Childhood obesity and cardiovascular disease: links and prevention strategies.

PubWeight™: 1.38‹?› | Rank: Top 10%

🔗 View Article (PMC 4292916)

Published in Nat Rev Cardiol on June 14, 2011

Authors

Kristen J Nadeau1, David M Maahs, Stephen R Daniels, Robert H Eckel

Author Affiliations

1: The Children's Hospital, Department of Pediatrics, University of Colorado School of Medicine, Building A, 13123 East 16th Avenue, Aurora, CO 80045, USA. nadeau.kristen@tchden.org

Articles citing this

The child as proband for future parental cardiometabolic disease: the 26-year prospective Princeton Lipid Research Clinics Follow-up Study. J Pediatr (2012) 1.41

School year versus summer differences in child weight gain: a narrative review. Child Obes (2013) 1.03

Insulin resistance determined by Homeostasis Model Assessment (HOMA) and associations with metabolic syndrome among Chinese children and teenagers. Diabetol Metab Syndr (2013) 1.02

Childhood obesity: a life-long health risk. Acta Pharmacol Sin (2012) 0.93

The Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in school children: study protocol for a randomised controlled trial. Trials (2013) 0.91

Risk factors for cardiovascular disease and type 2 diabetes retained from childhood to adulthood predict adult outcomes: the Princeton LRC Follow-up Study. Int J Pediatr Endocrinol (2012) 0.89

Gender Differences Time Trends for Metabolic Syndrome and Its Components among Tehranian Children and Adolescents. Cholesterol (2012) 0.89

Rationale for New York City's regulations on nutrition, physical activity, and screen time in early child care centers. Prev Chronic Dis (2014) 0.89

Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine. Physiol Genomics (2013) 0.87

Obesity and infection: two sides of one coin. Eur J Pediatr (2013) 0.87

Growth and obesity through the first 7 y of life in association with levels of maternal glycemia during pregnancy: a prospective cohort study. Am J Clin Nutr (2016) 0.87

A primary-school-based study to reduce the prevalence of childhood obesity--the EdAl (Educació en Alimentació) study: a randomized controlled trial. Trials (2014) 0.86

BMI and waist circumference; cross-sectional and prospective associations with blood pressure and cholesterol in 12-year-olds. PLoS One (2012) 0.85

Cardiovascular disease in children and adolescents with diabetes: where are we, and where are we going? Diabetes Technol Ther (2012) 0.84

High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study. BMC Med (2013) 0.84

'FIFA 11 for Health' for Europe. II: effect on health markers and physical fitness in Danish schoolchildren aged 10-12 years. Br J Sports Med (2016) 0.83

Cardiovascular disease risk factors are elevated in urban minority children enrolled in head start. Child Obes (2014) 0.82

An interval of the obesity QTL Nob3.38 within a QTL hotspot on chromosome 1 modulates behavioral phenotypes. PLoS One (2013) 0.81

CARD9 knockout ameliorates myocardial dysfunction associated with high fat diet-induced obesity. J Mol Cell Cardiol (2016) 0.81

Pediatric obesity. An introduction. Appetite (2015) 0.81

Impact of the FITKids physical activity intervention on adiposity in prepubertal children. Pediatrics (2014) 0.80

Body mass, cardiovascular risk and metabolic characteristics of young persons presenting for mental healthcare in Sydney, Australia. BMJ Open (2015) 0.80

Free Sugars and Total Fat Are Important Characteristics of a Dietary Pattern Associated with Adiposity across Childhood and Adolescence. J Nutr (2016) 0.80

Human Adenovirus 36 Infection Increased the Risk of Obesity: A Meta-Analysis Update. Medicine (Baltimore) (2015) 0.78

Musculoskeletal Pain, Self-reported Physical Function, and Quality of Life in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Cohort. JAMA Pediatr (2015) 0.76

Heterogeneous vascular responses to lifestyle intervention in obese Latino adolescents. Metab Syndr Relat Disord (2014) 0.76

Metabolic endotoxaemia in childhood obesity. BMC Obes (2016) 0.76

Longitudinal development of obesity in the post-Fontan population. Eur J Clin Nutr (2015) 0.76

