PubRank

Megan Sykes

Author PubWeight™ 154.56‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008 7.42
2 Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2004 3.63
3 Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 2012 3.21
4 Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol 2009 2.70
5 Clinical trial of islet xenotransplantation in Mexico. Xenotransplantation 2006 2.51
6 CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant 2004 2.45
7 In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature 2011 2.44
8 Organ transplantation--how much of the promise has been realized? Nat Med 2005 2.26
9 An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J Exp Med 2006 1.94
10 Tolerance induction in clinical transplantation. Transpl Immunol 2004 1.90
11 Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance. J Clin Oncol 2004 1.87
12 Xenotransplantation: current status and a perspective on the future. Nat Rev Immunol 2007 1.80
13 Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A 2007 1.80
14 Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation 2002 1.75
15 Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells. Blood 2002 1.68
16 Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites. Blood 2003 1.64
17 Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood 2008 1.60
18 The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 2002 1.49
19 Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation 2003 1.47
20 Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood 2006 1.44
21 The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood 2007 1.37
22 Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. Transplantation 2003 1.36
23 Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 2003 1.35
24 Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells. J Immunol 2003 1.34
25 HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2013 1.29
26 Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol 2002 1.28
27 A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med 2012 1.27
28 Early regulation of CD8 T cell alloreactivity by CD4+CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation. Eur J Immunol 2005 1.26
29 Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells. Blood 2004 1.26
30 Mixed chimerism, lymphocyte recovery, and evidence for early donor-specific unresponsiveness in patients receiving combined kidney and bone marrow transplantation to induce tolerance. Transplantation 2010 1.25
31 Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells. Blood 2002 1.24
32 Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol 2005 1.22
33 Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions. Blood 2006 1.22
34 Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction. Semin Immunol 2011 1.21
35 Emerging concepts in haematopoietic cell transplantation. Nat Rev Immunol 2012 1.20
36 Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway. Blood 2008 1.19
37 Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood 2004 1.19
38 Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma. Blood 2003 1.19
39 Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs. J Immunol 2010 1.18
40 Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury. Blood 2009 1.16
41 Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. J Clin Invest 2003 1.16
42 Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization. Stem Cells 2002 1.14
43 Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L. Am J Transplant 2004 1.14
44 Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. Biol Blood Marrow Transplant 2006 1.13
45 Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism. Transplantation 2003 1.12
46 An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2007 1.12
47 Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin Immunol 2011 1.12
48 Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation. Exp Hematol 2003 1.12
49 Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation 2011 1.12
50 Mechanisms of the antitumor responses and host-versus-graft reactions induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: a critical role for recipient CD4+ T cells and recipient leukocyte infusion-derived IFN-gamma-producing CD8+ T cells. J Immunol 2005 1.10
51 Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol. J Immunol 2005 1.08
52 Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine. Exp Hematol 2007 1.07
53 Tolerance in mixed chimerism - a role for regulatory cells? Trends Immunol 2004 1.06
54 Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation. J Clin Invest 2010 1.04
55 CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance. Blood 2009 1.04
56 Elimination of porcine hemopoietic cells by macrophages in mice. J Immunol 2002 1.02
57 Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants. Biol Blood Marrow Transplant 2003 1.01
58 The host environment regulates the function of CD8+ graft-versus-host-reactive effector cells. J Immunol 2008 1.01
