Published in J Biol Chem on June 12, 2011
Biomolecular computing systems: principles, progress and potential. Nat Rev Genet (2012) 1.59
Synthetic biology: advancing the design of diverse genetic systems. Annu Rev Chem Biomol Eng (2013) 1.06
Epigenetic virtues of chromodomains. Crit Rev Biochem Mol Biol (2011) 1.03
Chromatin regulation at the frontier of synthetic biology. Nat Rev Genet (2015) 1.01
Attention deficits and hyperactivity-impulsivity: what have we learned, what next? Dev Psychopathol (2013) 0.86
Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics. Nat Nanotechnol (2013) 0.83
Unraveling the 3D genome: genomics tools for multiscale exploration. Trends Genet (2015) 0.83
Future directions in ADHD etiology research. J Clin Child Adolesc Psychol (2012) 0.82
Chromatin computation. PLoS One (2012) 0.79
The impact of chromatin dynamics on Cas9-mediated genome editing in human cells. ACS Synth Biol (2016) 0.77
Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices. J Biol Eng (2015) 0.77
The epigenome: the next substrate for engineering. Genome Biol (2016) 0.77
Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways. PLoS One (2015) 0.77
Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. ACS Synth Biol (2014) 0.75
Mammalian synthetic biology for studying the cell. J Cell Biol (2016) 0.75
Regulation of cancer epigenomes with a histone-binding synthetic transcription factor. NPJ Genom Med (2017) 0.75
Molecular structures guide the engineering of chromatin. Nucleic Acids Res (2017) 0.75
Chromatin modifications and their function. Cell (2007) 55.98
Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol (2008) 15.90
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer (2006) 11.48
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
The essence of senescence. Genes Dev (2010) 8.21
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008) 7.59
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol (2006) 5.99
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev (2003) 5.77
A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci U S A (1998) 5.46
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A (2010) 4.52
Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev Cancer (2009) 4.40
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell (2010) 4.31
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet (1992) 3.43
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38
Functional analysis of the chromo domain of HP1. EMBO J (1995) 3.30
Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development (2009) 2.69
A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Development (1996) 2.33
Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature (1995) 1.80
Core promoter specificities of the Sp1 and VP16 transcriptional activation domains. Mol Cell Biol (1995) 1.68
Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development (1997) 1.65
Interpretation of developmental signaling at chromatin: the Polycomb perspective. Dev Cell (2010) 1.59
Eukaryotic systems broaden the scope of synthetic biology. J Cell Biol (2009) 1.34
Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation. Mol Cancer (2010) 1.16
Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts. Cytometry A (2009) 0.90
pc1 and psc1, zebrafish homologs of Drosophila Polycomb and Posterior sex combs, encode nuclear proteins capable of complex interactions. Biochem Biophys Res Commun (2002) 0.78
Genome-wide analysis of estrogen receptor binding sites. Nat Genet (2006) 18.63
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell (2005) 14.32
Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell (2004) 4.95
Organization of intracellular reactions with rationally designed RNA assemblies. Science (2011) 3.65
Programmable bacteria detect and record an environmental signal in the mammalian gut. Proc Natl Acad Sci U S A (2014) 3.50
Learning a prior on regulatory potential from eQTL data. PLoS Genet (2009) 3.31
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell (2003) 3.29
Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet (2003) 3.25
Functional specificity among ribosomal proteins regulates gene expression. Cell (2007) 3.22
Protein and RNA export from the nucleus. Dev Cell (2002) 3.14
Nuclear transport and cancer: from mechanism to intervention. Nat Rev Cancer (2004) 2.85
Designing biological systems. Genes Dev (2007) 2.78
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. J Biol Chem (2004) 2.64
Rational design of memory in eukaryotic cells. Genes Dev (2007) 2.52
An alternative splicing network links cell-cycle control to apoptosis. Cell (2010) 2.43
Human cell proteins and human immunodeficiency virus DNA integration. Front Biosci (2004) 2.32
Engineering cyanobacteria to generate high-value products. Trends Biotechnol (2011) 2.31
Developmentally induced changes in transcriptional program alter spatial organization across chromosomes. Genes Dev (2005) 2.27
Engineering synthetic TAL effectors with orthogonal target sites. Nucleic Acids Res (2012) 2.25
Spatially ordered dynamics of the bacterial carbon fixation machinery. Science (2010) 2.22
Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. Genes Dev (2008) 2.17
Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway. PLoS Biol (2012) 2.15
Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells. Genome Biol (2005) 2.11
The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Mol Cell (2002) 2.10
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol (2005) 2.08
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc Natl Acad Sci U S A (2003) 1.98
A systems view of mRNP biology. Genes Dev (2004) 1.98
Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. ACS Chem Biol (2007) 1.94
Retrovirus-delivered siRNA. BMC Biotechnol (2002) 1.92
Coupling and coordination in gene expression processes: a systems biology view. Nat Rev Genet (2008) 1.90
Emergent cooperation in microbial metabolism. Mol Syst Biol (2010) 1.87
Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure (2005) 1.86
Genome-wide mRNA surveillance is coupled to mRNA export. Genes Dev (2004) 1.83
CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Cancer Res (2008) 1.83
Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. J Biol Chem (2003) 1.82
Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev (2011) 1.81
Intron status and 3'-end formation control cotranscriptional export of mRNA. Genes Dev (2002) 1.79
Global analysis of mRNA splicing. RNA (2007) 1.77
Nuclear transport as a target for cell growth. Drug Discov Today (2003) 1.72
Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors. Genes Dev (2004) 1.66
Intron length increases oscillatory periods of gene expression in animal cells. Genes Dev (2008) 1.63
Requirements for the nuclear export of the small ribosomal subunit. J Cell Sci (2002) 1.62
Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates. Mol Cell (2006) 1.51
Engineering cyanobacteria to synthesize and export hydrophilic products. Appl Environ Microbiol (2010) 1.50
Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors. Genome Biol (2006) 1.49
Dynamics in the mixed microbial concourse. Genes Dev (2010) 1.45
Intron delays and transcriptional timing during development. Dev Cell (2008) 1.43
Transcriptional regulation at the nuclear pore complex. Curr Opin Genet Dev (2007) 1.42
Rerouting carbon flux to enhance photosynthetic productivity. Appl Environ Microbiol (2012) 1.40
Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling. Genetics (2002) 1.40
Natural strategies for the spatial optimization of metabolism in synthetic biology. Nat Chem Biol (2012) 1.39
Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev (2007) 1.38
The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae. Genetics (2006) 1.38
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev (2012) 1.38
Cell-to-cell variability of alternative RNA splicing. Mol Syst Biol (2011) 1.38
PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits. EMBO J (2004) 1.37
Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J Biol Chem (2004) 1.36
A tunable zinc finger-based framework for Boolean logic computation in mammalian cells. Nucleic Acids Res (2012) 1.35
Exon expression profiling reveals stimulus-mediated exon use in neural cells. Genome Biol (2007) 1.35
Eukaryotic systems broaden the scope of synthetic biology. J Cell Biol (2009) 1.34
Tailored fatty acid synthesis via dynamic control of fatty acid elongation. Proc Natl Acad Sci U S A (2013) 1.33
Making cellular memories. Cell (2010) 1.30
Modularity of a carbon-fixing protein organelle. Proc Natl Acad Sci U S A (2011) 1.29
Differential recruitment of the splicing machinery during transcription predicts genome-wide patterns of mRNA splicing. Mol Cell (2006) 1.27
Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell (2003) 1.26
Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. RNA (2009) 1.23
Defossiling fuel: how synthetic biology can transform biofuel production. ACS Chem Biol (2008) 1.19
Systems perspectives on mRNA processing. Cell Res (2007) 1.17
Insulation of a synthetic hydrogen metabolism circuit in bacteria. J Biol Eng (2010) 1.15
The psammaplysenes, specific inhibitors of FOXO1a nuclear export. J Nat Prod (2005) 1.13
Autoregulation of ribosome biosynthesis by a translational response in fission yeast. Mol Cell Biol (2006) 1.12
Synthetic memory circuits for tracking human cell fate. Genes Dev (2012) 1.11
Informing biological design by integration of systems and synthetic biology. Cell (2011) 1.10
Intracellular transport of human immunodeficiency virus type 1 integrase. J Cell Sci (2003) 1.10
Motion as a phenotype: the use of live-cell imaging and machine visual screening to characterize transcription-dependent chromosome dynamics. BMC Cell Biol (2006) 1.09
Designing biological compartmentalization. Trends Cell Biol (2012) 1.09
Transcriptional regulation by the proteasome as a mechanism for cellular protein homeostasis. Cell Cycle (2006) 1.07
Communication between levels of transcriptional control improves robustness and adaptivity. Mol Syst Biol (2006) 1.06
Rewiring hydrogenase-dependent redox circuits in cyanobacteria. Proc Natl Acad Sci U S A (2011) 1.06
Genomic localization of RNA binding proteins reveals links between pre-mRNA processing and transcription. Genome Res (2006) 1.06
Nuclear protein transport. Methods Enzymol (2002) 1.05
A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. J Cell Biol (2009) 1.03
Two- and three-input TALE-based AND logic computation in embryonic stem cells. Nucleic Acids Res (2013) 1.03
Therapeutic potential of retroviral RNAi vectors. Expert Opin Biol Ther (2004) 1.00
Harnessing nature's toolbox: regulatory elements for synthetic biology. J R Soc Interface (2009) 1.00
The role of protein arginine methylation in the formation of silent chromatin. Genes Dev (2006) 0.99
The bacterial carbon-fixing organelle is formed by shell envelopment of preassembled cargo. PLoS One (2013) 0.99
Identifying proteins that affect mRNA localization in living cells. Methods (2002) 0.98
Designing and using RNA scaffolds to assemble proteins in vivo. Nat Protoc (2012) 0.98
Enhancement of cell type specificity by quantitative modulation of a chimeric ligand. J Biol Chem (2008) 0.97
The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins. Mol Biol Cell (2006) 0.97
Parts plus pipes: synthetic biology approaches to metabolic engineering. Metab Eng (2011) 0.97
DNA ends alter the molecular composition and localization of Ku multicomponent complexes. Mol Cell Proteomics (2012) 0.96
HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. Virology (2005) 0.96
Spatial and temporal organization of chromosome duplication and segregation in the cyanobacterium Synechococcus elongatus PCC 7942. PLoS One (2012) 0.93
Systems-level engineering of nonfermentative metabolism in yeast. Genetics (2009) 0.93