Published in Proc Natl Acad Sci U S A on February 07, 2011
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Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease. Biochim Biophys Acta (2011) 1.16
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Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem (2004) 4.33
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Different species of alpha-synuclein oligomers induce calcium influx and seeding. J Neurosci (2007) 3.16
Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry (2001) 2.96
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Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease. Biochemistry (2003) 2.54
FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils. Protein Sci (2004) 2.31
Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism. Biochemistry (2002) 2.29
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The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. J Biol Chem (2004) 2.02
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Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro. Biochemistry (2002) 1.71
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Lipid bilayer disruption by oligomeric alpha-synuclein depends on bilayer charge and accessibility of the hydrophobic core. Biochim Biophys Acta (2009) 1.20
Methionine oxidation, alpha-synuclein and Parkinson's disease. Biochim Biophys Acta (2004) 1.19
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The structure of dopamine induced alpha-synuclein oligomers. Eur Biophys J (2010) 1.08
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Structure of the Escherichia coli ribosomal termination complex with release factor 2. Nature (2003) 2.54
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A cryo-electron microscopic study of ribosome-bound termination factor RF2. Nature (2003) 2.42
Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proc Natl Acad Sci U S A (2007) 2.09
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Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci U S A (2006) 1.85
Interactions between folding factors and bacterial outer membrane proteins. Mol Microbiol (2005) 1.81
Structural basis for autoinhibition of ESCRT-III CHMP3. J Mol Biol (2008) 1.78
The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands. J Biol Chem (2002) 1.76
X-ray scattering study of activated Arp2/3 complex with bound actin-WCA. Structure (2008) 1.75
The structure and binding behavior of the bacterial cell surface layer protein SbsC. Structure (2008) 1.72
Structural insights into the molecular organization of the S-layer from Clostridium difficile. Mol Microbiol (2009) 1.71
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol (2012) 1.69
Structural basis of dcp2 recognition and activation by dcp1. Mol Cell (2008) 1.65
A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments. Structure (2009) 1.61
Structural insights into eRF3 and stop codon recognition by eRF1. Genes Dev (2009) 1.57
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering. Mol Biosyst (2011) 1.56
Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly. Nat Commun (2010) 1.56
A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. PLoS Biol (2007) 1.56
Addition of missing loops and domains to protein models by x-ray solution scattering. Biophys J (2002) 1.54
The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure. Mol Cell (2005) 1.53
Absence of equilibrium cluster phase in concentrated lysozyme solutions. Proc Natl Acad Sci U S A (2008) 1.50
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat Struct Mol Biol (2011) 1.46
Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus. J Biol Chem (2008) 1.42
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. Proc Natl Acad Sci U S A (2012) 1.40
Conformational space of flexible biological macromolecules from average data. J Am Chem Soc (2010) 1.39
Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB. Structure (2013) 1.39
Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proc Natl Acad Sci U S A (2007) 1.36
High-throughput small angle X-ray scattering from proteins in solution using a microfluidic front-end. Anal Chem (2008) 1.36
Small-angle X-ray scattering on biological macromolecules and nanocomposites in solution. Annu Rev Phys Chem (2012) 1.36
Structure and RNA interactions of the N-terminal RRM domains of PTB. Structure (2004) 1.35
The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis. J Biol Chem (2006) 1.34
Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin. J Biol Chem (2009) 1.31
Conformation of polypyrimidine tract binding protein in solution. Structure (2006) 1.30
A different conformation for EGC stator subcomplex in solution and in the assembled yeast V-ATPase: possible implications for regulatory disassembly. Structure (2008) 1.28
X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlB. J Mol Biol (2008) 1.27
Structural characterization of protein-protein complexes by integrating computational docking with small-angle scattering data. J Mol Biol (2010) 1.26
SDS-induced fibrillation of alpha-synuclein: an alternative fibrillation pathway. J Mol Biol (2010) 1.22
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate. FEBS Lett (2005) 1.22
