Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls.

PubWeight™: 3.92‹?› | Rank: Top 1%

🔗 View Article (PMID 18026754)

Published in Hum Genet on November 17, 2007

Authors

Fotini K Kavvoura1, John P A Ioannidis

Author Affiliations

1: Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina, 45110, Greece.

Articles citing this

Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26

The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry (2011) 6.66

Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol (2009) 4.70

Validating, augmenting and refining genome-wide association signals. Nat Rev Genet (2009) 4.56

Bayesian statistical methods for genetic association studies. Nat Rev Genet (2009) 4.37

Meta-analysis of genome-wide association studies: no efficiency gain in using individual participant data. Genet Epidemiol (2010) 3.84

Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet (2013) 3.65

Meta-analysis in genome-wide association studies. Pharmacogenomics (2009) 3.39

Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ (2011) 2.68

Meta-analysis methods for genome-wide association studies and beyond. Nat Rev Genet (2013) 2.58

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47

On the relative efficiency of using summary statistics versus individual-level data in meta-analysis. Biometrika (2010) 2.06

Leveraging genetic variability across populations for the identification of causal variants. Am J Hum Genet (2010) 2.00

Replication in genome-wide association studies. Stat Sci (2009) 1.89

Meta-analysis of genome-wide association studies with overlapping subjects. Am J Hum Genet (2009) 1.83

Systematic reviews of genetic association studies. Human Genome Epidemiology Network. PLoS Med (2009) 1.60

Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures. Biol Psychiatry (2009) 1.37

FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med (2011) 1.34

Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation. Genetics (2008) 1.33

Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia (2008) 1.23

Genetics of osteoporosis: accelerating pace in gene identification and validation. Hum Genet (2009) 1.14

Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. PLoS One (2010) 1.05

Systematic reviews and meta-analyses of home telemonitoring interventions for patients with chronic diseases: a critical assessment of their methodological quality. J Med Internet Res (2013) 1.05

Imputation aware meta-analysis of genome-wide association studies. Genet Epidemiol (2010) 1.05

Genome wide association for addiction: replicated results and comparisons of two analytic approaches. PLoS One (2010) 1.04

Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. Mol Psychiatry (2011) 1.02

Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression. Mol Psychiatry (2013) 1.01

A multicenter study to map genes for Fuchs endothelial corneal dystrophy: baseline characteristics and heritability. Cornea (2012) 1.00

Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. Am J Clin Nutr (2012) 0.99

Searching for genes that matter in acute kidney injury: a systematic review. Clin J Am Soc Nephrol (2009) 0.99

Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants. J Psychiatry Neurosci (2009) 0.98

Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population. PLoS One (2013) 0.94

A functional variant in ERAP1 predisposes to multiple sclerosis. PLoS One (2012) 0.93

Association of the 5HTR2A gene with suicidal behavior: case-control study and updated meta-analysis. BMC Psychiatry (2013) 0.91

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Cancer Epidemiol Biomarkers Prev (2008) 0.89

Meta-analysis of diabetic nephropathy associated genetic variants in inflammation and angiogenesis involved in different biochemical pathways. BMC Med Genet (2014) 0.88

Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis. BMC Psychiatry (2014) 0.87

Association of the GNAS locus with severe malaria. Hum Genet (2008) 0.87

A meta-analysis of gene expression quantitative trait loci in brain. Transl Psychiatry (2014) 0.87

Association of vitamin D receptor gene polymorphisms with asthma risk: systematic review and updated meta-analysis of case-control studies. Lung (2014) 0.87

An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. DNA Repair (Amst) (2011) 0.86

Rs143383 in the growth differentiation factor 5 (GDF5) gene significantly associated with osteoarthritis (OA)-a comprehensive meta-analysis. Int J Med Sci (2013) 0.85

No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data. BMC Psychiatry (2011) 0.85

Interferon-Inducible Transmembrane Protein 3 Genetic Variant rs12252 and Influenza Susceptibility and Severity: A Meta-Analysis. PLoS One (2015) 0.85

Meta-analysis of genetic association studies under heterogeneity. Eur J Hum Genet (2012) 0.84

Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. Breast Cancer Res Treat (2012) 0.81

To replicate or not to replicate: the case of pharmacogenetic studies: Establishing validity of pharmacogenomic findings: from replication to triangulation. Circ Cardiovasc Genet (2013) 0.81

On individual genome-wide association studies and their meta-analysis. Hum Genet (2013) 0.81

Association between toll-like receptors 9 (TLR9) gene polymorphism and risk of pulmonary tuberculosis: meta-analysis. BMC Pulm Med (2015) 0.80

Statistical and Computational Methods for Genetic Diseases: An Overview. Comput Math Methods Med (2015) 0.80

The impact of imputation on meta-analysis of genome-wide association studies. PLoS One (2012) 0.80

Microsomal epoxide hydrolase gene polymorphisms and risk of chronic obstructive pulmonary disease: A comprehensive meta-analysis. Oncol Lett (2012) 0.80

Association of matrix metalloproteinase family gene polymorphisms with lung cancer risk: logistic regression and generalized odds of published data. Sci Rep (2015) 0.79

The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: systematic review and meta-analysis. Int J Clin Exp Med (2015) 0.79

The VNTR polymorphism of the DC-SIGNR gene and susceptibility to HIV-1 infection: a meta-analysis. PLoS One (2012) 0.78

No association of functional polymorphisms in methlylenetetrahydrofolate reductase and the risk and minor physical anomalies of schizophrenia in Korean population. J Korean Med Sci (2011) 0.78

Statistical significance in genetic association studies. Clin Invest Med (2010) 0.78

Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and Graves' disease risk: a meta-analysis of 11 case-control studies. PLoS One (2014) 0.78

What did we learn from the genome-wide association study for tuberculosis susceptibility? J Med Genet (2011) 0.77

A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1. Am J Med Genet B Neuropsychiatr Genet (2013) 0.77

The common variant rs4444235 near BMP4 confers genetic susceptibility of colorectal cancer: an updated meta-analysis based on a comprehensive statistical strategy. PLoS One (2014) 0.77

Increased risk of major depression by childhood abuse is not modified by CNR1 genotype. Am J Med Genet B Neuropsychiatr Genet (2012) 0.76

Credible genetic associations? Int J Mol Epidemiol Genet (2009) 0.76

Statistical Approaches to Combine Genetic Association Data. J Biom Biostat (2013) 0.75

Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics. Environ Mol Mutagen (2010) 0.75

Toll-like receptor 4 polymorphisms to determine acute pancreatitis susceptibility and severity: a meta-analysis. World J Gastroenterol (2014) 0.75

Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures. Front Genet (2016) 0.75

Polymorphisms in the nuclear excision repair gene ERCC2/XPD and susceptibility to cutaneous basal cell carcinoma. Int J Clin Exp Med (2015) 0.75

Association of IL4, IL13, and IL4R polymorphisms with gastrointestinal cancer risk: A meta-analysis. J Epidemiol (2017) 0.75

Association between polymorphisms in lysyl oxidase-like 1 and susceptibility to pseudoexfoliation syndrome and pseudoexfoliation glaucoma. PLoS One (2014) 0.75

XPC Ala499Val and XPG Asp1104His polymorphisms and digestive system cancer risk: a meta-analysis based on model-free approach. Int J Clin Exp Med (2015) 0.75

Big data challenges in bone research: genome-wide association studies and next-generation sequencing. Bonekey Rep (2015) 0.75

Targeted Therapy Database (TTD): a model to match patient's molecular profile with current knowledge on cancer biology. PLoS One (2010) 0.75

Meta-analysis for genome-wide association studies using case-control design: application and practice. Epidemiol Health (2016) 0.75

Articles cited by this

(truncated to the top 100)

Meta-analysis in clinical trials. Control Clin Trials (1986) 144.91

Measuring inconsistency in meta-analyses. BMJ (2003) 128.20

Bias in meta-analysis detected by a simple, graphical test. BMJ (1997) 122.24

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst (1959) 94.48

Quantifying heterogeneity in a meta-analysis. Stat Med (2002) 83.16

Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA (2000) 55.37

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

Operating characteristics of a rank correlation test for publication bias. Biometrics (1994) 47.97

