Published in PLoS Pathog on March 17, 2011
Cross-presentation by dendritic cells. Nat Rev Immunol (2012) 3.95
Immune mechanisms in malaria: new insights in vaccine development. Nat Med (2013) 1.40
Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annu Rev Immunol (2014) 1.38
Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine. PLoS One (2012) 1.35
Looking under the skin: the first steps in malarial infection and immunity. Nat Rev Microbiol (2013) 1.20
Malaria parasite pre-erythrocytic infection: preparation meets opportunity. Cell Microbiol (2012) 1.06
Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. J Immunol (2011) 1.04
Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites. Genes Immun (2013) 0.98
The skin: where malaria infection and the host immune response begin. Semin Immunopathol (2012) 0.95
Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses. PLoS Pathog (2015) 0.94
Memory CD8 T cells specific for plasmodia liver-stage antigens maintain protracted protection against malaria. Front Immunol (2012) 0.94
Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy. Infect Immun (2013) 0.93
Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development. Mem Inst Oswaldo Cruz (2011) 0.90
CD8+ T cells specific for a malaria cytoplasmic antigen form clusters around infected hepatocytes and are protective at the liver stage of infection. Infect Immun (2013) 0.89
Malaria and the liver: immunological hide-and-seek or subversion of immunity from within? Front Microbiol (2015) 0.88
CD8+ T cells eliminate liver-stage Plasmodium berghei parasites without detectable bystander effect. Infect Immun (2014) 0.88
CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes. PLoS One (2012) 0.87
Dendritic cells treated with crude Plasmodium berghei extracts acquire immune-modulatory properties and suppress the development of autoimmune neuroinflammation. Immunology (2014) 0.87
Antigen export during liver infection of the malaria parasite augments protective immunity. MBio (2014) 0.87
Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria. EMBO Mol Med (2012) 0.85
UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major. J Biol Chem (2013) 0.85
The chemokine receptor CXCR6 is required for the maintenance of liver memory CD8⁺ T cells specific for infectious pathogens. J Infect Dis (2014) 0.84
Proteolytic Cleavage of the Plasmodium falciparum Circumsporozoite Protein Is a Target of Protective Antibodies. J Infect Dis (2015) 0.84
Plasmodium cellular effector mechanisms and the hepatic microenvironment. Front Microbiol (2015) 0.84
P. falciparum and P. vivax Epitope-Focused VLPs Elicit Sterile Immunity to Blood Stage Infections. PLoS One (2015) 0.83
A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria. PLoS One (2012) 0.81
Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites. Front Microbiol (2014) 0.81
Antigen-driven focal inflammatory death of malaria liver stages. Front Microbiol (2015) 0.80
The Use of Synthetic Carriers in Malaria Vaccine Design. Vaccines (Basel) (2015) 0.80
Protective immunity to liver-stage malaria. Clin Transl Immunology (2016) 0.78
Systemic toll-like receptor ligation and selective killing of dendritic cell subsets fail to dissect priming pathways for anti-vaccinia virus CD8⁺ T cells. J Virol (2013) 0.78
Do you see what I see: Recognition of protozoan parasites by Toll-like receptors. Curr Immunol Rev (2013) 0.77
Angiotensin II type-1 receptor (AT1R) regulates expansion, differentiation, and functional capacity of antigen-specific CD8(+) T cells. Sci Rep (2016) 0.76
Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria. Malar J (2015) 0.75
The Threshold of Protection from Liver-Stage Malaria Relies on a Fine Balance between the Number of Infected Hepatocytes and Effector CD8+ T Cells Present in the Liver. J Immunol (2017) 0.75
Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses. J Immunol (2016) 0.75
T cell receptor antagonist peptides induce positive selection. Cell (1994) 18.66
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57
CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med (2000) 7.46
Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science (2004) 7.01
A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science (2004) 6.16
Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei. Nature (1967) 6.08
Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature (1988) 5.99
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83
Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity (1997) 5.44
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature (2008) 5.15
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell (1992) 4.76
Quantitative imaging of Plasmodium transmission from mosquito to mammal. Nat Med (2006) 4.08
Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature (1989) 4.08
Migration of Plasmodium sporozoites through cells before infection. Science (2001) 3.89
Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite. Science (1980) 3.71
Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int J Parasitol (2001) 3.51
Cross-presentation: underlying mechanisms and role in immune surveillance. Immunol Rev (2005) 2.98
Quantification of antigen specific CD8+ T cells using an ELISPOT assay. J Immunol Methods (1995) 2.82
CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat Med (2007) 2.79
Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites. Parasitol Res (1994) 2.65
Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe (2007) 2.64
Inducing tumor immunity through the selective engagement of activating Fcgamma receptors on dendritic cells. J Exp Med (2002) 2.54
Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes. Nat Immunol (2008) 2.52
Immune complex-mediated antigen presentation induces tumor immunity. J Clin Invest (2002) 2.13
