Wnt signaling in the murine diastema.

Three-dimensional analysis of the early development of the dentition. Aust Dent J (2014) 0.88

RSK2 is a modulator of craniofacial development. PLoS One (2014) 0.77

Wnt signaling during tooth replacement in zebrafish (Danio rerio): pitfalls and perspectives. Front Physiol (2014) 0.77

Expression of Sox genes in tooth development. Int J Dev Biol (2015) 0.75

Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09

The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63

Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60

LDL-receptor-related proteins in Wnt signal transduction. Nature (2000) 6.94

WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63

An LDL-receptor-related protein mediates Wnt signalling in mice. Nature (2000) 6.34

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev (1994) 6.07

Wnt signaling in disease and in development. Cell Res (2005) 5.53

arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature (2000) 5.13

Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene (2006) 5.12

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell (1998) 4.40

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol (2001) 4.38

X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet (1996) 3.90

The earliest known eutherian mammal. Nature (2002) 3.48

Modulation of signalling by Sprouty: a developing story. Nat Rev Mol Cell Biol (2004) 3.46

Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev (1995) 2.99

Signalling networks regulating dental development. Mech Dev (1997) 2.73

Lipoprotein receptors in the nervous system. Annu Rev Biochem (2001) 2.61

Primitive fossil rodent from Inner Mongolia and its implications for mammalian phylogeny. Nature (1994) 2.34

Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell (2006) 2.27

Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A (2006) 2.25

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development (2006) 2.23

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17

Regulation of mammalian tooth cusp patterning by ectodin. Science (2005) 2.05

Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development (1999) 2.03

Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene (2003) 1.99

Wise, a context-dependent activator and inhibitor of Wnt signalling. Development (2003) 1.97

Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. Cancer Res (2004) 1.93

Stimulation of ectodermal organ development by Ectodysplasin-A1. Dev Biol (2003) 1.88

Loss of the Tg737 protein results in skeletal patterning defects. Dev Dyn (2003) 1.71

Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol (2002) 1.60

Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One (2008) 1.60

Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development (2009) 1.59

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem (2001) 1.57

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet (2005) 1.56

The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol (2002) 1.54

Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Dev Biol (2000) 1.52

Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape. Development (1992) 1.49

Expression of Wnt signalling pathway genes during tooth development. Mech Dev (1999) 1.48

Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis (2007) 1.46

The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development. Dev Biol (2004) 1.36

Phylogenetic memory of developing mammalian dentition. J Exp Zool B Mol Dev Evol (2006) 1.35

Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth. Development (1993) 1.35

Primary cilia regulate Shh activity in the control of molar tooth number. Development (2009) 1.31

Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J Cell Biol (1995) 1.14

Developmental biology. Making head or tail of Dickkopf. Nature (2001) 1.11

The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis. J Embryol Exp Morphol (1966) 1.06

Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis. Gene Expr Patterns (2003) 1.06

Molecular regulation of tooth development. Bone (1999) 1.03

Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis. J Exp Zool B Mol Dev Evol (2009) 1.02

Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions. Dev Genes Evol (1999) 1.00

Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development. Dev Biol (2007) 0.95

The Wnt signaling pathway in retinal degenerations. IUBMB Life (2005) 0.94

The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors. Arch Oral Biol (2005) 0.93

Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. Biochem Biophys Res Commun (2008) 0.90

Dentition development and budding morphogenesis. J Craniofac Genet Dev Biol (2001) 0.88

Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development. Dev Biol (2008) 0.88

Comparison of expression of the msx-1, msx-2, BMP-2 and BMP-4 genes in the mouse upper diastemal and molar tooth primordia. Int J Dev Biol (1995) 0.85

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst (2005) 13.00

Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11

LRP: role in vascular wall integrity and protection from atherosclerosis. Science (2003) 3.89

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science (2005) 3.61

Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers? Trends Mol Med (2004) 3.44

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron (2005) 3.25

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A (2002) 3.03

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J Biol Chem (2010) 2.72

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem (2002) 2.67

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron (2007) 2.55

TDP-43 is a developmentally regulated protein essential for early embryonic development. J Biol Chem (2009) 2.40

Reelin activates SRC family tyrosine kinases in neurons. Curr Biol (2003) 2.29

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.01

The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell (2005) 1.90

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem (2011) 1.88

Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem (2002) 1.88

Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet (2013) 1.87

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem (2002) 1.83

Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol (2004) 1.81

Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proc Natl Acad Sci U S A (2011) 1.77

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2. J Clin Invest (2010) 1.77

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae. J Biol Chem (2002) 1.74

Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest (2007) 1.73

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. PLoS One (2009) 1.67

Receptor clustering is involved in Reelin signaling. Mol Cell Biol (2004) 1.66

Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. EMBO J (2006) 1.66

Reelin modulates NMDA receptor activity in cortical neurons. J Neurosci (2005) 1.65

TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor. Mol Cell Biol (2010) 1.64

Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J Biol Chem (2003) 1.63

Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One (2008) 1.60

Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate. Nat Genet (2012) 1.60

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis. Arterioscler Thromb Vasc Biol (2008) 1.58

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc Natl Acad Sci U S A (2010) 1.57

Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem (2003) 1.56

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet (2005) 1.56

Interaction of reelin signaling and Lis1 in brain development. Nat Genet (2003) 1.56

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J (2006) 1.51

Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. J Biol Chem (2003) 1.48

Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure (2003) 1.48

Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo. J Bone Miner Res (2013) 1.47

Apolipoprotein E induces antiinflammatory phenotype in macrophages. Arterioscler Thromb Vasc Biol (2011) 1.47

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem (2002) 1.47

Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem (2009) 1.45

Neural crest contribution to mammalian tooth formation. Birth Defects Res C Embryo Today (2004) 1.44

Tooth and jaw: molecular mechanisms of patterning in the first branchial arch. Arch Oral Biol (2003) 1.44

Reelin signaling directly affects radial glia morphology and biochemical maturation. Development (2003) 1.44

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome. PLoS One (2007) 1.44

Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration. J Biol Chem (2012) 1.43

The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development. J Neurosci (2004) 1.42

Restriction of sonic hedgehog signalling during early tooth development. Development (2004) 1.40

Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease. Hum Mol Genet (2005) 1.39

Gamma-secretase limits the inflammatory response through the processing of LRP1. Sci Signal (2008) 1.38

LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. Am J Hum Genet (2010) 1.37

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem (2008) 1.36

TDP-43 aggregation in neurodegeneration: are stress granules the key? Brain Res (2012) 1.35

Normal and abnormal dental development. Hum Mol Genet (2003) 1.33

Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo. Arthritis Rheum (2011) 1.33

Reelin signaling antagonizes beta-amyloid at the synapse. Proc Natl Acad Sci U S A (2009) 1.32

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell (2007) 1.31

Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1. J Biol Chem (2004) 1.31

Primary cilia regulate Shh activity in the control of molar tooth number. Development (2009) 1.31

Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2. Dev Biol (2004) 1.29

Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing. PLoS One (2011) 1.28

Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci (2006) 1.26

The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits. J Biol Chem (2005) 1.25

Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. J Clin Invest (2007) 1.22

Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog. J Clin Invest (2007) 1.22

Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta). J Biol Chem (2005) 1.21

Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem (2003) 1.19

Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev Dyn (2004) 1.18

Stem cell-based biological tooth repair and regeneration. Trends Cell Biol (2010) 1.17

Emerging topics in Reelin function. Eur J Neurosci (2010) 1.17

Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion. PLoS Negl Trop Dis (2011) 1.17

Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1. Neuron (2012) 1.14

Mouse models of tooth abnormalities. Eur J Oral Sci (2008) 1.14

Role of Islet1 in the patterning of murine dentition. Development (2003) 1.14

Regeneration of teeth using stem cell-based tissue engineering. Expert Opin Biol Ther (2006) 1.13

Functions of lipoprotein receptors in neurons. J Lipid Res (2003) 1.11

Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome. Dev Dyn (2009) 1.11

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol (2011) 1.11

Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease. Genomics (2006) 1.10

Expression of Axin2 indicates a role for canonical Wnt signaling in development of the crown and root during pre- and postnatal tooth development. Dev Dyn (2010) 1.10

Genetic modulation of tau phosphorylation in the mouse. J Neurosci (2003) 1.09

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One (2009) 1.09

The Ectodysplasin and NFkappaB signalling pathways in odontogenesis. Arch Oral Biol (2005) 1.08

ApoE receptor 2 controls neuronal survival in the adult brain. Curr Biol (2006) 1.08

Mutations in VLDLR as a cause for autosomal recessive cerebellar ataxia with mental retardation (dysequilibrium syndrome). J Child Neurol (2009) 1.08

Insulin-secreting beta-cell dysfunction induced by human lipoproteins. J Biol Chem (2003) 1.08

Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission. Neuron (2013) 1.07

Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family. Biol Chem (2010) 1.07

Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen. Proc Natl Acad Sci U S A (2005) 1.07

Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice. J Comp Neurol (2003) 1.06

Sonic hedgehog in the pharyngeal endoderm controls arch pattern via regulation of Fgf8 in head ectoderm. Dev Biol (2006) 1.05

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol (2004) 1.05

"Devolution" of bipedality. Proc Natl Acad Sci U S A (2008) 1.05

Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis. J Exp Zool B Mol Dev Evol (2009) 1.04

Signaling through LRP1: Protection from atherosclerosis and beyond. Biochem Pharmacol (2010) 1.03