Published in RNA on October 30, 2008
NMD: a multifaceted response to premature translational termination. Nat Rev Mol Cell Biol (2012) 3.64
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell (2009) 3.43
Regulation of cytoplasmic mRNA decay. Nat Rev Genet (2012) 3.30
SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nat Struct Mol Biol (2008) 2.73
Organizing principles of mammalian nonsense-mediated mRNA decay. Annu Rev Genet (2013) 2.55
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell (2010) 2.53
Nonsense-mediated mRNA decay (NMD) mechanisms. Nat Struct Mol Biol (2009) 2.31
A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay. Mol Cell (2009) 2.26
Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Mol Cell (2010) 2.09
All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay. Nat Rev Mol Cell Biol (2010) 2.07
Translation drives mRNA quality control. Nat Struct Mol Biol (2012) 1.97
TERRA: telomeric repeat-containing RNA. EMBO J (2009) 1.94
RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1. J Biol Chem (2009) 1.93
Autoregulation of the nonsense-mediated mRNA decay pathway in human cells. RNA (2011) 1.76
Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA. Mol Cell Biol (2009) 1.67
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes. Nat Rev Mol Cell Biol (2015) 1.61
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res (2011) 1.55
Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain. Proc Natl Acad Sci U S A (2009) 1.53
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev (2011) 1.52
Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol (2009) 1.44
Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis. Mol Cancer Res (2010) 1.44
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
XRN 5'→3' exoribonucleases: structure, mechanisms and functions. Biochim Biophys Acta (2013) 1.42
Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. Mol Cell (2011) 1.36
Differential utilization of decapping enzymes in mammalian mRNA decay pathways. RNA (2011) 1.29
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs. Nat Struct Mol Biol (2013) 1.26
A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Genes Dev (2009) 1.25
How and where are nonsense mRNAs degraded in mammalian cells? RNA Biol (2010) 1.23
Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1. PLoS Pathog (2011) 1.21
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA. Nucleic Acids Res (2009) 1.20
Processing bodies are not required for mammalian nonsense-mediated mRNA decay. RNA (2009) 1.20
Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism. RNA (2010) 1.20
Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs. Proc Natl Acad Sci U S A (2011) 1.18
Rules that govern UPF1 binding to mRNA 3' UTRs. Proc Natl Acad Sci U S A (2013) 1.13
Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes. Genes Dev (2014) 1.13
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J (2011) 1.11
3' UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblasts. Genome Res (2013) 1.10
Global analysis of mRNA decay intermediates in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2012) 1.10
A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes Dev (2014) 1.09
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev (2010) 1.08
Aberrant growth and lethality of Arabidopsis deficient in nonsense-mediated RNA decay factors is caused by autoimmune-like response. Nucleic Acids Res (2012) 1.08
Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways. RNA (2013) 1.07
The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev (2013) 1.07
RNA surveillance is required for endoplasmic reticulum homeostasis. Proc Natl Acad Sci U S A (2012) 1.03
Mechanisms of endonuclease-mediated mRNA decay. Wiley Interdiscip Rev RNA (2011) 1.03
Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry. RNA (2012) 1.02
Cotranscriptional effect of a premature termination codon revealed by live-cell imaging. RNA (2011) 1.02
Structural and functional analysis of the archaeal endonuclease Nob1. Nucleic Acids Res (2011) 1.01
The role of deadenylation in the degradation of unstable mRNAs in trypanosomes. Nucleic Acids Res (2009) 1.01
Engineering RNA endonucleases with customized sequence specificities. Nat Commun (2012) 1.01
Nonsense-mediated mRNA decay in humans at a glance. J Cell Sci (2016) 1.01
Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic Acids Res (2011) 1.00
Proofreading and spellchecking: a two-tier strategy for pre-mRNA splicing quality control. RNA (2011) 1.00
CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Cold Spring Harb Symp Quant Biol (2011) 1.00
Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells. Nat Struct Mol Biol (2013) 1.00
Mechanism and regulation of the nonsense-mediated decay pathway. Nucleic Acids Res (2016) 0.99
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev (2013) 0.99
SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay. Nucleic Acids Res (2012) 0.98
Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story. Annu Rev Genet (2015) 0.98
Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans. RNA (2009) 0.97
Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochem Soc Trans (2009) 0.96
Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. RNA (2011) 0.96
The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells. J Biol Chem (2013) 0.95
An atlas of chromatoid body components. RNA (2014) 0.95
Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1. RNA (2013) 0.95
The dharma of nonsense-mediated mRNA decay in mammalian cells. Mol Cells (2014) 0.95
Nonsense-mediated mRNA decay: inter-individual variability and human disease. Neurosci Biobehav Rev (2013) 0.94