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16

Why most published research findings are false. PLoS Med (2005) 41.68

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88

Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA (2004) 23.87

Publication bias in clinical research. Lancet (1991) 22.85

Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics (2000) 19.26

Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis (1985) 19.03

Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst (2004) 19.00

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36

The hazards of scoring the quality of clinical trials for meta-analysis. JAMA (1999) 17.00

Association mapping in structured populations. Am J Hum Genet (2000) 16.79

A comprehensive review of genetic association studies. Genet Med (2002) 16.75

'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51

Replication validity of genetic association studies. Nat Genet (2001) 16.30

Replicating genotype-phenotype associations. Nature (2007) 16.11

New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet (2007) 12.13

Factors influencing publication of research results. Follow-up of applications submitted to two institutional review boards. JAMA (1992) 10.84

Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research. CMAJ (2004) 10.75

Population stratification and spurious allelic association. Lancet (2003) 10.53

Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. JAMA (1998) 9.91

Sifting the evidence-what's wrong with significance tests? BMJ (2001) 9.50

How should meta-regression analyses be undertaken and interpreted? Stat Med (2002) 8.96

Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice. J Health Serv Res Policy (2002) 8.49

Detecting and describing heterogeneity in meta-analysis. Stat Med (1998) 8.44

Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods (2006) 8.42

The case of the misleading funnel plot. BMJ (2006) 8.26

Comparison of two methods to detect publication bias in meta-analysis. JAMA (2006) 7.34

Language bias in randomised controlled trials published in English and German. Lancet (1997) 7.29

Design and analysis of admixture mapping studies. Am J Hum Genet (2004) 7.20

Genomic control, a new approach to genetic-based association studies. Theor Popul Biol (2001) 6.90

Meta-analysis of the literature or of individual patient data: is there a difference? Lancet (1993) 6.16

Invited commentary: a critical look at some popular meta-analytic methods. Am J Epidemiol (1994) 6.01

Gene-environment interactions in human diseases. Nat Rev Genet (2005) 5.93

Heterogeneity in meta-analyses of genome-wide association investigations. PLoS One (2007) 5.77

Uncertainty in heterogeneity estimates in meta-analyses. BMJ (2007) 5.69

Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model. Am J Hum Genet (2001) 5.66

A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med (2006) 5.43

Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors. BMJ (2005) 5.36

Genotyping errors: causes, consequences and solutions. Nat Rev Genet (2005) 5.00

Summing up evidence: one answer is not always enough. Lancet (1998) 4.66

The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer. Breast Cancer Res (2004) 4.54

Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst (2000) 4.51

A Bayesian measure of the probability of false discovery in genetic epidemiology studies. Am J Hum Genet (2007) 4.21

Relative citation impact of various study designs in the health sciences. JAMA (2005) 4.19

Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. J Clin Epidemiol (2005) 4.14

5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol (2000) 3.94

An exploratory test for an excess of significant findings. Clin Trials (2007) 3.83

Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet (2005) 3.76

Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet (2005) 3.60

Selective reporting biases in cancer prognostic factor studies. J Natl Cancer Inst (2005) 3.41

The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey. CMAJ (2007) 3.40

A road map for efficient and reliable human genome epidemiology. Nat Genet (2006) 3.21

To IPD or not to IPD? Advantages and disadvantages of systematic reviews using individual patient data. Eval Health Prof (2002) 3.11

Clinical epidemiological quality in molecular genetic research: the need for methodological standards. JAMA (1999) 3.07

Counterpoint: bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer. Cancer Epidemiol Biomarkers Prev (2002) 2.99

Non-replication and inconsistency in the genome-wide association setting. Hum Hered (2007) 2.99

How vague is vague? A simulation study of the impact of the use of vague prior distributions in MCMC using WinBUGS. Stat Med (2005) 2.95

Misleading funnel plot for detection of bias in meta-analysis. J Clin Epidemiol (2000) 2.90

