Published in RNA on June 21, 2011
Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol (2012) 1.56
The functions of microRNAs in pluripotency and reprogramming. Nat Cell Biol (2012) 1.23
Genome-wide functional analysis reveals factors needed at the transition steps of induced reprogramming. Cell Rep (2014) 1.23
Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. Oncogene (2012) 1.18
Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles. RNA (2011) 1.13
Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem (2013) 1.11
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Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells. EMBO J (2014) 0.91
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MicroRNAs as pharmacological targets in diabetes. Pharmacol Res (2013) 0.88
MicroRNAs and Cardiac Regeneration. Circ Res (2015) 0.86
Epigenetics and ncRNAs in brain function and disease: mechanisms and prospects for therapy. Neurotherapeutics (2013) 0.85
miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets. Angew Chem Int Ed Engl (2012) 0.84
RNA-based tools for nuclear reprogramming and lineage-conversion: towards clinical applications. J Cardiovasc Transl Res (2013) 0.84
Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst (2012) 0.84
MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells. Adv Drug Deliv Rev (2015) 0.83
Generation of a drug-inducible reporter system to study cell reprogramming in human cells. J Biol Chem (2012) 0.82
Staged miRNA re-regulation patterns during reprogramming. Genome Biol (2013) 0.82
Toward pluripotency by reprogramming: mechanisms and application. Protein Cell (2013) 0.81
Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact. J Neurosci (2015) 0.81
Switching cell fate, ncRNAs coming to play. Cell Death Dis (2013) 0.81
Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. PLoS One (2012) 0.80
Modeling neurological disorders by human induced pluripotent stem cells. J Biomed Biotechnol (2011) 0.79
Synergetic cooperation of microRNAs with transcription factors in iPS cell generation. PLoS One (2012) 0.79
Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemia. Cancer Sci (2015) 0.78
microRNAs and Cardiac Cell Fate. Cells (2014) 0.78
MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming. RNA (2014) 0.78
Micro-management of pluripotent stem cells. Protein Cell (2014) 0.78
Dissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotency. Cell Regen (Lond) (2016) 0.78
MicroRNAs and induced pluripotent stem cells for human disease mouse modeling. J Biomed Biotechnol (2012) 0.76
Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports (2016) 0.76
A review of Rett syndrome (RTT) with induced pluripotent stem cells. Stem Cell Investig (2016) 0.76
A Compendium of Preparation and Application of Stem Cells in Parkinson's Disease: Current Status and Future Prospects. Front Aging Neurosci (2016) 0.75
Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning. PeerJ (2016) 0.75
Cell Pluripotency Levels Associated with Imprinted Genes in Human. Comput Math Methods Med (2015) 0.75
Retracted Regulatory factors of induced pluripotency: current status. Stem Cell Investig (2014) 0.75
Mechanisms underlying the formation of induced pluripotent stem cells. Wiley Interdiscip Rev Dev Biol (2015) 0.75
Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death Dis (2017) 0.75
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Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol (2007) 21.93
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet (2007) 10.78
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature (2008) 10.73
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell (2009) 10.50
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature (2009) 9.75
Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature (2009) 8.70
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature (2009) 7.96
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet (2006) 7.53
Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46
The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature (2009) 7.39
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
c-MYC: more than just a matter of life and death. Nat Rev Cancer (2002) 6.73
Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol (2007) 6.11
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature (2002) 5.25
Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol (2009) 5.14
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature (2010) 5.10
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol (2008) 4.81
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev (2009) 4.69
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell (2009) 4.64
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development (2009) 4.25
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A (2009) 3.76
TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol (2001) 3.69
Small RNA-mediated regulation of iPS cell generation. EMBO J (2011) 2.95
Transcriptional repression by Myc. Trends Cell Biol (2003) 2.19
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
Myc represses primitive endoderm differentiation in pluripotent stem cells. Cell Stem Cell (2010) 1.90
Small RNAs: regulators and guardians of the genome. J Cell Physiol (2007) 1.86
Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell-based regeneration. Circulation (2010) 1.54
Progress and promise towards safe induced pluripotent stem cells for therapy. Stem Cell Rev (2010) 1.02
Mouse induced pluripotent stem cells. Int J Dev Biol (2008) 0.81
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol (2006) 6.41
siRNA function in RNAi: a chemical modification analysis. RNA (2003) 4.93
RNAi in human cells: basic structural and functional features of small interfering RNA. Mol Cell (2002) 3.81
Specific and potent RNAi in the nucleus of human cells. Nat Struct Mol Biol (2005) 3.16
Cellular microRNA and P bodies modulate host-HIV-1 interactions. Mol Cell (2009) 3.05
Small RNA-mediated regulation of iPS cell generation. EMBO J (2011) 2.95
Small-molecule inhibition of HIV-1 Vif. Nat Biotechnol (2008) 2.83
RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol Cell (2007) 2.72
Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog (2006) 2.61
Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol (2004) 2.05
Small RNAs: regulators and guardians of the genome. J Cell Physiol (2007) 1.86
Target accessibility dictates the potency of human RISC. Nat Struct Mol Biol (2005) 1.78
The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL. Proc Natl Acad Sci U S A (2013) 1.78
The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure. Proc Natl Acad Sci U S A (2002) 1.46
TAR RNA loop: a scaffold for the assembly of a regulatory switch in HIV replication. Proc Natl Acad Sci U S A (2002) 1.44
HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants. J Am Chem Soc (2008) 1.43
Tat stimulates cotranscriptional capping of HIV mRNA. Mol Cell (2002) 1.43
Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G: correlating function and subcellular localization. J Biol Chem (2004) 1.42
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance. J Virol (2010) 1.39
MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle. EMBO Rep (2010) 1.34
Potent RNAi by short RNA triggers. RNA (2008) 1.29
Deep annotation of mouse iso-miR and iso-moR variation. Nucleic Acids Res (2012) 1.27
Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1). J Virol (2004) 1.26
Specific HIV-1 TAR RNA loop sequence and functional groups are required for human cyclin T1-Tat-TAR ternary complex formation. Biochemistry (2002) 1.21
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands. J Med Chem (2006) 1.17
Design and creation of new nanomaterials for therapeutic RNAi. ACS Chem Biol (2007) 1.16
A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun (2012) 1.14
Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis. Chem Biol Drug Des (2007) 1.12
Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication. J Biol Chem (2003) 1.11
Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation. Stem Cells (2011) 1.08
Dissecting RNA-interference pathway with small molecules. Chem Biol (2005) 1.07
Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology (2004) 1.05
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A (2010) 1.03
Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Res (2011) 1.02
Evolutionary emergence of microRNAs in human embryonic stem cells. PLoS One (2008) 0.98
Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres. J Med Chem (2007) 0.97
Selective binding of TAR RNA by a Tat-derived beta-peptide. Org Lett (2003) 0.96
Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. J Biol Chem (2008) 0.96
Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication. Chembiochem (2009) 0.95
Additivity in the analysis and design of HIV protease inhibitors. J Med Chem (2009) 0.95
Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones. J Med Chem (2010) 0.93
Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol (2013) 0.92
RNA-based mechanisms regulating host-virus interactions. Immunol Rev (2013) 0.92
P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes. J Biol Chem (2010) 0.87
Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication. ChemMedChem (2012) 0.87
U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex. J Mol Biol (2009) 0.86
Molecular mechanisms of RNA-triggered gene silencing machineries. Acc Chem Res (2012) 0.86
Nanotubes functionalized with lipids and natural amino acid dendrimers: a new strategy to create nanomaterials for delivering systemic RNAi. Bioconjug Chem (2010) 0.85
Delivery of therapeutic RNAi by nanovehicles. Chembiochem (2009) 0.85
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem Biol (2013) 0.84
Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst (2012) 0.84
Inhibition of HIV tat-TAR interactions by an antisense oligo-2'-O-methylribonucleoside methylphosphonate. Bioorg Med Chem Lett (2003) 0.84
Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proc Natl Acad Sci U S A (2013) 0.84
miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets. Angew Chem Int Ed Engl (2012) 0.84
Staged miRNA re-regulation patterns during reprogramming. Genome Biol (2013) 0.82
Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation. RNA Biol (2014) 0.82
A bimolecular mechanism of HIV-1 Tat protein interaction with RNA polymerase II transcription elongation complexes. J Mol Biol (2002) 0.82
Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration. J Chem Theory Comput (2013) 0.82
Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol (2013) 0.81
Orientation and affinity of HIV-1 Tat fragments in Tat-TAR complex determined by fluorescence resonance energy transfer. Bioconjug Chem (2006) 0.81
Interfering nanoparticles for silencing microRNAs. Methods Enzymol (2012) 0.81
Dynamics of nascent mRNA folding and RNA-protein interactions: an alternative TAR RNA structure is involved in the control of HIV-1 mRNA transcription. Nucleic Acids Res (2006) 0.81
Mechanism of site-specific psoralen photoadducts formation in triplex DNA directed by psoralen-conjugated oligonucleotides. Biochemistry (2005) 0.81
Using microRNAs to enhance the generation of induced pluripotent stem cells. Curr Protoc Stem Cell Biol (2012) 0.81
A new class of RNA-binding oligomers: peptoid amide and ester analogues. Bioconjug Chem (2002) 0.79
Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem (2012) 0.79
Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine. Bioorg Med Chem Lett (2005) 0.78
Design, microwave-assisted synthesis, and photophysical properties of small molecule organic antennas for luminescence resonance energy transfer. J Comb Chem (2005) 0.78
Microwave-assisted parallel synthesis of a 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine library. J Comb Chem (2004) 0.77
In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs). ACS Med Chem Lett (2013) 0.77
Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation. J Cell Physiol (2012) 0.77
Quantitative analysis of RNA-mediated protein-protein interactions in living cells by FRET. Chem Biol Drug Des (2007) 0.75
Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines. Bioconjug Chem (2010) 0.75
Solid-phase synthesis of alpha-(2-(benzylthio)-1,4-dihydro-6-methyl-4-p-tolylpyrimidine-5-carboxamido) acids: a new strategy to create diversity in heterocyclic scaffolds. J Comb Chem (2004) 0.75
Strategies to antagonize miRNA functions in vitro and in vivo. Nanomedicine (Lond) (2014) 0.75