59 Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II. J Immunol 2008 1.01
60 Clinical relevance of recipient leukocyte infusion as antitumor therapy following nonmyeloablative allogeneic hematopoietic cell transplantation. Exp Hematol 2006 1.01
61 Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness. Transplantation 2003 1.00
62 A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo. Blood 2009 1.00
63 GalT-KO pigs: is the cup half empty or half full? Transplantation 2007 0.99
64 NK cell tolerance in mixed allogeneic chimeras. J Immunol 2003 0.98
65 Induction of tolerance through mixed chimerism. Cold Spring Harb Perspect Med 2014 0.97
66 Xenotransplantation: immunological hurdles and progress toward tolerance. Immunol Rev 2014 0.97
67 CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors. Biol Blood Marrow Transplant 2008 0.96
68 Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution. Transplantation 2005 0.96
69 Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier. Blood 2002 0.94
70 Human natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model. J Immunol 2011 0.94
71 Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells. J Immunol 2008 0.92
72 Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity. Diabetes 2004 0.92
73 Clinical experience with mixed chimerism to induce transplantation tolerance. Transpl Int 2008 0.91
74 LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. Blood 2011 0.91
75 Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates. Transplantation 2006 0.91
76 CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase. Transplantation 2007 0.90
77 NK cell recovery, chimerism, function, and recognition in recipients of haploidentical hematopoietic cell transplantation following nonmyeloablative conditioning using a humanized anti-CD2 mAb, Medi-507. Exp Hematol 2003 0.89
78 Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses. J Immunol 2010 0.89
79 Occurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons. Xenotransplantation 2010 0.89
80 Role of indirect allo- and autoreactivity in anti-tumor responses induced by recipient leukocyte infusions (RLI) in mixed chimeras prepared with nonmyeloablative conditioning. Clin Immunol 2006 0.88
81 Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation. Biol Blood Marrow Transplant 2006 0.87
82 Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance. Transpl Int 2002 0.85
83 Fetal porcine thymus engraftment, survival and CD4 reconstitution in alphaGal-KO mice is impaired in the presence of high levels of antibodies against alphaGal. Xenotransplantation 2003 0.85
84 Decay-accelerating factor prevents acute humoral rejection induced by low levels of anti-alphaGal natural antibodies. Transplantation 2006 0.85
85 The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 1: Key ethical requirements and progress toward the definition of an international regulatory framework. Xenotransplantation 2009 0.84
86 Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. Transpl Immunol 2008 0.84
87 Short-term immunosuppression facilitates induction of mixed chimerism and tolerance after bone marrow transplantation without cytoreductive conditioning. Transplantation 2005 0.83
88 Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism. Immunol Rev 2008 0.83
89 Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice. J Clin Invest 2004 0.83
90 Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement. Transplantation 2016 0.82
91 Nonalloreactive T cells prevent donor lymphocyte infusion-induced graft-versus-host disease by controlling microbial stimuli. J Immunol 2012 0.82
92 Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant. Cytokines Cell Mol Ther 2002 0.82
93 Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity. Transplantation 2003 0.81
94 Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: role of PGE2 in chemokine and cytokine expression by MoDCs. Int Immunol 2005 0.81
95 International human xenotransplantation inventory. Transplantation 2010 0.81
96 Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L. Am J Transplant 2003 0.81
97 Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts. Transplantation 2008 0.81
98 Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantation. J Immunol 2008 0.81
99 Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent. Transplantation 2007 0.81
100 Anti-CD40L monoclonal antibodies can replace anti-CD4 monoclonal antibodies for the nonmyeloablative induction of mixed xenogeneic chimerism. Transplantation 2006 0.80
101 Murine CD4 T cells selected in a highly disparate xenogeneic porcine thymus graft do not show rapid decay in the absence of selecting MHC in the periphery. J Immunol 2002 0.80
102 Stem cell activity of porcine c-kit+ hematopoietic cells. Exp Hematol 2003 0.80
103 Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction. J Infect Dis 2007 0.80
