Published in Nat Struct Mol Biol on April 24, 2005
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol (2006) 6.41
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA (2006) 4.72
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res (2006) 3.22
Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe (2008) 3.14
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell (2009) 2.27
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell (2012) 2.07
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA (2011) 1.59
Computational estimation and experimental verification of off-target silencing during posttranscriptional gene silencing in plants. Plant Physiol (2006) 1.43
Potent RNAi by short RNA triggers. RNA (2008) 1.29
A systematic analysis of the effect of target RNA structure on RNA interference. Nucleic Acids Res (2007) 1.27
Action and reaction: the biological response to siRNA and its delivery vehicles. Mol Ther (2012) 1.18
On future's doorstep: RNA interference and the pharmacopeia of tomorrow. J Clin Invest (2007) 1.05
Improving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features. BMC Bioinformatics (2007) 0.99
Genome-wide profiling of mouse RNA secondary structures reveals key features of the mammalian transcriptome. Genome Biol (2014) 0.98
Impact of target mRNA structure on siRNA silencing efficiency: A large-scale study. Biotechnol Bioeng (2008) 0.98
Evolutionary emergence of microRNAs in human embryonic stem cells. PLoS One (2008) 0.98
Modeling RNA interference in mammalian cells. BMC Syst Biol (2011) 0.96
Silencing mutant ATXN3 expression resolves molecular phenotypes in SCA3 transgenic mice. Mol Ther (2013) 0.94
Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol (2013) 0.92
siRNA efficiency: structure or sequence-that is the question. J Biomed Biotechnol (2006) 0.92
RNA-based mechanisms regulating host-virus interactions. Immunol Rev (2013) 0.92
Artificial MicroRNAs highly accessible to targets confer efficient virus resistance in plants. J Virol (2008) 0.92
The dynamics and efficacy of antiviral RNA silencing: A model study. BMC Syst Biol (2008) 0.90
MREdictor: a two-step dynamic interaction model that accounts for mRNA accessibility and Pumilio binding accurately predicts microRNA targets. Nucleic Acids Res (2013) 0.89
HIV-l and the microRNA-guided silencing pathway: an intricate and multifaceted encounter. Virus Res (2006) 0.87
RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences. Nucleic Acids Res (2009) 0.86
Molecular mechanisms of RNA-triggered gene silencing machineries. Acc Chem Res (2012) 0.86
Emergence of a complex relationship between HIV-1 and the microRNA pathway. Methods Mol Biol (2009) 0.86
Effects of local mRNA structure on posttranscriptional gene silencing. Proc Natl Acad Sci U S A (2008) 0.84
Design of siRNA Therapeutics from the Molecular Scale. Pharmaceuticals (Basel) (2013) 0.84
Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells. Int J Cell Biol (2012) 0.83
In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus. Sci Rep (2014) 0.82
Role of virus-encoded microRNAs in Avian viral diseases. Viruses (2014) 0.81
Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy. Exp Eye Res (2008) 0.80
Asymmetrically designed siRNAs and shRNAs enhance the strand specificity and efficacy in RNAi. J RNAi Gene Silencing (2007) 0.80
Detection of miRNA expression in intact cells using activatable sensor oligonucleotides. Chem Biol (2014) 0.79
Improved asymmetry prediction for short interfering RNAs. FEBS J (2014) 0.79
RNAi revised - target mRNA-dependent enhancement of gene silencing. Nucleic Acids Res (2015) 0.78
Variables and strategies in development of therapeutic post-transcriptional gene silencing agents. J Ophthalmol (2011) 0.76
Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90. Cell Stress Chaperones (2016) 0.75
A cellular high-throughput screening approach for therapeutic trans-cleaving ribozymes and RNAi against arbitrary mRNA disease targets. Exp Eye Res (2016) 0.75
Targeting Highly Structured RNA by Cooperative Action of siRNAs and Helper Antisense Oligomers in Living Cells. PLoS One (2015) 0.75
Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7. RNA Biol (2012) 0.75
Experimental procedures to identify and validate specific mRNA targets of miRNAs. EXCLI J (2015) 0.75
Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA. Mol Ther Nucleic Acids (2017) 0.75
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol (2006) 6.41
siRNA function in RNAi: a chemical modification analysis. RNA (2003) 4.93
RNAi in human cells: basic structural and functional features of small interfering RNA. Mol Cell (2002) 3.81
Specific and potent RNAi in the nucleus of human cells. Nat Struct Mol Biol (2005) 3.16
Cellular microRNA and P bodies modulate host-HIV-1 interactions. Mol Cell (2009) 3.05
Small RNA-mediated regulation of iPS cell generation. EMBO J (2011) 2.95
Small-molecule inhibition of HIV-1 Vif. Nat Biotechnol (2008) 2.83
RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol Cell (2007) 2.72
Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog (2006) 2.61
Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol (2004) 2.05
Small RNAs: regulators and guardians of the genome. J Cell Physiol (2007) 1.86
The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL. Proc Natl Acad Sci U S A (2013) 1.78
The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure. Proc Natl Acad Sci U S A (2002) 1.46
TAR RNA loop: a scaffold for the assembly of a regulatory switch in HIV replication. Proc Natl Acad Sci U S A (2002) 1.44
HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants. J Am Chem Soc (2008) 1.43
Tat stimulates cotranscriptional capping of HIV mRNA. Mol Cell (2002) 1.43
Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G: correlating function and subcellular localization. J Biol Chem (2004) 1.42
The new face of the old molecules: crustin Pm4 and transglutaminase type I serving as rnps down-regulate astakine-mediated hematopoiesis. PLoS One (2013) 1.40
