Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy.

Targeting cancer cell mitochondria as a therapeutic approach. Future Med Chem (2013) 1.08

Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics. Future Med Chem (2012) 0.86

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis (2015) 0.83

Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing. Antioxid Redox Signal (2011) 0.82

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer (2015) 0.80

Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells. PLoS One (2013) 0.79

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer. Antioxid Redox Signal (2016) 0.78

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev (2017) 0.76

Drug Delivery Innovations for Enhancing the Anticancer Potential of Vitamin E Isoforms and Their Derivatives. Biomed Res Int (2015) 0.75

Using AIE Luminogen for Long-term and Low-background Three-Photon Microscopic Functional Bioimaging. Sci Rep (2015) 0.75

Multifunctional decoration of alpha-tocopheryl succinate-based NP for cancer treatment: effect of TPP and LTVSPWY peptide. J Mater Sci Mater Med (2017) 0.75

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol (2003) 9.07

Mitochondria, oxidative stress and cell death. Apoptosis (2007) 4.29

Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol (2007) 4.16

Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol (2007) 3.90

Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA (2004) 3.85

The serine protease TMPRSS6 is required to sense iron deficiency. Science (2008) 3.70

Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci U S A (2002) 3.57

Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol (2004) 3.43

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10

Mitochondria in cancer cells: what is so special about them? Trends Cell Biol (2008) 2.97

Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A (2004) 2.85

HIV infection and bone mineral density in middle-aged women. Clin Infect Dis (2006) 2.67

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem (2002) 2.46

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J (2005) 2.33

DNA damage-induced apoptosis. Oncogene (2004) 2.32

Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension (2009) 2.28

Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal (2008) 2.24

EPO-mediated reduction in Hamp expression in vivo corrects iron deficiency anaemia in TMPRSS6 deficiency. Br J Haematol (2010) 2.20

Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med (2010) 2.12

Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04

Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. Am J Pathol (2005) 1.98

Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell (2012) 1.98

Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection. AIDS (2007) 1.95

Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. J Biol Chem (2005) 1.89

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87

HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms. Mini Rev Med Chem (2009) 1.85

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy. Mol Aspects Med (2010) 1.84

Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization. Cardiovasc Res (2006) 1.80

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78

Familial and cultural perceptions and beliefs of oral hygiene and dietary practices among ethnically and socio-economicall diverse groups. Community Dent Health (2004) 1.78

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord (2010) 1.72

Cysteine protease mcII-Pa executes programmed cell death during plant embryogenesis. Proc Natl Acad Sci U S A (2005) 1.72

Obesity and dental caries in children: a systematic review and meta-analysis. Community Dent Oral Epidemiol (2012) 1.71

Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF). Biochem Biophys Res Commun (2010) 1.70

Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J (2003) 1.70

Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. J Biol Chem (2003) 1.62

Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome. Nat Cell Biol (2009) 1.60

Oral health-related quality of life for 8-10-year-old children: an assessment of a new measure. Community Dent Oral Epidemiol (2005) 1.60

The European perspective on vitamin E: current knowledge and future research. Am J Clin Nutr (2002) 1.57

Tumour-initiating cells vs. cancer 'stem' cells and CD133: what's in the name? Biochem Biophys Res Commun (2007) 1.57

Metacaspase-dependent programmed cell death is essential for plant embryogenesis. Curr Biol (2004) 1.56

A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic. Chem Biol (2012) 1.55

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int (2010) 1.54

Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim Biophys Acta (2006) 1.54

Mechanisms of Interferon-alpha induced apoptosis in malignant cells. Oncogene (2002) 1.50

Mathematical modelling of cell-fate decision in response to death receptor engagement. PLoS Comput Biol (2010) 1.49

Empirical evidence of the relationship between parental and child dental fear: a structured review and meta-analysis. Int J Paediatr Dent (2010) 1.49

Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res (2006) 1.48

Association of pelvic organ prolapse and fractures in postmenopausal women: analysis of baseline data from the Women's Health Initiative Estrogen Plus Progestin trial. Menopause (2008) 1.47

Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes. Blood (2005) 1.44

Cell death mechanisms and their implications in toxicology. Toxicol Sci (2010) 1.43

Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells. J Cell Mol Med (2011) 1.42

Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett (2004) 1.38

The Warburg effect and mitochondrial stability in cancer cells. Mol Aspects Med (2009) 1.37

Reliability and validity of a faces version of the Modified Child Dental Anxiety Scale. Int J Paediatr Dent (2007) 1.37

Reforming NHS dentistry. BMJ (2008) 1.35

Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells. Exp Hematol (2008) 1.34

International comparisons of health inequalities in childhood dental caries. Community Dent Health (2004) 1.34

Psychological stress in undergraduate dental students: baseline results from seven European dental schools. Eur J Dent Educ (2002) 1.34

Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation. Biochem J (2010) 1.33

Recognizing and reporting child physical abuse: a survey of primary healthcare professionals. J Adv Nurs (2006) 1.33

Antioxidant properties of MitoTEMPOL and its hydroxylamine. Free Radic Res (2009) 1.31

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. Mol Biol Cell (2005) 1.29

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem J (2008) 1.28

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2. Blood (2007) 1.27

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med (2009) 1.26

Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1. J Biol Chem (2002) 1.26

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med (2008) 1.24

Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J Biol Chem (2004) 1.24

Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep (2004) 1.21

Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G. Basic Res Cardiol (2013) 1.21

Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. Arch Biochem Biophys (2004) 1.21

MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells. Cancer Res (2012) 1.21

Mitochondria as targets for chemotherapy. Apoptosis (2009) 1.20

Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. J Biol Chem (2004) 1.20

Evaluation of caspase activity in apoptotic cells. J Immunol Methods (2002) 1.20

Tissue vibration induces carotid artery endothelial dysfunction: a mechanism linking snoring and carotid atherosclerosis? Sleep (2011) 1.20

Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment. Oncogene (2002) 1.20

Fat distribution in HIV-infected women in the United States: DEXA substudy in the Women's Interagency HIV Study. J Acquir Immune Defic Syndr (2005) 1.20

HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression. Carcinogenesis (2013) 1.19

Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation. Autophagy (2012) 1.19

The unpredictable caspase-2: what can it do? Trends Cell Biol (2010) 1.19

Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes. Atherosclerosis (2009) 1.18

Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem (2002) 1.18

Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover. Ann N Y Acad Sci (2004) 1.17

Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J Biol Chem (2007) 1.16

Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. J Exp Med (2006) 1.16

Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett (2006) 1.16

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II. J Biol Chem (2010) 1.16