Published in Cell on June 27, 2008
Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37
Annotation of functional variation in personal genomes using RegulomeDB. Genome Res (2012) 11.47
HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res (2011) 11.03
Integrative analysis of 111 reference human epigenomes. Nature (2015) 10.32
JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles. Nucleic Acids Res (2009) 9.42
A census of human transcription factors: function, expression and evolution. Nat Rev Genet (2009) 9.19
Diversity and complexity in DNA recognition by transcription factors. Science (2009) 9.07
UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic Acids Res (2008) 6.83
An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24
STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell (2010) 5.67
High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res (2009) 5.11
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell (2008) 4.49
Origins of specificity in protein-DNA recognition. Annu Rev Biochem (2010) 4.43
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell (2010) 4.02
Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell (2009) 3.69
Universal protein-binding microarrays for the comprehensive characterization of the DNA-binding specificities of transcription factors. Nat Protoc (2009) 3.48
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell (2011) 3.40
Finding distal regulatory elements in the human genome. Curr Opin Genet Dev (2009) 3.02
A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell (2009) 3.02
Determination and inference of eukaryotic transcription factor sequence specificity. Cell (2014) 2.84
Conservation of core gene expression in vertebrate tissues. J Biol (2009) 2.84
Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence. Nat Rev Genet (2011) 2.60
Circuitry and dynamics of human transcription factor regulatory networks. Cell (2012) 2.56
From DNA sequence to transcriptional behaviour: a quantitative approach. Nat Rev Genet (2009) 2.54
Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays. Hepatology (2010) 2.51
An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins. Nucleic Acids Res (2008) 2.42
Hox specificity unique roles for cofactors and collaborators. Curr Top Dev Biol (2009) 2.37
Evaluation of methods for modeling transcription factor sequence specificity. Nat Biotechnol (2013) 2.34
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
UniPROBE, update 2011: expanded content and search tools in the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res (2010) 2.16
The homeodomain protein HOXB13 regulates the cellular response to androgens. Mol Cell (2009) 2.07
De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis. Nat Biotechnol (2010) 2.05
Distinguishing direct versus indirect transcription factor-DNA interactions. Genome Res (2009) 2.05
Rapid turnover of long noncoding RNAs and the evolution of gene expression. PLoS Genet (2012) 2.05
Discriminative prediction of mammalian enhancers from DNA sequence. Genome Res (2011) 2.02
Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. PLoS Pathog (2010) 2.00
Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells. Cancer Res (2009) 1.97
Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments. Nucleic Acids Res (2013) 1.96
Exhaustive search for over-represented DNA sequence motifs with CisFinder. DNA Res (2009) 1.94
Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A (2011) 1.92
MochiView: versatile software for genome browsing and DNA motif analysis. BMC Biol (2010) 1.89
Integrating multiple evidence sources to predict transcription factor binding in the human genome. Genome Res (2010) 1.84
Absence of a simple code: how transcription factors read the genome. Trends Biochem Sci (2014) 1.84
Identification of transcriptional regulators in the mouse immune system. Nat Immunol (2013) 1.79
LUX ARRHYTHMO encodes a nighttime repressor of circadian gene expression in the Arabidopsis core clock. Curr Biol (2011) 1.78
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell (2012) 1.75
High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states. Nat Protoc (2013) 1.73
The interplay between transcription factors and microRNAs in genome-scale regulatory networks. Bioessays (2009) 1.72
Disentangling the many layers of eukaryotic transcriptional regulation. Annu Rev Genet (2012) 1.68
Low affinity binding site clusters confer hox specificity and regulatory robustness. Cell (2014) 1.64
Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. Elife (2013) 1.64
TFBSshape: a motif database for DNA shape features of transcription factor binding sites. Nucleic Acids Res (2013) 1.60
Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors. PLoS Biol (2012) 1.52
The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease. Cell Mol Life Sci (2009) 1.51
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol (2009) 1.46
Web-queryable large-scale data sets for hypothesis generation in plant biology. Plant Cell (2009) 1.44
Comparative analysis of regulatory information and circuits across distant species. Nature (2014) 1.41
Transcription Factors Encoded on Core and Accessory Chromosomes of Fusarium oxysporum Induce Expression of Effector Genes. PLoS Genet (2016) 1.39
Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev (2010) 1.39
Specificity landscapes of DNA binding molecules elucidate biological function. Proc Natl Acad Sci U S A (2010) 1.39
Integrated approaches reveal determinants of genome-wide binding and function of the transcription factor Pho4. Mol Cell (2011) 1.38
hPDI: a database of experimental human protein-DNA interactions. Bioinformatics (2009) 1.37
Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity. Nat Neurosci (2013) 1.36
