Published in J Cell Physiol on June 01, 2012
PPARγ signaling and metabolism: the good, the bad and the future. Nat Med (2013) 3.71
Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats. J Mol Cell Cardiol (2013) 1.49
Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-κB signaling pathway. J Cell Physiol (2013) 0.89
Preventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injury. Oxid Med Cell Longev (2013) 0.86
Increased unbound retinol-binding protein 4 concentration induces apoptosis through receptor-mediated signaling. J Biol Chem (2012) 0.83
Therapeutic effect of MG132 on the aortic oxidative damage and inflammatory response in OVE26 type 1 diabetic mice. Oxid Med Cell Longev (2013) 0.81
Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septum. Physiol Genomics (2014) 0.78
Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B(-/-) (Wilson disease) mice. Hepatology (2016) 0.78
Loss of myocardial retinoic acid receptor α induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice. J Mol Cell Cardiol (2016) 0.77
Retinoid X receptor α overexpression alleviates mitochondrial dysfunction-induced insulin resistance through transcriptional regulation of insulin receptor substrate 1. Mol Cells (2015) 0.76
Cocaine induces nuclear export and degradation of neuronal retinoid X receptor-γ via a TNF-α/JNK- mediated mechanism. J Neuroimmune Pharmacol (2015) 0.75
The PI3K/AKT Pathway and FOXO3a Transcription Factor Mediate High Glucose-Induced Apoptosis in Neonatal Rat Ventricular Myocytes. Iran Red Crescent Med J (2014) 0.75
Molecular Mechanisms of Retinoid Receptors in Diabetes-Induced Cardiac Remodeling. J Clin Med (2014) 0.75
Electronegative low density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved. J Lipid Res (2016) 0.75
Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle. Redox Biol (2017) 0.75
A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27
Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA (2006) 11.78
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature (2005) 10.10
Oxidative stress and diabetic complications. Circ Res (2010) 9.37
Role of oxidative stress in development of complications in diabetes. Diabetes (1991) 8.27
The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol (1993) 8.01
Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene (2004) 3.41
RAR and RXR modulation in cancer and metabolic disease. Nat Rev Drug Discov (2007) 3.07
Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest (1997) 2.44
Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. J Am Coll Cardiol (2006) 2.21
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest (2001) 1.97
Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell (1997) 1.91
Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins. Proc Natl Acad Sci U S A (1999) 1.88
Nuclear receptors: integration of multiple signalling pathways through phosphorylation. Cell Signal (2003) 1.72
Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure. Circulation (2002) 1.65
1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes. J Clin Invest (1996) 1.65
All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system. Am J Physiol Heart Circ Physiol (2007) 1.57
Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response. Am J Physiol Endocrinol Metab (2004) 1.44
Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol (2010) 1.42
Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats. J Mol Cell Cardiol (2004) 1.40
Biochemical pathways of retinoid transport, metabolism, and signal transduction. Clin Immunol Immunopathol (1996) 1.38
All-trans retinoic acid inhibits type 1 diabetes by T regulatory (Treg)-dependent suppression of interferon-gamma-producing T-cells without affecting Th17 cells. Diabetes (2008) 1.34
Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes. Circ Res (1999) 1.31
Phosphorylation of the retinoic acid receptor-alpha by protein kinase A. Mol Endocrinol (1995) 1.26
Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels. Am J Clin Nutr (1988) 1.24
Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. Am J Physiol Heart Circ Physiol (2009) 1.24
Diabetic cardiomyopathy. J Card Fail (2010) 1.21
Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation. EMBO J (2002) 1.18
Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res (2001) 1.16
Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha. J Clin Invest (1999) 1.16