A health literate approach to the prevention of childhood overweight and obesity. Patient Educ Couns (2013) 0.76

Body mass index and dental caries in children aged 5 to 8 years attending a dental paediatric referral practice in the Netherlands. BMC Res Notes (2015) 0.75

Association of Metabolic Syndrome with Body Fat Percent, Anthropometric Indices in 10 To 18 Year Old Adolescents. Iran J Public Health (2014) 0.75

Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children. Int J Endocrinol (2017) 0.75

Diabetes Complications in Childhood Diabetes-New Biomarkers and Technologies. Curr Pediatr Rep (2015) 0.75

Missed opportunities for improving nutrition through institutional food: the case for food worker training. Am J Public Health (2013) 0.75

Articles cited by this

(truncated to the top 100)

Prevalence of overweight and obesity in the United States, 1999-2004. JAMA (2006) 72.59

Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation (2003) 23.97

A potential decline in life expectancy in the United States in the 21st century. N Engl J Med (2005) 19.63

The metabolic syndrome. Lancet (2005) 19.47

Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med (1998) 15.09

Obesity and the metabolic syndrome in children and adolescents. N Engl J Med (2004) 13.99

The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics (1999) 11.20

Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med (1992) 10.44

Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med (2007) 8.84

Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med (2010) 8.70

Prevalence of fatty liver in children and adolescents. Pediatrics (2006) 7.00

Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr (2000) 6.82

Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA (2003) 6.60

Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics (2001) 6.06

Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial. JAMA (2010) 5.77

Adolescent overweight and future adult coronary heart disease. N Engl J Med (2007) 5.74

Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med (1996) 5.20

Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study. J Am Coll Cardiol (1996) 4.92

Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA (2003) 4.88

Adolescent BMI trajectory and risk of diabetes versus coronary disease. N Engl J Med (2011) 4.61

Effectiveness of weight management interventions in children: a targeted systematic review for the USPSTF. Pediatrics (2010) 4.41

Biomarkers of cardiovascular disease: molecular basis and practical considerations. Circulation (2006) 4.35

Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology (2005) 4.21

Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial. JAMA (2007) 4.09

Systematic review of school-based interventions that focus on changing dietary intake and physical activity levels to prevent childhood obesity: an update to the obesity guidance produced by the National Institute for Health and Clinical Excellence. Obes Rev (2008) 3.78

Insulin resistance and associated compensatory responses in african-american and Hispanic children. Diabetes Care (2002) 3.73

Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: The Muscatine Study. Circulation (2001) 3.64

The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr (2005) 3.61

Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation (2009) 3.59

Tracking of blood lipids and blood pressures in school age children: the Muscatine study. Circulation (1978) 3.59

Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation (2002) 3.49

Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes (2005) 3.36

Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up Study. Pediatrics (2007) 3.25

Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association. Hypertension (2009) 3.22

Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort. Am J Clin Nutr (1998) 3.21

Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab (2003) 3.01

Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. Circulation (2000) 2.94

Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation (2004) 2.90

Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism (1996) 2.60

Early adiposity rebound in childhood and risk of Type 2 diabetes in adult life. Diabetologia (2003) 2.60

Excess weight and the risk of incident coronary heart disease among men and women. Obesity (Silver Spring) (2009) 2.56

Persistence of multiple cardiovascular risk clustering related to syndrome X from childhood to young adulthood. The Bogalusa Heart Study. Arch Intern Med (1994) 2.55

Size at birth, maternal weight, and type 2 diabetes in South India. Diabet Med (1998) 2.50

Patterns of growth associated with the timing of adiposity rebound. Obesity (Silver Spring) (2008) 2.48

Body mass index and height from childhood to adulthood in the 1958 British born cohort. Am J Clin Nutr (1997) 2.43

Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children's Blood Pressure Study. Circulation (1999) 2.43

Overweight and obesity from childhood to adulthood: a follow-up of participants in the 1985 Australian Schools Health and Fitness Survey. Med J Aust (2007) 2.30

Relationship of childhood weight status to morbidity in adults. HSMHA Health Rep (1971) 2.26

Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study. Diabetes (2004) 2.22

Insulin sensitivity among obese children and adolescents, according to degree of weight loss. Pediatrics (2004) 2.10

