Published in Dis Model Mech on July 04, 2011
An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening. Dis Model Mech (2011) 1.17
A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Dis Model Mech (2012) 1.00
Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One (2013) 0.96
Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. PLoS One (2014) 0.93
Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. PLoS One (2013) 0.89
Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway. PLoS One (2014) 0.89
The expanding role of fish models in understanding non-alcoholic fatty liver disease. Dis Model Mech (2013) 0.88
A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12. Dis Model Mech (2013) 0.88
RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biol (2014) 0.87
Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish. PLoS One (2013) 0.87
Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish. PLoS One (2013) 0.86
Zebrafish models of human liver development and disease. Compr Physiol (2013) 0.84
Liver hyperplasia after tamoxifen induction of Myc in a transgenic medaka model. Dis Model Mech (2012) 0.82
Through the looking glass: visualizing leukemia growth, migration, and engraftment using fluorescent transgenic zebrafish. Adv Hematol (2012) 0.81
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. Neoplasia (2015) 0.80
Oncogenic KRAS promotes malignant brain tumors in zebrafish. Mol Cancer (2015) 0.80
Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective. Evid Based Complement Alternat Med (2016) 0.79
Cross-species oncogenomics using zebrafish models of cancer. Curr Opin Genet Dev (2015) 0.77
Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. Br J Haematol (2014) 0.77
Xenotransplantation of human adipose-derived stem cells in zebrafish embryos. PLoS One (2015) 0.77
Zebrafish as a disease model for studying human hepatocellular carcinoma. World J Gastroenterol (2015) 0.76
Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras(V12) expression in transgenic zebrafish. Sci Rep (2016) 0.76
The DNA repair function of CUX1 contributes to radioresistance. Oncotarget (2017) 0.75
Males develop faster and more severe hepatocellular carcinoma than females in kras(V12) transgenic zebrafish. Sci Rep (2017) 0.75
Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. J Biomed Sci (2015) 0.75
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri. Oncotarget (2017) 0.75
Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 62.52
Cancer-related inflammation. Nature (2008) 34.21
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature (2005) 19.56
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature (2006) 11.18
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis. Nat Genet (2004) 10.92
Tumour biology: senescence in premalignant tumours. Nature (2005) 10.15
Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer (2006) 10.05
Animal models of human disease: zebrafish swim into view. Nat Rev Genet (2007) 8.36
Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91
Molecular targeted therapies in hepatocellular carcinoma. Hepatology (2008) 6.16
The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov (2006) 5.11
Modulation of the antitumor immune response by complement. Nat Immunol (2008) 4.53
PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15
Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet (2004) 3.97
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology (2006) 3.95
Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology (2007) 3.85
Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev (2007) 3.45
p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet (2007) 3.19
Tol2 transposon-mediated enhancer trap to identify developmentally regulated zebrafish genes in vivo. Dev Dyn (2004) 2.97
MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology (2008) 2.88
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat Biotechnol (2005) 2.51
Oncogene-induced liver neoplasia in transgenic mice. Oncogene (1989) 2.20
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res (2004) 2.01
Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy. Annu Rev Med (2010) 1.86
The state of the art of the zebrafish model for toxicology and toxicologic pathology research--advantages and current limitations. Toxicol Pathol (2003) 1.79
Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A (2007) 1.70
Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish. BMC Dev Biol (2008) 1.62
Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features. Hepatology (2002) 1.55
Increased MAPK expression and activity in primary human hepatocellular carcinoma. Biochem Biophys Res Commun (1997) 1.53
In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio). FEBS Lett (2003) 1.49
The cancer genome anatomy project: online resources to reveal the molecular signatures of cancer. Cancer Invest (2002) 1.46
Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish. Dev Biol (2008) 1.46
Trans-kingdom transposition of the maize dissociation element. Genetics (2006) 1.39
Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology (2008) 1.36
Genetic models of cancer in zebrafish. Int Rev Cell Mol Biol (2008) 1.35
A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations. Oncogene (2008) 1.26
Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Dis Model Mech (2009) 1.21
Modeling liver cancer using zebrafish: a comparative oncogenomics approach. Cell Cycle (2006) 1.10
Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. Hepatology (2000) 1.09
Tumor suppressor and hepatocellular carcinoma. World J Gastroenterol (2008) 1.09
JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma. Mol Cancer (2009) 1.07
Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma. J Hepatol (2004) 1.07
Generation of clonal zebrafish lines and transplantable hepatic tumors. Nat Protoc (2010) 1.06
Genetic modeling of Li-Fraumeni syndrome in zebrafish. Dis Model Mech (2010) 0.95
Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. J Biol Chem (2005) 0.95
Zebrafish spotted-microarray for genome-wide expression profiling experiments. Part I: array printing and hybridization. Methods Mol Biol (2009) 0.86
Zebrafish spotted-microarray for genome-wide expression profiling experiments: data acquisition and analysis. Methods Mol Biol (2009) 0.84
NBS1 is required for IGF-1 induced cellular proliferation through the Ras/Raf/MEK/ERK cascade. Cell Signal (2008) 0.84
Protein level of apolipoprotein E increased in human hepatocellular carcinoma. Int J Oncol (2006) 0.81
Tol2 transposon-mediated enhancer trap to identify developmentally regulated zebrafish genes in vivo. Dev Dyn (2004) 2.97
Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study. Chem Res Toxicol (2009) 2.80
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat Biotechnol (2005) 2.51
Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genet (2005) 2.32
Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome Res (2011) 2.29
Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation. Cancer Cell (2013) 2.20
Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nat Genet (2007) 2.14
Prepatterning of developmental gene expression by modified histones before zygotic genome activation. Dev Cell (2011) 2.05
Toxicity of silver nanoparticles in zebrafish models. Nanotechnology (2008) 1.89
Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood (2010) 1.69
Recommendations for control of pathogens and infectious diseases in fish research facilities. Comp Biochem Physiol C Toxicol Pharmacol (2008) 1.66
Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish. BMC Dev Biol (2008) 1.62
Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish. Dev Biol (2008) 1.46
Trans-kingdom transposition of the maize dissociation element. Genetics (2006) 1.39
RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling. Cell Signal (2005) 1.35
Zebrafish transgenic Enhancer TRAP line database (ZETRAP). BMC Dev Biol (2006) 1.35
Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci (2002) 1.33
Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish. Dev Biol (2008) 1.32
Luna stain, an improved selective stain for detection of microsporidian spores in histologic sections. Dis Aquat Organ (2011) 1.30
Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Exp Cell Res (2006) 1.28
Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Dev Biol (2009) 1.26
Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung. PLoS One (2011) 1.25
Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos. Nanotoxicology (2010) 1.24
Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas. Dev Dyn (2004) 1.22
Genome-wide analysis of Tol2 transposon reintegration in zebrafish. BMC Genomics (2009) 1.20
Pseudocapillaria tomentosa, a nematode pathogen, and associated neoplasms of zebrafish (Danio rerio) kept in research colonies. Comp Med (2002) 1.18
An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening. Dis Model Mech (2011) 1.17
The role of autophagy in liver cancer: molecular mechanisms and potential therapeutic targets. Biochim Biophys Acta (2013) 1.17
Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa. Hum Mol Genet (2010) 1.13
Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio. Gene (2005) 1.12
Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Gene (2002) 1.11
Modeling liver cancer using zebrafish: a comparative oncogenomics approach. Cell Cycle (2006) 1.10
Chromatin states of developmentally-regulated genes revealed by DNA and histone methylation patterns in zebrafish embryos. Int J Dev Biol (2010) 1.10
Retracted Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1). PLoS One (2011) 1.09
Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish. J Hepatol (2011) 1.09
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol (2013) 1.04
Recapitulation of fast skeletal muscle development in zebrafish by transgenic expression of GFP under the mylz2 promoter. Dev Dyn (2003) 1.03
Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics (2010) 1.03
Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Mol Cell Neurosci (2007) 1.02
Normal anatomy and histology of the adult zebrafish. Toxicol Pathol (2011) 1.01
New ways to admire zebrafish: progress in functional genomics research methodology. Biotechniques (2005) 1.01
Demonstration of site-directed recombination in transgenic zebrafish using the Cre/loxP system. Transgenic Res (2005) 1.01
K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis. PLoS One (2008) 1.01
Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate. Development (2005) 1.01
Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genet (2008) 1.00
A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Dis Model Mech (2012) 1.00
Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. BMC Genomics (2010) 0.99
Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert Opin Drug Metab Toxicol (2011) 0.98
SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Hum Mol Genet (2013) 0.98
Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One (2013) 0.96
Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. BMC Genomics (2011) 0.95
Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver. Physiol Genomics (2006) 0.94
Ziwi, the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults. Mech Dev (2002) 0.93
Wnt signaling is required for early development of zebrafish swimbladder. PLoS One (2011) 0.92
Proteomic analysis of protein profiles during early development of the zebrafish, Danio rerio. Proteomics (2006) 0.90
Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development. BMC Dev Biol (2007) 0.90
Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. PLoS One (2013) 0.89
Incorporating zebrafish omics into chemical biology and toxicology. Zebrafish (2010) 0.89
Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry. Mol Biosyst (2013) 0.89
Deciphering the mechanism of HNE-induced apoptosis in cultured murine cortical neurons: transcriptional responses and cellular pathways. Neuropharmacology (2007) 0.89
Development of estrogen-responsive transgenic medaka for environmental monitoring of endocrine disrupters. Environ Sci Technol (2005) 0.89
Development of a heat shock inducible gfp transgenic zebrafish line by using the zebrafish hsp27 promoter. Gene (2007) 0.88
Ziwi, the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults. Gene Expr Patterns (2002) 0.88
Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17beta-estradiol. Gene (2004) 0.87
Super resolution microscopy reveals that caveolin-1 is required for spatial organization of CRFB1 and subsequent antiviral signaling in zebrafish. PLoS One (2013) 0.87
An investigation of the bioactivation potential and metabolism profile of Zebrafish versus human. J Biomol Screen (2012) 0.87
Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons. Biochem Biophys Res Commun (2004) 0.87
Molecular evolution of vertebrate goose-type lysozyme genes. J Mol Evol (2003) 0.87
Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. BMC Genomics (2013) 0.86
Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes. PLoS One (2008) 0.86
The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Dev Biol (2011) 0.86
Zebrafish spotted-microarray for genome-wide expression profiling experiments. Part I: array printing and hybridization. Methods Mol Biol (2009) 0.86
Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. PLoS One (2011) 0.86
Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes. Future Oncol (2012) 0.86
Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish. Dev Biol (2006) 0.86
Fluorescent transgenic zebrafish Tg(nkx2.2a:mEGFP) provides a highly sensitive monitoring tool for neurotoxins. PLoS One (2013) 0.86
Maize Ac/Ds transposon system leads to highly efficient germline transmission of transgenes in medaka (Oryzias latipes). Biochimie (2011) 0.86