Published in J Biol Chem on March 18, 2005
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal (2013) 2.59
Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal (2009) 2.17
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin. Nat Immunol (2009) 1.88
Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. PLoS Genet (2009) 1.77
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol (2008) 1.74
Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces. Am J Physiol Cell Physiol (2010) 1.53
Adhesive and signaling functions of cadherins and catenins in vertebrate development. Cold Spring Harb Perspect Biol (2009) 1.52
Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMV. J Virol (2006) 1.44
The role of cytoskeleton in the regulation of vascular endothelial barrier function. Microvasc Res (2008) 1.44
Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy. J Mol Cell Cardiol (2014) 1.41
Endothelial signaling in paracellular and transcellular leukocyte transmigration. Front Biosci (Landmark Ed) (2009) 1.31
The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo. Cardiovasc Res (2013) 1.30
Novel role of NADPH oxidase in angiogenesis and stem/progenitor cell function. Antioxid Redox Signal (2009) 1.30
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1. J Cell Biol (2010) 1.28
Redox regulation of cell migration and adhesion. Trends Cell Biol (2011) 1.28
SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther (2008) 1.23
Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. J Thromb Haemost (2008) 1.23
The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin. J Exp Med (2009) 1.21
Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation. Proc Natl Acad Sci U S A (2007) 1.18
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med (2011) 1.17
Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung. Cancer Res (2008) 1.04
The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence. Br J Cancer (2007) 1.02
Mechanisms of neutrophil transendothelial migration. Front Biosci (Landmark Ed) (2009) 0.98
Similarities and differences in the regulation of leukocyte extravasation and vascular permeability. Semin Immunopathol (2014) 0.97
Retracted Reactive oxygen species and tumor metastasis. Mol Cells (2013) 0.94
CRNK gene transfer improves function and reverses the myosin heavy chain isoenzyme switch during post-myocardial infarction left ventricular remodeling. J Mol Cell Cardiol (2008) 0.93
B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem (2009) 0.93
Regulation of adherens junction dynamics by phosphorylation switches. J Signal Transduct (2012) 0.92
Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2. Am J Respir Cell Mol Biol (2012) 0.89
Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk? J Signal Transduct (2011) 0.87
Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner. Exp Cell Res (2011) 0.86
HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase. Herpesviridae (2010) 0.85
An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP). Hum Genet (2007) 0.84
Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease. Oncoscience (2014) 0.82
Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. FASEB J (2013) 0.81
HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability. BMC Neurosci (2014) 0.79
Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells. Int J Clin Exp Pathol (2014) 0.79
Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration. PLoS One (2013) 0.78
Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction. Sci Rep (2016) 0.76
Pyk2 Phosphorylation of VE-PTP Downstream of STIM1 induced Ca2+ entry Regulates Disassembly of Adherens Junctions. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Neoatherosclerosis after Drug-Eluting Stent Implantation: Roles and Mechanisms. Oxid Med Cell Longev (2016) 0.75
In Development …A New Paradigm for Understanding Vascular Disease. J Cardiovasc Pharmacol (2017) 0.75
Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6. Am J Respir Cell Mol Biol (2016) 0.75
Human epicardial cell-conditioned medium contains HGF/IgG complexes that phosphorylate RYK and protect against vascular injury. Cardiovasc Res (2015) 0.75
Cell migration: integrating signals from front to back. Science (2003) 29.13
Integrin signaling to the actin cytoskeleton. Curr Opin Cell Biol (2003) 3.11
Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J Cell Biol (2002) 2.99
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J Immunol (2007) 2.66
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol (2010) 2.61
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Analysis of activated GAPs and GEFs in cell lysates. Methods Enzymol (2006) 2.45
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol (2011) 2.45
The 'invisible hand': regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol (2011) 2.39
VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration. Am J Physiol Cell Physiol (2003) 2.37
RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol (2003) 2.34
Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem (2003) 2.28
Rho protein crosstalk: another social network? Trends Cell Biol (2011) 2.19
RhoA and ROCK promote migration by limiting membrane protrusions. J Biol Chem (2003) 2.17
Simultaneous stretching and contraction of stress fibers in vivo. Mol Biol Cell (2004) 2.12
Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. J Biol Chem (2006) 2.07
Calcium signaling regulates translocation and activation of Rac. J Biol Chem (2003) 1.94
Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem (2005) 1.84
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr Biol (2003) 1.84
Catching a GEF by its tail. Trends Cell Biol (2006) 1.79
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem (2002) 1.78
VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2. Exp Cell Res (2007) 1.76
Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci (2002) 1.72
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J Cell Biol (2007) 1.71
RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem (2002) 1.70
The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species. J Biol Chem (2009) 1.69
Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion. Biol Res (2002) 1.63
P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium. Arterioscler Thromb Vasc Biol (2007) 1.63
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. J Cell Sci (2007) 1.63
Coupling membrane protrusion and cell adhesion. J Cell Sci (2003) 1.61
Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol (2008) 1.57
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol (2008) 1.56
Cadherin engagement inhibits RhoA via p190RhoGAP. J Biol Chem (2003) 1.50
Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif. PLoS One (2009) 1.46
The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity. J Biol Chem (2003) 1.45
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals. PLoS One (2011) 1.43
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Mol Biol Cell (2004) 1.42
Biomedical research publication system. Science (2004) 1.39
The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties. J Biol Chem (2011) 1.32
Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET. EMBO J (2007) 1.31
Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J Cell Sci (2010) 1.31
Regulation of cell adhesion by protein-tyrosine phosphatases: II. Cell-cell adhesion. J Biol Chem (2006) 1.29
Signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2004) 1.28
Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol (2006) 1.26
Chapter 1. Focal adhesions: new angles on an old structure. Int Rev Cell Mol Biol (2009) 1.24
PTP-PEST controls motility through regulation of Rac1. J Cell Sci (2002) 1.24
From mechanical force to RhoA activation. Biochemistry (2012) 1.23
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes. J Immunol (2004) 1.23
The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. J Cell Sci (2011) 1.23
The role of ubiquitylation and degradation in RhoGTPase signalling. J Cell Sci (2010) 1.22
Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr Biol (2012) 1.20
Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol (2014) 1.19
PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. Eur J Cell Biol (2008) 1.17
Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4. J Biol Chem (2003) 1.17
Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis. J Leukoc Biol (2006) 1.16
Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol (2009) 1.15
PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP. J Biol Chem (2006) 1.14
SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. J Biol Chem (2011) 1.13
Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin. J Immunol (2002) 1.13
Continuous translocation of Rac2 and the NADPH oxidase component p67(phox) during phagocytosis. J Biol Chem (2003) 1.12
Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies. Arterioscler Thromb Vasc Biol (2003) 1.11
cAMP signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2007) 1.09
Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration. Curr Opin Hematol (2005) 1.09
Filamin B mediates ICAM-1-driven leukocyte transendothelial migration. J Biol Chem (2008) 1.09
Front and back by Rho and Rac. Nat Cell Biol (2006) 1.09
Endogenous RhoG is rapidly activated after epidermal growth factor stimulation through multiple guanine-nucleotide exchange factors. Mol Biol Cell (2010) 1.08
MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF. Mol Cell (2008) 1.07
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol Cell Biol (2007) 1.07
Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions. Small GTPases (2011) 1.07
The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization. Am J Pathol (2010) 1.06
Endothelial signaling by Ig-like cell adhesion molecules. Arterioscler Thromb Vasc Biol (2007) 1.05
Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho. Exp Cell Res (2008) 1.04
Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells. Stem Cells (2011) 1.04
The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion. PLoS One (2012) 1.03
Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1. Exp Eye Res (2006) 1.02
The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. PLoS One (2011) 1.02
Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes. J Biol Chem (2004) 1.02
Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts. J Biol Chem (2010) 1.00
Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration. PLoS One (2013) 1.00
Endothelial adapter proteins in leukocyte transmigration. Thromb Haemost (2009) 1.00
Latent KSHV infection increases the vascular permeability of human endothelial cells. Blood (2011) 1.00
Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. Blood (2008) 0.99
The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE. Invest Ophthalmol Vis Sci (2011) 0.99
Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics. J Cell Sci (2010) 0.98
Targeting and localized signalling by small GTPases. Biol Cell (2007) 0.98