Published in J Biol Chem on September 28, 2011
Adenosine A2A receptor deficiency up-regulates cystatin F expression in white matter lesions induced by chronic cerebral hypoperfusion. PLoS One (2012) 0.84
Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells. Front Immunol (2014) 0.83
The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk. Curr Protein Pept Sci (2012) 0.77
Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F. Oncotarget (2015) 0.76
Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer (2006) 5.06
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (1998) 3.98
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev (2010) 3.56
Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science (2004) 3.08
Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages. J Exp Med (1989) 2.74
Specialized roles for cysteine cathepsins in health and disease. J Clin Invest (2010) 2.69
Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des (2007) 2.26
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J (2000) 2.09
Cystatins. Biochem Soc Symp (2003) 1.94
Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med (2005) 1.69
Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. J Biol Chem (1997) 1.63
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem Biol (2000) 1.62
Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site. J Biol Chem (1999) 1.52
Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem (2003) 1.51
FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron (2000) 1.50
Proteinases in chronic obstructive pulmonary disease. Biochem Soc Trans (2002) 1.47
Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo. J Biol Chem (2003) 1.36
Pivotal role of cathepsin K in lung fibrosis. Am J Pathol (2004) 1.35
Thymocyte expression of cathepsin L is essential for NKT cell development. Nat Immunol (2002) 1.27
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis. Atherosclerosis (2008) 1.13
Endolysosomal proteases and their inhibitors in immunity. Nat Rev Immunol (2009) 1.10
Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages. J Exp Med (2003) 1.08
Novel cell-permeable acyloxymethylketone inhibitors of asparaginyl endopeptidase. Biol Chem (2003) 1.04
Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis. EMBO J (2008) 1.04
Invariant chain controls the activity of extracellular cathepsin L. J Exp Med (2002) 1.02
The p41 isoform of invariant chain is a chaperone for cathepsin L. EMBO J (2001) 1.00
The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci (2005) 0.98
Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancer. Biol Chem Hoppe Seyler (1995) 0.98
Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor. J Biol Chem (1998) 0.97
A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification. Hum Mol Genet (2002) 0.97
Structural basis of reduction-dependent activation of human cystatin F. J Biol Chem (2006) 0.97
Diverse regulatory roles for lysosomal proteases in the immune response. Eur J Immunol (2009) 0.97
Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. J Biol Chem (1997) 0.96
Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase. J Invest Dermatol (2001) 0.94
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J (2006) 0.94
Hereditary cystatin C amyloid angiopathy. Amyloid (2000) 0.93
Inhibitory properties of cystatin F and its localization in U937 promonocyte cells. FEBS J (2005) 0.93
Distinct protease requirements for antigen presentation in vitro and in vivo. J Immunol (2010) 0.92
Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting. Exp Cell Res (2004) 0.91
Leukocystatin, a new Class II cystatin expressed selectively by hematopoietic cells. J Biol Chem (1998) 0.91
Glycosylation directs targeting and activation of cystatin f from intracellular and extracellular sources. Traffic (2009) 0.89
Regulated expression and intracellular localization of cystatin F in human U937 cells. Eur J Biochem (2002) 0.86
Legumain and cathepsin-L expression in human unstable carotid plaque. Atherosclerosis (2009) 0.85
Applications for chemical probes of proteolytic activity. Curr Protoc Protein Sci (2004) 0.80
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci U S A (2013) 5.68
Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science (2004) 3.08
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev (2013) 1.88
An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours. J Neurosci Methods (2009) 1.82
Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody. J Control Release (2007) 1.73
Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP. Nat Immunol (2002) 1.61
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol (2007) 1.53
Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo. J Biol Chem (2003) 1.36
Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain (2007) 1.31
Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14. J Cell Sci (2010) 1.29
Cysteine cathepsins (proteases)--on the main stage of cancer? Cancer Cell (2004) 1.27
Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol Cell (2008) 1.25
Cystatins in immune system. J Cancer (2012) 1.22
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro. Exp Cell Res (2003) 1.20
Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice. Eur J Neurosci (2009) 1.13
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem (2006) 1.10
Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules. J Biol Chem (2005) 1.08
Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer. Adv Enzyme Regul (2002) 1.08
Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone. Immunity (2003) 1.07
Human stem cell-derived neurons: a system to study human tau function and dysfunction. PLoS One (2010) 1.07
Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells. Exp Cell Res (2006) 1.05
A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase. J Clin Invest (2009) 1.05
Role of cysteine cathepsins in matrix degradation and cell signalling. Connect Tissue Res (2008) 1.05
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Ther (2003) 1.05
Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis. EMBO J (2008) 1.04
Novel cell-permeable acyloxymethylketone inhibitors of asparaginyl endopeptidase. Biol Chem (2003) 1.04
Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro. J Cell Biochem (2006) 1.04
Proliferating neuronal progenitors in the postnatal hippocampus transiently express the proneural gene Ngn2. Eur J Neurosci (2007) 1.02
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent. J Cell Biol (2008) 1.02
The role of cathepsin X in the migration and invasiveness of T lymphocytes. J Cell Sci (2008) 1.01
Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Mol Biochem Parasitol (2005) 1.01
Antibody modulation of antigen presentation: positive and negative effects on presentation of the tetanus toxin antigen via the murine B cell isoform of FcgammaRII. Eur J Immunol (2002) 1.01
Reconstruction of a pathway of antigen processing and class II MHC peptide capture. EMBO J (2007) 0.99
High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas. Acta Neuropathol (2009) 0.99
Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins. Immunology (2008) 0.98
Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds. ChemMedChem (2011) 0.97
Structural basis of reduction-dependent activation of human cystatin F. J Biol Chem (2006) 0.97
Cell therapy in Huntington disease. Neurosurg Focus (2008) 0.97
Diverse regulatory roles for lysosomal proteases in the immune response. Eur J Immunol (2009) 0.97
The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease. J Neurol Neurosurg Psychiatry (2013) 0.96
γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways. Biochem J (2012) 0.95
Cystatin C as a potential marker for relapse in patients with non-Hodgkin B-cell lymphoma. Cancer Lett (2006) 0.95
A role for ARF6 in dendritic cell podosome formation and migration. Eur J Immunol (2008) 0.94
Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing. Eur J Immunol (2005) 0.93
Inhibitory properties of cystatin F and its localization in U937 promonocyte cells. FEBS J (2005) 0.93
Distinct protease requirements for antigen presentation in vitro and in vivo. J Immunol (2010) 0.92
NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature. Neuro Oncol (2011) 0.92
Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells. Int J Biochem Cell Biol (2009) 0.91
Asparaginyl endopeptidase: case history of a class II MHC compartment protease. Immunol Rev (2005) 0.91
Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors. J Cancer Res Clin Oncol (2009) 0.91
Nanoscale polymer carriers to deliver chemotherapeutic agents to tumours. Expert Opin Biol Ther (2005) 0.90
Bivalent carbohydrate binding is required for biological activity of Clitocybe nebularis lectin (CNL), the N,N'-diacetyllactosediamine (GalNAcβ1-4GlcNAc, LacdiNAc)-specific lectin from basidiomycete C. nebularis. J Biol Chem (2012) 0.90
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer. Anticancer Res (2003) 0.90
Proteins of higher fungi--from forest to application. Trends Biotechnol (2012) 0.89