Transcriptome-wide modulation of splicing by the exon junction complex. Genome Biol (2014) 0.94
The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay. RNA (2014) 0.94
Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics. Nat Commun (2015) 0.93
Human UPF1 participates in small RNA-induced mRNA downregulation. Mol Cell Biol (2009) 0.93
Structure and Activities of the Eukaryotic RNA Exosome. Enzymes (2012) 0.90
NMD: At the crossroads between translation termination and ribosome recycling. Biochimie (2014) 0.90
Interplay between viruses and host mRNA degradation. Biochim Biophys Acta (2012) 0.90
Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6. Nucleic Acids Res (2014) 0.89
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Res (2013) 0.89
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic Acids Res (2014) 0.88
The structure and function of the rous sarcoma virus RNA stability element. J Cell Biochem (2011) 0.88
Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway. Elife (2016) 0.88
SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA. PLoS One (2013) 0.87
Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. Nucleic Acids Res (2014) 0.85
The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. Cell Rep (2014) 0.85
The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation. RNA (2013) 0.85
Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems. RNA Biol (2014) 0.83
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. RNA (2012) 0.83
Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Biochem Soc Trans (2010) 0.83
Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2. Nucleic Acids Res (2013) 0.83
Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms. PLoS One (2014) 0.82
hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0. RNA Biol (2015) 0.81
Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. RNA (2012) 0.80
Molecular characterization of protease activity in Serratia sp. strain SCBI and its importance in cytotoxicity and virulence. J Bacteriol (2014) 0.80
Physiological and pathophysiological role of nonsense-mediated mRNA decay. Pflugers Arch (2016) 0.80
Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay. PLoS One (2012) 0.79
RNA stability: is it the endo' the world as we know it? Nat Struct Mol Biol (2009) 0.79
Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID). PLoS One (2016) 0.78
The Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality Control. ISRN Mol Biol (2013) 0.77
Viral Evasion and Manipulation of Host RNA Quality Control Pathways. J Virol (2016) 0.77
Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. PLoS One (2014) 0.77
Yeast hEST1A/B (SMG5/6)-like proteins contribute to environment-sensing adaptive gene expression responses. G3 (Bethesda) (2013) 0.77
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
RNA-quality control by the exosome. Nat Rev Mol Cell Biol (2006) 5.26
Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Curr Opin Cell Biol (2005) 4.45
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell (2003) 4.17
Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol (2005) 3.99
Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J (1998) 3.79
The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev (1998) 3.71
A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics (1989) 3.69
Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J (2003) 3.68
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol (1999) 3.18
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell (2004) 3.05
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature (2004) 2.80
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell (2005) 2.71
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16
A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J (2007) 2.11
Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci (2006) 2.07
Nob1p is required for cleavage of the 3' end of 18S rRNA. Mol Cell Biol (2003) 1.99
PIN domain of Nob1p is required for D-site cleavage in 20S pre-rRNA. RNA (2004) 1.94
smg-7 is required for mRNA surveillance in Caenorhabditis elegans. Genetics (1999) 1.90
SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J (2003) 1.83
Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem (2001) 1.74
Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway. Mol Cell Biol (2003) 1.60
Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes Dev (2006) 1.51
A GFP-based reporter system to monitor nonsense-mediated mRNA decay. Nucleic Acids Res (2005) 1.49
A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation. J Biol Chem (2002) 1.43
Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. Nucleic Acids Res (2007) 1.18
Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet (2011) 9.79
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev (2006) 8.78
P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol (2007) 7.96
Getting to the root of miRNA-mediated gene silencing. Cell (2008) 7.17
GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol (2008) 5.57
A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA (2005) 5.15
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92
P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol (2007) 4.90
Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Curr Opin Cell Biol (2005) 4.45
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol (2004) 4.38
Deadenylation is a widespread effect of miRNA regulation. RNA (2008) 3.98
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev (2007) 3.92
Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol (2006) 3.80
Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J (2003) 3.68
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. RNA (2005) 3.11
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell (2004) 3.05