Childhood obesity--the shape of things to come. N Engl J Med (2007) 2.09

Utility of currently recommended pediatric dyslipidemia classifications in predicting dyslipidemia in adulthood: evidence from the Childhood Determinants of Adult Health (CDAH) study, Cardiovascular Risk in Young Finns Study, and Bogalusa Heart Study. Circulation (2007) 2.07

Childhood obesity predicts adult metabolic syndrome: the Fels Longitudinal Study. J Pediatr (2007) 2.07

NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology (2006) 2.06

Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet (2007) 2.01

The association of pediatric low- and high-density lipoprotein cholesterol dyslipidemia classifications and change in dyslipidemia status with carotid intima-media thickness in adulthood evidence from the cardiovascular risk in Young Finns study, the Bogalusa Heart study, and the CDAH (Childhood Determinants of Adult Health) study. J Am Coll Cardiol (2009) 2.00

Predicting adult metabolic syndrome from childhood body mass index: follow-up of the New Delhi birth cohort. Arch Dis Child (2008) 1.98

Childhood overweight and maturational timing in the development of adult overweight and fatness: the Newton Girls Study and its follow-up. Pediatrics (2005) 1.94

Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J Pediatr Gastroenterol Nutr (2005) 1.94

Coronary artery calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol (2006) 1.92

Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study. J Am Coll Cardiol (2009) 1.91

C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis (2000) 1.90

Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial. Diabetes Care (2002) 1.88

Progression of normotensive adolescents to hypertensive adults: a study of 26,980 teenagers. Hypertension (2010) 1.87

Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: effect of differences in insulin sensitivity. Arch Intern Med (2007) 1.87

Childhood overweight and cardiovascular disease risk factors: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr (2007) 1.83

Adiposity in childhood predicts obesity and insulin resistance in young adulthood. J Pediatr (2001) 1.83

Effects of persistent physical activity and inactivity on coronary risk factors in children and young adults. The Cardiovascular Risk in Young Finns Study. Am J Epidemiol (1994) 1.75

Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation (2005) 1.72

The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study. Int J Obes (Lond) (2008) 1.66

Long-term follow-up of cardiovascular disease risk factors in children after an obesity intervention. Am J Clin Nutr (2006) 1.65

Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab (2009) 1.65

A 40-year history of overweight children in Stockholm: life-time overweight, morbidity, and mortality. Int J Obes Relat Metab Disord (1994) 1.58

Persistent elevation of plasma insulin levels is associated with increased cardiovascular risk in children and young adults. The Bogalusa Heart Study. Circulation (1996) 1.54

Cholesterol and arterial distensibility in the first decade of life: a population-based study. Circulation (2000) 1.53

The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol (2003) 1.52

Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening. Int J Obes Relat Metab Disord (2004) 1.51

Relation of body mass index and insulin resistance to cardiovascular risk factors, inflammatory factors, and oxidative stress during adolescence. Circulation (2005) 1.48

Association of Coronary Heart Disease Risk Factors with microscopic qualities of coronary atherosclerosis in youth. Circulation (2000) 1.43

Insulin resistance in nonalcoholic fatty liver disease. Curr Pharm Des (2010) 1.41

Changes of cardiovascular risk factors in obese children effects of inpatient and outpatient interventions. J Pediatr Gastroenterol Nutr (2006) 1.41

Lifetime risk factors and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study. Hypertension (2010) 1.41

Stability of the association between birth weight and childhood overweight during the development of the obesity epidemic. Obes Res (2005) 1.39

Exercise training and the cardiovascular consequences of type 2 diabetes and hypertension: plausible mechanisms for improving cardiovascular health. JAMA (2002) 1.38

Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors. Circulation (2005) 1.37

Clustering of long-term trends in metabolic syndrome variables from childhood to adulthood in Blacks and Whites: the Bogalusa Heart Study. Am J Epidemiol (2007) 1.36

Risk in childhood of development of severe adult obesity: retrospective, population-based case-cohort study. Am J Epidemiol (1988) 1.35

Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J Clin Endocrinol Metab (2002) 1.35

Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study. Eur Heart J (2010) 1.34

Gender and Tanner stage differences in body composition and insulin sensitivity in early pubertal children. J Clin Endocrinol Metab (1995) 1.33

