Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering.

From sequence and forces to structure, function, and evolution of intrinsically disordered proteins. Structure (2013) 1.76

Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation. Structure (2012) 1.73

An unusual topological structure of the HIV-1 Rev response element. Cell (2013) 1.26

Validation of macromolecular flexibility in solution by small-angle X-ray scattering (SAXS). Eur Biophys J (2012) 1.13

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic Acids Res (2013) 1.13

Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10

Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA. Structure (2012) 1.07

Relating sequence encoded information to form and function of intrinsically disordered proteins. Curr Opin Struct Biol (2015) 1.06

Minimal effects of macromolecular crowding on an intrinsically disordered protein: a small-angle neutron scattering study. Biophys J (2014) 0.94

Intrinsic disorder in the human spliceosomal proteome. PLoS Comput Biol (2012) 0.93

Protein-DNA and ion-DNA interactions revealed through contrast variation SAXS. Biophys Rev (2016) 0.93

Interpretation of solution x-ray scattering by explicit-solvent molecular dynamics. Biophys J (2015) 0.92

Global structures of IgG isotypes expressing identical variable regions. Mol Immunol (2013) 0.90

Developing advanced X-ray scattering methods combined with crystallography and computation. Methods (2013) 0.88

Reconstruction of SAXS Profiles from Protein Structures. Comput Struct Biotechnol J (2013) 0.85

p15PAF is an intrinsically disordered protein with nonrandom structural preferences at sites of interaction with other proteins. Biophys J (2014) 0.85

Prion Protein-Antibody Complexes Characterized by Chromatography-Coupled Small-Angle X-Ray Scattering. Biophys J (2015) 0.83

Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling. Chem Rev (2016) 0.82

The statistical conformation of a highly flexible protein: small-angle X-ray scattering of S. aureus protein A. Structure (2014) 0.82

Calponin-like Chd64 is partly disordered. PLoS One (2014) 0.82

Computational approaches for inferring the functions of intrinsically disordered proteins. Front Mol Biosci (2015) 0.81

Finding Our Way in the Dark Proteome. J Am Chem Soc (2016) 0.80

QUAFIT: a novel method for the quaternary structure determination from small-angle scattering data. Biophys J (2012) 0.80

High-resolution structural characterization of Noxa, an intrinsically disordered protein, by microsecond molecular dynamics simulations. Mol Biosyst (2015) 0.80

Juxtanodin is an intrinsically disordered F-actin-binding protein. Sci Rep (2012) 0.80

Low-resolution structure of the full-length barley (Hordeum vulgare) SGT1 protein in solution, obtained using small-angle X-ray scattering. PLoS One (2014) 0.79

Probing the average local structure of biomolecules using small-angle scattering and scaling laws. Biophys J (2014) 0.79

Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein. J Biol Chem (2015) 0.79

Intrinsically disordered energy landscapes. Sci Rep (2015) 0.78

Very 'sticky' proteins - not too sticky after all? Cell Commun Signal (2012) 0.78

Olfactomedin-1 Has a V-shaped Disulfide-linked Tetrameric Structure. J Biol Chem (2015) 0.77

Intramolecular interactions stabilizing compact conformations of the intrinsically disordered kinase-inhibitor domain of Sic1: a molecular dynamics investigation. Front Physiol (2012) 0.77

The roles of conditional disorder in redox proteins. Curr Opin Struct Biol (2013) 0.77

Emerging applications of small angle solution scattering in structural biology. Protein Sci (2015) 0.77

Comprehensive structural and dynamical view of an unfolded protein from the combination of single-molecule FRET, NMR, and SAXS. Proc Natl Acad Sci U S A (2016) 0.77

Structural ensembles reveal intrinsic disorder for the multi-stimuli responsive bio-mimetic protein Rec1-resilin. Sci Rep (2015) 0.76

Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding. PLoS One (2014) 0.76

Biophysical Evidence for Intrinsic Disorder in the C-terminal Tails of the EGFR and HER3 Receptor Tyrosine Kinases. J Biol Chem (2016) 0.76

Dynamic footprint of sequestration in the molecular fluctuations of osteopontin. J R Soc Interface (2015) 0.76

DNA structure directs positioning of the mitochondrial genome packaging protein Abf2p. Nucleic Acids Res (2016) 0.75

A Structure-free Method for Quantifying Conformational Flexibility in proteins. Sci Rep (2016) 0.75

Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners. Nucleic Acids Res (2015) 0.75

Formation of covalent di-tyrosine dimers in recombinant α-synuclein. Intrinsically Disord Proteins (2015) 0.75

Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism. Nucleic Acids Res (2017) 0.75

Structure of the Escherichia coli ProQ RNA-binding protein. RNA (2017) 0.75

Phosphorylation regulates the secondary structure and function of dentin phosphoprotein peptides. Bone (2016) 0.75