Gene targeting in malaria parasites. Methods (1997) 2.03
Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. J Exp Med (2001) 1.99
Plasmodium sporozoites trickle out of the injection site. Cell Microbiol (2007) 1.98
Host cell traversal is important for progression of the malaria parasite through the dermis to the liver. Cell Host Microbe (2008) 1.92
Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell (2007) 1.90
Monoclonal antibodies identify the protective antigens of sporozoites of Plasmodium knowlesi. Proc Natl Acad Sci U S A (1982) 1.82
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data. Malar J (2009) 1.72
Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J Immunol (2009) 1.66
Antibodies to the protective antigen of Plasmodium berghei sporozoites prevent entry into cultured cells. J Immunol (1982) 1.63
Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset. Proc Natl Acad Sci U S A (2008) 1.53
Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. J Exp Med (2009) 1.42
Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLoS Pathog (2010) 1.39
Plasmodium berghei sporozoite invasion is blocked in vitro by sporozoite-immobilizing antibodies. Infect Immun (1986) 1.37
Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells. PLoS Pathog (2010) 1.32
Development of the malaria parasite in the skin of the mammalian host. Proc Natl Acad Sci U S A (2010) 1.27
Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoelii, homolog of Plasmodium falciparum exported protein 1. J Biol Chem (1996) 1.25
Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo. J Immunol (2006) 1.22
UNC93B1 mediates host resistance to infection with Toxoplasma gondii. PLoS Pathog (2010) 1.22
Plasmodium berghei-infected primary hepatocytes process and present the circumsporozoite protein to specific CD8+ T cells in vitro. J Immunol (2007) 1.16
Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens. J Immunol (2009) 1.09
Release of malaria circumsporozoite protein into the host cell cytoplasm and interaction with ribosomes. Mol Biochem Parasitol (1996) 1.06
Memory CD8+ T cell responses expand when antigen presentation overcomes T cell self-regulation. J Immunol (2008) 1.04
Immunization with radiation-attenuated Plasmodium berghei sporozoites induces liver cCD8alpha+DC that activate CD8+T cells against liver-stage malaria. PLoS One (2009) 1.04
Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites. Eur J Immunol (2006) 0.98
Direct processing and presentation of antigen from malaria sporozoites by professional antigen-presenting cells in the induction of CD8 T-cell responses. Immunol Cell Biol (2005) 0.93
Early hepatic stages of Plasmodium berghei: release of circumsporozoite protein and host cellular inflammatory response. Infect Immun (1992) 0.90
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57
The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature (2006) 3.31
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe (2008) 2.98
CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat Med (2007) 2.79
Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe (2007) 2.64
Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med (2006) 2.43
Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected anopheline mosquitoes. Infect Immun (2005) 2.29
Plasmodium sporozoites trickle out of the injection site. Cell Microbiol (2007) 1.98
IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages. Nat Med (2002) 1.86
The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion. J Exp Med (2005) 1.85
Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions. Methods (2012) 1.75
Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity. Nat Med (2008) 1.65
Protective CD8 T cells against Plasmodium liver stages: immunobiology of an 'unnatural' immune response. Immunol Rev (2008) 1.64
The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. J Exp Med (2011) 1.62
Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling. Mol Microbiol (2013) 1.59
Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice. Vaccine (2010) 1.54
Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage. J Immunol (2008) 1.53
Analysis of the Plasmodium and Anopheles transcriptional repertoire during ookinete development and midgut invasion. J Biol Chem (2003) 1.49
T cells as mediators of protective immunity against liver stages of Plasmodium. Trends Parasitol (2003) 1.45
Malaria in India: the center for the study of complex malaria in India. Acta Trop (2011) 1.42
Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS One (2007) 1.41
PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature (2013) 1.40
Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLoS Pathog (2010) 1.39
Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host Microbe (2008) 1.34
IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. J Exp Med (2005) 1.31
The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. PLoS Pathog (2009) 1.28
Noninvasive real-time monitoring of liver-stage development of bioluminescent Plasmodium parasites. J Infect Dis (2009) 1.28
Neuropathogenesis of human and murine malaria. Trends Parasitol (2010) 1.24
HIV protease inhibitors inhibit the development of preerythrocytic-stage plasmodium parasites. J Infect Dis (2009) 1.24
Effector and memory CD8+ T cells as seen in immunity to malaria. Immunol Rev (2004) 1.22
Looking under the skin: the first steps in malarial infection and immunity. Nat Rev Microbiol (2013) 1.20
Total and putative surface proteomics of malaria parasite salivary gland sporozoites. Mol Cell Proteomics (2013) 1.19
Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions. Mol Biochem Parasitol (2005) 1.18
Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges. J Exp Biol (2003) 1.18