Does childhood obesity track into adulthood? Crit Rev Food Sci Nutr (1993) 1.30

Association of body mass index measured in childhood, adolescence, and young adulthood with risk of ischemic heart disease and stroke: findings from 3 historical cohort studies. Am J Clin Nutr (2006) 1.30

Obesity and low-grade inflammation: a paediatric perspective. Obes Rev (2009) 1.28

Effects of nonlipid risk factors on atherosclerosis in youth with a favorable lipoprotein profile. Circulation (2001) 1.26

Risk of obesity in relation to physical activity tracking from youth to adulthood. Med Sci Sports Exerc (2006) 1.24

Association of body mass index and obesity measured in early childhood with risk of coronary heart disease and stroke in middle age: findings from the aberdeen children of the 1950s prospective cohort study. Circulation (2005) 1.23

Efficacy of exercise for treating overweight in children and adolescents: a systematic review. Int J Obes (Lond) (2006) 1.23

Temporal association between obesity and hyperinsulinemia in children, adolescents, and young adults: the Bogalusa Heart Study. Metabolism (1999) 1.20

Distribution and metabolic syndrome correlates of plasma C-reactive protein in biracial (black-white) younger adults: the Bogalusa Heart Study. Metabolism (2006) 1.17

Risk factors and adult body mass index among overweight children: the Bogalusa Heart Study. Pediatrics (2009) 1.14

Articles by these authors

Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation (2005) 43.74

Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation (2009) 35.24

2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 17.18

2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 16.52

Evidence based physical activity for school-age youth. J Pediatr (2005) 13.50

Obesity and metabolic syndrome in circadian Clock mutant mice. Science (2005) 12.66

AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Science Advisory and Coordinating Committee. Circulation (2002) 9.04

Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation (2005) 8.59

Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med (2011) 7.16

Decline in physical activity in black girls and white girls during adolescence. N Engl J Med (2002) 7.06

Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment. Circulation (2005) 7.04

Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2010) 6.93

Lipid screening and cardiovascular health in childhood. Pediatrics (2008) 6.62

Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension (2006) 5.59

The metabolic syndrome. Endocr Rev (2008) 5.33

Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics (2004) 5.01

Relation between the changes in physical activity and body-mass index during adolescence: a multicentre longitudinal study. Lancet (2005) 4.65

Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation (2004) 4.29

Lipoprotein lipase: genetics, lipid uptake, and regulation. J Lipid Res (2002) 4.09

Guidelines for lipid screening in children and adolescents: bringing evidence to the debate. Pediatrics (2012) 3.98

A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab (2003) 3.93

Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation (2007) 3.90

A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82

Physical activity intervention studies: what we know and what we need to know: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity); Council on Cardiovascular Disease in the Young; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research. Circulation (2006) 3.72

2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 3.63

Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation (2009) 3.59

Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 3.48

2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 3.35

Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation (2003) 3.33

Lipoprotein lipase: from gene to obesity. Am J Physiol Endocrinol Metab (2009) 3.29

Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents. J Pediatr (2005) 3.23

Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association. Hypertension (2009) 3.22

Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology. Circulation (2010) 3.16

Correlates of beverage intake in adolescent girls: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr (2006) 3.15

Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol (2006) 3.11

Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. Circulation (2006) 3.00

Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary. Cardiol Rev (2006) 2.99

Cardiovascular health in childhood: A statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation (2002) 2.96

Population approaches to improve diet, physical activity, and smoking habits: a scientific statement from the American Heart Association. Circulation (2012) 2.95

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med (2006) 2.86

Racial differences in the relation between uncoupling protein genes and resting energy expenditure. Am J Clin Nutr (2002) 2.84

Most youth with type 1 diabetes in the T1D Exchange Clinic Registry do not meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes clinical guidelines. Diabetes Care (2013) 2.73

Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association. Circulation (2013) 2.71

Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. Diabetes (2003) 2.51

American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. Circulation (2003) 2.51

Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc Natl Acad Sci U S A (2013) 2.50

Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care (2003) 2.49

American Heart Association guide for improving cardiovascular health at the community level: a statement for public health practitioners, healthcare providers, and health policy makers from the American Heart Association Expert Panel on Population and Prevention Science. Circulation (2003) 2.49