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature (2004) 2.95
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell (2011) 2.80
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature (2004) 2.80
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell (2005) 2.71
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol (2004) 2.70
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol (2004) 2.65
Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA (2005) 2.59
REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol (2002) 2.55
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA (2009) 2.37
The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nat Struct Mol Biol (2004) 2.36
The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol (2009) 2.28
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature (2005) 2.27
mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett (2007) 2.22
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16
A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J (2007) 2.11
A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol (2003) 2.11
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA (2009) 2.11
A C-terminal silencing domain in GW182 is essential for miRNA function. RNA (2009) 2.10
Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci (2006) 2.07
The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol (2003) 2.03
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol (2002) 1.71
Genome-wide analysis of nuclear mRNA export pathways in Drosophila. EMBO J (2003) 1.70
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J (2010) 1.64
The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO Rep (2005) 1.63
Complex genomic rearrangements lead to novel primate gene function. Genome Res (2005) 1.62
Dom34:hbs1 plays a general role in quality-control systems by dissociation of a stalled ribosome at the 3' end of aberrant mRNA. Mol Cell (2012) 1.61
Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A (2011) 1.56
Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes Dev (2006) 1.51
The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta (2005) 1.49
Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet (2009) 1.46
Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol (2009) 1.44
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell (2009) 1.43
The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res (2009) 1.42
Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep (2010) 1.39
Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nat Rev Mol Cell Biol (2010) 1.36
The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J (2011) 1.29
The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes Dev (2013) 1.29
RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Mol Cell Biol (2004) 1.26
A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol (2007) 1.23
HPat provides a link between deadenylation and decapping in metazoa. J Cell Biol (2010) 1.23
Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol (2008) 1.22
The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res (2012) 1.19
Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Mol Cell Biol (2002) 1.18
GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J (2013) 1.17
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts. Mol Ther (2006) 1.17
CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes Dev (2011) 1.14
A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol (2012) 1.13
The role of GW182 proteins in miRNA-mediated gene silencing. Adv Exp Med Biol (2013) 1.13
Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J Biol Chem (2007) 1.09
Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Rep (2004) 1.09
NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol (2013) 1.09
DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A (2009) 1.08
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev (2010) 1.08
The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res (2012) 1.07
The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev (2013) 1.07
Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev (2014) 1.04
The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res (2012) 1.03
The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. RNA (2008) 1.02
Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol (2013) 1.02
The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J (2010) 1.00
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev (2013) 0.99
The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. BMC Bioinformatics (2003) 0.97
A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs. Cold Spring Harb Perspect Biol (2012) 0.97
Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Mol Cell (2013) 0.95
miRISC recruits decapping factors to miRNA targets to enhance their degradation. Nucleic Acids Res (2013) 0.93
Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP. Nat Struct Mol Biol (2011) 0.93
The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Res (2014) 0.92
NMR assignment of the Drosophila Argonaute2 PAZ domain. J Biomol NMR (2004) 0.91
Transcriptome-wide identification of RNA binding sites by CLIP-seq. Methods (2013) 0.88
RNAi: finding the elusive endonuclease. RNA (2004) 0.88
A role for eIF4AII in microRNA-mediated mRNA silencing. Nat Struct Mol Biol (2013) 0.79
CELF and PTB proteins modulate the inclusion of the β-tropomyosin exon 6B during myogenic differentiation. Exp Cell Res (2010) 0.79
Directing mRNA export. Nat Struct Mol Biol (2004) 0.77
Making sense of nonsense. Nat Struct Mol Biol (2013) 0.77
A tiny helper lightens the maternal load. Cell (2006) 0.77
Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms. EMBO Rep (2007) 0.75