Published in Dev Cell on May 01, 2002
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A (2003) 4.69
Scratching the surface of skin development. Nature (2007) 4.61
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest (2006) 3.41
Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature (2012) 3.34
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet (2004) 3.21
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16
A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet (2007) 2.84
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell (2009) 2.74
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell (2009) 2.72
Coat variation in the domestic dog is governed by variants in three genes. Science (2009) 2.70
Skin stem cells: rising to the surface. J Cell Biol (2008) 2.66
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol (2003) 2.65
beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell (2010) 2.60
Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev (2003) 2.59
The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc Natl Acad Sci U S A (2004) 2.53
Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet (2008) 2.45
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A (2006) 2.25
Stem cells of the skin epithelium. Proc Natl Acad Sci U S A (2003) 2.20
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Epidermal stem cell diversity and quiescence. EMBO Mol Med (2009) 2.14
Sox2 is required for development of taste bud sensory cells. Genes Dev (2006) 1.97
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
Shift of localized growth zones contributes to skin appendage morphogenesis: role of the Wnt/beta-catenin pathway. J Invest Dermatol (2003) 1.95
Physiological factors that regulate skin pigmentation. Biofactors (2009) 1.93
Manifestations and mechanisms of stem cell aging. J Cell Biol (2011) 1.93
Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell (2011) 1.92
Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development (2012) 1.89
FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev (2002) 1.88
Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet (2006) 1.86
Evo-Devo of amniote integuments and appendages. Int J Dev Biol (2004) 1.84
The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One (2009) 1.83
Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. Am J Hum Genet (2007) 1.82
Cryptic patterning of avian skin confers a developmental facility for loss of neck feathering. PLoS Biol (2011) 1.82
Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol (2009) 1.73
Review of hair follicle dermal cells. J Dermatol Sci (2010) 1.72
Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway. Am J Pathol (2004) 1.72
Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A (2006) 1.72
A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol (2004) 1.63
Mitotic and mitogenic Wnt signalling. EMBO J (2012) 1.62
Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J Cell Biol (2004) 1.56
Analysis of the temporal requirement for eda in hair and sweat gland development. J Invest Dermatol (2008) 1.55
β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science (2014) 1.55
The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. PLoS One (2008) 1.53
WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation. Cell (2016) 1.52
Man's best friend becomes biology's best in show: genome analyses in the domestic dog. Annu Rev Genet (2010) 1.51
The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet (2011) 1.48
Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. J Invest Dermatol (2012) 1.48
The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One (2009) 1.47
Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A (2007) 1.46
DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation. J Biol Chem (2008) 1.44
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. Cell Host Microbe (2017) 1.44
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev (2008) 1.41
Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling. Semin Cell Dev Biol (2012) 1.41
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41
Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell Mol Life Sci (2012) 1.40
Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. PLoS Genet (2006) 1.40
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol (2012) 1.39
EDA signaling and skin appendage development. Cell Cycle (2006) 1.39
Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance. Proc Natl Acad Sci U S A (2004) 1.36
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A (2011) 1.35
MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS One (2009) 1.33
Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling. Genes Dev (2014) 1.33
Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc Natl Acad Sci U S A (2003) 1.33
Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development (2008) 1.32
Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet (2009) 1.31
Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers. Mech Dev (2004) 1.26
Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals. Proc Natl Acad Sci U S A (2005) 1.26
Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia. Proc Natl Acad Sci U S A (2006) 1.23
Hedgehog signaling regulates sebaceous gland development. Am J Pathol (2003) 1.23
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol (2012) 1.22
Hairy tale of signaling in hair follicle development and cycling. Semin Cell Dev Biol (2012) 1.22
Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals. J Cell Physiol (2008) 1.21
Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. Genome Biol (2007) 1.18
Wnt/β-catenin signaling regulates postnatal development and regeneration of the salivary gland. Stem Cells Dev (2010) 1.17
Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol (2010) 1.15
Targeting stem cells-clinical implications for cancer therapy. Curr Stem Cell Res Ther (2009) 1.15
Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages. Cold Spring Harb Perspect Biol (2012) 1.14
Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice. Mol Cell Biol (2005) 1.14
The glandular stem/progenitor cell niche in airway development and repair. Proc Am Thorac Soc (2008) 1.13
Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation. J Invest Dermatol (2012) 1.13
Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. J Invest Dermatol (2012) 1.13
Building epithelial tissues from skin stem cells. Cold Spring Harb Symp Quant Biol (2008) 1.12
Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure. Dev Biol (2008) 1.12
Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol (2013) 1.11
Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell (2004) 1.11
Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev (2013) 1.10
Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest (2010) 1.08
A new scenario for the evolutionary origin of hair, feather, and avian scales. J Anat (2009) 1.08
Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev (2005) 1.08
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature (2007) 5.19
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet (2008) 2.45
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature (2005) 2.37
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (2004) 2.24
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science (2011) 1.96
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell (2010) 1.75
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem (2002) 1.59
Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem (2011) 1.51
Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res (2013) 1.49
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41
The mammary bud as a skin appendage: unique and shared aspects of development. J Mammary Gland Biol Neoplasia (2006) 1.39
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med (2013) 1.33
Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development (2008) 1.32
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol (2006) 1.28
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc Natl Acad Sci U S A (2012) 1.19
Wnt/β-catenin signaling regulates postnatal development and regeneration of the salivary gland. Stem Cells Dev (2010) 1.17
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (2012) 1.11
Expression of Frizzled genes in developing and postnatal hair follicles. J Invest Dermatol (2004) 1.04
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development (2013) 1.02
DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. PLoS One (2010) 0.99
A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Hum Mol Genet (2005) 0.96
Hairy math: insights into hair-follicle spacing and orientation. Cell (2007) 0.91
Cell biology: The not-so-odd couple. Nature (2009) 0.87
Wnt signaling influences the development of murine epidermal Langerhans cells. J Invest Dermatol (2011) 0.78