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A (2010) 1.32
Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol (2011) 1.32
UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res (2014) 1.31
Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression. Mol Syst Biol (2013) 1.31
Sequence specificity is obtained from the majority of modular C2H2 zinc-finger arrays. Nucleic Acids Res (2011) 1.27
Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins. Proc Natl Acad Sci U S A (2011) 1.26
Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C. Genome Res (2014) 1.26
Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol (2011) 1.25
Genome-wide tissue-specific occupancy of the Hox protein Ultrabithorax and Hox cofactor Homothorax in Drosophila. PLoS One (2011) 1.23
Distinct transcriptional regulatory modules underlie STAT3's cell type-independent and cell type-specific functions. Nucleic Acids Res (2013) 1.21
The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges. Brief Funct Genomics (2013) 1.20
Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Dev Cell (2015) 1.19
Transcriptional regulation and stabilization of left-right neuronal identity in C. elegans. Genes Dev (2009) 1.17
Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Nucleic Acids Res (2011) 1.16
Using protein design algorithms to understand the molecular basis of disease caused by protein-DNA interactions: the Pax6 example. Nucleic Acids Res (2010) 1.16
Coevolution within a transcriptional network by compensatory trans and cis mutations. Genome Res (2010) 1.16
Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Res (2010) 1.16
Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants. Nucleic Acids Res (2011) 1.15
Experimental determination of the evolvability of a transcription factor. Proc Natl Acad Sci U S A (2009) 1.12
Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency. Cell Rep (2014) 1.12
Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res (2012) 1.11
Dissecting the functional specificities of two Hox proteins. Genes Dev (2010) 1.11
A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis. PLoS Genet (2012) 1.10
Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nat Neurosci (2013) 1.09
Recognition models to predict DNA-binding specificities of homeodomain proteins. Bioinformatics (2012) 1.09
Protein-DNA binding: complexities and multi-protein codes. Nucleic Acids Res (2013) 1.09
The importance of being cis: evolution of orthologous fish and mammalian enhancer activity. Mol Biol Evol (2010) 1.08
GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR. Database (Oxford) (2011) 1.08
Assessment of the optimization of affinity and specificity at protein-DNA interfaces. Nucleic Acids Res (2009) 1.07
Global analysis of Drosophila Cys₂-His₂ zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants. Genome Res (2013) 1.07
ATAF1 transcription factor directly regulates abscisic acid biosynthetic gene NCED3 in Arabidopsis thaliana. FEBS Open Bio (2013) 1.07
Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity. Development (2012) 1.05
Covariation between homeodomain transcription factors and the shape of their DNA binding sites. Nucleic Acids Res (2013) 1.05
Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development. Development (2012) 1.05
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res (2003) 29.26
Transcriptional regulatory code of a eukaryotic genome. Nature (2004) 27.21
JASPAR: an open-access database for eukaryotic transcription factor binding profiles. Nucleic Acids Res (2004) 19.32
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell (2005) 14.32
The Mouse Genome Database (MGD): integrating biology with the genome. Nucleic Acids Res (2004) 8.91
JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update. Nucleic Acids Res (2007) 8.79
Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nat Biotechnol (2006) 8.38
Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions. Cell (1990) 7.99
Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nat Genet (2004) 6.33
Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol (2008) 6.30
DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell (1989) 5.89
Additivity in protein-DNA interactions: how good an approximation is it? Nucleic Acids Res (2002) 5.04
Measuring absolute expression with microarrays with a calibrated reference sample and an extended signal intensity range. Proc Natl Acad Sci U S A (2002) 4.44
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell (1989) 4.05
A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell (1992) 3.46
Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell (2007) 3.34
Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins. Trends Genet (1996) 3.25
DNA binding specificity of homeodomains. Biochemistry (1991) 3.17
Core transcriptional regulatory circuitry in human hepatocytes. Mol Syst Biol (2006) 3.15
The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix. Mol Cell Biol (1994) 3.06
MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules. Nat Genet (2005) 2.63
Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. J Biol Chem (1995) 2.62
Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes. Structure (2001) 2.55
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J (1994) 2.33
Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J (1992) 2.32
Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins. Mol Cell Biol (1993) 2.12
Mapping functional specificity in the Dfd and Ubx homeo domains. Genes Dev (1992) 1.93
RankMotif++: a motif-search algorithm that accounts for relative ranks of K-mers in binding transcription factors. Bioinformatics (2007) 1.86
The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences. Genes Dev (1993) 1.75