Tick receptor for outer surface protein A from Ixodes ricinus - the first intrinsically disordered protein involved in vector-microbe recognition. Sci Rep (2016) 0.75

Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments. Sci Rep (2017) 0.75

Intrinsic Disorder of the C-Terminal Domain of Drosophila Methoprene-Tolerant Protein. PLoS One (2016) 0.75

The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil. PLoS One (2017) 0.75

Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes. Langmuir (2016) 0.75

Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function. Biophys J (2017) 0.75

Methods of probing the interactions between small molecules and disordered proteins. Cell Mol Life Sci (2017) 0.75

Functions of intrinsic disorder in transmembrane proteins. Cell Mol Life Sci (2017) 0.75

Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies. Oncotarget (2017) 0.75

Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements. Proc Natl Acad Sci U S A (2017) 0.75

To be disordered or not to be disordered: is that still a question for proteins in the cell? Cell Mol Life Sci (2017) 0.75

Global rigid body modeling of macromolecular complexes against small-angle scattering data. Biophys J (2005) 7.10

Structural characterization of flexible proteins using small-angle X-ray scattering. J Am Chem Soc (2007) 6.53

Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution. Q Rev Biophys (2003) 4.54

Structural characterization of proteins and complexes using small-angle X-ray solution scattering. J Struct Biol (2010) 3.44

Analysis of X-ray and neutron scattering from biomacromolecular solutions. Curr Opin Struct Biol (2007) 2.50

Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14

Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proc Natl Acad Sci U S A (2007) 2.09

Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution. Acta Crystallogr D Biol Crystallogr (2012) 2.04

Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS). Curr Opin Struct Biol (2013) 1.90

Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci U S A (2006) 1.85

Structural basis for autoinhibition of ESCRT-III CHMP3. J Mol Biol (2008) 1.78

X-ray scattering study of activated Arp2/3 complex with bound actin-WCA. Structure (2008) 1.75

The structure and binding behavior of the bacterial cell surface layer protein SbsC. Structure (2008) 1.72

Structural insights into the molecular organization of the S-layer from Clostridium difficile. Mol Microbiol (2009) 1.71

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol (2012) 1.69

Structural basis of dcp2 recognition and activation by dcp1. Mol Cell (2008) 1.65

A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments. Structure (2009) 1.61

Structural insights into eRF3 and stop codon recognition by eRF1. Genes Dev (2009) 1.57

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. PLoS Biol (2007) 1.56

Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly. Nat Commun (2010) 1.56

Addition of missing loops and domains to protein models by x-ray solution scattering. Biophys J (2002) 1.54

The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure. Mol Cell (2005) 1.53

Absence of equilibrium cluster phase in concentrated lysozyme solutions. Proc Natl Acad Sci U S A (2008) 1.50

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat Struct Mol Biol (2011) 1.46

Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus. J Biol Chem (2008) 1.42

Conformational space of flexible biological macromolecules from average data. J Am Chem Soc (2010) 1.39

Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB. Structure (2013) 1.39

Small-angle X-ray scattering on biological macromolecules and nanocomposites in solution. Annu Rev Phys Chem (2012) 1.36

Structure and RNA interactions of the N-terminal RRM domains of PTB. Structure (2004) 1.35

The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis. J Biol Chem (2006) 1.34

Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin. J Biol Chem (2009) 1.31

Conformation of polypyrimidine tract binding protein in solution. Structure (2006) 1.30

Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation. Proc Natl Acad Sci U S A (2011) 1.29

A different conformation for EGC stator subcomplex in solution and in the assembled yeast V-ATPase: possible implications for regulatory disassembly. Structure (2008) 1.28

X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlB. J Mol Biol (2008) 1.27

Structural characterization of protein-protein complexes by integrating computational docking with small-angle scattering data. J Mol Biol (2010) 1.26

Applications of small-angle X-ray scattering to biomacromolecular solutions. Int J Biochem Cell Biol (2012) 1.20

Domain conformation of tau protein studied by solution small-angle X-ray scattering. Biochemistry (2008) 1.20

Joint use of small-angle X-ray and neutron scattering to study biological macromolecules in solution. Eur Biophys J (2006) 1.20

Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein. J Mol Biol (2007) 1.17

Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS. J Mol Biol (2010) 1.15

The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces. PLoS Pathog (2012) 1.14

Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering. EMBO J (2003) 1.13

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. EMBO J (2009) 1.13

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic Acids Res (2013) 1.13

Monitoring intermediate filament assembly by small-angle x-ray scattering reveals the molecular architecture of assembly intermediates. Proc Natl Acad Sci U S A (2006) 1.13

Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12. J Am Chem Soc (2008) 1.12

Solution scattering suggests cross-linking function of telethonin in the complex with titin. J Biol Chem (2002) 1.10

Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies. Nucleic Acids Res (2007) 1.09