104 Immune evasion by chimeric trachea. N Engl J Med 2010 0.80
105 Induction of tolerance. Surgery 2004 0.79
106 B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells. Blood 2006 0.79
107 Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation 2016 0.79
108 Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning. Blood 2003 0.78
109 Expression and purification of soluble murine CD40L monomers and polymers in yeast Pichia pastoris. Protein Expr Purif 2010 0.78
110 Role of VLA-4 and VLA-5 in ex vivo maintenance of human and pig hematopoiesis in human stroma-supported long-term cultures. Exp Hematol 2005 0.78
111 Characterization of anti-Gal antibody-producing cells of baboons and humans. Transplantation 2006 0.78
112 Central tolerance to myogenic cell transplants does not include muscle neoantigens. Transplantation 2008 0.78
113 Long-term survival of xenogeneic heart grafts achieved by costimulatory blockade and transient mixed chimerism. Transplantation 2006 0.77
114 T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model. Transplantation 2004 0.77
115 Clinical strategy for induction of transplantation tolerance through mixed chimerism. Clin Transpl 2013 0.77
116 T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction. Exp Hematol 2005 0.77
117 B cell tolerance to xenoantigens. Xenotransplantation 2003 0.77
118 Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice. Transpl Immunol 2005 0.77
119 Use of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol 2002 0.77
120 Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts. J Immunol 2014 0.77
121 Porcine mononuclear cells adhere to human fibronectin independently of very late antigen-5: implications for donor-specific tolerance induction in xenotransplantation. Xenotransplantation 2002 0.77
122 Guidelines for xenotransplantation. N Engl J Med 2003 0.77
123 International cooperation on xenotransplantation. Nat Med 2004 0.76
124 Protecting the host naturally. Nat Med 2005 0.76
125 Induction of mixed vs full chimerism to potentiate GVL effects after bone-marrow transplantation. Methods Mol Med 2005 0.76
126 Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras. PLoS One 2012 0.76
127 Distinct requirements for achievement of allotolerance versus reversal of autoimmunity via nonmyeloablative mixed chimerism induction in NOD mice. Transplantation 2010 0.76
128 A New Window into the Human Alloresponse. Transplantation 2016 0.76
129 Persistence of donor-derived protein in host myeloid cells after induced rejection of engrafted allogeneic bone marrow cells. Exp Hematol 2010 0.75
130 High antigen levels do not preclude B-cell tolerance induction to alpha1,3-Gal via mixed chimerism. Xenotransplantation 2009 0.75
131 Xenotransplantation of pig islets into Mexican children: were the fundamental ethical requirements to proceed with such a study really met? Eur J Endocrinol 2006 0.75
132 Reply to 'Critics slam Russian trial to test pig pancreas for diabetes'. Nat Med 2007 0.75
133 Use of skin grafting to demonstrate tolerance before kidney transplantation without immunosuppression in the recipient of a previous bone marrow transplant. Transplantation 2005 0.75
134 Response to Valdes-Gonzalez ''Clinical trial of islet xenotransplantation in Mexico''. Xenotransplantation 2007 0.75
135 Layers of regulation in induction of mixed chimerism by anti-CD40L. Chimerism 2012 0.75
136 Dynamics of B cell recovery following kidney/bone marrow transplant recipients. Transplantation 2017 0.75
137 Tolerance in xenotransplantation. Curr Opin Organ Transplant 2017 0.75
138 Megan Sykes, MD: Michael J. Friedlander Professor of Medicine and Professor of Microbiology & Immunology and Surgical Sciences (in Surgery) and Director of Columbia Center for Translational Immunology Columbia University, New York City, NY. Transplantation 2017 0.75
139 Alloimmune T cells in transplantation. J Clin Invest 2017 0.75
140 Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-alpha and tumor growth factor-beta antibodies. Transplantation 2002 0.75
141 The first Joint Conference of the Cell Transplant Society (CTS), International Pancreas and Islet Transplant Association (IPITA), and International Xenotransplantation Association (IXA), all sections of The Transplantation Society (TTS), took place in Minneapolis, Minn, USA, from September 15-20, 2007. Preface. Transplant Proc 2008 0.75
142 My most interesting cases. Clin Transpl 2006 0.75
143 Long-Term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation. Transplantation 2016 0.75
144 Tribute to Carl-Gustav Groth (1933-2014), first president of the International Xenotransplantation Association. Xenotransplantation 2014 0.75
145 JAKing up immunosuppression. Nat Med 2003 0.75
146 Advances in transplantation. Semin Immunol 2011 0.75
147 Designer meetings. Nat Immunol 2002 0.75
148 International inventory of xenotransplantation practices in humans. Xenotransplantation 2006 0.75
149 Transplantation. Curr Opin Immunol 2002 0.75