The Plasmodium TRAP/MIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites. Cell Microbiol (2008) 1.17
Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity. PLoS Pathog (2012) 1.16
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host Microbe (2012) 1.16
Variant genes and the spleen in Plasmodium vivax malaria. Int J Parasitol (2004) 1.16
Antimalarial activity of allicin, a biologically active compound from garlic cloves. Antimicrob Agents Chemother (2006) 1.14
Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages. Proc Natl Acad Sci U S A (2002) 1.10
In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages. Proc Natl Acad Sci U S A (2013) 1.10
The Plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoites. Mol Biochem Parasitol (2004) 1.10
Viral vectors for malaria vaccine development. Vaccine (2006) 1.10
Plasmodium sporozoite-host interactions from the dermis to the hepatocyte. Curr Opin Microbiol (2009) 1.10
Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes. J Infect Dis (2011) 1.10
IL-4 induces a wide-spectrum intracellular signaling cascade in CD8+ T cells. J Leukoc Biol (2007) 1.05
Memory CD8+ T cell responses expand when antigen presentation overcomes T cell self-regulation. J Immunol (2008) 1.04
Effector CD8+ T lymphocytes against liver stages of Plasmodium yoelii do not require gamma interferon for antiparasite activity. Infect Immun (2008) 0.99
Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum. J Chem Inf Model (2010) 0.99
Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum. Infect Immun (2013) 0.99
Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites. Eur J Immunol (2006) 0.98
Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6. J Biol Chem (2005) 0.97
Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria. J Immunol (2003) 0.96
HIV nonnucleoside reverse transcriptase inhibitors and trimethoprim-sulfamethoxazole inhibit plasmodium liver stages. J Infect Dis (2012) 0.96
The skin: where malaria infection and the host immune response begin. Semin Immunopathol (2012) 0.95
High mobility group protein HMGB2 is a critical regulator of plasmodium oocyst development. J Biol Chem (2008) 0.94
CD4+ T cells modulate expansion and survival but not functional properties of effector and memory CD8+ T cells induced by malaria sporozoites. PLoS One (2011) 0.94
Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole. PLoS Pathog (2011) 0.93
Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy. Infect Immun (2013) 0.93
The skin stage of malaria infection: biology and relevance to the malaria vaccine effort. Future Microbiol (2008) 0.92
Adenovirus particles that display the Plasmodium falciparum circumsporozoite protein NANP repeat induce sporozoite-neutralizing antibodies in mice. Vaccine (2011) 0.92
Furuncular myiasis caused by Dermatobia hominis in a returning traveler. Am J Trop Med Hyg (2007) 0.91
Regulation of the CD8+ T cell responses against Plasmodium liver stages in mice. Int J Parasitol (2004) 0.91
Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria. Arterioscler Thromb Vasc Biol (2011) 0.91
Regulation of anti-Plasmodium immunity by a LITAF-like transcription factor in the malaria vector Anopheles gambiae. PLoS Pathog (2012) 0.91
Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity. FEBS J (2007) 0.90
Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development. Mem Inst Oswaldo Cruz (2011) 0.90
A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites. Cell Host Microbe (2013) 0.89
CD8+ T cells eliminate liver-stage Plasmodium berghei parasites without detectable bystander effect. Infect Immun (2014) 0.88
Novel isoforms of tau that lack the microtubule-binding domain. J Neurochem (2004) 0.88
Mapping and characterization of the primary and anamnestic H-2(d)-restricted cytotoxic T-lymphocyte response in mice against human metapneumovirus. J Virol (2007) 0.88
The effect of antiretrovirals on Plasmodium falciparum liver stages. AIDS (2013) 0.88
A key role for lipoic acid synthesis during Plasmodium liver stage development. Cell Microbiol (2013) 0.87
Malaria vaccines: if at first you don't succeed... Trends Parasitol (2004) 0.87
Tau exon 6 is regulated by an intricate interplay of trans factors and cis elements, including multiple branch points. J Neurochem (2006) 0.86
CpG-enhanced CD8+ T-cell responses to peptide immunization are severely inhibited by B cells. Eur J Immunol (2010) 0.86
Transgenic Plasmodium berghei sporozoites expressing beta-galactosidase for quantification of sporozoite transmission. Mol Biochem Parasitol (2005) 0.86
Efficient development of plasmodium liver stage-specific memory CD8+ T cells during the course of blood-stage malarial infection. J Infect Dis (2007) 0.86
T cell memory in malaria. Curr Opin Immunol (2007) 0.85
Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P. Proc Natl Acad Sci U S A (2012) 0.84
Extrahepatic exoerythrocytic forms of rodent malaria parasites at the site of inoculation: clearance after immunization, susceptibility to primaquine, and contribution to blood-stage infection. Infect Immun (2012) 0.84
Anergy in memory CD4+ T cells is induced by B cells. J Immunol (2008) 0.83
Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay. Clin Vaccine Immunol (2013) 0.83
TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4. Am J Physiol Regul Integr Comp Physiol (2012) 0.82
Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression. Infect Immun (2006) 0.81
Development and use of TCR transgenic mice for malaria immunology research. Methods Mol Biol (2013) 0.80
Genetic detoxification of an aroA Salmonella enterica serovar Typhimurium vaccine strain does not compromise protection against virulent Salmonella and enhances the immune responses towards a protective malarial antigen. FEMS Immunol Med Microbiol (2008) 0.80