Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 3139598)

Published in PLoS One on July 19, 2011

Authors

Yuhki Saito1, Mayu Akiyama, Yoichi Araki, Akio Sumioka, Maki Shiono, Hidenori Taru, Tadashi Nakaya, Tohru Yamamoto, Toshiharu Suzuki

Author Affiliations

1: Laboratory of Neuroscience, Graduate School of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.

Articles citing this

Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex. J Biol Chem (2013) 0.87

Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease. Neurobiol Aging (2013) 0.86

Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP). J Biol Chem (2012) 0.80

Constitutive cleavage of the single-pass transmembrane protein alcadeinα prevents aberrant peripheral retention of Kinesin-1. PLoS One (2012) 0.80

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease. Mol Neurodegener (2012) 0.79

New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies. Int J Mol Sci (2015) 0.78

Amyloid-precursor-protein-lowering small molecules for disease modifying therapy of Alzheimer's disease. PLoS One (2013) 0.78

A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS One (2013) 0.76

APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci (2017) 0.75

Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage. J Biol Chem (2014) 0.75

Articles cited by this

Rab proteins as membrane organizers. Nat Rev Mol Cell Biol (2001) 19.95

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol (2007) 17.69

ER-to-Golgi transport visualized in living cells. Nature (1997) 10.24

Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation. Cell (1983) 6.83

Amyloid precursor protein trafficking, processing, and function. J Biol Chem (2008) 4.79

Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science (2000) 4.14

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A (2003) 2.03

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem (2001) 1.83

Generation and maintenance of neuronal polarity: mechanisms of transport and targeting. Neuron (1999) 1.77

Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. J Biol Chem (1997) 1.71

The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J (2007) 1.55

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem (2003) 1.52

Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. J Neurochem (2000) 1.48

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. J Biol Chem (1998) 1.45

Structure of the Golgi and distribution of reporter molecules at 20 degrees C reveals the complexity of the exit compartments. Mol Biol Cell (2002) 1.44

Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein. J Biol Chem (2003) 1.42

Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions. J Biol Chem (2008) 1.35

Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism. J Biol Chem (1998) 1.31

The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice. J Biol Chem (2003) 1.27

Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem (2004) 1.26

A one-step procedure for biotinylation and chemical cross-linking of lymphocyte surface and intracellular membrane-associated molecules. Anal Biochem (1995) 1.25

Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J Neurosci (1999) 1.24

X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion. J Biol Chem (1998) 1.21

Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. J Biol Chem (1999) 1.20

Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. J Biol Chem (2006) 1.19

X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. J Biol Chem (2008) 1.17

Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun (2004) 1.16

The X11/Mint family of adaptor proteins. Brain Res Rev (2006) 1.14

The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice. J Biol Chem (2004) 1.12

X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein. Biochem Biophys Res Commun (1999) 1.11

X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. Mol Cell Neurosci (2000) 1.09

Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network. Mol Biol Cell (2007) 1.09

Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis. J Biol Chem (2008) 1.08

Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem. Nat Struct Mol Biol (2005) 1.07

Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease. Eur J Neurosci (1999) 1.04

Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. J Biochem (2006) 1.04

Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. J Biol Chem (2004) 1.03

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. J Cell Biol (2008) 0.93

X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein. J Neurochem (2004) 0.92

The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila. Dev Biol (2005) 0.91

PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein. J Biol Chem (2000) 0.89

Suppression of APP-containing vesicle trafficking and production of beta-amyloid by AID/DHHC-12 protein. J Neurochem (2009) 0.87

The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm. Exp Cell Res (2007) 0.85

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain. Mol Neurodegener (2010) 0.84

Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins. J Alzheimers Dis (2009) 0.84

Role of the GTPase Rab1b in ebolavirus particle formation. J Virol (2010) 0.84

Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP. J Neurochem (2009) 0.83

Expression and characterization of the Drosophila X11-like/Mint protein during neural development. J Neurochem (2002) 0.82

Articles by these authors

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am J Hum Genet (2011) 2.86

A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci U S A (2011) 2.68

A transmembrane accessory subunit that modulates kainate-type glutamate receptors. Neuron (2009) 2.07

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci (2004) 2.07

Escherichia coli phage-shock protein A (PspA) binds to membrane phospholipids and repairs proton leakage of the damaged membranes. Mol Microbiol (2007) 1.74

SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS. Nat Neurosci (2006) 1.74

A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem (2003) 1.65

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Mol Genet (2012) 1.62

The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J (2007) 1.55

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem (2003) 1.52

Thermophilic ATP synthase has a decamer c-ring: indication of noninteger 10:3 H+/ATP ratio and permissive elastic coupling. Proc Natl Acad Sci U S A (2004) 1.48

Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J Biol Chem (2002) 1.46

ATP-driven stepwise rotation of FoF1-ATP synthase. Proc Natl Acad Sci U S A (2005) 1.43

Cytapheresis therapy for ulcerative colitis in three pediatric patients. J Pediatr Gastroenterol Nutr (2004) 1.41