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance. J Virol (2010) 1.39
MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle. EMBO Rep (2010) 1.34
Potent RNAi by short RNA triggers. RNA (2008) 1.29
Deep annotation of mouse iso-miR and iso-moR variation. Nucleic Acids Res (2012) 1.27
Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1). J Virol (2004) 1.26
Specific HIV-1 TAR RNA loop sequence and functional groups are required for human cyclin T1-Tat-TAR ternary complex formation. Biochemistry (2002) 1.21
microRNAs modulate iPS cell generation. RNA (2011) 1.19
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands. J Med Chem (2006) 1.17
Design and creation of new nanomaterials for therapeutic RNAi. ACS Chem Biol (2007) 1.16
A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun (2012) 1.14
Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis. Chem Biol Drug Des (2007) 1.12
Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication. J Biol Chem (2003) 1.11
Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation. Stem Cells (2011) 1.08
Dissecting RNA-interference pathway with small molecules. Chem Biol (2005) 1.07
Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology (2004) 1.05
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A (2010) 1.03
Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Res (2011) 1.02
Evolutionary emergence of microRNAs in human embryonic stem cells. PLoS One (2008) 0.98
Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres. J Med Chem (2007) 0.97
Selective binding of TAR RNA by a Tat-derived beta-peptide. Org Lett (2003) 0.96
Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. J Biol Chem (2008) 0.96
Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication. Chembiochem (2009) 0.95
Additivity in the analysis and design of HIV protease inhibitors. J Med Chem (2009) 0.95
Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones. J Med Chem (2010) 0.93
Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol (2013) 0.92
RNA-based mechanisms regulating host-virus interactions. Immunol Rev (2013) 0.92
Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication. ChemMedChem (2012) 0.87
P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes. J Biol Chem (2010) 0.87
U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex. J Mol Biol (2009) 0.86
Molecular mechanisms of RNA-triggered gene silencing machineries. Acc Chem Res (2012) 0.86
Nanotubes functionalized with lipids and natural amino acid dendrimers: a new strategy to create nanomaterials for delivering systemic RNAi. Bioconjug Chem (2010) 0.85
Delivery of therapeutic RNAi by nanovehicles. Chembiochem (2009) 0.85
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem Biol (2013) 0.84
Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proc Natl Acad Sci U S A (2013) 0.84
Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst (2012) 0.84
Inhibition of HIV tat-TAR interactions by an antisense oligo-2'-O-methylribonucleoside methylphosphonate. Bioorg Med Chem Lett (2003) 0.84
miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets. Angew Chem Int Ed Engl (2012) 0.84
Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation. RNA Biol (2014) 0.82
A bimolecular mechanism of HIV-1 Tat protein interaction with RNA polymerase II transcription elongation complexes. J Mol Biol (2002) 0.82
Staged miRNA re-regulation patterns during reprogramming. Genome Biol (2013) 0.82
Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration. J Chem Theory Comput (2013) 0.82
Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol (2013) 0.81
Dynamics of nascent mRNA folding and RNA-protein interactions: an alternative TAR RNA structure is involved in the control of HIV-1 mRNA transcription. Nucleic Acids Res (2006) 0.81
Using microRNAs to enhance the generation of induced pluripotent stem cells. Curr Protoc Stem Cell Biol (2012) 0.81
Orientation and affinity of HIV-1 Tat fragments in Tat-TAR complex determined by fluorescence resonance energy transfer. Bioconjug Chem (2006) 0.81
Interfering nanoparticles for silencing microRNAs. Methods Enzymol (2012) 0.81
Mechanism of site-specific psoralen photoadducts formation in triplex DNA directed by psoralen-conjugated oligonucleotides. Biochemistry (2005) 0.81
A new class of RNA-binding oligomers: peptoid amide and ester analogues. Bioconjug Chem (2002) 0.79
Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem (2012) 0.79
Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine. Bioorg Med Chem Lett (2005) 0.78
Calreticulin activates β1 integrin via fucosylation by fucosyltransferase 1 in J82 human bladder cancer cells. Biochem J (2014) 0.78
Design, microwave-assisted synthesis, and photophysical properties of small molecule organic antennas for luminescence resonance energy transfer. J Comb Chem (2005) 0.78
Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation. J Cell Physiol (2012) 0.77
Microwave-assisted parallel synthesis of a 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine library. J Comb Chem (2004) 0.77
In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs). ACS Med Chem Lett (2013) 0.77
Quantitative analysis of RNA-mediated protein-protein interactions in living cells by FRET. Chem Biol Drug Des (2007) 0.75
Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines. Bioconjug Chem (2010) 0.75
Solid-phase synthesis of alpha-(2-(benzylthio)-1,4-dihydro-6-methyl-4-p-tolylpyrimidine-5-carboxamido) acids: a new strategy to create diversity in heterocyclic scaffolds. J Comb Chem (2004) 0.75
Strategies to antagonize miRNA functions in vitro and in vivo. Nanomedicine (Lond) (2014) 0.75
Correction: The New Face of the Old Molecules: Crustin Pm4 and Transglutaminase Type I Serving as RNPs Down-Regulate Astakine-Mediated Hematopoiesis. PLoS One (2017) 0.75
Analysis of melanoma-related microRNAs expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs. Pigment Cell Melanoma Res (2014) 0.75