Unique identification of supramolecular structures in amyloid fibrils by solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2009) 1.21
Strategies to increase the reproducibility of protein fibrillization in plate reader assays. Anal Biochem (2010) 1.21
Applications of small-angle X-ray scattering to biomacromolecular solutions. Int J Biochem Cell Biol (2012) 1.20
Domain conformation of tau protein studied by solution small-angle X-ray scattering. Biochemistry (2008) 1.20
Joint use of small-angle X-ray and neutron scattering to study biological macromolecules in solution. Eur Biophys J (2006) 1.20
Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein. J Mol Biol (2007) 1.17
Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS. J Mol Biol (2010) 1.15
The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces. PLoS Pathog (2012) 1.14
Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering. EMBO J (2003) 1.13
Monitoring intermediate filament assembly by small-angle x-ray scattering reveals the molecular architecture of assembly intermediates. Proc Natl Acad Sci U S A (2006) 1.13
Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. EMBO J (2009) 1.13
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic Acids Res (2013) 1.13
Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12. J Am Chem Soc (2008) 1.12
Solution scattering suggests cross-linking function of telethonin in the complex with titin. J Biol Chem (2002) 1.10
Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies. Nucleic Acids Res (2007) 1.09
A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain. Proc Natl Acad Sci U S A (2008) 1.08
Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex. J Struct Biol (2011) 1.07
Structure and Dynamics of Ribosomal Protein L12: An Ensemble Model Based on SAXS and NMR Relaxation. Biophys J (2010) 1.07
Amyloid-a state in many guises: survival of the fittest fibril fold. Protein Sci (2007) 1.06
Unfolding of beta-sheet proteins in SDS. Biophys J (2007) 1.06
Dynamics in a pure encounter complex of two proteins studied by solution scattering and paramagnetic NMR spectroscopy. J Am Chem Soc (2008) 1.05
Fibrillation of the major curli subunit CsgA under a wide range of conditions implies a robust design of aggregation. Biochemistry (2011) 1.05
Hydrophilization of Magnetic Nanoparticles with Modified Alternating Copolymers. Part 1: The Influence of the Grafting. J Phys Chem C Nanomater Interfaces (2010) 1.05
The stability of transmembrane helix interactions measured in a biological membrane. J Mol Biol (2006) 1.04
Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure. J Mol Biol (2007) 1.04
Ligand-binding properties and conformational dynamics of autolysin repeat domains in staphylococcal cell wall recognition. J Bacteriol (2012) 1.03
A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR). J Biol Chem (2012) 1.03
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. Biophys J (2008) 1.03
Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp. J Biol Chem (2010) 1.02
Structural characterization of the active and inactive states of Src kinase in solution by small-angle X-ray scattering. J Mol Biol (2007) 1.02
Interdomain flexibility in full-length matrix metalloproteinase-1 (MMP-1). J Biol Chem (2009) 1.02
Structural and functional aspects of the sensor histidine kinase PrrB from Mycobacterium tuberculosis. Structure (2006) 1.02
Low-resolution structures of transient protein-protein complexes using small-angle X-ray scattering. J Am Chem Soc (2009) 1.01
Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. J Biol Chem (2011) 1.01
Time-resolved SAXS measurements facilitated by online HPLC buffer exchange. J Synchrotron Radiat (2010) 1.00
The crystal and solution structures of glyceraldehyde-3-phosphate dehydrogenase reveal different quaternary structures. J Biol Chem (2006) 1.00
Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2. J Biol Chem (2006) 1.00
Hydrophilic Monodisperse Magnetic Nanoparticles Protected by an Amphiphilic Alternating Copolymer. J Phys Chem C Nanomater Interfaces (2008) 1.00
Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation. Microbiologyopen (2013) 0.99
Structural analysis of the stalk subunit Vma5p of the yeast V-ATPase in solution. FEBS Lett (2004) 0.99
A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target. Proc Natl Acad Sci U S A (2011) 0.99
Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds α-maltose 1-phosphate and forms a maltosyl-enzyme intermediate. Biochemistry (2014) 0.98
Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist. J Mol Biol (2008) 0.98
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J (2007) 0.98
Analysis of intrinsically disordered proteins by small-angle X-ray scattering. Methods Mol Biol (2012) 0.97
Recognition by tryptophanyl-tRNA synthetases of discriminator base on tRNATrp from three biological domains. J Biol Chem (2002) 0.97
Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization. J Biol Chem (2010) 0.97
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Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex. Blood (2011) 0.97
The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis. Structure (2004) 0.97
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96
Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS. J Biol Chem (2013) 0.96