Published in Nature on September 02, 2009
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell (2010) 17.48
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature (2010) 17.31
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature (2010) 16.12
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature (2010) 15.63
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VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. Mol Cell Biol (2010) 0.90
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Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Mol Cell Biol (2012) 0.87
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KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp Cell Res (2010) 0.84
Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. Proc Natl Acad Sci U S A (2010) 0.84
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Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature (2016) 0.80
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Complexity in KSR function revealed by Raf inhibitor and KSR structure studies. Small GTPases (2011) 0.79
MEK-1 activates C-Raf through a Ras-independent mechanism. Biochim Biophys Acta (2013) 0.79
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SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells. Mol Oncol (2013) 0.78
Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. Cancer Res (2015) 0.78
Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation. Mol Cell Biol (2014) 0.77
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Interplay of PKA and Rac: fine-tuning of Rac localization and signaling. Small GTPases (2013) 0.76
Backbone and side chain 1H, 15N and 13C assignments of the KSR1 CA1 domain. Biomol NMR Assign (2010) 0.76
Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations. Case Rep Oncol (2014) 0.75
The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF. J Biol Chem (2012) 0.75
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Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. J Biol Chem (2013) 0.75
CRAF R391W is a melanoma driver oncogene. Sci Rep (2016) 0.75
Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. J Biol Chem (2016) 0.75
Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK. Mol Cell Proteomics (2017) 0.75
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Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation. ACS Chem Biol (2016) 0.75
Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1. Proc Natl Acad Sci U S A (2017) 0.75
Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition. EMBO J (2017) 0.75
Mechanism of substrate specificity of phosphatidylinositol phosphate kinases. Proc Natl Acad Sci U S A (2016) 0.75
Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras. F1000Res (2017) 0.75
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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51
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Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol (2005) 7.07
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CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation. Curr Biol (2006) 1.69
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Genes Dev (2006) 1.35
The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Genes Dev (2006) 1.07
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell (2003) 5.72
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell (2008) 4.59
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Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell (2005) 3.38
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell (2010) 2.74
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A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics (2008) 2.56
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53
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An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
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The John Charnley Award: The functional outcome of hip resurfacing and large-head THA is the same: a randomized, double-blind study. Clin Orthop Relat Res (2009) 2.23
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CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Proc Natl Acad Sci U S A (2008) 0.99
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"Unraveling the tail" of how SRPK1 phosphorylates ASF/SF2. Mol Cell (2008) 0.81
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The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila. Genetics (2008) 0.80
Structural basis for specificity of TGFβ family receptor small molecule inhibitors. Cell Signal (2011) 0.80
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Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila. Dev Biol (2006) 0.77
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A polo match for Plk1. Cell (2003) 0.75
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