Published in Cell on January 08, 2010
The Drosophila melanogaster Genetic Reference Panel. Nature (2012) 7.94
Lipid droplets and cellular lipid metabolism. Annu Rev Biochem (2012) 4.02
Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. Hepatology (2012) 2.93
Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell (2016) 2.75
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature (2011) 2.65
A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell (2012) 2.29
Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity. Hepatology (2014) 2.23
RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods (2011) 1.82
Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development. Genes Dev (2014) 1.57
Overcoming obstacles to developing new analgesics. Nat Med (2010) 1.54
Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation. Scientifica (Cairo) (2013) 1.51
RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip Rev RNA (2011) 1.48
Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog. Genes Dev (2016) 1.39
Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology (2012) 1.36
SH2B regulation of growth, metabolism, and longevity in both insects and mammals. Cell Metab (2010) 1.34
Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A (2012) 1.33
Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. J Biol Chem (2010) 1.33
Automated monitoring and quantitative analysis of feeding behaviour in Drosophila. Nat Commun (2014) 1.26
Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biol (2013) 1.21
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis. Genes Dev (2013) 1.18
Rab32 is important for autophagy and lipid storage in Drosophila. PLoS One (2012) 1.16
A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods. Mol Endocrinol (2012) 1.13
Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta (2013) 1.12
Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics (2013) 1.11
Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe. Genes Dev (2010) 1.10
A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability. PLoS Genet (2010) 1.06
Brown adipose tissue: development, metabolism and beyond. Biochem J (2013) 1.03
Differentiation of Human Adipose-Derived Stem Cells into "Brite" (Brown-in-White) Adipocytes. Front Endocrinol (Lausanne) (2011) 1.03
Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases. Dis Model Mech (2014) 1.02
Reliable Drosophila body fat quantification by a coupled colorimetric assay. PLoS One (2011) 1.00
White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol (2014) 1.00
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun (2016) 0.99
The role of JAK-STAT signaling in adipose tissue function. Biochim Biophys Acta (2013) 0.99
Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis. Diabetes (2011) 0.98
MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. EMBO Mol Med (2014) 0.98
Identification of new genes involved in human adipogenesis and fat storage. PLoS One (2012) 0.98
Drosophila lipophorin receptors mediate the uptake of neutral lipids in oocytes and imaginal disc cells by an endocytosis-independent mechanism. PLoS Genet (2011) 0.97
Colorimetric measurement of triglycerides cannot provide an accurate measure of stored fat content in Drosophila. PLoS One (2010) 0.96
Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential. Adipocyte (2012) 0.96
Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system. PLoS Genet (2012) 0.94
Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Res (2011) 0.92
Drosophila tools and assays for the study of human diseases. Dis Model Mech (2016) 0.91
A conserved role for syndecan family members in the regulation of whole-body energy metabolism. PLoS One (2010) 0.90
Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity. Curr Opin Pharmacol (2010) 0.90
Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster. Genetics (2014) 0.90
Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila. Proc Natl Acad Sci U S A (2014) 0.89
Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89
An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. FEBS Lett (2010) 0.89
Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3. Development (2012) 0.88
RNAi screening in Drosophila cells and in vivo. Methods (2014) 0.87
A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. G3 (Bethesda) (2012) 0.86
High- and low-throughput scoring of fat mass and body fat distribution in C. elegans. Methods (2014) 0.86
Endocannabinoids are conserved inhibitors of the Hedgehog pathway. Proc Natl Acad Sci U S A (2015) 0.85
Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. BMC Genomics (2013) 0.85
Modeling obesity and its associated disorders in Drosophila. Physiology (Bethesda) (2013) 0.85
Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling. PLoS One (2012) 0.83
14-3-3ζ coordinates adipogenesis of visceral fat. Nat Commun (2015) 0.83
Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol (2014) 0.83
C13C4.5/Spinster, an evolutionarily conserved protein that regulates fertility in C. elegans through a lysosome-mediated lipid metabolism process. Protein Cell (2013) 0.83
From fat fruit fly to human obesity. Physiol Behav (2014) 0.82
Quantitative Genetics of Food Intake in Drosophila melanogaster. PLoS One (2015) 0.82
T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One (2015) 0.81
Drosophila as a model for antiviral immunity. World J Biol Chem (2010) 0.81
CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila. Development (2015) 0.81
The Little Fly that Could: Wizardry and Artistry of Drosophila Genomics. Genes (Basel) (2014) 0.81
Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform. Aging (Albany NY) (2014) 0.80
The paradox of overnutrition in aging and cognition. Ann N Y Acad Sci (2013) 0.80
The Heat is on: A New Avenue to Study Brown Fat Formation in Humans. Front Endocrinol (Lausanne) (2012) 0.80
The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis. Cell (2015) 0.80
Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PLoS One (2014) 0.80
Metabolic regulation and energy homeostasis through the primary Cilium. Cell Metab (2014) 0.80
Incomplete and transitory decrease of glycolysis: a new paradigm for anti-angiogenic therapy? Cell Cycle (2013) 0.79
Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis. Cell Rep (2015) 0.79
Interaction of Veratrum nigrum with Panax ginseng against Obesity: A Sang-ban Relationship. Evid Based Complement Alternat Med (2013) 0.79
Using Drosophila larval imaginal discs to study low-dose radiation-induced cell cycle arrest. Methods Mol Biol (2011) 0.79
Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. Wiley Interdiscip Rev Syst Biol Med (2010) 0.79
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep (2016) 0.79
Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation. Mol Cell Biol (2012) 0.78
Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila. G3 (Bethesda) (2014) 0.78
Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish. Biochim Biophys Acta (2013) 0.78
Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol (2016) 0.78