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain. Proc Natl Acad Sci U S A (2008) 1.08

Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex. J Struct Biol (2011) 1.07

Structure and Dynamics of Ribosomal Protein L12: An Ensemble Model Based on SAXS and NMR Relaxation. Biophys J (2010) 1.07

Dynamics in a pure encounter complex of two proteins studied by solution scattering and paramagnetic NMR spectroscopy. J Am Chem Soc (2008) 1.05

Hydrophilization of Magnetic Nanoparticles with Modified Alternating Copolymers. Part 1: The Influence of the Grafting. J Phys Chem C Nanomater Interfaces (2010) 1.05

Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure. J Mol Biol (2007) 1.04

Ligand-binding properties and conformational dynamics of autolysin repeat domains in staphylococcal cell wall recognition. J Bacteriol (2012) 1.03

A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR). J Biol Chem (2012) 1.03

Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. Biophys J (2008) 1.03

Interdomain flexibility in full-length matrix metalloproteinase-1 (MMP-1). J Biol Chem (2009) 1.02

Structural characterization of the active and inactive states of Src kinase in solution by small-angle X-ray scattering. J Mol Biol (2007) 1.02

Structural and functional aspects of the sensor histidine kinase PrrB from Mycobacterium tuberculosis. Structure (2006) 1.02

Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. J Biol Chem (2011) 1.01

Low-resolution structures of transient protein-protein complexes using small-angle X-ray scattering. J Am Chem Soc (2009) 1.01

The crystal and solution structures of glyceraldehyde-3-phosphate dehydrogenase reveal different quaternary structures. J Biol Chem (2006) 1.00

Hydrophilic Monodisperse Magnetic Nanoparticles Protected by an Amphiphilic Alternating Copolymer. J Phys Chem C Nanomater Interfaces (2008) 1.00

Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2. J Biol Chem (2006) 1.00

Structural analysis of the stalk subunit Vma5p of the yeast V-ATPase in solution. FEBS Lett (2004) 0.99

A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target. Proc Natl Acad Sci U S A (2011) 0.99

Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds α-maltose 1-phosphate and forms a maltosyl-enzyme intermediate. Biochemistry (2014) 0.98

Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J (2007) 0.98

Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist. J Mol Biol (2008) 0.98

Analysis of intrinsically disordered proteins by small-angle X-ray scattering. Methods Mol Biol (2012) 0.97

The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis. Structure (2004) 0.97

Looking behind the beamstop: X-ray solution scattering studies of structure and conformational changes of biological macromolecules. Methods Enzymol (2003) 0.97

Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization. J Biol Chem (2010) 0.97

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex. Blood (2011) 0.97

Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96

Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS. J Biol Chem (2013) 0.96

The active conformation of glutamate synthase and its binding to ferredoxin. J Mol Biol (2003) 0.96

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module. J Mol Biol (2009) 0.96

Intrinsic structural disorder of mouse proNGF. Proteins (2009) 0.96

Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state. J Biol Chem (2013) 0.95

Quaternary structure of Azospirillum brasilense NADPH-dependent glutamate synthase in solution as revealed by synchrotron radiation x-ray scattering. J Biol Chem (2003) 0.95

Structural flexibility of RNA as molecular basis for Hfq chaperone function. Nucleic Acids Res (2012) 0.95

Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody. J Mol Biol (2008) 0.94

Studies on structure-function relationships of indolepyruvate decarboxylase from Enterobacter cloacae, a key enzyme of the indole acetic acid pathway. Eur J Biochem (2003) 0.94

Hydrophilization of Magnetic Nanoparticles with Modified Alternating Copolymers. Part 2: Behavior in solution. J Phys Chem C Nanomater Interfaces (2010) 0.94

Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation. J Biomol NMR (2006) 0.94

Structural characterization of unphosphorylated STAT5a oligomerization equilibrium in solution by small-angle X-ray scattering. Protein Sci (2009) 0.94

A mechanism for histone chaperoning activity of nucleoplasmin: thermodynamic and structural models. J Mol Biol (2009) 0.93

Structural characterization of the nonameric assembly of an Archaeal alpha-L-fucosidase by synchrotron small angle X-ray scattering. Biochem Biophys Res Commun (2004) 0.93

Poly-Ig tandems from I-band titin share extended domain arrangements irrespective of the distinct features of their modular constituents. J Muscle Res Cell Motil (2005) 0.93

Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis. J Bacteriol (2008) 0.93

Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold. Biophys J (2013) 0.92

Recognition of nucleoplasmin by its nuclear transport receptor importin α/β: insights into a complete import complex. Biochemistry (2010) 0.92

Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering. Proteins (2011) 0.92

Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein. J Biol Chem (2002) 0.91

Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering. J Biol Chem (2009) 0.91

A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase. J Mol Biol (2009) 0.91