In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias. J Clin Epidemiol (2005) 2.77

Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care. J Clin Epidemiol (1995) 2.74

The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med (2006) 2.74

A candidate gene approach to searching for low-penetrance breast and prostate cancer genes. Nat Rev Cancer (2005) 2.62

Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol (2002) 2.56

Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch Neurol (2004) 2.45

Welcome to the genomic era. N Engl J Med (2003) 2.38

Tracking the epidemiology of human genes in the literature: the HuGE Published Literature database. Am J Epidemiol (2006) 2.34

Random-effects meta-analyses are not always conservative. Am J Epidemiol (1999) 2.32

The merits of testing Hardy-Weinberg equilibrium in the analysis of unmatched case-control data: a cautionary note. Ann Hum Genet (2006) 2.29

Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol (2000) 2.20

Local literature bias in genetic epidemiology: an empirical evaluation of the Chinese literature. PLoS Med (2005) 2.18

The path from genome-based research to population health: development of an international public health genomics network. Genet Med (2006) 2.15

Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol (2003) 2.11

Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Ann Intern Med (2001) 2.05

Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J Bone Miner Res (1996) 1.96

Flexible design for following up positive findings. Am J Hum Genet (2007) 1.94

Assessing publication bias in genetic association studies: evidence from a recent meta-analysis. Psychiatry Res (2004) 1.92

Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis. Stroke (2005) 1.71

Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease. PLoS One (2007) 1.69

Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. PLoS Med (2006) 1.68

Genetic variation and willingness to participate in epidemiologic research: data from three studies. Cancer Epidemiol Biomarkers Prev (2005) 1.66

The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology (2007) 1.61

Commentary: meta-analysis of individual participants' data in genetic epidemiology. Am J Epidemiol (2002) 1.59

Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Hum Mutat (2002) 1.44

A network of investigator networks in human genome epidemiology. Am J Epidemiol (2005) 1.43

Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls. Stroke (2005) 1.43

Estimation of magnitude in gene-environment interactions in the presence of measurement error. Stat Med (2004) 1.41

Articles by these authors

(truncated to the top 100)

Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (2009) 22.18

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med (2009) 21.74

Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci (2013) 13.37

Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS One (2008) 13.32

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med (2009) 12.16

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol (2009) 11.80

The case of the misleading funnel plot. BMJ (2006) 8.26

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ (2014) 7.21

Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ (2011) 6.80

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71

Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation. Int J Epidemiol (2008) 5.88

Research grants: Conform and be funded. Nature (2012) 5.83

Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials. JAMA (2002) 5.81

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48

Assessment of claims of improved prediction beyond the Framingham risk score. JAMA (2009) 5.36

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32

Why current publication practices may distort science. PLoS Med (2008) 5.09

Evaluation of networks of randomized trials. Stat Methods Med Res (2007) 4.70

Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment. Lancet (2003) 4.58

Number of published systematic reviews and global burden of disease: database analysis. BMJ (2003) 4.53

The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med (2015) 4.49

Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis. J Natl Cancer Inst (2005) 4.48

Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol (2005) 4.45

Public availability of published research data in high-impact journals. PLoS One (2011) 4.41

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27

Relative citation impact of various study designs in the health sciences. JAMA (2005) 4.19

Comparisons of established risk prediction models for cardiovascular disease: systematic review. BMJ (2012) 4.16

Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol (2010) 4.10

The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol (2010) 4.04

Predicting death: an empirical evaluation of predictive tools for mortality. Arch Intern Med (2011) 3.81

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research. BMJ (2002) 3.78

Translation of highly promising basic science research into clinical applications. Am J Med (2003) 3.74

Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med (2012) 3.63

Overlapping meta-analyses on the same topic: survey of published studies. BMJ (2013) 3.57

Empirical evaluation of very large treatment effects of medical interventions. JAMA (2012) 3.48

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48

Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials (2010) 3.45

Selective reporting biases in cancer prognostic factor studies. J Natl Cancer Inst (2005) 3.41

