Published in Wiley Interdiscip Rev RNA on February 10, 2011
Regulation of cytoplasmic mRNA decay. Nat Rev Genet (2012) 3.30
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability. RNA (2012) 1.32
Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing. Biol Direct (2013) 1.14
Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability. Cell Rep (2012) 1.10
The roles of 3'-exoribonucleases and the exosome in trypanosome mRNA degradation. RNA (2013) 1.02
mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end. RNA (2012) 0.98
Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs. Nucleic Acids Res (2014) 0.92
Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast cancer cells. Mol Cancer (2013) 0.91
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic Acids Res (2014) 0.88
SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA. PLoS One (2013) 0.87
The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation. RNA (2013) 0.85
Long noncoding RNA turnover. Biochimie (2015) 0.84
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. RNA (2012) 0.83
Inhibition and avoidance of mRNA degradation by RNA viruses. Curr Opin Microbiol (2012) 0.82
Influence of untranslated regions on retroviral mRNA transfer and expression. BMC Biotechnol (2013) 0.77
The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives. Wiley Interdiscip Rev RNA (2017) 0.76
Putative RNA-Directed Adaptive Mutations in Cancer Evolution. Transcription (2016) 0.75
Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences. Nat Commun (2016) 0.75
Effects of post-mortem and physical degradation on RNA integrity and quality. Biomol Detect Quantif (2015) 0.75
Nuclease escape elements protect messenger RNA against cleavage by multiple viral endonucleases. PLoS Pathog (2017) 0.75
The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem (2007) 8.94
The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev (1989) 7.03
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science (2006) 6.75
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev (1998) 5.88
The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol (2006) 5.33
The RasGAP-associated endoribonuclease G3BP assembles stress granules. J Cell Biol (2003) 4.97
Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation. Nature (2006) 4.89
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell (2009) 4.65
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell (2010) 4.20
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell (2003) 4.17
Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J (2003) 3.68
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature (2009) 3.50
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res (2008) 3.48
Messenger RNA regulation: to translate or to degrade. EMBO J (2008) 3.38
Estrogen stabilizes vitellogenin mRNA against cytoplasmic degradation. Cell (1983) 3.13
Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature (2008) 3.11
The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet (2008) 3.00
Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant. Genes Dev (1992) 2.90
The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities. Nat Struct Mol Biol (2008) 2.81
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature (2004) 2.80
SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nat Struct Mol Biol (2008) 2.73
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev (2000) 2.72
Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening. EMBO J (1994) 2.70
Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA. EMBO J (1989) 2.54
SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA (2008) 2.54
CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell (2009) 2.38
Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component. Mol Cell Biol (1989) 2.33
The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome. Nucleic Acids Res (2009) 2.28
A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. Mol Cell Biol (1998) 2.21
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16
RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Mol Cell Biol (2001) 2.11
Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Mol Cell (2010) 2.09
Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci (2006) 2.07
Coordinate regulation of two estrogen-dependent genes in avian liver. Proc Natl Acad Sci U S A (1980) 2.00
Four highly stable eukaryotic mRNAs assemble 3' untranslated region RNA-protein complexes sharing cis and trans components. Proc Natl Acad Sci U S A (1997) 1.97
Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila. Genes Dev (1993) 1.82
Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxid Redox Signal (2009) 1.81
The half-life of c-myc mRNA in growing and serum-stimulated cells: influence of the coding and 3' untranslated regions and role of ribosome translocation. Mol Cell Biol (1994) 1.76
Purification and characterization of an estrogen-regulated Xenopus liver polysomal nuclease involved in the selective destabilization of albumin mRNA. J Biol Chem (1995) 1.62
Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5'-AAU-3'/5'-UAA-3' elements in single-stranded loop domains of the 3'-noncoding region. J Biol Chem (1989) 1.61
Processing of 9E3 mRNA and regulation of its stability in normal and Rous sarcoma virus-transformed cells. Mol Cell Biol (1989) 1.57
Secondary structure analysis of apolipoprotein II mRNA using enzymatic probes and reverse transcriptase. Evaluation of primer extension for high resolution structure mapping of mRNA. J Biol Chem (1985) 1.51
Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA. J Biol Chem (1994) 1.49
Vigilin, a ubiquitous protein with 14 K homology domains, is the estrogen-inducible vitellogenin mRNA 3'-untranslated region-binding protein. J Biol Chem (1997) 1.48
Endonucleolysis in the turnover of insulin-like growth factor II mRNA. J Biol Chem (1992) 1.45
Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA. FEBS J (2009) 1.44
Identification of an erythroid-enriched endoribonuclease activity involved in specific mRNA cleavage. EMBO J (2000) 1.44
Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes. Genes Dev (1990) 1.44
Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant. Mol Cell Biol (2002) 1.43
Overexpression of an mRNA-binding protein in human colorectal cancer. Oncogene (2001) 1.40
A guanosine quadruplex and two stable hairpins flank a major cleavage site in insulin-like growth factor II mRNA. Nucleic Acids Res (1994) 1.40
A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay. Mol Cell Biol (2007) 1.38
Estrogen-induced ribonuclease activity in Xenopus liver. Biochemistry (1991) 1.37
Analysis of Dom34 and its function in no-go decay. Mol Biol Cell (2009) 1.37
Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon. Proc Natl Acad Sci U S A (2002) 1.33
Coordinate estrogen-regulated instability of serum protein-coding messenger RNAs in Xenopus laevis. Mol Endocrinol (1991) 1.33
Vigilin binding selectively inhibits cleavage of the vitellogenin mRNA 3'-untranslated region by the mRNA endonuclease polysomal ribonuclease 1. Proc Natl Acad Sci U S A (2000) 1.33
Identification of a consensus element recognized and cleaved by IRE1 alpha. Nucleic Acids Res (2010) 1.32
A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family. RNA (1998) 1.30
Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals. J Biochem (2009) 1.29
Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA. Mol Cell (2004) 1.28
Premature termination codons enhance mRNA decapping in human cells. Nucleic Acids Res (2004) 1.24
Purification and characterization of a polysome-associated endoribonuclease that degrades c-myc mRNA in vitro. J Biol Chem (1998) 1.22
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA. Nucleic Acids Res (2009) 1.20
Cleavage properties of an estrogen-regulated polysomal ribonuclease involved in the destabilization of albumin mRNA. Nucleic Acids Res (1997) 1.20
Estrogen-induced destabilization of yolk precursor protein mRNAs in avian liver. J Biol Chem (1988) 1.16
Extranuclear estrogen-regulated destabilization of Xenopus laevis serum albumin mRNA. Mol Endocrinol (1989) 1.15
Polysomal ribonuclease 1 exists in a latent form on polysomes prior to estrogen activation of mRNA decay. Nucleic Acids Res (2001) 1.12
Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP. Mol Cell Biol (2005) 1.12
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage. Nucleic Acids Res (2008) 1.09
Endonuclease-mediated mRNA decay requires tyrosine phosphorylation of polysomal ribonuclease 1 (PMR1) for the targeting and degradation of polyribosome-bound substrate mRNA. J Biol Chem (2004) 1.09
Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression. BMC Mol Biol (2010) 1.09
Specific endonucleolytic cleavage of IGF-II mRNAs. Biochem Biophys Res Commun (1991) 1.08
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev (2010) 1.08
Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene. Nucleic Acids Res (1992) 1.06
c-Src activates endonuclease-mediated mRNA decay. Mol Cell (2007) 0.99
The nuclease that selectively degrades albumin mRNA in vitro associates with Xenopus liver polysomes through the 80S ribosome complex. Arch Biochem Biophys (1993) 0.99
Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1. Mol Cell Biol (2006) 0.98
The identification of an endonuclease that cleaves within an HuR binding site in mRNA. Nucleic Acids Res (2000) 0.98
Identification of in vivo mRNA decay intermediates corresponding to sites of in vitro cleavage by polysomal ribonuclease 1. J Biol Chem (2001) 0.95
Predicted structures of apolipoprotein II mRNA constrained by nuclease and dimethyl sulfate reactivity: stable secondary structures occur predominantly in local domains via intraexonic base pairing. J Biol Chem (1989) 0.95
Distinct RNA structural domains cooperate to maintain a specific cleavage site in the 3'-UTR of IGF-II mRNAs. J Mol Biol (2000) 0.94
Differential regulation and polyadenylation of transferrin mRNA in Xenopus liver and oviduct. J Steroid Biochem Mol Biol (1992) 0.93
Identification of RNA sequences and structures involved in site-specific cleavage of IGF-II mRNAs. RNA (1998) 0.90
Shared stabilization functions of pyrimidine-rich determinants in the erythroid 15-lipoxygenase and alpha-globin mRNAs. Mol Cell Biol (2006) 0.89
The 3'-untranslated region of apolipoprotein II mRNA contains two independent domains that bind distinct cytosolic factors. J Biol Chem (1990) 0.88
Growth-condition-dependent regulation of insulin-like growth factor II mRNA stability. Biochem J (1996) 0.87
The cytoskeleton-associated Ena/VASP proteins are unanticipated partners of the PMR1 mRNA endonuclease. RNA (2009) 0.86
The 90-kDa heat shock protein stabilizes the polysomal ribonuclease 1 mRNA endonuclease to degradation by the 26S proteasome. Mol Biol Cell (2007) 0.85
Transcriptional and post-transcriptional inhibition of albumin gene expression by estrogen in Xenopus liver. Mol Cell Endocrinol (1986) 0.84
The cis-acting elements involved in endonucleolytic cleavage of the 3' UTR of human IGF-II mRNAs bind a 50 kDa protein. Nucleic Acids Res (1996) 0.84
Detection and characterization of degradative intermediates of avian apo very low density lipoprotein II mRNA present in estrogen-treated birds and following destabilization by hormone withdrawal. J Biol Chem (1989) 0.83
Posttranscriptional regulation of albumin gene expression in Xenopus liver: evidence for an estrogen receptor-dependent mechanism. Mol Endocrinol (1987) 0.83
KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. BMC Cell Biol (2009) 0.81
An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA. Trends Cell Biol (2004) 0.80
Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells. Biochem Biophys Res Commun (2003) 0.78