Published in Nat Genet on May 05, 2013
Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet (2013) 4.61
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat Genet (2014) 2.91
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev (2013) 2.07
Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes. Cell (2013) 2.04
Chromatin dynamics during cellular reprogramming. Nature (2013) 1.79
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Proc Natl Acad Sci U S A (2014) 1.71
Molecular genetics of clear-cell renal cell carcinoma. J Clin Oncol (2014) 1.65
Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation. Genes Dev (2015) 1.58
Targeting EZH2 in cancer. Nat Med (2016) 1.51
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A chemical probe toolbox for dissecting the cancer epigenome. Nat Rev Cancer (2017) 1.40
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat Commun (2015) 1.35
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics. Sci Adv (2015) 1.33
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis. Cancer Cell (2014) 1.30
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation. Mol Cell Biol (2014) 1.28
An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes. Nat Genet (2015) 1.25
Vulnerabilities of mutant SWI/SNF complexes in cancer. Cancer Cell (2014) 1.20
A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet (2014) 1.17
Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis. J Natl Cancer Inst (2014) 1.14
Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts. Neuron (2014) 1.11
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat Med (2015) 1.10
PBRM1 and BAP1 as novel targets for renal cell carcinoma. Cancer J (2013) 1.07
Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights. Clin Cancer Res (2013) 1.07
Long noncoding RNAs in cancer: from function to translation. Trends Cancer (2015) 1.06
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability. Nat Rev Mol Cell Biol (2016) 1.05
The role of BAF (mSWI/SNF) complexes in mammalian neural development. Am J Med Genet C Semin Med Genet (2014) 1.03
SWI/SNF chromatin remodeling complexes and cancer. Am J Med Genet C Semin Med Genet (2014) 1.03
Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies. Neuro Oncol (2016) 1.02
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nat Commun (2014) 1.02
The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies. Cancer Res (2015) 0.99
Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs. Cancer Cell (2016) 0.98
Epigenomic regulation of oncogenesis by chromatin remodeling. Oncogene (2016) 0.97
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev (2015) 0.96
Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Exp Hematol (2015) 0.95
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy. Clin Epigenetics (2016) 0.95
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem (2016) 0.94
BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization. Cancer Res (2014) 0.93
Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression. Cell Cycle (2016) 0.93
Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells. Stem Cell Reports (2014) 0.92
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type. J Pathol (2015) 0.92
Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes. PLoS Genet (2015) 0.92
Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1. PLoS One (2014) 0.92
The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res (2013) 0.91
Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis. Neuro Oncol (2016) 0.91
A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Rep (2015) 0.91
SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease. Cardiovasc Pathol (2013) 0.91
The changing landscape of hepatocellular carcinoma: etiology, genetics, and therapy. Am J Pathol (2013) 0.89
Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas. Mod Pathol (2016) 0.89
A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63. Genome Biol (2015) 0.88
Genetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis. Sci Rep (2014) 0.88
The SWI/SNF tumor suppressor complex: Regulation of promoter nucleosomes and beyond. Nucleus (2013) 0.88
Gene silencing associated with SWI/SNF complex loss during NSCLC development. Mol Cancer Res (2014) 0.87
BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos. Cell Death Differ (2014) 0.87
Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Cell Stem Cell (2016) 0.87
Neuron-specific chromatin remodeling: a missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders. Neuropharmacology (2013) 0.87
PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma. PLoS One (2016) 0.87
Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis. Metabolomics (2015) 0.86
Chromatin Remodelers: From Function to Dysfunction. Genes (Basel) (2015) 0.86
Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine. Gastroenterology (2015) 0.86
Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy. Cancer Discov (2015) 0.86
Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: a systematic review and meta-analysis. Oncotarget (2015) 0.85
Reprogramming of human cancer cells to pluripotency for models of cancer progression. EMBO J (2015) 0.85
Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation. Front Oncol (2015) 0.85
Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. Nat Genet (2016) 0.85
Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition. Nat Chem Biol (2016) 0.84
Expression inactivation of SMARCA4 by microRNAs in lung tumors. Hum Mol Genet (2014) 0.84
9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain. J Med Chem (2015) 0.84
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas. Nat Genet (2015) 0.84
EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex. Genes Dev (2017) 0.84
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet (2016) 0.84
Genetic alterations in hepatocellular carcinoma: An update. World J Gastroenterol (2016) 0.83
The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway. PLoS Genet (2015) 0.83
ARID1A and TERT promoter mutations in dedifferentiated meningioma. Cancer Genet (2015) 0.83
Chromatin-Remodeling-Factor ARID1B Represses Wnt/β-Catenin Signaling. Am J Hum Genet (2015) 0.83
7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol (2016) 0.82
Alisertib is active as single agent in recurrent atypical teratoid rhabdoid tumors in 4 children. Neuro Oncol (2015) 0.82
Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86. Mol Cell Biol (2015) 0.82
BAF250a Protein Regulates Nucleosome Occupancy and Histone Modifications in Priming Embryonic Stem Cell Differentiation. J Biol Chem (2015) 0.81
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Nat Commun (2016) 0.81
From trans to cis: transcriptional regulatory networks in neocortical development. Trends Genet (2015) 0.81
Linking the SWI/SNF complex to prostate cancer. Nat Genet (2013) 0.81
The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation. J Cell Physiol (2015) 0.81
Drugging Chromatin in Cancer: Recent Advances and Novel Approaches. Mol Cell (2015) 0.81
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer. Cold Spring Harb Perspect Med (2016) 0.81
CARMA: CARM1 methylation of SWI/SNF in breast cancer. Cancer Cell (2014) 0.80
ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy. Adv Cancer Res (2014) 0.80
Cancer genomics: why rare is valuable. J Mol Med (Berl) (2015) 0.80
Genomic profiling of breast cancers. Curr Opin Obstet Gynecol (2015) 0.80
Potential therapeutic targets in ARID1A-mutated cancers. Expert Opin Ther Targets (2015) 0.80
SWI/SNF complexes are required for full activation of the DNA-damage response. Oncotarget (2015) 0.80
The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Cell Rep (2017) 0.79
Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Rare Dis (2014) 0.79
ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol (2017) 0.79
ATP-dependent chromatin remodeling during mammalian development. Development (2016) 0.79
It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brain. Semin Cell Dev Biol (2014) 0.79
BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription. Am J Hum Genet (2016) 0.79
Exploiting receptor tyrosine kinase co-activation for cancer therapy. Drug Discov Today (2016) 0.79
The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy. BMC Cancer (2015) 0.79
Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type. Mod Pathol (2015) 0.79
Mechanism of BRG1 silencing in primary cancers. Oncotarget (2016) 0.78
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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
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Comprehensive genomic characterization of squamous cell lung cancers. Nature (2012) 18.90
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The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature (2010) 14.50
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med (2010) 13.07
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The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature (2012) 11.91
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell (2012) 11.69
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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet (2010) 10.97
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (2010) 10.78
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