A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters. EMBO J (2008) 1.16
Protein kinases and the proteasome join in the combinatorial control of transcription by nuclear retinoic acid receptors. Trends Cell Biol (2007) 1.14
Retinoid-dependent pathways suppress myocardial cell hypertrophy. Proc Natl Acad Sci U S A (1995) 1.09
The role of JNK proteins in metabolism. Sci Transl Med (2010) 1.09
Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes. Acta Pharmacol Sin (2011) 1.08
Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells. J Mol Cell Cardiol (1998) 1.07
Stress pathway activation induces phosphorylation of retinoid X receptor. J Biol Chem (2000) 1.05
Quantification of physiological levels of retinoic acid. Methods Enzymol (1986) 1.03
Acute hyperglycemia and oxidative stress: direct cause and effect? Free Radic Biol Med (2007) 1.03
Vitamin A (retinol) status of first nation adults with non-insulin-dependent diabetes mellitus. J Am Coll Nutr (1997) 1.02
Mitogen-activated protein kinases and mitogen-activated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes. J Biol Chem (2004) 1.02
Serum vitamin A and retinol-binding protein in patients with insulin-dependent diabetes mellitus. Am J Clin Nutr (1989) 1.01
Retinoid receptors in transcriptional regulation. Curr Opin Genet Dev (1996) 1.01
All-trans retinoic acid prevents angiotensin II- and mechanical stretch-induced reactive oxygen species generation and cardiomyocyte apoptosis. J Cell Physiol (2008) 1.01
Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity. Cell Signal (2005) 0.98
Cellular retinol-binding protein type I (CRBP-I) regulates adipogenesis. Mol Cell Biol (2010) 0.96
Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7. Proc Natl Acad Sci U S A (2005) 0.95
Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases. J Biol Chem (1999) 0.94
High glucose promotes the production of collagen types I and III by cardiac fibroblasts through a pathway dependent on extracellular-signal-regulated kinase 1/2. Mol Cell Biochem (2007) 0.94
c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha. Mol Cell Biol (2005) 0.93
Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system. J Cell Physiol (2011) 0.91
Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus. Eur J Clin Nutr (2002) 0.91
Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A (retinol). Br J Nutr (1996) 0.86
Effects of all-trans retinoic acid on angiotensin II-induced myocyte hypertrophy. J Appl Physiol (1985) (2002) 0.85
High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage migration inhibitory factor and c-Jun N-terminal kinase. Clin Exp Pharmacol Physiol (2010) 0.85
Plasma vitamin A and E in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) adult diabetic patients. Int J Vitam Nutr Res (1991) 0.85
c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells. Cancer Sci (2011) 0.84
Association of a polymorphism in the promoter of the cellular retinoic acid-binding protein II gene (CRABP2) with increased circulating low-density lipoprotein cholesterol. Clin Chem Lab Med (2007) 0.80
The metabolic availability of vitamin A is decreased at the onset of diabetes in BB rats. J Nutr (2000) 0.79
Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in early stage of type I diabetes mellitus through activation of JNK. Biochem Biophys Res Commun (2004) 0.79
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature (2005) 4.53
High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes. Am J Physiol Heart Circ Physiol (2007) 2.18
Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis (2012) 1.84
ATM controls meiotic double-strand-break formation. Nature (2011) 1.68
All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system. Am J Physiol Heart Circ Physiol (2007) 1.57
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes (2008) 1.57
Novel small-molecule inhibitors of RNA polymerase III. Eukaryot Cell (2003) 1.56
Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats. J Mol Cell Cardiol (2013) 1.49
Wnt5a enhances the response of CML cells to Imatinib Mesylate through JNK activation and γ-catenin inhibition. Leuk Res (2013) 1.43
CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder. PLoS One (2012) 1.29
Tissue transglutaminase mediates activation of RhoA and MAP kinase pathways during retinoic acid-induced neuronal differentiation of SH-SY5Y cells. J Biol Chem (2002) 1.26
Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized. Mol Cancer (2007) 1.24
Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells. Oncogene (2004) 1.23
The intracellular renin-angiotensin system: a new paradigm. Trends Endocrinol Metab (2007) 1.19
The intracellular renin-angiotensin system: implications in cardiovascular remodeling. Curr Opin Nephrol Hypertens (2008) 1.17
Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease. Prog Neurobiol (2012) 1.16
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production. Am J Physiol Heart Circ Physiol (2008) 1.15
Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate. Proc Natl Acad Sci U S A (2010) 1.15
Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure. J Mol Cell Cardiol (2002) 1.15
Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. Diabetes (2013) 1.14
PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes. J Cell Physiol (2005) 1.14
DNA polymerase beta is critical for mouse meiotic synapsis. EMBO J (2009) 1.09
Retinoic acid and the heart. Vitam Horm (2007) 1.09
Loss of dermatan-4-sulfotransferase 1 function results in adducted thumb-clubfoot syndrome. Am J Hum Genet (2009) 1.09
High-content screening moves to the front of the line. Drug Discov Today (2006) 1.05
Impact of high-dose, chemically modified sulfamidase on pathology in a murine model of MPS IIIA. Exp Neurol (2011) 1.04
A population-based study on the risks of cervical lesion and human papillomavirus infection among women in Beijing, People's Republic of China. Cancer Epidemiol Biomarkers Prev (2010) 1.03
CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease. J Neuroinflammation (2011) 1.03
Intracardiac intracellular angiotensin system in diabetes. Am J Physiol Regul Integr Comp Physiol (2011) 1.03
MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J Neurosci (2012) 1.02
Mitogen-activated protein kinases and mitogen-activated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes. J Biol Chem (2004) 1.02
Safety evaluation of chronic intrathecal administration of idursulfase-IT in cynomolgus monkeys. Toxicol Pathol (2011) 1.01
All-trans retinoic acid prevents angiotensin II- and mechanical stretch-induced reactive oxygen species generation and cardiomyocyte apoptosis. J Cell Physiol (2008) 1.01
The intracrine renin-angiotensin system. Clin Sci (Lond) (2012) 1.01
Bcl6 is required for the development of mouse CD4+ and CD8α+ dendritic cells. J Immunol (2010) 0.98
Oxidative damage of biomolecules in mouse liver induced by morphine and protected by antioxidants. Basic Clin Pharmacol Toxicol (2004) 0.98
Cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. Cardiovasc Res (2010) 0.97
Integrins: novel therapeutic targets for cardiovascular diseases. Cardiovasc Hematol Agents Med Chem (2007) 0.97
Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield. J Neurochem (2005) 0.96
Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II. Mol Genet Metab (2007) 0.95
The Wnt5a/Ror2 noncanonical signaling pathway inhibits canonical Wnt signaling in K562 cells. Int J Mol Med (2010) 0.95
Cyr61/CCN1 is regulated by Wnt/β-catenin signaling and plays an important role in the progression of hepatocellular carcinoma. PLoS One (2012) 0.94
Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese. Neurosci Lett (2012) 0.94
Preterm births in countries with a very high human development index. Lancet (2013) 0.93
Acetylation of RNA processing proteins and cell cycle proteins in mitosis. J Proteome Res (2010) 0.93
Heterogeneity in retinoic acid signaling in neuroblastomas: Role of matrix metalloproteinases in retinoic acid-induced differentiation. Biochim Biophys Acta (2007) 0.92
Differential response of cardiac fibroblasts from young adult and senescent rats to ANG II. Am J Physiol Heart Circ Physiol (2002) 0.91
Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system. J Cell Physiol (2011) 0.91
Oversulfated chondroitin sulfate is not the sole contaminant in heparin. Nat Biotechnol (2010) 0.91
IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cell Microbiol (2014) 0.90
Sleep disorders in Chinese patients with Parkinson's disease: validation study of a Chinese version of Parkinson's disease sleep scale. J Neurol Sci (2008) 0.90
New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity. Eur J Neurosci (2007) 0.90
Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells. FASEB J (2012) 0.89
Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-κB signaling pathway. J Cell Physiol (2013) 0.89
Retracted Comprehensive gene expression analysis reveals multiple signal pathways associated with prostate cancer. J Appl Genet (2013) 0.88
2-methoxyestradiol attenuates autophagy activation after global ischemia. Can J Neurol Sci (2011) 0.88
The intracellular renin-angiotensin system in the heart. Curr Hypertens Rep (2009) 0.88
Microneedle integrated transdermal patch for fast onset and sustained delivery of lidocaine. Mol Pharm (2013) 0.87
Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. Free Radic Biol Med (2010) 0.87
A double antigen bridging immunogenicity ELISA for the detection of antibodies to polyethylene glycol polymers. J Pharmacol Toxicol Methods (2011) 0.87
Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. Mol Carcinog (2011) 0.86
Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts. Cardiovasc Res (2010) 0.86
KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. J Neurosci (2013) 0.86
Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline. Am J Physiol Heart Circ Physiol (2012) 0.86
Protective effects of erythropoietin on tau phosphorylation induced by beta-amyloid. J Neurosci Res (2008) 0.86
Hyperglycemia inhibits retinoic acid-induced activation of Rac1, prevents differentiation of cortical neurons, and causes oxidative stress in a rat model of diabetic pregnancy. Diabetes (2006) 0.85
Glycated albumin is a potential diagnostic tool for diabetes mellitus. Clin Med (2012) 0.85
High affinity glycosaminoglycan and autoantigen interaction explains joint specificity in a mouse model of rheumatoid arthritis. J Biol Chem (2008) 0.85
Endothelial nitric oxide synthase protects neurons against ischemic injury through regulation of brain-derived neurotrophic factor expression. CNS Neurosci Ther (2014) 0.84
Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: role in regulation of the local renin-angiotensin system. Regul Pept (2005) 0.84
The tumor necrosis factor receptor-associated factor (TRAF)-like family protein SEVEN IN ABSENTIA 2 (SINA2) promotes drought tolerance in an ABA-dependent manner in Arabidopsis. New Phytol (2013) 0.84
Agonist-dependent internalization of the angiotensin II type one receptor (AT1): role of C-terminus phosphorylation in recruitment of beta-arrestins. Regul Pept (2004) 0.83
Neuroprotective effects of PACAP27 in mice model of Parkinson's disease involved in the modulation of K(ATP) subunits and D2 receptors in the striatum. Neuropeptides (2008) 0.83
Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation. Basic Res Cardiol (2003) 0.83
Novel self-assembly endows human serum albumin nanoparticles with an enhanced antitumor efficacy. AAPS PharmSciTech (2013) 0.83
Kinase inhibitors for cardiovascular disease. J Mol Cell Cardiol (2006) 0.83
WNT5A expression is regulated by the status of its promoter methylation in leukaemia and can inhibit leukemic cell malignant proliferation. Oncol Rep (2010) 0.83
Ureteral triplication combined with right renal ectopia and ureteral cyst. Urol Int (2009) 0.82
Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Cardiovasc Diabetol (2013) 0.82
Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor. Clin Sci (Lond) (2013) 0.81
Activated contact system and abnormal glycosaminoglycans in lupus and other auto- and non-autoimmune diseases. Prog Mol Biol Transl Sci (2010) 0.81
Single cell cytometry of protein function in RNAi treated cells and in native populations. BMC Cell Biol (2008) 0.81
Gamma-pyranone derivatives and other constituents from Erigeron annuus. Pharmazie (2006) 0.81
Rapid analysis of alpha-fetoprotein by chemiluminescence microfluidic immunoassay system based on super-paramagnetic microbeads. Biomed Microdevices (2009) 0.80
A high-performance molluscicidal ingredient against Oncomelania hupensis produced by a rhizospheric strain from Phytolacca acinosa Roxb. Pharmacogn Mag (2011) 0.80
Chondroitin sulfate and abnormal contact system in rheumatoid arthritis. Prog Mol Biol Transl Sci (2010) 0.79
Hydrothermal synthesis of Mo-doped VO2/TiO2 composite nanocrystals with enhanced thermochromic performance. ACS Appl Mater Interfaces (2014) 0.79
NudC deacetylation regulates mitotic progression. PLoS One (2013) 0.79
Starvation triggers Abeta42 generation from human umbilical vascular endothelial cells. FEBS Lett (2010) 0.79