Published in Nucleic Acids Res on December 14, 2006
Human Protein Reference Database--2009 update. Nucleic Acids Res (2008) 21.25
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab (2009) 1.94
HGVbaseG2P: a central genetic association database. Nucleic Acids Res (2008) 1.90
Coexpression network based on natural variation in human gene expression reveals gene interactions and functions. Genome Res (2009) 1.74
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes (2009) 1.63
Detailed transcriptome atlas of the pancreatic beta cell. BMC Med Genomics (2009) 1.55
Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes. Diabetes (2010) 1.48
DNA microarrays: a powerful genomic tool for biomedical and clinical research. Mol Med (2007) 1.38
PADB: published association database. BMC Bioinformatics (2007) 1.12
MOPAT: a graph-based method to predict recurrent cis-regulatory modules from known motifs. Nucleic Acids Res (2008) 1.11
Genomic convergence of genome-wide investigations for complex traits. Ann Hum Genet (2009) 1.01
Ranking causal variants and associated regions in genome-wide association studies by the support vector machine and random forest. Nucleic Acids Res (2011) 1.00
T2D-Db: an integrated platform to study the molecular basis of Type 2 diabetes. BMC Genomics (2008) 0.98
Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. J Immunol (2010) 0.96
Data management: it starts at the bench. Nat Immunol (2009) 0.95
The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model. J Immunol (2012) 0.92
Type 2 diabetes genetic association database manually curated for the study design and odds ratio. BMC Med Inform Decis Mak (2010) 0.92
POINeT: protein interactome with sub-network analysis and hub prioritization. BMC Bioinformatics (2009) 0.92
Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. J Immunol (2011) 0.88
Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes. J Immunol (2013) 0.88
Glucose-induced ERM protein activation and translocation regulates insulin secretion. Am J Physiol Endocrinol Metab (2010) 0.88
Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation. J Biol Chem (2012) 0.85
EuroDia: a beta-cell gene expression resource. Database (Oxford) (2010) 0.84
T-HOD: a literature-based candidate gene database for hypertension, obesity and diabetes. Database (Oxford) (2013) 0.83
GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist. Exp Diabetes Res (2008) 0.81
Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mamm Genome (2013) 0.80
Current status and the future for the genetics of type I diabetes. Genes Immun (2009) 0.80
Predicting Type 1 Diabetes Candidate Genes using Human Protein-Protein Interaction Networks. J Comput Sci Syst Biol (2009) 0.80
IthaGenes: an interactive database for haemoglobin variations and epidemiology. PLoS One (2014) 0.79
Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes. PLoS One (2015) 0.77
Detection of molecular paths associated with insulitis and type 1 diabetes in non-obese diabetic mouse. PLoS One (2009) 0.77
Accounting for chance in the calculus of autoimmune disease. Med Hypotheses (2009) 0.75
Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol (2015) 0.75
TarNet: An Evidence-Based Database for Natural Medicine Research. PLoS One (2016) 0.75
Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review. Front Pharmacol (2017) 0.75
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
A haplotype map of the human genome. Nature (2005) 105.70
Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76
The International HapMap Project. Nature (2003) 73.65
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res (2006) 44.35
The generic genome browser: a building block for a model organism system database. Genome Res (2002) 42.64
Reactome: a knowledgebase of biological pathways. Nucleic Acids Res (2005) 20.05
Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2006) 18.85
EnsMart: a generic system for fast and flexible access to biological data. Genome Res (2004) 17.64
MINT: a Molecular INTeraction database. FEBS Lett (2002) 17.21
The Gene Ontology (GO) project in 2006. Nucleic Acids Res (2006) 13.79
The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res (2005) 12.94
Human protein reference database--2006 update. Nucleic Acids Res (2006) 12.16
Ensembl 2006. Nucleic Acids Res (2006) 11.66
OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups. Nucleic Acids Res (2006) 11.43
The UCSC Genome Browser Database: update 2006. Nucleic Acids Res (2006) 11.05
Inparanoid: a comprehensive database of eukaryotic orthologs. Nucleic Acids Res (2005) 9.90
The Mouse Genome Database (MGD): updates and enhancements. Nucleic Acids Res (2006) 8.87
The Vertebrate Genome Annotation (Vega) database. Nucleic Acids Res (2005) 7.06
A first-draft human protein-interaction map. Genome Biol (2004) 3.64
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes (2005) 2.85
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
The Rat Genome Database (RGD): developments towards a phenome database. Nucleic Acids Res (2005) 2.77
Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databases. BMC Genomics (2003) 1.88
Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden. Am J Hum Genet (2006) 1.50
T1DBase, a community web-based resource for type 1 diabetes research. Nucleic Acids Res (2005) 1.44
TissueInfo: high-throughput identification of tissue expression profiles and specificity. Nucleic Acids Res (2001) 1.38
Transcriptional program of the endocrine pancreas in mice and humans. Diabetes (2003) 1.23
Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics. Hum Genomics (2004) 1.08
Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet (2005) 25.34
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Analysis of genetic inheritance in a family quartet by whole-genome sequencing. Science (2010) 18.45
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered (2003) 14.37
Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet (2005) 14.30
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Prepublication data sharing. Nature (2009) 12.24
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 6.11
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes (2005) 5.54
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes (2004) 4.81
A method to address differential bias in genotyping in large-scale association studies. PLoS Genet (2007) 4.51
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 4.36
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest (2003) 4.11
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet (2010) 3.50
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf) (2007) 3.17
Ensembl Genomes 2013: scaling up access to genome-wide data. Nucleic Acids Res (2013) 3.08
Reevaluating human gene annotation: a second-generation analysis of chromosome 22. Genome Res (2003) 3.03
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes (2005) 2.85
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med (2005) 2.83
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes (2008) 2.74
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet (2009) 2.38
Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe (2008) 2.30
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30
Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses. PLoS One (2008) 2.28
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem (2006) 2.26
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet (2011) 2.25
The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci (2006) 2.22
Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett (2002) 2.21
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J (2012) 2.21
NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis. J Exp Med (2006) 2.16
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes (2009) 2.02
Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes (2004) 2.02
Non-invasive quantification of the beta cell mass by SPECT with ¹¹¹In-labelled exendin. Diabetologia (2014) 2.00
Metagenomics and personalized medicine. Cell (2011) 2.00
Parameters for reliable results in genetic association studies in common disease. Nat Genet (2002) 2.00
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity (2004) 2.00
Heritability of body composition measured by DXA in the diabetes heart study. Obes Res (2005) 1.94
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature (2013) 1.79
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol (2006) 1.79
Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes (2011) 1.78