Pineal dysfunction (low melatonin production) as a cause of sudden death in a long-term survivor of Langerhans cell histiocytosis? Med Pediatr Oncol (2003) 1.39

Axle-less F1-ATPase rotates in the correct direction. Science (2008) 1.36

Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions. J Biol Chem (2008) 1.35

Regulatory interplay between proton motive force, ADP, phosphate, and subunit epsilon in bacterial ATP synthase. J Biol Chem (2006) 1.32

Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem (2004) 1.26

Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. Biochem J (2007) 1.24

Two-dimensional molecular electronics circuits. Chemphyschem (2002) 1.22

Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. J Biol Chem (2006) 1.19

X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. J Biol Chem (2008) 1.17

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. PLoS One (2006) 1.14

Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. J Neurosci (2011) 1.14

The role of subunit epsilon in the catalysis and regulation of FOF1-ATP synthase. Biochim Biophys Acta (2006) 1.12

Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J Biol Chem (2002) 1.09

Real-time monitoring of conformational dynamics of the epsilon subunit in F1-ATPase. J Biol Chem (2005) 1.07

Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. J Biol Chem (2009) 1.06

Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD. Genes Cells (2006) 1.06

Torque generation and utilization in motor enzyme F0F1-ATP synthase: half-torque F1 with short-sized pushrod helix and reduced ATP Synthesis by half-torque F0F1. J Biol Chem (2011) 1.05

Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. J Biochem (2006) 1.04

Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. J Biol Chem (2004) 1.03

Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion. J Biochem (2005) 1.02

Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation. Proc Natl Acad Sci U S A (2013) 1.02

Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells. J Biol Chem (2008) 1.02

SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. J Biol Chem (2002) 1.01

Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. J Biol Chem (2007) 1.01

Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J Biol Chem (2004) 1.00

Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis. Proc Natl Acad Sci U S A (2011) 0.99

Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J Biol Chem (2002) 0.98

Essential arginine residue of the F(o)-a subunit in F(o)F(1)-ATP synthase has a role to prevent the proton shortcut without c-ring rotation in the F(o) proton channel. Biochem J (2010) 0.97

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain (2009) 0.96

Intracellular replication of Edwardsiella tarda in murine macrophage is dependent on the type III secretion system and induces an up-regulation of anti-apoptotic NF-kappaB target genes protecting the macrophage from staurosporine-induced apoptosis. Microb Pathog (2006) 0.96

ATP synthase that lacks F0a-subunit: isolation, properties, and indication of F0b2-subunits as an anchor rail of a rotating c-ring. J Biol Chem (2004) 0.96

PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proc Natl Acad Sci U S A (2014) 0.96

The role of the betaDELSEED-loop of ATP synthase. J Biol Chem (2009) 0.95

A small peptide sequence is sufficient for initiating kinesin-1 activation through part of TPR region of KLC1. Traffic (2012) 0.95

Paths, elongation, and projections of ascending chick embryonic spinal commissural neurons after crossing the floor plate. Brain Res (2008) 0.94

Control of bacteriophage T4 tail lysozyme activity during the infection process. J Mol Biol (2005) 0.94

Activation and stiffness of the inhibited states of F1-ATPase probed by single-molecule manipulation. J Biol Chem (2010) 0.94

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Ann Neurol (2011) 0.93

Neither helix in the coiled coil region of the axle of F1-ATPase plays a significant role in torque production. Biophys J (2008) 0.93

Assessing liver function using dynamic Gd-EOB-DTPA-enhanced MRI with a standard 5-phase imaging protocol. J Magn Reson Imaging (2012) 0.93

A new solution structure of ATP synthase subunit c from thermophilic Bacillus PS3, suggesting a local conformational change for H+-translocation. J Mol Biol (2006) 0.92

Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment. J Biol Chem (2005) 0.92

Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans. J Cell Biol (2013) 0.91

Probing conformations of the beta subunit of F0F1-ATP synthase in catalysis. Biochem Biophys Res Commun (2006) 0.90

Functional analysis of membranous Fo-a subunit of F1Fo-ATP synthase by in vitro protein synthesis. Biochem J (2012) 0.89

The presence of phosphate at a catalytic site suppresses the formation of the MgADP-inhibited form of F(1)-ATPase. Eur J Biochem (2002) 0.89

Efficient ATP synthesis by thermophilic Bacillus FoF1-ATP synthase. FEBS J (2011) 0.88

The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement. FASEB J (2009) 0.88

Suppression of APP-containing vesicle trafficking and production of beta-amyloid by AID/DHHC-12 protein. J Neurochem (2009) 0.87

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. J Biol Chem (2010) 0.87

Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. J Biol Chem (2009) 0.87

X11-like protein deficiency is associated with impaired conflict resolution in mice. J Neurosci (2009) 0.87

MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains. Brain Res (2006) 0.87

IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons. Dev Dyn (2011) 0.86

Kinetic equivalence of transmembrane pH and electrical potential differences in ATP synthesis. J Biol Chem (2012) 0.86

FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Mol Neurodegener (2012) 0.86

The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm. Exp Cell Res (2007) 0.85