Published in J Biol Chem on September 01, 2011
A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol (2012) 2.47
Regulation of NF-κB by deubiquitinases. Immunol Rev (2012) 1.78
Molecular control of the NEMO family of ubiquitin-binding proteins. Nat Rev Mol Cell Biol (2013) 1.12
Emerging role of ubiquitination in antiviral RIG-I signaling. Microbiol Mol Biol Rev (2012) 1.04
The TLR and IL-1 signalling network at a glance. J Cell Sci (2014) 1.01
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection. PLoS Pathog (2012) 0.96
Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways. J Leukoc Biol (2012) 0.94
RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling. PLoS One (2013) 0.89
Mechanisms and pathways of innate immune activation and regulation in health and cancer. Hum Vaccin Immunother (2014) 0.82
TRAF3: a novel tumor suppressor gene in macrophages. Macrophage (Houst) (2015) 0.79
Up-regulation of A20/ABIN1 contributes to inefficient M1 macrophage polarization during Hepatitis C virus infection. Virol J (2015) 0.79
Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. J Biol Chem (2015) 0.77
SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity. Mol Cell Biol (2015) 0.76
Expression, purification and crystallization of the SKICH domain of human TAX1BP1. Acta Crystallogr F Struct Biol Commun (2014) 0.75
The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling. Cell Mol Immunol (2012) 0.75
Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death. Cell Death Differ (2017) 0.75
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science (2006) 16.00
5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62
Interferon-inducible antiviral effectors. Nat Rev Immunol (2008) 9.68
Viruses and interferons. Annu Rev Microbiol (2001) 7.12
Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci (2008) 5.95
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature (2005) 5.56
The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21
Intracellular toll-like receptors. Immunity (2010) 4.66
Type I interferon: friend or foe? J Exp Med (2010) 4.40
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science (2010) 4.03
DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 3.88
TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol (2006) 3.75
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol (2007) 2.78
Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene (2008) 2.71
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep (2008) 2.65
VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway. Mol Cell (2005) 2.55
Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem (2003) 2.45
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon. Nat Immunol (2009) 2.12
A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett (2004) 1.98
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J (2007) 1.95
ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. J Biol Chem (2006) 1.91
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J (2008) 1.87
Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem (2008) 1.78
Type I interferons: crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol (2010) 1.73
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature (2008) 1.72
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol (2007) 1.66
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7. J Immunol (2007) 1.62
Negative regulation of cytoplasmic RNA-mediated antiviral signaling. Cytokine (2008) 1.54
ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling. Biochem Pharmacol (2009) 1.48
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med (2011) 1.42
Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection. PLoS Pathog (2010) 1.39
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity. Pharmacol Ther (2009) 1.37
TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. J Biol Chem (2010) 1.29
Regulation of the cytosolic DNA-sensing system in innate immunity: a current view. Curr Opin Immunol (2009) 1.19
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol (2011) 1.05
Regulation of inflammatory and antiviral signaling by A20. Microbes Infect (2010) 0.92
The study of innate immunity in Japan: a historical perspective. Int Immunol (2009) 0.76
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature (2004) 12.41
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol (2004) 9.42
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med (2002) 5.64
Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol (2002) 4.36
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet (2008) 4.33
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science (2010) 4.03
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol (2008) 3.55
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem (2004) 3.35
Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol (2013) 3.23
The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity (2008) 3.19
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J (2004) 3.01
Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med (2008) 2.80
Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J Exp Med (2004) 2.78
Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice. J Exp Med (2003) 2.51
Cytokines and autoimmunity. Nat Rev Immunol (2002) 2.51
IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med (2008) 2.33
Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell (2011) 2.32
IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol Cell Biol (2007) 2.31
Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev (2008) 2.29
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. EMBO J (2009) 2.17
IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory. Proc Natl Acad Sci U S A (2003) 2.07
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity (2010) 1.97
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J (2007) 1.95
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A (2006) 1.87
Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells. J Immunol (2004) 1.85
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol (2011) 1.77
Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity (2009) 1.75
New insights into NF-kappaB regulation and function. Trends Immunol (2008) 1.73
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature (2008) 1.72
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol (2003) 1.69
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol (2007) 1.66
A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat Cell Biol (2009) 1.60
TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J Exp Med (2009) 1.58
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J Cell Sci (2008) 1.52
Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. J Biol Chem (2006) 1.45
MAP kinase kinase kinases and innate immunity. Trends Immunol (2005) 1.44
Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation. EMBO J (2012) 1.39
Identification of a macrophage-specific chromatin signature in the IL-10 locus. J Immunol (2005) 1.37
ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. Curr Biol (2009) 1.34
Regulation of NF-κB signaling by the A20 deubiquitinase. Cell Mol Immunol (2012) 1.33
Expression, biological activities and mechanisms of action of A20 (TNFAIP3). Biochem Pharmacol (2010) 1.33
Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection. J Immunol (2009) 1.32
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nat Immunol (2006) 1.31
Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation. Nat Immunol (2008) 1.30
TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. J Biol Chem (2010) 1.29
IκB kinase regulation of the TPL-2/ERK MAPK pathway. Immunol Rev (2012) 1.29
Latent membrane protein 1 of Epstein-Barr virus stimulates processing of NF-kappa B2 p100 to p52. J Biol Chem (2003) 1.27
DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol (2006) 1.26
Ubiquitin makes its mark on immune regulation. Immunity (2010) 1.25
Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle. J Clin Invest (2004) 1.23
Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem (2006) 1.23
Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol (2008) 1.22
Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells. Gastroenterology (2003) 1.22
Regulation of lymphoid homeostasis by interleukin-15. Cytokine Growth Factor Rev (2002) 1.22
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase. Cell Res (2010) 1.20
Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax. J Biol Chem (2003) 1.20
The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling. Sci Signal (2013) 1.16
Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha. Adv Exp Med Biol (2002) 1.15
Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13
Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity (2013) 1.13
A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme. J Exp Med (2009) 1.12
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation. Proc Natl Acad Sci U S A (2012) 1.08
Detecting cellulase and esterase enzyme activities encoded by novel genes present in environmental DNA libraries. Extremophiles (2003) 1.08
A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals. Hepatology (2013) 1.06
The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis. J Biol Chem (2002) 1.06
IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. Blood (2007) 1.06
Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1. J Virol (2011) 1.05
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol (2011) 1.05
Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation. Am J Physiol Gastrointest Liver Physiol (2003) 1.03
Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105. Mol Cell Biol (2012) 1.02
Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 induction. J Immunol (2003) 1.01
A20 inactivation in ocular adnexal MALT lymphoma. Haematologica (2011) 1.00
TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production. J Immunol (2013) 0.99
Interleukin-15 and the regulation of lymphoid homeostasis. Mol Immunol (2002) 0.98
Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. Retrovirology (2015) 0.97
A cell-type specific CD1d expression program modulates invariant NKT cell development and function. J Immunol (2006) 0.96
IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400. Mol Cell Biol (2012) 0.95
An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation. J Virol (2012) 0.94
IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells. J Immunol (2012) 0.92
Regulation of inflammatory and antiviral signaling by A20. Microbes Infect (2010) 0.92
Recent advances in understanding NF-kappaB regulation. Inflamm Bowel Dis (2002) 0.92
TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy (2015) 0.91
Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome. Blood (2013) 0.90
Family physician attitudes about prescribing using a drug formulary. BMC Fam Pract (2009) 0.90
Making patient-centered care come alive: achieving full integration of the patient's perspective. J Nurs Adm (2003) 0.89
TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability. Sci Signal (2010) 0.89
RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling. PLoS One (2013) 0.89
Deregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients. Virology (2007) 0.88
NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation. J Immunol (2011) 0.85
Interleukin-2-deficient mice develop colitis in the absence of CD28 costimulation. Inflamm Bowel Dis (2002) 0.84
Role of post-translational modifications of HTLV-1 Tax in NF-κB activation. World J Biol Chem (2010) 0.84
Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol (2013) 0.84
NF-κB signaling mediates homeostatic maturation of new T cells. Proc Natl Acad Sci U S A (2014) 0.84
A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS One (2013) 0.84
RNF11, a new piece in the A20 puzzle. EMBO J (2009) 0.83
Is There a Tension between Clinical Practice and Reimbursement Policy? The Case of Osteoarthritis Prescribing Practices in Ontario. Healthc Policy (2007) 0.83
Connecting the dots from Toll-like receptors to innate immune cells and inflammatory bowel disease. J Clin Invest (2003) 0.82
A20 deficiency causes spontaneous neuroinflammation in mice. J Neuroinflammation (2014) 0.82