Published in J Cell Physiol on January 01, 2012
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Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance. J Virol (2010) 1.39
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Design and creation of new nanomaterials for therapeutic RNAi. ACS Chem Biol (2007) 1.16
A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun (2012) 1.14
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Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis. Chem Biol Drug Des (2007) 1.12
Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication. J Biol Chem (2003) 1.11
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Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. J Biol Chem (2010) 1.08
Dissecting RNA-interference pathway with small molecules. Chem Biol (2005) 1.07
Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology (2004) 1.05
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Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres. J Med Chem (2007) 0.97
Selective binding of TAR RNA by a Tat-derived beta-peptide. Org Lett (2003) 0.96
Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. J Biol Chem (2008) 0.96
Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication. Chembiochem (2009) 0.95
Additivity in the analysis and design of HIV protease inhibitors. J Med Chem (2009) 0.95
Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones. J Med Chem (2010) 0.93
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P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes. J Biol Chem (2010) 0.87
Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication. ChemMedChem (2012) 0.87
U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex. J Mol Biol (2009) 0.86
Molecular mechanisms of RNA-triggered gene silencing machineries. Acc Chem Res (2012) 0.86
Nanotubes functionalized with lipids and natural amino acid dendrimers: a new strategy to create nanomaterials for delivering systemic RNAi. Bioconjug Chem (2010) 0.85
Delivery of therapeutic RNAi by nanovehicles. Chembiochem (2009) 0.85
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem Biol (2013) 0.84
Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst (2012) 0.84
The human Rad51 K133A mutant is functional for DNA double-strand break repair in human cells. Biochemistry (2007) 0.84
Inhibition of HIV tat-TAR interactions by an antisense oligo-2'-O-methylribonucleoside methylphosphonate. Bioorg Med Chem Lett (2003) 0.84
Immunofluorescence imaging of DNA damage response proteins: optimizing protocols for super-resolution microscopy. Methods (2009) 0.84
Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proc Natl Acad Sci U S A (2013) 0.84
miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets. Angew Chem Int Ed Engl (2012) 0.84
Human Rad51 promotes mitochondrial DNA synthesis under conditions of increased replication stress. Mitochondrion (2013) 0.83
Staged miRNA re-regulation patterns during reprogramming. Genome Biol (2013) 0.82
Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation. RNA Biol (2014) 0.82
A bimolecular mechanism of HIV-1 Tat protein interaction with RNA polymerase II transcription elongation complexes. J Mol Biol (2002) 0.82
Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration. J Chem Theory Comput (2013) 0.82
Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol (2013) 0.81
Dynamics of nascent mRNA folding and RNA-protein interactions: an alternative TAR RNA structure is involved in the control of HIV-1 mRNA transcription. Nucleic Acids Res (2006) 0.81
Interfering nanoparticles for silencing microRNAs. Methods Enzymol (2012) 0.81
Using microRNAs to enhance the generation of induced pluripotent stem cells. Curr Protoc Stem Cell Biol (2012) 0.81
Mechanism of site-specific psoralen photoadducts formation in triplex DNA directed by psoralen-conjugated oligonucleotides. Biochemistry (2005) 0.81
Orientation and affinity of HIV-1 Tat fragments in Tat-TAR complex determined by fluorescence resonance energy transfer. Bioconjug Chem (2006) 0.81
A new class of RNA-binding oligomers: peptoid amide and ester analogues. Bioconjug Chem (2002) 0.79
Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem (2012) 0.79
RecA dimers serve as a functional unit for assembly of active nucleoprotein filaments. Biochemistry (2006) 0.79
Design, microwave-assisted synthesis, and photophysical properties of small molecule organic antennas for luminescence resonance energy transfer. J Comb Chem (2005) 0.78
Modulating cellular recombination potential through alterations in RecA structure and regulation. Mol Microbiol (2010) 0.78
Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine. Bioorg Med Chem Lett (2005) 0.78
Microwave-assisted parallel synthesis of a 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine library. J Comb Chem (2004) 0.77
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Quantitative analysis of RNA-mediated protein-protein interactions in living cells by FRET. Chem Biol Drug Des (2007) 0.75
Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines. Bioconjug Chem (2010) 0.75
Solid-phase synthesis of alpha-(2-(benzylthio)-1,4-dihydro-6-methyl-4-p-tolylpyrimidine-5-carboxamido) acids: a new strategy to create diversity in heterocyclic scaffolds. J Comb Chem (2004) 0.75
Strategies to antagonize miRNA functions in vitro and in vivo. Nanomedicine (Lond) (2014) 0.75