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. Cancer Res (1981) 1.17
Cycloheximide, an inhibitor of peptide chain termination or release in liver in vivo and in vitro. Biochem Biophys Res Commun (1971) 1.17
Pre-cancerous steps in carcinogenesis. Their physiological adaptive nature. Biochim Biophys Acta (1984) 1.16
Biochemistry of carcinogenesis. Cancer Res (1968) 1.15
Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures. Cancer Res (1981) 1.15
A growth-constrained environment drives tumor progression invivo. Proc Natl Acad Sci U S A (2001) 1.11
Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene. Lab Invest (1985) 1.10
Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells. A sequential study. Am J Pathol (1984) 1.09
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis (1984) 1.08
Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP). Cell Death Differ (1999) 1.08
Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis. Cancer Res (1980) 1.08
ATP and cell integrity. Fed Proc (1973) 1.07
Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture. Am J Pathol (1982) 1.07
The biochemistry of preneoplastic liver: a common metabolic pattern in hepatocyte nodules. Can J Biochem Cell Biol (1984) 1.06
Nonrandom nature of in vivo methylation of dimethylnitrosamine and the subsequent removal of methylated products from rat liver chromatin DNA. Cancer Res (1976) 1.06
Effect of cycloheximide on the cell cycle of the crypts of the small intestine of the rat. J Cell Biol (1967) 1.06
Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism. Cancer Res (1967) 1.04
Newer insights into the pathogenesis of liver cancer. Am J Pathol (1977) 1.04
Hyperplastic areas, hyperplastic nodules, and hyperbasophilic areas as putative precursor lesions. Cancer Res (1976) 1.03
A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat. Cancer Res (1985) 1.02
Molecular pathology of in-vivo inhibition of protein synthesis. Electron microscopy of rat pancreatic acinar cells in puromycin-induced necrosis. Am J Pathol (1968) 1.02
5-azacytidine potentiates initiation induced by carcinogens in rat liver. Carcinogenesis (1985) 1.01
Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine. Biochem J (1971) 0.98
The cancer-initiating potential of the fumonisin B mycotoxins. Carcinogenesis (1992) 0.97
Transplantation of normal hepatocytes modulates the development of chronic liver lesions induced by a pyrrolizidine alkaloid, lasiocarpine. Carcinogenesis (1995) 0.97
The influence of tryptophan on hepatic polyribosomes and protein synthesis in fasted mice. Biochem Biophys Res Commun (1967) 0.97
Biochemical pathology. Annu Rev Pharmacol (1971) 0.97
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride. Cancer Res (1983) 0.97
The biochemical pathology of inhibition of protein synthesis in vivo. The effects of cycloheximide on hepatic parenchymal cell ultrastructure. Lab Invest (1969) 0.97
Non-random nature of in vivo interaction of 3H-N-hydroxy-2-acetylaminofluorene and its subsequent removal from rat liver chromatin-DNA. Chem Biol Interact (1976) 0.97
Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. Carcinogenesis (1995) 0.97
Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: a new perspective. Lab Invest (1993) 0.96
Inability of mitogen-induced liver hyperplasia to support the induction of enzyme-altered islands induced by liver carcinogens. Cancer Res (1987) 0.96
The disorganization of hepatic cell nucleoli induced by ethionine and its reversal by adenine. J Cell Biol (1968) 0.96
Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis. Cancer Res (1982) 0.96
In vitro measurement of carcinogen-resistant liver cells during hepatocarcinogenesis. Int J Cancer (1978) 0.95
Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver. Cancer Res (1983) 0.95
The effect of cycloheximide on the interaction between mitochondrial respiration and gluconeogenesis in guinea pig and rat liver. J Biol Chem (1973) 0.95
Acute pancreatic necrosis induced by puromycin. Lab Invest (1967) 0.95
Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene. Int J Cancer (1987) 0.95
Sequential analysis of hepatic carcinogenesis: a comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver. Lab Invest (1979) 0.94
Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis. Environ Health Perspect (1983) 0.94
Inhibition of protein synthesis in rat liver by D-galactosamine. Res Commun Chem Pathol Pharmacol (1973) 0.94
Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. Cancer Res (1984) 0.94
Nature of early appearing, carcinogen-induced liver lesions to iron accumulation. J Natl Cancer Inst (1976) 0.93
Sequential alterations in growth control and cell dynamics of rat hepatocytes in early precancerous steps in hepatocarcinogenesis. Cancer Res (1986) 0.93
Deoxyribonucleoside incorporation and the role of hydroxyurea in a model lymphocyte system for studying DNA repair in carcinogenesis. Cancer Res (1971) 0.93
A probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard, or X-irradiation. Cancer Res (1970) 0.93
The biochemical pathology of ethionine-induced pancreatic damage: ethionine incorporation into proteins, and ATP levels in pancreas of rats. Arch Biochem Biophys (1968) 0.92
The binding of 2-acetylaminofluorene to rat liver ribonucleic acid in vivo. Cancer Res (1965) 0.92
Effects of ethionine on adenosine triphosphate levels and ionic composition of liver cell nuclei. J Biol Chem (1968) 0.91
Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine. Cancer Lett (1984) 0.91
Chordoma: a case report. Surg Neurol (1997) 0.91
Differences in the steady-state levels of c-fos, c-jun and c-myc messenger RNA during mitogen-induced liver growth and compensatory regeneration. Hepatology (1993) 0.91
The effects of cycloheximide on energy transfer in rat and guinea pig liver mitochondria. J Biol Chem (1973) 0.90
Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine. Cancer Res (1985) 0.90
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics. Biochem J (1979) 0.90
Highly selective in vivo ethylation of rat liver nuclear protein by ethionine. Biochem Biophys Res Commun (1969) 0.90
Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver. Br J Cancer (1979) 0.90
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver. Cancer Res (1977) 0.90
Morphologic and metabolic alterations in hepatic cell nucleoli induced by varying doses of actinomycin D. Cancer Res (1969) 0.89
Chemical carcinogenesis: persistence of bound forms of 2-fluorenylacetamide. Science (1968) 0.89
Putative precursor lesions: summary and some analytical considerations. Cancer Res (1976) 0.89
Synthesis and fragmentation of DNA in phytohaemagglutinin-stimulated human peripheral blood lymphocytes. Immunol Commun (1973) 0.89
Studies on carcinogen chromatin--DNA interaction: inhibition of N-methyl-N-nitrosourea-induced methylation of chromatin--DNA by spermine and distamycin A. Biochemistry (1978) 0.89