Published in Database (Oxford) on July 08, 2011
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RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91
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NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem (2007) 2.22
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Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J Biol Chem (2000) 2.18
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat Genet (2007) 2.04
Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis. J Biol Chem (2001) 2.02
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JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms. J Cell Sci (2002) 1.99
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood (2001) 1.93
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Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem (1999) 1.75
RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci U S A (2008) 1.68
Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol (2006) 1.67
Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues. Bone (1999) 1.66
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol (2002) 1.53
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest (2008) 1.53
RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice. J Clin Invest (2008) 1.52
NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis. J Clin Invest (2005) 1.50
Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers. Cancer Biol Ther (2009) 1.45
Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity. J Clin Invest (2001) 1.45
Central control of fever and female body temperature by RANKL/RANK. Nature (2009) 1.42
Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. Am J Pathol (2003) 1.38
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". J Immunol (2007) 1.34
Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha. J Biol Chem (2004) 1.30
A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation. J Biol Chem (2001) 1.17
Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase. J Biol Chem (2001) 1.17
RANK ligand is a prerequisite for cancer-associated osteolytic lesions. J Pathol (2002) 1.10
Catalytic properties of ADAM19. J Biol Chem (2003) 1.09
JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts. J Bone Miner Res (2008) 1.07
PathBuilder--open source software for annotating and developing pathway resources. Bioinformatics (2009) 1.07
Structural and functional insights of RANKL-RANK interaction and signaling. J Immunol (2010) 1.05
Long-lived immature dendritic cells mediated by TRANCE-RANK interaction. Blood (2002) 1.05
Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling. Mol Oncol (2009) 1.05
New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target? Keio J Med (2009) 1.01
Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. J Biol Chem (2001) 1.01
VISIBIOweb: visualization and layout services for BioPAX pathway models. Nucleic Acids Res (2010) 0.99
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 0.97
Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand. J Bone Miner Res (2002) 0.96
Osteoclast lineage commitment of bone marrow precursors through expression of membrane-bound TRANCE. Bone (2000) 0.96
Tumour cells produce receptor activator of NF-kappaB ligand (RANKL) in skeletal metastases. J Clin Pathol (2002) 0.96
Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts. J Biol Chem (2008) 0.95
Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding. J Biol Chem (2005) 0.92
Molecular interactions and data standardisation. Methods Mol Biol (2010) 0.88
Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis. J Cell Biochem (2009) 0.87
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics (2002) 30.58
Integration of biological networks and gene expression data using Cytoscape. Nat Protoc (2007) 27.10
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
Human Protein Reference Database--2009 update. Nucleic Acids Res (2008) 21.25
International network of cancer genome projects. Nature (2010) 20.35
ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia (2004) 17.08
The genetic landscape of a cell. Science (2010) 16.52
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Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Human protein reference database--2006 update. Nucleic Acids Res (2006) 12.16
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res (2010) 10.97
Cytoscape Web: an interactive web-based network browser. Bioinformatics (2010) 10.03
Human protein reference database as a discovery resource for proteomics. Nucleic Acids Res (2004) 9.99
Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci U S A (2004) 9.42
The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19
Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res (2010) 9.18
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24
Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol (2007) 8.03
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell (2011) 7.33
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science (2001) 7.08
Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat Genet (2006) 6.74
Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS One (2010) 6.61
A travel guide to Cytoscape plugins. Nat Methods (2012) 6.53
PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine. BMC Bioinformatics (2003) 6.31
PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods (2011) 5.01
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab (2006) 4.50
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol (2007) 4.29
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A (2007) 4.01
Probabilistic model of the human protein-protein interaction network. Nat Biotechnol (2005) 3.99
Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci Rep (2013) 3.92
Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome. Trends Biotechnol (2002) 3.85
A curated compendium of phosphorylation motifs. Nat Biotechnol (2007) 3.79
An evaluation of human protein-protein interaction data in the public domain. BMC Bioinformatics (2006) 3.33
cPath: open source software for collecting, storing, and querying biological pathways. BMC Bioinformatics (2006) 3.24
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol (2012) 3.18
A specificity map for the PDZ domain family. PLoS Biol (2008) 3.16
Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell (2011) 3.11
A compendium of potential biomarkers of pancreatic cancer. PLoS Med (2009) 3.00
Pathway information for systems biology. FEBS Lett (2005) 2.97
Germ-line DNA copy number variation frequencies in a large North American population. Hum Genet (2007) 2.94
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood (2007) 2.93
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Preventing tuberculosis flare in patients with inflammatory rheumatic diseases receiving tumor necrosis factor-alpha inhibitors in India -- An audit report. J Rheumatol (2009) 2.89
SeqHound: biological sequence and structure database as a platform for bioinformatics research. BMC Bioinformatics (2002) 2.84
A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med (2004) 2.81
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76
GeneMANIA prediction server 2013 update. Nucleic Acids Res (2013) 2.74
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods (2010) 2.67
Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol Cell Proteomics (2005) 2.66
NetPath: a public resource of curated signal transduction pathways. Genome Biol (2010) 2.62
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems. J Clin Invest (2007) 2.57
clusterMaker: a multi-algorithm clustering plugin for Cytoscape. BMC Bioinformatics (2011) 2.56
Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. Proc Natl Acad Sci U S A (2005) 2.51
Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biology. Methods Mol Biol (2009) 2.47
Computational prediction of protein-protein interactions. Mol Biotechnol (2007) 2.35
Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae. Mol Cell Biol (2005) 2.33
Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A (2006) 2.30
Human Proteinpedia: a unified discovery resource for proteomics research. Nucleic Acids Res (2008) 2.30
Positive selection of tyrosine loss in metazoan evolution. Science (2009) 2.28
From biological databases to platforms for biomedical discovery. Trends Biotechnol (2003) 2.27
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J (2009) 2.17
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. Sci Signal (2009) 2.16
BioBuilder as a database development and functional annotation platform for proteins. BMC Bioinformatics (2004) 2.13
Quantitative proteomics using stable isotope labeling with amino acids in cell culture. Nat Protoc (2008) 2.07
Comparison of antipyretic effect of nimesulide and paracetamol in children attending a secondary level hospital. Indian Pediatr (2002) 2.05
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A (2007) 2.03
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A (2008) 2.01
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J Biol Chem (2009) 1.97
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Global impact of oncogenic Src on a phosphotyrosine proteome. J Proteome Res (2008) 1.94