Published in PLoS Med on March 15, 2011
Reporting and methods in clinical prediction research: a systematic review. PLoS Med (2012) 2.26
Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration. BMC Med (2013) 1.84
Random forests for genetic association studies. Stat Appl Genet Mol Biol (2011) 1.45
Relation of completeness of reporting of health research to journals' endorsement of reporting guidelines: systematic review. BMJ (2014) 1.41
Integrative cancer epidemiology--the next generation. Cancer Discov (2012) 1.16
Commentary: Reporting standards are needed for evaluations of risk reclassification. Int J Epidemiol (2011) 1.11
Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study. Circ Cardiovasc Genet (2015) 1.07
Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics. Clin Chem (2011) 0.95
Better reporting of scientific studies: why it matters. PLoS Med (2013) 0.90
Long noncoding RNAs as novel predictors of survival in human cancer: a systematic review and meta-analysis. Mol Cancer (2016) 0.87
A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis. PLoS One (2011) 0.87
Environmental risk score as a new tool to examine multi-pollutants in epidemiologic research: an example from the NHANES study using serum lipid levels. PLoS One (2014) 0.84
Reporting guidelines: optimal use in preventive medicine and public health. Am J Prev Med (2012) 0.81
RiGoR: reporting guidelines to address common sources of bias in risk model development. Biomark Res (2015) 0.76
Genetic risk prediction for CKD: a journey of a thousand miles. Am J Kidney Dis (2012) 0.75
Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med (2008) 57.29
The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med (2001) 37.70
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med (2009) 21.74
Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation (2007) 20.44
Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ (2003) 10.80
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. PLoS Med (2007) 10.43
The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Ann Intern Med (2003) 10.28
The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med (2007) 9.48
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med (2007) 8.46
Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association. Circulation (2009) 8.11
Reporting recommendations for tumor marker prognostic studies. J Clin Oncol (2005) 6.31
Assessment of claims of improved prediction beyond the Framingham risk score. JAMA (2009) 5.36
Prognosis and prognostic research: application and impact of prognostic models in clinical practice. BMJ (2009) 4.38
The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol (2010) 4.04
A catalogue of reporting guidelines for health research. Eur J Clin Invest (2010) 3.83
Cancer risk prediction models: a workshop on development, evaluation, and application. J Natl Cancer Inst (2005) 3.75
Selective reporting biases in cancer prognostic factor studies. J Natl Cancer Inst (2005) 3.41
Almost all articles on cancer prognostic markers report statistically significant results. Eur J Cancer (2007) 2.46
STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med (2009) 2.39
REporting recommendations for tumor MARKer prognostic studies (REMARK). Nat Clin Pract Urol (2005) 1.72
The scandal of poor epidemiological research. BMJ (2004) 1.60
STREGA, STROBE, STARD, SQUIRE, MOOSE, PRISMA, GNOSIS, TREND, ORION, COREQ, QUOROM, REMARK... and CONSORT: for whom does the guideline toll? J Clin Epidemiol (2009) 1.51
Quality of reporting of cancer prognostic marker studies: association with reported prognostic effect. J Natl Cancer Inst (2007) 1.42
The Human Genome Epidemiology Network. Am J Epidemiol (1998) 1.15
Assessment of improved prediction beyond traditional risk factors: when does a difference make a difference? Circ Cardiovasc Genet (2010) 0.99
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (2009) 22.18
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med (2009) 21.74
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
GenABEL: an R library for genome-wide association analysis. Bioinformatics (2007) 18.10
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci (2013) 13.37
Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS One (2008) 13.32
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med (2009) 12.16
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol (2009) 11.80
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med (2012) 10.16
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science (2002) 9.90
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Letting the genome out of the bottle--will we get our wish? N Engl J Med (2008) 9.10
Deploying whole genome sequencing in clinical practice and public health: meeting the challenge one bin at a time. Genet Med (2011) 8.48
The case of the misleading funnel plot. BMJ (2006) 8.26
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. Am J Epidemiol (2006) 7.66
Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ (2014) 7.21
Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ (2011) 6.80
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics (2010) 6.46
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet (2008) 5.89
Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation. Int J Epidemiol (2008) 5.88
Research grants: Conform and be funded. Nature (2012) 5.83
Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials. JAMA (2002) 5.81
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
The Rotterdam Study: objectives and design update. Eur J Epidemiol (2007) 5.78
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Assessment of claims of improved prediction beyond the Framingham risk score. JAMA (2009) 5.36
Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet (2002) 5.32
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Genomewide association studies of stroke. N Engl J Med (2009) 5.29
Why current publication practices may distort science. PLoS Med (2008) 5.09
A navigator for human genome epidemiology. Nat Genet (2008) 5.07
Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol (2007) 4.96
Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Evaluation of networks of randomized trials. Stat Methods Med Res (2007) 4.70
Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment. Lancet (2003) 4.58
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Number of published systematic reviews and global burden of disease: database analysis. BMJ (2003) 4.53
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53
The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med (2015) 4.49
Predictive testing for complex diseases using multiple genes: fact or fiction? Genet Med (2006) 4.48
Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis. J Natl Cancer Inst (2005) 4.48
How many genes underlie the occurrence of common complex diseases in the population? Int J Epidemiol (2005) 4.46
Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol (2005) 4.45
Public availability of published research data in high-impact journals. PLoS One (2011) 4.41
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Cleft lip and palate. Lancet (2009) 4.29
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27
Sodium and potassium intake and mortality among US adults: prospective data from the Third National Health and Nutrition Examination Survey. Arch Intern Med (2011) 4.22
Relative citation impact of various study designs in the health sciences. JAMA (2005) 4.19
Comparisons of established risk prediction models for cardiovascular disease: systematic review. BMJ (2012) 4.16
Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol (2010) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol (2010) 4.04
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nat Genet (2008) 4.04
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. Hum Genet (2007) 3.92
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Predicting death: an empirical evaluation of predictive tools for mortality. Arch Intern Med (2011) 3.81
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research. BMJ (2002) 3.78
Can family history be used as a tool for public health and preventive medicine? Genet Med (2002) 3.76
Translation of highly promising basic science research into clinical applications. Am J Med (2003) 3.74
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
National Institutes of Health approaches to dissemination and implementation science: current and future directions. Am J Public Health (2012) 3.72
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med (2012) 3.63
Overlapping meta-analyses on the same topic: survey of published studies. BMJ (2013) 3.57
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes (2008) 3.54
Empirical evaluation of very large treatment effects of medical interventions. JAMA (2012) 3.48
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
A genomic background based method for association analysis in related individuals. PLoS One (2007) 3.46
Genome-based prediction of common diseases: advances and prospects. Hum Mol Genet (2008) 3.45
Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials (2010) 3.45