The balance between extracellular cathepsins and cystatin C is of importance for ovarian cancer. Eur J Clin Invest (2010) 0.89
Cisplatin-tethered gold nanospheres for multimodal chemo-radiotherapy of glioblastoma. Nanoscale (2014) 0.89
Glycosylation directs targeting and activation of cystatin f from intracellular and extracellular sources. Traffic (2009) 0.89
Lysosomal enzymes, cathepsins in brain tumour invasion. J Neurooncol (2002) 0.89
Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome. Brain (2013) 0.89
Cystatins in non-small cell lung cancer: tissue levels, localization and relation to prognosis. Oncol Rep (2006) 0.89
Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with antiproliferative activity against human leukemic T cells. Biochim Biophys Acta (2008) 0.89
Natural killer cells as effectors of selection and differentiation of stem cells: role in resolution of inflammation. J Immunotoxicol (2014) 0.88
Asparagine endopeptidase is required for normal kidney physiology and homeostasis. FASEB J (2011) 0.88
The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow. J Biol Chem (2013) 0.88
Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patients. Cancer Detect Prev (2002) 0.87
Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells. Eur J Cell Biol (2012) 0.87
Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X. J Leukoc Biol (2008) 0.87
Cystatin incorporated in poly(lactide-co-glycolide) nanoparticles: development and fundamental studies on preservation of its activity. Eur J Pharm Sci (2004) 0.87
Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness. Mol Cancer (2009) 0.87
Stefin a and stefin B: markers for prognosis in operable squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys (2007) 0.87
Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells. J Biol Chem (2012) 0.86
Structural basis of trypsin inhibition and entomotoxicity of cospin, serine protease inhibitor involved in defense of Coprinopsis cinerea fruiting bodies. J Biol Chem (2011) 0.85
Versatile loops in mycocypins inhibit three protease families. J Biol Chem (2009) 0.85
DC-SIGN ligation greatly affects dendritic cell differentiation from monocytes compromising their normal function. J Leukoc Biol (2011) 0.85
Poly(lactide-co-glycolide) nanoparticles as a carrier system for delivering cysteine protease inhibitor cystatin into tumor cells. Exp Cell Res (2004) 0.85
Cysteine cathepsins in neurological disorders. Mol Neurobiol (2013) 0.85
Immunonanoparticles--an effective tool to impair harmful proteolysis in invasive breast tumor cells. FEBS J (2007) 0.84
γ-1-syntrophin mediates trafficking of γ-enolase towards the plasma membrane and enhances its neurotrophic activity. Neurosignals (2011) 0.84
Differentiation- and maturation-dependent content, localization, and secretion of cystatin C in human dendritic cells. J Leukoc Biol (2005) 0.84
Serum cystatin C in patients with head and neck carcinoma. Clin Chim Acta (2004) 0.83
Microbial and fungal protease inhibitors--current and potential applications. Appl Microbiol Biotechnol (2012) 0.83
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor. J Med Chem (2014) 0.83
Profilin 1 as a target for cathepsin X activity in tumor cells. PLoS One (2013) 0.82
Cathepsin X prevents an effective immune response against Helicobacter pylori infection. Eur J Cell Biol (2009) 0.82
A review of the role of stem cells in the development and treatment of glioma. Acta Neurochir (Wien) (2012) 0.82
Cathepsin X in serum from patients with colorectal cancer: relation to prognosis. Radiol Oncol (2012) 0.82
Cysteine cathepsins: regulators of antitumour immune response. Expert Opin Biol Ther (2006) 0.82
Enhanced stability and activity of temozolomide in primary glioblastoma multiforme cells with cucurbit[n]uril. Chem Commun (Camb) (2012) 0.82
Genotoxicity of trivalent chromium in bacterial cells. Possible effects on DNA topology. Chem Res Toxicol (2002) 0.82
Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety. PLoS One (2011) 0.81
3-phosphoinositide-dependent kinase 1 deficiency perturbs Toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells. J Biol Chem (2007) 0.81
Basidiomycete Clitocybe nebularis is rich in lectins with insecticidal activities. Appl Microbiol Biotechnol (2011) 0.81
CNL, a ricin B-like lectin from mushroom Clitocybe nebularis, induces maturation and activation of dendritic cells via the toll-like receptor 4 pathway. Immunology (2011) 0.81
Procoagulant properties of bare and highly PEGylated vinyl-modified silica nanoparticles. Nanomedicine (Lond) (2010) 0.81