Published in J Biol Chem on September 12, 2003
Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci (2008) 2.29
The many substrates of presenilin/γ-secretase. J Alzheimers Dis (2011) 2.02
The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J (2007) 1.55
Calsyntenin-1 docks vesicular cargo to kinesin-1. Mol Biol Cell (2006) 1.53
Golgi defects enhance APP amyloidogenic processing in Alzheimer's disease. Bioessays (2014) 1.48
Physiological functions of APP family proteins. Cold Spring Harb Perspect Med (2012) 1.44
Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions. J Biol Chem (2008) 1.35
CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2008) 1.19
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. J Biol Chem (2008) 1.17
Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network. Mol Biol Cell (2007) 1.09
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. J Biol Chem (2009) 1.06
Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production. Hum Mol Genet (2012) 1.02
Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1. J Cell Sci (2011) 1.00
A conserved function of C. elegans CASY-1 calsyntenin in associative learning. PLoS One (2009) 0.98
The specific α-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse development. Neuron (2013) 0.97
Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Ann Neurol (2011) 0.93
Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription. J Biol Chem (2008) 0.93
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. J Cell Biol (2008) 0.93
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PLoS One (2009) 0.91
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice. Hum Mol Genet (2009) 0.91
Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents. Biol Psychiatry (2008) 0.91
Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like. PLoS One (2011) 0.88
Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep (2014) 0.88
The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. Neurochem Res (2006) 0.87
X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice. Neurobiol Dis (2009) 0.87
APP Receptor? To Be or Not To Be. Trends Pharmacol Sci (2016) 0.85
Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS One (2008) 0.85
Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus of prematurity. Mol Cell Proteomics (2011) 0.85
Calsyntenin-3 molecular architecture and interaction with neurexin 1α. J Biol Chem (2014) 0.84
Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport. Biol Open (2012) 0.84
Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. Mol Neurodegener (2012) 0.84
Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP. J Neurochem (2009) 0.83
Calsyntenin-1 regulates axon branching and endosomal trafficking during sensory neuron development in vivo. J Neurosci (2014) 0.83
Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain. J Neurochem (2012) 0.82
Constitutive cleavage of the single-pass transmembrane protein alcadeinα prevents aberrant peripheral retention of Kinesin-1. PLoS One (2012) 0.80
Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production. Hum Mol Genet (2013) 0.79
Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system. Mol Neurodegener (2011) 0.79
Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease. Mol Neurodegener (2012) 0.79
Mechanism of intramembrane cleavage of alcadeins by γ-secretase. PLoS One (2013) 0.78
UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci (2014) 0.77
Calsyntenins are secretory granule proteins in anterior pituitary gland and pancreatic islet alpha cells. J Histochem Cytochem (2007) 0.76
Zebrafish calsyntenins mediate homophilic adhesion through their amino-terminal cadherin repeats. Neuroscience (2014) 0.76
The Kinesin Adaptor Calsyntenin-1 Organizes Microtubule Polarity and Regulates Dynamics during Sensory Axon Arbor Development. Front Cell Neurosci (2017) 0.75
APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci (2017) 0.75
Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage. J Biol Chem (2014) 0.75
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23
Auxiliary subunits assist AMPA-type glutamate receptors. Science (2006) 3.10
State-dependent sensory gating in olfactory cortex. Neuron (2005) 2.49
Time-dependent reorganization of the brain components underlying memory retention in trace eyeblink conditioning. J Neurosci (2003) 2.43
A transmembrane accessory subunit that modulates kainate-type glutamate receptors. Neuron (2009) 2.07
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci (2004) 2.07
TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity. Nat Neurosci (2005) 2.04
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nat Neurosci (2011) 2.00
Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Neuron (2007) 1.76
Escherichia coli phage-shock protein A (PspA) binds to membrane phospholipids and repairs proton leakage of the damaged membranes. Mol Microbiol (2007) 1.74
A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem (2003) 1.65
Dropped head syndrome in Parkinson's disease. Mov Disord (2006) 1.64
The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J (2007) 1.55
Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2002) 1.51
Thermophilic ATP synthase has a decamer c-ring: indication of noninteger 10:3 H+/ATP ratio and permissive elastic coupling. Proc Natl Acad Sci U S A (2004) 1.48
Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J Biol Chem (2002) 1.46
Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron (2010) 1.45
A seed for Alzheimer amyloid in the brain. J Neurosci (2004) 1.45
ATP-driven stepwise rotation of FoF1-ATP synthase. Proc Natl Acad Sci U S A (2005) 1.43
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci (2002) 1.42
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem (2006) 1.37
Axle-less F1-ATPase rotates in the correct direction. Science (2008) 1.36
The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits. Curr Opin Neurobiol (2011) 1.33
Regulatory interplay between proton motive force, ADP, phosphate, and subunit epsilon in bacterial ATP synthase. J Biol Chem (2006) 1.32
TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers. Neuron (2010) 1.30
Autoinactivation of neuronal AMPA receptors via glutamate-regulated TARP interaction. Neuron (2009) 1.30
Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem (2004) 1.26
Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. Biochem J (2007) 1.24
Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. J Biol Chem (2006) 1.19
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. J Biol Chem (2008) 1.17
Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases. Neuropharmacology (2003) 1.17
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition. J Neurosci (2007) 1.17
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun (2004) 1.16
Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Res (2005) 1.16
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. PLoS One (2006) 1.14
Defined criteria for auxiliary subunits of glutamate receptors. J Physiol (2011) 1.14
Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. J Neurosci (2011) 1.14
mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning. Eur J Neurosci (2002) 1.12
The role of subunit epsilon in the catalysis and regulation of FOF1-ATP synthase. Biochim Biophys Acta (2006) 1.12
Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors. Mol Pharmacol (2003) 1.10
Kainate receptors mediate signaling in both transient and sustained OFF bipolar cell pathways in mouse retina. J Neurosci (2014) 1.10
Time-limited role of the hippocampus in the memory for trace eyeblink conditioning in mice. Brain Res (2002) 1.09
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J Biol Chem (2002) 1.09
Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. J Neurosci (2011) 1.08
Systems consolidation requires postlearning activation of NMDA receptors in the medial prefrontal cortex in trace eyeblink conditioning. J Neurosci (2006) 1.08
Real-time monitoring of conformational dynamics of the epsilon subunit in F1-ATPase. J Biol Chem (2005) 1.07
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD. Genes Cells (2006) 1.06
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. J Biol Chem (2009) 1.06
Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Dis (2009) 1.06
Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex. J Neurosci (2010) 1.05
Torque generation and utilization in motor enzyme F0F1-ATP synthase: half-torque F1 with short-sized pushrod helix and reduced ATP Synthesis by half-torque F0F1. J Biol Chem (2011) 1.05
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. J Biol Chem (2004) 1.03
Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion. J Biochem (2005) 1.02
Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation. Proc Natl Acad Sci U S A (2013) 1.02
Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells. J Biol Chem (2008) 1.02
SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. J Biol Chem (2002) 1.01
Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. J Biol Chem (2007) 1.01
PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity. Nat Neurosci (2011) 1.00
Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J Biol Chem (2004) 1.00
Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response. J Neurosci (2006) 1.00
Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol Dis (2005) 1.00
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia. EMBO Rep (2008) 1.00
Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors. Eur J Neurosci (2014) 1.00
Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis. Proc Natl Acad Sci U S A (2011) 0.99
Effects of intervention using a community-based walking program for prevention of mental decline: a randomized controlled trial. J Am Geriatr Soc (2012) 0.98
Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J Biol Chem (2002) 0.98
Essential arginine residue of the F(o)-a subunit in F(o)F(1)-ATP synthase has a role to prevent the proton shortcut without c-ring rotation in the F(o) proton channel. Biochem J (2010) 0.97
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain (2009) 0.96
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. EMBO Mol Med (2012) 0.96
ATP synthase that lacks F0a-subunit: isolation, properties, and indication of F0b2-subunits as an anchor rail of a rotating c-ring. J Biol Chem (2004) 0.96
Pathology of clinical and preclinical Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci (2013) 0.96
Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain. Neurobiol Aging (2005) 0.95
The role of the betaDELSEED-loop of ATP synthase. J Biol Chem (2009) 0.95
Assembly of hereditary amyloid beta-protein variants in the presence of favorable gangliosides. FEBS Lett (2005) 0.95
A small peptide sequence is sufficient for initiating kinesin-1 activation through part of TPR region of KLC1. Traffic (2012) 0.95
Plasmodium falciparum: selenium-induced cytotoxicity to P. falciparum. Exp Parasitol (2004) 0.94
Paths, elongation, and projections of ascending chick embryonic spinal commissural neurons after crossing the floor plate. Brain Res (2008) 0.94
Control of bacteriophage T4 tail lysozyme activity during the infection process. J Mol Biol (2005) 0.94
Activation and stiffness of the inhibited states of F1-ATPase probed by single-molecule manipulation. J Biol Chem (2010) 0.94
Purkinje cell activity during learning a new timing in classical eyeblink conditioning. Brain Res (2003) 0.94
Slow Ca2+ dynamics in pharyngeal muscles in Caenorhabditis elegans during fast pumping. EMBO Rep (2004) 0.94
Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Ann Neurol (2011) 0.93
Neither helix in the coiled coil region of the axle of F1-ATPase plays a significant role in torque production. Biophys J (2008) 0.93
Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue. Brain Res (2003) 0.93
NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace, but not delay eyeblink conditioning. Learn Mem (2005) 0.93
A new solution structure of ATP synthase subunit c from thermophilic Bacillus PS3, suggesting a local conformational change for H+-translocation. J Mol Biol (2006) 0.92
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice. Neurobiol Aging (2006) 0.92