Published in Small GTPases on March 01, 2011
Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29. Proc Natl Acad Sci U S A (2013) 1.06
Topological and functional properties of the small GTPases protein interaction network. PLoS One (2012) 0.98
PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth. PLoS One (2013) 0.96
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nat Commun (2015) 0.92
Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation. Mol Cell Biol (2015) 0.91
The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. J Exp Med (2014) 0.91
Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms. Tissue Barriers (2013) 0.90
ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells. J Mol Cell Cardiol (2013) 0.86
Regulation of signaling events involved in the pathophysiology of neovascular AMD. Mol Vis (2016) 0.85
Rap1 signaling in endothelial barrier control. Cell Adh Migr (2014) 0.84
The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem (2014) 0.84
Rap1 and Rap2 antagonistically control endothelial barrier resistance. PLoS One (2013) 0.83
Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I. PLoS One (2011) 0.83
Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo. PLoS One (2013) 0.83
Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. FASEB J (2013) 0.81
Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B. J Mol Biol (2016) 0.77
Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1. Biochim Biophys Acta (2014) 0.77
N-glycosylation controls the function of junctional adhesion molecule-A. Mol Biol Cell (2015) 0.77
In vivo, cardiac-specific knockdown of a target protein, malic enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA. Curr Gene Ther (2012) 0.76
Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP. J Biol Chem (2016) 0.76
Purinergic A2b Receptor Activation by Extracellular Cues Affects Positioning of the Centrosome and Nucleus and Causes Reduced Cell Migration. J Biol Chem (2016) 0.75
Isoproterenol increases histone deacetylase 6 expression and cell migration by inhibiting ERK signaling via PKA and Epac pathways in human lung cancer cells. Exp Mol Med (2016) 0.75
Mechanism of Diapedesis: Importance of the Transcellular Route. Adv Immunol (2015) 0.75
Leukocyte transcellular diapedesis: Rap1b is in control. Tissue Barriers (2015) 0.75
Cell migration: integrating signals from front to back. Science (2003) 29.13
Integrin signaling to the actin cytoskeleton. Curr Opin Cell Biol (2003) 3.11
Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J Cell Biol (2002) 2.99
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J Immunol (2007) 2.66
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol (2010) 2.61
Analysis of activated GAPs and GEFs in cell lysates. Methods Enzymol (2006) 2.45
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol (2011) 2.45
The 'invisible hand': regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol (2011) 2.39
RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol (2003) 2.34
Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem (2003) 2.28
Rho protein crosstalk: another social network? Trends Cell Biol (2011) 2.19
RhoA and ROCK promote migration by limiting membrane protrusions. J Biol Chem (2003) 2.17
Simultaneous stretching and contraction of stress fibers in vivo. Mol Biol Cell (2004) 2.12
Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. J Biol Chem (2006) 2.07
Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem (2005) 1.84
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr Biol (2003) 1.84
Catching a GEF by its tail. Trends Cell Biol (2006) 1.79
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem (2002) 1.78
VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2. Exp Cell Res (2007) 1.76
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J Cell Biol (2007) 1.71
RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem (2002) 1.70
The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species. J Biol Chem (2009) 1.69
Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion. Biol Res (2002) 1.63
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. J Cell Sci (2007) 1.63
Coupling membrane protrusion and cell adhesion. J Cell Sci (2003) 1.61
Cadherin engagement inhibits RhoA via p190RhoGAP. J Biol Chem (2003) 1.50
Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif. PLoS One (2009) 1.46
Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation. J Biol Chem (2005) 1.45
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals. PLoS One (2011) 1.43
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Mol Biol Cell (2004) 1.42
Biomedical research publication system. Science (2004) 1.39
The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties. J Biol Chem (2011) 1.32
Regulation of cell adhesion by protein-tyrosine phosphatases: II. Cell-cell adhesion. J Biol Chem (2006) 1.29
Chapter 1. Focal adhesions: new angles on an old structure. Int Rev Cell Mol Biol (2009) 1.24
PTP-PEST controls motility through regulation of Rac1. J Cell Sci (2002) 1.24
From mechanical force to RhoA activation. Biochemistry (2012) 1.23
Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr Biol (2012) 1.20
Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol (2014) 1.19
Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol (2009) 1.15
PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP. J Biol Chem (2006) 1.14
SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. J Biol Chem (2011) 1.13
Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration. Curr Opin Hematol (2005) 1.09
Front and back by Rho and Rac. Nat Cell Biol (2006) 1.09
Endogenous RhoG is rapidly activated after epidermal growth factor stimulation through multiple guanine-nucleotide exchange factors. Mol Biol Cell (2010) 1.08
MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF. Mol Cell (2008) 1.07
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol Cell Biol (2007) 1.07
The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization. Am J Pathol (2010) 1.06
Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho. Exp Cell Res (2008) 1.04
Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells. Stem Cells (2011) 1.04
Redox regulation of Ras and Rho GTPases: mechanism and function. Antioxid Redox Signal (2012) 1.02
Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1. Exp Eye Res (2006) 1.02
The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. PLoS One (2011) 1.02
Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes. J Biol Chem (2004) 1.02
Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration. PLoS One (2013) 1.00
Latent KSHV infection increases the vascular permeability of human endothelial cells. Blood (2011) 1.00
The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE. Invest Ophthalmol Vis Sci (2011) 0.99
Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation. J Biol Chem (2007) 0.97
Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication. Biochim Biophys Acta (2008) 0.97
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA. J Cell Sci (2009) 0.95
Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammation. PLoS One (2012) 0.92
IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry. J Biol Chem (2006) 0.91
Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J Biol Chem (2009) 0.90
The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration. J Immunol (2014) 0.89
Cell biology: a break in the chain? Nature (2006) 0.88
Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells (2013) 0.88
Analysis of low molecular weight GTPase activity in endothelial cell cultures. Methods Enzymol (2008) 0.87
The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. PLoS One (2013) 0.85
Vinculin regulation of F-actin bundle formation: what does it mean for the cell? Cell Adh Migr (2013) 0.84
Foot in mouth: do focal adhesions disassemble by endocytosis? Nat Cell Biol (2005) 0.84
Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica. J Biol Chem (2011) 0.83
Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4. Biochim Biophys Acta (2013) 0.83
Phosphorylation at Y1065 in vinculin mediates actin bundling, cell spreading, and mechanical responses to force. Biochemistry (2014) 0.81
Nuclear mechanotransduction: forcing the nucleus to respond. Nucleus (2015) 0.81
VE-cadherin status as an indicator of microvascular permeability. Methods Mol Biol (2013) 0.76
Undressing a cellular corset: septins exposed. Nat Cell Biol (2009) 0.76
Keith Burridge: cultivating knowledge on Rho. Interview by Caitlin Sedwick. J Cell Biol (2012) 0.75
In vitro modeling of nonhypoxic cold ischemia-reperfusion simulating lung transplantation. J Thorac Cardiovasc Surg (2009) 0.75