Published in Immunol Cell Biol on October 11, 2011
An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation. BMC Genomics (2012) 0.83
ERK1 is important for Th2 differentiation and development of experimental asthma. FASEB J (2012) 0.80
TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma. J Clin Cell Immunol (2012) 0.77
The regulation and role of c-FLIP in human Th cell differentiation. PLoS One (2014) 0.77
Gene set enrichment analysis identifies LIF as a negative regulator of human Th2 cell differentiation. Sci Rep (2012) 0.75
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell (1994) 16.30
Dynamic regulation of nucleosome positioning in the human genome. Cell (2008) 15.60
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem (1998) 13.93
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68
The lineage decisions of helper T cells. Nat Rev Immunol (2002) 10.61
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev (1993) 10.01
NFAT signaling: choreographing the social lives of cells. Cell (2002) 8.17
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity (1996) 8.16
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature (1992) 8.15
MAP kinases in the immune response. Annu Rev Immunol (2001) 7.62
Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56
The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol (1999) 6.19
Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors (2006) 5.58
Activated signal transduction kinases frequently occupy target genes. Science (2006) 4.01
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science (1999) 3.85
Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell (2009) 3.69
Signalling ballet in space and time. Nat Rev Mol Cell Biol (2010) 3.32
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol (2000) 2.52
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity (2004) 2.18
Subcellular localization determines MAP kinase signal output. Curr Biol (2005) 1.78
Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn Mem (2001) 1.62
Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J Exp Med (1994) 1.54
ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J Immunol (2006) 1.49
T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc Natl Acad Sci U S A (1999) 1.46
Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells. J Immunol (2003) 1.35
Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem (2004) 1.33
Erk1/2 MAP kinases are required for epidermal G2/M progression. J Cell Biol (2009) 1.32
Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol (2003) 1.32
Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Mol Syst Biol (2009) 1.31
Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation. J Immunol (2000) 1.31
Variability of airways hyper-reactivity and allergy in cystic fibrosis. Arch Dis Child (1981) 1.28
MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly. EMBO J (2000) 1.28
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J Immunol (2007) 1.28
Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes. J Immunol (2003) 1.02
Integration of a phosphatase cascade with the mitogen-activated protein kinase pathway provides for a novel signal processing function. J Biol Chem (2009) 0.96
Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells. Mol Immunol (2007) 0.91
The N-terminal domain of ERK1 accounts for the functional differences with ERK2. PLoS One (2008) 0.88
MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription. Eur J Immunol (2007) 0.87
Transcription regulation from a TATA and INR-less promoter: spatial segregation of promoter function. EMBO J (2006) 0.87
Regulation of interleukin 4 gene transcription: alterations in atopic disease? Am J Respir Crit Care Med (2000) 0.82
Role of extracellular signal-regulated kinase in regulating expression of interleukin 13 in lymphocytes from an asthmatic rat model. Chin Med J (Engl) (2010) 0.76
Copy number variation and selection during reprogramming to pluripotency. Nature (2011) 8.24
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Exosomes with immune modulatory features are present in human breast milk. J Immunol (2007) 3.47
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nat Biotechnol (2010) 3.21
Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell (2010) 2.91
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med (2008) 2.79
A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments. BMC Genomics (2009) 2.70
Genomic views of STAT function in CD4+ T helper cell differentiation. Nat Rev Immunol (2011) 2.09
Is nuchal cord justified as a cause of obstetrician anxiety? Arch Gynecol Obstet (2013) 2.05
Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial. Aust N Z J Obstet Gynaecol (2009) 2.02
Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response. Immunity (2006) 1.95
Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells. J Leukoc Biol (2007) 1.90
Difference in gene expression between human fetal liver and adult bone marrow mesenchymal stem cells. Haematologica (2005) 1.90
Gene expression signatures of seven individual human embryonic stem cell lines. Stem Cells (2005) 1.86
The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell (2005) 1.83
Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen. PLoS Pathog (2010) 1.65
Timing of infant feeding in relation to childhood asthma and allergic diseases. J Allergy Clin Immunol (2012) 1.62
Systematic construction of gene coexpression networks with applications to human T helper cell differentiation process. Bioinformatics (2007) 1.54
Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype. Cell Host Microbe (2012) 1.47
Integrating probe-level expression changes across generations of Affymetrix arrays. Nucleic Acids Res (2005) 1.42
Genetic and epigenetic stability of human pluripotent stem cells. Nat Rev Genet (2012) 1.38
Early target genes of IL-12 and STAT4 signaling in th cells. J Immunol (2004) 1.31
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity (2010) 1.28
Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity (2013) 1.27
Genome-wide identification of novel genes involved in early Th1 and Th2 cell differentiation. J Immunol (2007) 1.21
Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol (2003) 1.20
Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages. J Immunol (2005) 1.15
Identification of genes involved in the initiation of human Th1 or Th2 cell commitment. Eur J Immunol (2005) 1.12
Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies. Genome Biol (2009) 1.10
Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol (2005) 1.08
PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. Blood (2009) 1.08
Th1 response and cytotoxicity genes are down-regulated in cutaneous T-cell lymphoma. Clin Cancer Res (2006) 1.05
Characterizing virulence-specific perturbations in the mitochondrial function of macrophages infected with Mycobacterium tuberculosis. Sci Rep (2013) 1.03
Regulation of transcript elongation through cooperative and ordered recruitment of cofactors. J Biol Chem (2007) 1.02
Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes. J Immunol (2003) 1.02
Gene expression profiling of immune-competent human cells exposed to engineered zinc oxide or titanium dioxide nanoparticles. PLoS One (2013) 1.02
Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response. Mol Syst Biol (2007) 1.02
Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances. Microbes Infect (2010) 1.01
RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation. Stem Cells (2012) 1.01
Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage. Mol Immunol (2004) 1.01
A comparative evaluation of software for the analysis of liquid chromatography-tandem mass spectrometry data from isotope coded affinity tag experiments. Proteomics (2005) 1.00
The primary antibody repertoire represents a linked network of degenerate antigen specificities. J Immunol (2002) 1.00
Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. J Immunol (2002) 1.00
Quality classification of tandem mass spectrometry data. Bioinformatics (2005) 1.00
Identification of early gene expression changes during human Th17 cell differentiation. Blood (2012) 0.99
CD73 participates in cellular multiresistance program and protects against TRAIL-induced apoptosis. J Immunol (2008) 0.99
Genome-wide comparison of two RNA-stabilizing reagents for transcriptional profiling of peripheral blood. Transl Res (2012) 0.98
Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes. ACS Nano (2011) 0.97
Unique gene expression signature by human embryonic stem cells cultured under serum-free conditions correlates with their enhanced and prolonged growth in an undifferentiated stage. Stem Cells (2005) 0.97
Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev (2014) 0.97
Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation. Mol Cell Proteomics (2008) 0.97
A GPI-linked isoform of the IgD receptor regulates resting B cell activation. Nat Immunol (2002) 0.96
Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells. Fertil Steril (2006) 0.96
An insight into molecular mechanisms of human T helper cell differentiation. Ann Med (2008) 0.96
Integration of a phosphatase cascade with the mitogen-activated protein kinase pathway provides for a novel signal processing function. J Biol Chem (2009) 0.96
Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation. Immunology (2005) 0.95
Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature. Antioxid Redox Signal (2014) 0.94
Activating transcription factor 3 is a positive regulator of human IFNG gene expression. J Immunol (2010) 0.94
PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation. Blood (2008) 0.94
SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation. Blood (2010) 0.93
Reproducibility-optimized test statistic for ranking genes in microarray studies. IEEE/ACM Trans Comput Biol Bioinform (2008) 0.93
GIMAP Proteins in T-Lymphocytes. J Signal Transduct (2010) 0.92
New separation-free assay technique for SNPs using two-photon excitation fluorometry. Nucleic Acids Res (2004) 0.92
Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling. J Autoimmun (2010) 0.91
IL-12 up-regulates T-bet independently of IFN-gamma in human CD4+ T cells. Eur J Immunol (2005) 0.91
High-throughput karyotyping of human pluripotent stem cells. Stem Cell Res (2012) 0.90
Enrichment of nucleofected primary human CD4+ T cells: a novel and efficient method for studying gene function and role in human primary T helper cell differentiation. J Immunol Methods (2006) 0.90
A mutant collagen XIII alters intestinal expression of immune response genes and predisposes transgenic mice to develop B-cell lymphomas. Cancer Res (2008) 0.88
Fetotoxicity of warfarin anticoagulation. Arch Gynecol Obstet (2010) 0.88
Tuberculous psoas abscess in obstetrics: concerning Kumar S, Malhotra N, Chanana C, Lal S (2009) Psoas abscess in obstetrics. Arch Gynecol Obstet 279:247-249. Arch Gynecol Obstet (2009) 0.88
Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation. Mol Cell Proteomics (2010) 0.87
An unusual etiology of spontaneous pyometra perforation; a case report. J Reprod Infertil (2011) 0.87
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells. Proc Natl Acad Sci U S A (2012) 0.86
Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells. Fertil Steril (2006) 0.86
Transcriptional response of human dendritic cells to Borrelia garinii--defective CD38 and CCR7 expression detected. J Leukoc Biol (2007) 0.86
Mimicry of native peptide antigens by the corresponding retro-inverso analogs is dependent on their intrinsic structure and interaction propensities. J Immunol (2003) 0.85
Chlamydia pneumoniae infection in IL-10 knock out mice: accelerated clearance but severe pulmonary inflammatory response. Microb Pathog (2008) 0.85
High-efficiency gene transfer to primary T lymphocytes by recombinant adenovirus vectors. J Immunol Methods (2002) 0.85
Interleukin-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human T helper 2 cell differentiation. Mol Cell Proteomics (2006) 0.85
Hierarchical grid transformation for image warping in the analysis of two-dimensional electrophoresis gels. Proteomics (2002) 0.85
Comparison of PDQuest and Progenesis software packages in the analysis of two-dimensional electrophoresis gels. Proteomics (2003) 0.84
Proteome profiling of interleukin-12 treated human T helper cells. Proteomics (2005) 0.84
Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features. Front Immunol (2013) 0.84
IFN-alpha and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and IRF-8 gene expression in human NK and T cells. Cytokine (2003) 0.83
An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation. BMC Genomics (2012) 0.83
Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels. PLoS One (2013) 0.83
Proteome characterization of human T helper 1 and 2 cells. Proteomics (2004) 0.83
Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells. J Cell Sci (2014) 0.82
NanoMiner - integrative human transcriptomics data resource for nanoparticle research. PLoS One (2013) 0.82
Immunomodulatory Role of an Ayurvedic Formulation on Imbalanced Immunometabolics during Inflammatory Responses of Obesity and Prediabetic Disease. Evid Based Complement Alternat Med (2013) 0.82
Gene expression signatures characterizing the development of lymphocyte response during experimental Chlamydia pneumoniae infection. Microb Pathog (2009) 0.82
Dilantin as anticonvulsant in eclampsia. J Indian Med Assoc (2002) 0.82
Regulatory cascades of protein phosphatases: implications for cancer treatment. Anticancer Agents Med Chem (2011) 0.82
Characteristics and treatment outcomes of patients with multi-drug resistant tuberculosis at a tertiary care hospital in Peshawar, Pakistan. Saudi Med J (2015) 0.81
Role of misoprostol in overcoming an unsatisfactory colposcopy: a randomized double-blind placebo-controlled clinical trial. Gynecol Obstet Invest (2006) 0.81
Morbidly adherent placenta: a critical review. J Obstet Gynaecol India (2012) 0.81