Published in Diabetes on October 07, 2011
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci. Nat Commun (2015) 1.32
GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes (2012) 1.16
The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity. Cell Death Dis (2014) 1.12
The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells. PLoS One (2012) 1.03
USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. Cell Death Dis (2012) 0.98
Regulation of Bim in Health and Disease. Oncotarget (2015) 0.95
CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A (2014) 0.91
Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis. Cell Commun Signal (2014) 0.88
Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells. Proc Natl Acad Sci U S A (2013) 0.87
The pancreatic β cell and type 1 diabetes: innocent bystander or active participant? Trends Endocrinol Metab (2013) 0.86
Altered immune regulation in type 1 diabetes. Clin Dev Immunol (2013) 0.85
Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance. Cell Death Dis (2013) 0.84
Viral infections in type 1 diabetes mellitus - why the β cells? Nat Rev Endocrinol (2016) 0.83
A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. J Biol Chem (2014) 0.82
How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review. Apoptosis (2015) 0.81
Effects of E2HSA, a Long-Acting Glucagon Like Peptide-1 Receptor Agonist, on Glycemic Control and Beta Cell Function in Spontaneous Diabetic db/db Mice. J Diabetes Res (2015) 0.81
Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22. Rev Diabet Stud (2012) 0.80
JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. PLoS One (2014) 0.80
Clic4, a novel protein that sensitizes β-cells to apoptosis. Mol Metab (2015) 0.80
BH3-only molecule Bim mediates β-cell death in IRS2 deficiency. Diabetes (2014) 0.79
On the immense variety and complexity of circumstances conditioning pancreatic β-cell apoptosis in type 1 diabetes. Diabetes (2012) 0.79
JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway. Cell Death Differ (2014) 0.79
MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research. Eur J Endocrinol (2015) 0.78
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway. Cell Death Differ (2016) 0.78
Protein phosphatases in pancreatic islets. J Endocrinol (2014) 0.77
The impact of anti-inflammatory cytokines on the pancreatic β-cell. Islets (2014) 0.77
Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice. Diabetologia (2014) 0.76
Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality. Int J Endocrinol (2015) 0.76
Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease. Front Cell Infect Microbiol (2015) 0.75
Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus. Med Sci Monit (2015) 0.75
Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced β-cell death. Ups J Med Sci (2014) 0.75
Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis. Genes (Basel) (2017) 0.75
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF). J Biol Chem (2017) 0.75
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Genomewide association studies and human disease. N Engl J Med (2009) 9.05
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell (2010) 6.79
The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev (2007) 5.19
The role of BH3-only proteins in the immune system. Nat Rev Immunol (2005) 4.69
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia (2009) 3.70
Genetics of type 1A diabetes. N Engl J Med (2009) 3.18
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A (2007) 3.11
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron (2003) 2.86
Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell (2008) 2.16
Interferon expression in the pancreases of patients with type I diabetes. Diabetes (1995) 1.69
Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A (2008) 1.66
p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem (2006) 1.64
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes (2009) 1.63
Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction. Trends Cell Biol (2011) 1.54
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. PLoS Genet (2011) 1.54
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells. J Biol Chem (2005) 1.50
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes (2009) 1.50
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem (2010) 1.49
Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis. Cell Death Differ (2009) 1.47
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem (2010) 1.39
Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes (2009) 1.39
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation. Mol Endocrinol (2006) 1.39
Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes (2009) 1.37
Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia (2008) 1.34
Viral trigger for type 1 diabetes: pros and cons. Diabetes (2008) 1.33
Environmental factors in the development of Type 1 diabetes. Rev Endocr Metab Disord (2006) 1.31
Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes (2010) 1.26
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. Hum Mol Genet (2010) 1.25
T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. Immunol Rev (2009) 1.25
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. J Neurosci (2004) 1.24
An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells. Genes Immun (2010) 1.22
Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus: relationship with coxsackievirus B infection. J Infect Dis (2000) 1.20
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood (2004) 1.20
Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes. Diabetes (2005) 1.18
STAT activation and differential complex formation dictate selectivity of interferon responses. Acta Biochim Pol (2007) 1.18
PTP1B and TC-PTP: novel roles in immune-cell signaling. Can J Physiol Pharmacol (2006) 1.11
Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2. Gastroenterology (2009) 1.04
Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Arthritis Rheum (2011) 1.00
IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice. J Immunol (2004) 1.00
Protein tyrosine phosphatase non-receptor Type 2 regulates IFN-γ-induced cytokine signaling in THP-1 monocytes. Inflamm Bowel Dis (2010) 0.99
A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes. Immunogenetics (2011) 0.98
Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance. PLoS Pathog (2011) 0.96
Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes. J Autoimmun (2009) 0.95
Enterovirus infection induces cytokine and chemokine expression in insulin-producing cells. J Med Virol (2010) 0.90
Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions. Am J Pathol (2003) 0.87
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes (2005) 5.54
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003. Transplantation (2003) 3.79
T1DBase: integration and presentation of complex data for type 1 diabetes research. Nucleic Acids Res (2006) 3.25
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A (2007) 3.11
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci (2008) 2.99
Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes (2005) 2.47
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem (2006) 2.26
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J (2012) 2.21
The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy (2011) 2.18
Non-invasive quantification of the beta cell mass by SPECT with ¹¹¹In-labelled exendin. Diabetologia (2014) 2.00
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab (2008) 1.91
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab (2005) 1.72
Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One (2010) 1.68
Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression. Transplantation (2005) 1.66
Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets. PLoS One (2012) 1.66
Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab (2004) 1.66
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes (2009) 1.63
Detailed transcriptome atlas of the pancreatic beta cell. BMC Med Genomics (2009) 1.55
Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Sci Transl Med (2013) 1.55
Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction. Trends Cell Biol (2011) 1.54
Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes (2002) 1.54
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells. J Biol Chem (2005) 1.50
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes (2009) 1.50
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem (2010) 1.49
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway. Endocrinology (2012) 1.49
Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets? Diabetes (2005) 1.45
T1DBase, a community web-based resource for type 1 diabetes research. Nucleic Acids Res (2005) 1.44
Segmental live donor pancreas transplantation: review and critique of rationale, outcomes, and current recommendations. Clin Transplant (2010) 1.42
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem (2010) 1.39
Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes (2009) 1.39
The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes. J Clin Endocrinol Metab (2006) 1.36
Lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes (2002) 1.34
Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. Diabetes (2011) 1.33
The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes. J Clin Endocrinol Metab (2008) 1.32
Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway. PLoS One (2007) 1.27
Lipotoxicity disrupts incretin-regulated human β cell connectivity. J Clin Invest (2013) 1.27
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. Hum Mol Genet (2010) 1.25
Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. J Biol Chem (2008) 1.25
Guidelines for the treatment and management of new-onset diabetes after transplantation. Clin Transplant (2005) 1.22
Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem (2011) 1.20
GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19
Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A (2009) 1.17
Reduction of circulating neutrophils precedes and accompanies type 1 diabetes. Diabetes (2013) 1.17
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes (2012) 1.16
Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes. Diabetologia (2013) 1.15
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass. Cell Metab (2011) 1.14
Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways. Diabetes (2008) 1.14
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. Biochem Biophys Res Commun (2005) 1.13
SUMO wrestling with type 1 diabetes. J Mol Med (Berl) (2005) 1.13
Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. J Nutr Biochem (2007) 1.13
Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression. Hum Mol Genet (2008) 1.12
Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. Mol Genet Metab (2010) 1.10
Hepatitis C virus infection and human pancreatic beta-cell dysfunction. Diabetes Care (2005) 1.09
Pleiotropic effects of GIP on islet function involve osteopontin. Diabetes (2011) 1.08
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem (2010) 1.08
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes (2003) 1.08
Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. Biochem Soc Trans (2008) 1.08
Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus. PLoS One (2011) 1.07
Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism. Diabetes (2002) 1.07
Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells. FASEB J (2004) 1.07
Effects of pancreas-kidney transplantation on diabetic retinopathy. Transpl Int (2005) 1.06
Type 2 diabetes mellitus--an autoimmune disease? Nat Rev Endocrinol (2013) 1.06