Mortality, health outcomes, and body mass index in the overweight range: a science advisory from the American Heart Association. Circulation (2009) 2.49

Parental report of outdoor playtime as a measure of physical activity in preschool-aged children. Arch Pediatr Adolesc Med (2004) 2.41

Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Curr Opin Cardiol (2006) 2.41

Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) Consortium. Circulation (2010) 2.39

Effect of blinded peer review on abstract acceptance. JAMA (2006) 2.38

Effects of sibutramine treatment in obese adolescents: a randomized trial. Ann Intern Med (2006) 2.38

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest (2002) 2.38

Dietary recommendations for children and adolescents: a guide for practitioners. Pediatrics (2006) 2.36

Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing. Am J Respir Crit Care Med (2004) 2.34

Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults. J Pediatr (2011) 2.34

Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement: Executive Summary. Crit Pathw Cardiol (2005) 2.31

Instability in the diagnosis of metabolic syndrome in adolescents. Circulation (2007) 2.29

Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. Circulation (2007) 2.26

Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variability. AJR Am J Roentgenol (2004) 2.26

Impact of objective and subjective social status on obesity in a biracial cohort of adolescents. Obes Res (2003) 2.24

Obesity as a disease: a white paper on evidence and arguments commissioned by the Council of the Obesity Society. Obesity (Silver Spring) (2008) 2.23

Age-specific reference intervals for indexed left ventricular mass in children. J Am Soc Echocardiogr (2009) 2.21

State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary. Circulation (2008) 2.17

Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reduction. Circulation (2002) 2.17

Dietary recommendations for children and adolescents: a guide for practitioners: consensus statement from the American Heart Association. Circulation (2005) 2.16

Fenofibrate improves vascular endothelial function by reducing oxidative stress while increasing endothelial nitric oxide synthase in healthy normolipidemic older adults. Hypertension (2012) 2.13

Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. Kidney Int (2010) 2.12

Prevalence of cardiovascular disease risk factors in U.S. children and adolescents with diabetes: the SEARCH for diabetes in youth study. Diabetes Care (2006) 2.09

Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. J Pediatr (2004) 2.08

Value of primordial and primary prevention for cardiovascular disease: a policy statement from the American Heart Association. Circulation (2011) 2.08

Childhood obesity predicts adult metabolic syndrome: the Fels Longitudinal Study. J Pediatr (2007) 2.07

Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: the SEARCH for Diabetes in Youth Study. J Pediatr (2006) 2.06

Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology. CA Cancer J Clin (2010) 2.05

Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry. J Clin Endocrinol Metab (2013) 1.92

Obesity development during adolescence in a biracial cohort: the NHLBI Growth and Health Study. Pediatrics (2002) 1.92

Systolic blood pressure in childhood predicts hypertension and metabolic syndrome later in life. Pediatrics (2007) 1.88

Assessing weight-related quality of life in adolescents. Obesity (Silver Spring) (2006) 1.85

American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. J Pediatr (2003) 1.85

Childhood overweight and cardiovascular disease risk factors: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr (2007) 1.83

Nontraditional risk factors and biomarkers for cardiovascular disease: mechanistic, research, and clinical considerations for youth: a scientific statement from the American Heart Association. Circulation (2011) 1.81

Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans. J Physiol (2010) 1.81

Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways. J Lipid Res (2008) 1.80

Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study. Diabetes (2010) 1.80

Psychological adjustment of obese youth presenting for weight management treatment. Obes Res (2004) 1.78

Summary of the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. Hypertension (2004) 1.78

Dietary patterns associated with fat and bone mass in young children. Am J Clin Nutr (2010) 1.76

Short-term triglyceride lowering with fenofibrate improves vasodilator function in subjects with hypertriglyceridemia. Arterioscler Thromb Vasc Biol (2003) 1.76

A randomized, placebo-controlled trial of amlodipine in children with hypertension. J Pediatr (2004) 1.75

Influence of race, ethnicity, and culture on childhood obesity: implications for prevention and treatment: a consensus statement of Shaping America's Health and the Obesity Society. Diabetes Care (2008) 1.74