Engrailed homeodomain-DNA complex at 2.2 A resolution: a detailed view of the interface and comparison with other engrailed structures. J Mol Biol (1998) 1.74
Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis. Development (2005) 1.71
The NK homeobox gene cluster predates the origin of Hox genes. Curr Biol (2007) 1.71
Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition. J Mol Biol (2001) 1.71
Hox transcription factors and their elusive mammalian gene targets. Heredity (Edinb) (2006) 1.70
A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos. EMBO J (1999) 1.67
Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites. Development (2002) 1.64
Homeodomain interactions. Curr Opin Struct Biol (1996) 1.53
Functional specificity of the Antennapedia homeodomain. Proc Natl Acad Sci U S A (1993) 1.39
A molecular code dictates sequence-specific DNA recognition by homeodomains. EMBO J (1996) 1.34
Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity. Structure (1997) 1.31
Structural basis of Hox specificity. Nat Struct Biol (1999) 1.20
The Homeodomain Resource: 2003 update. Nucleic Acids Res (2003) 1.18
Obox, a family of homeobox genes preferentially expressed in germ cells. Genomics (2002) 1.18
A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection. BMC Genomics (2006) 1.12
Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene. Dev Biol (1994) 0.99
Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1. Nucleic Acids Res (2004) 0.97
A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
The genetic landscape of a cell. Science (2010) 16.52
Structures of the bacterial ribosome at 3.5 A resolution. Science (2005) 12.63
A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet (2007) 12.21
The DNA-encoded nucleosome organization of a eukaryotic genome. Nature (2008) 11.41
Diversity and complexity in DNA recognition by transcription factors. Science (2009) 9.07
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
The first metal-organic framework (MOF) of Imazethapyr and its SHG, piezoelectric and ferroelectric properties. Dalton Trans (2008) 8.86
Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res (2011) 8.57
Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell (2007) 8.43
Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nat Biotechnol (2006) 8.38
FunSpec: a web-based cluster interpreter for yeast. BMC Bioinformatics (2002) 8.01
Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol Cell (2004) 7.32
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic Acids Res (2008) 6.83
Hydrogen-bonded ferroelectrics based on metal-organic coordination. J Am Chem Soc (2009) 6.69
Most "dark matter" transcripts are associated with known genes. PLoS Biol (2010) 6.60
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nat Genet (2004) 6.33
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell (2010) 5.67
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
DNA-binding specificities of human transcription factors. Cell (2013) 5.14
High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res (2009) 5.11
Additivity in protein-DNA interactions: how good an approximation is it? Nucleic Acids Res (2002) 5.04
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
Probing microRNAs with microarrays: tissue specificity and functional inference. RNA (2004) 4.91
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78
A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78
Supramolecular bola-like ferroelectric: 4-methoxyanilinium tetrafluoroborate-18-crown-6. J Am Chem Soc (2011) 4.73
Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet (2002) 4.68
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell (2008) 4.49
Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization. Adv Mater (2011) 4.30
An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell (2011) 4.29
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell (2010) 4.02
Rapid tRNA decay can result from lack of nonessential modifications. Mol Cell (2006) 3.86
Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Mol Cell Biol (2004) 3.72
Universal protein-binding microarrays for the comprehensive characterization of the DNA-binding specificities of transcription factors. Nat Protoc (2009) 3.48
Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol (2009) 3.44
Using expression profiling data to identify human microRNA targets. Nat Methods (2007) 3.37
Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection. Clin Infect Dis (2010) 3.12
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
Specific DNA-binding by apicomplexan AP2 transcription factors. Proc Natl Acad Sci U S A (2008) 3.10
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
G+C content dominates intrinsic nucleosome occupancy. BMC Bioinformatics (2009) 3.05
A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell (2009) 3.02
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
A multiferroic perdeutero metal-organic framework. Angew Chem Int Ed Engl (2011) 2.88
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell (2010) 2.87
Conservation of core gene expression in vertebrate tissues. J Biol (2009) 2.84
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80
Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science (2011) 2.78
Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. PLoS Biol (2008) 2.73
Why are there still over 1000 uncharacterized yeast genes? Genetics (2007) 2.71
SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase. Dev Cell (2007) 2.64
Net primary production of Chinese croplands from 1950 to 1999. Ecol Appl (2007) 2.61
Systematic identification of mammalian regulatory motifs' target genes and functions. Nat Methods (2008) 2.58