Modeling dietary influences on offspring metabolic programming in Drosophila melanogaster. Reproduction (2016) 0.78
Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Genetics (2016) 0.77
Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun Signal (2014) 0.77
Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. Dis Model Mech (2017) 0.77
In Vivo RNAi-Based Screens: Studies in Model Organisms. Genes (Basel) (2013) 0.77
Effects of Synthetic Diets Enriched in Specific Nutrients on Drosophila Development, Body Fat, and Lifespan. PLoS One (2016) 0.76
Genetics of fat storage in flies and worms: what went wrong? Front Genet (2011) 0.76
Drosophila melanogaster: An emerging model of transgenerational effects of maternal obesity. Mol Cell Endocrinol (2015) 0.76
A new way to look at fat. Nat Methods (2011) 0.76
Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc. Diabetes (2015) 0.76
Systemic control of brown fat thermogenesis: integration of peripheral and central signals. Ann N Y Acad Sci (2013) 0.76
Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. PLoS Genet (2017) 0.75
High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression. Sci Rep (2016) 0.75
The interplay between obesity and cancer: a fly view. Dis Model Mech (2016) 0.75
Dropping in on the lipid droplet- tumor protein D52 (TPD52) as a new regulator and resident protein. Adipocyte (2016) 0.75
RNAi screen in Drosophila yields a fat catch of Hedgehog. Protein Cell (2010) 0.75
More than just an engine: the heart regulates body weight. Circ Res (2012) 0.75
Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging. Transl Res (2013) 0.75
Comparative proteome analysis of brown adipose tissue in obese C57BL/6J mice using iTRAQ-coupled 2D LC-MS/MS. PLoS One (2015) 0.75
Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes (2007) 14.12
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes (2008) 10.74
Cerebral organoids model human brain development and microcephaly. Nature (2013) 9.07
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N Engl J Med (2015) 6.48
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A (2013) 5.88
Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med (2011) 5.66
Regulation of cancer cell migration and bone metastasis by RANKL. Nature (2006) 5.27
Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature (2002) 5.02
Mitogen-activated protein kinases in apoptosis regulation. Oncogene (2004) 4.76
An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol (2007) 4.12
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature (2010) 4.01
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82
Mutations in SUFU predispose to medulloblastoma. Nat Genet (2002) 3.78
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74
RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med (2005) 3.68
Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas. N Engl J Med (2004) 3.63
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature (2002) 3.63
Prebiotic effects: metabolic and health benefits. Br J Nutr (2010) 3.49
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity (2003) 3.36
D-dimer levels and risk of recurrent venous thromboembolism. JAMA (2003) 3.30
RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol (2001) 3.27
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med (2005) 3.26
Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development (2002) 3.26
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell (2005) 3.22
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell (2013) 3.19
AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Arch Phys Med Rehabil (2005) 3.17
Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature (2005) 3.09
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med (2006) 3.09
Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut (2012) 3.09
High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS). Blood (2008) 2.97
Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J (2008) 2.97
Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med (2013) 2.93
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91
Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem (2006) 2.91
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol (2004) 2.90
Rac function and regulation during Drosophila development. Nature (2002) 2.89
Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening. EMBO J (2003) 2.87
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity (2008) 2.81
Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr (2008) 2.77
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 2.76
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell (2011) 2.69
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature (2009) 2.68
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68
The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67
Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors. Cell (2006) 2.66
International Sleeve Gastrectomy Expert Panel Consensus Statement: best practice guidelines based on experience of >12,000 cases. Surg Obes Relat Dis (2011) 2.64
GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer (2006) 2.63
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev (2009) 2.59
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity (2008) 2.57
Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev (2006) 2.56
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet (2011) 2.47
Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science (2009) 2.47
Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes (2011) 2.46
Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol (2011) 2.44
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med (2006) 2.38
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab (2012) 2.36
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology (2011) 2.33
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell (2010) 2.27
The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med (2004) 2.27
Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing. Science (2012) 2.22
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke (2012) 2.18
The role of mitochondrial DNA copy number in mammalian fertility. Biol Reprod (2010) 2.15
Rac GTPases control axon growth, guidance and branching. Nature (2002) 2.14
CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. J Clin Endocrinol Metab (2008) 2.14
Microbial modulation of energy availability in the colon regulates intestinal transit. Cell Host Microbe (2013) 2.14
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev (2003) 2.12
Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science (2003) 2.11
RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci (2008) 2.10
Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. J Cell Sci (2004) 2.08
Effect of smoking on restenosis during the 1st year after lower-limb endovascular interventions. Radiology (2004) 2.07
The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci Signal (2009) 2.05
Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med (2003) 2.04