Meta-analysis in genome-wide association studies. Pharmacogenomics (2009) 3.39

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. Lancet Neurol (2011) 3.36

Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol (2004) 3.28

Medicine. Life cycle of translational research for medical interventions. Science (2008) 3.12

The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91

Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis. J Natl Cancer Inst (2006) 2.91

HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics (2005) 2.81

Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80

The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med (2006) 2.74

Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): explanation and elaboration. Ann Intern Med (2015) 2.71

Evaluation of excess significance bias in animal studies of neurological diseases. PLoS Biol (2013) 2.70

Extended-interval aminoglycoside administration for children: a meta-analysis. Pediatrics (2004) 2.60

Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immunol (2005) 2.59

Meta-analysis methods for genome-wide association studies and beyond. Nat Rev Genet (2013) 2.58

Reporting and interpretation of SF-36 outcomes in randomised trials: systematic review. BMJ (2009) 2.57

Transforming epidemiology for 21st century medicine and public health. Cancer Epidemiol Biomarkers Prev (2013) 2.56

Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study. BMJ (2013) 2.52

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA (2008) 2.52

Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. Intensive Care Med (2014) 2.51

Origin and funding of the most frequently cited papers in medicine: database analysis. BMJ (2006) 2.47

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47

Claims of sex differences: an empirical assessment in genetic associations. JAMA (2007) 2.46

Almost all articles on cancer prognostic markers report statistically significant results. Eur J Cancer (2007) 2.46

Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. J Clin Epidemiol (2009) 2.45

Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol (2012) 2.42

Sources of funding for Nobel Prize-winning work: public or private? FASEB J (2010) 2.42

Comparison of evidence on harms of medical interventions in randomized and nonrandomized studies. CMAJ (2006) 2.40

STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med (2009) 2.39

18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis. J Natl Cancer Inst (2008) 2.32

International ranking systems for universities and institutions: a critical appraisal. BMC Med (2007) 2.31

Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol (2008) 2.31

Treating anemia early in renal failure patients slows the decline of renal function: a randomized controlled trial. Kidney Int (2004) 2.30

A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. J Natl Cancer Inst (2008) 2.29

How to use an article reporting a multiple treatment comparison meta-analysis. JAMA (2012) 2.28

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology STROBE-ME: an extension of the STROBE statement. J Clin Epidemiol (2011) 2.24

Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis (2012) 2.21

Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet (2005) 2.21

Survival and disease-progression benefits with treatment regimens for advanced colorectal cancer: a meta-analysis. Lancet Oncol (2007) 2.19

A nutrient-wide association study on blood pressure. Circulation (2012) 2.19

Local literature bias in genetic epidemiology: an empirical evaluation of the Chinese literature. PLoS Med (2005) 2.18

Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18

Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am J Epidemiol (2009) 2.15

Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer. J Natl Cancer Inst (2008) 2.15

Effectiveness of antipsychotic treatments in a nationwide cohort of patients in community care after first hospitalisation due to schizophrenia and schizoaffective disorder: observational follow-up study. BMJ (2006) 2.14

What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. Int J Epidemiol (2011) 2.13

Modern health care as a game theory problem. Eur J Clin Invest (2015) 2.09

Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis. Circulation (2005) 2.06

Ensuring the integrity of clinical practice guidelines: a tool for protecting patients. BMJ (2013) 2.06

US studies may overestimate effect sizes in softer research. Proc Natl Acad Sci U S A (2013) 2.06

A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum (2010) 2.02

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet (2011) 1.98

Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology study. BMJ (2011) 1.97

Exploring the geometry of treatment networks. Ann Intern Med (2008) 1.95

Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurol (2006) 1.92

Optimal timing of coronary angiography and potential intervention in non-ST-elevation acute coronary syndromes. Eur Heart J (2010) 1.91

Persistence of contradicted claims in the literature. JAMA (2007) 1.90

Replication in genome-wide association studies. Stat Sci (2009) 1.89

Meta-analysis: test performance of ultrasonography for giant-cell arteritis. Ann Intern Med (2005) 1.88

Demystifying trial networks and network meta-analysis. BMJ (2013) 1.87

Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysis. AIDS (2004) 1.87