Published in Annu Rev Immunol on January 01, 2006
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell (2009) 8.62
Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol (2009) 5.72
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity (2010) 4.52
Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol (2011) 4.29
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97
Epigenetic regulation of the alternatively activated macrophage phenotype. Blood (2009) 3.76
Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol (2007) 3.72
Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci U S A (2012) 3.62
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity (2010) 3.24
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Heterogeneity and plasticity of T helper cells. Cell Res (2009) 3.09
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med (2009) 3.01
Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology (2009) 2.92
KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity (2009) 2.90
Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity (2007) 2.88
Genomic antagonism between retinoic acid and estrogen signaling in breast cancer. Cell (2009) 2.76
MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells. Immunity (2011) 2.71
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity (2010) 2.70
Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 2.61
Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity (2011) 2.53
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity (2011) 2.49
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol (2011) 2.47
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med (2009) 2.45
STATs shape the active enhancer landscape of T cell populations. Cell (2012) 2.45
IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol (2011) 2.44
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol (2009) 2.43
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity (2010) 2.38
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol (2008) 2.31
Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. J Exp Med (2007) 2.25
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity (2008) 2.13
Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu Rev Immunol (2012) 2.06
The transcription factor STAT3 is required for T helper 2 cell development. Immunity (2011) 2.03
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol (2009) 1.99
Th9 and allergic disease. Immunology (2009) 1.97
Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells. Trends Immunol (2009) 1.88
The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses. Immunity (2012) 1.84
Transcriptional regulation by STAT6. Immunol Res (2011) 1.81
GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol (2010) 1.80
Transdermal influenza immunization with vaccine-coated microneedle arrays. PLoS One (2009) 1.78
MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol (2013) 1.75
Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol Sci (2007) 1.73
The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol (2010) 1.72
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol (2011) 1.66
Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner. PLoS Biol (2010) 1.64
Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Blood (2007) 1.64
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood (2010) 1.55
How are T(H)1 and T(H)2 effector cells made? Curr Opin Immunol (2009) 1.54
An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation. Int Immunol (2011) 1.48
Metabolic shifts in immunity and inflammation. J Immunol (2010) 1.45
Kruppel-like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells. J Invest Dermatol (2015) 1.44
TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4. J Clin Invest (2008) 1.43
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol (2010) 1.39
An epigenome-wide association study of total serum immunoglobulin E concentration. Nature (2015) 1.37
Gata3 drives development of RORγt+ group 3 innate lymphoid cells. J Exp Med (2014) 1.36
Mechanisms and functions for the duration of intercellular contacts made by lymphocytes. Nat Rev Immunol (2009) 1.36
Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production. Gastroenterology (2009) 1.34
Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proc Natl Acad Sci U S A (2013) 1.34
Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion. Proc Natl Acad Sci U S A (2006) 1.32
New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation. Semin Cell Dev Biol (2008) 1.31
Interplay between effector Th17 and regulatory T cells. J Clin Immunol (2008) 1.29
T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain. Mol Cell Biol (2007) 1.28
BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells. Mol Cell Biol (2008) 1.28
Demethylation of a specific hypersensitive site in the Th2 locus control region. Proc Natl Acad Sci U S A (2007) 1.27
Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity (2013) 1.27
NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J (2011) 1.26
Intestinal effector T cells in health and disease. Immunity (2009) 1.24
Epigenetics in atherosclerosis and inflammation. J Cell Mol Med (2010) 1.21
Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility. Nat Immunol (2014) 1.20
Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Mol Syst Biol (2010) 1.19
Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. J Allergy Clin Immunol (2013) 1.19
Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity (2012) 1.19
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol (2014) 1.18
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation. Nat Immunol (2012) 1.18
STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med (2010) 1.18
Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J Exp Med (2008) 1.18
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements. Mol Cell Biol (2011) 1.17
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity (2010) 1.17
The transcriptional control of the perforin locus. Immunol Rev (2010) 1.15
T follicular helper cell diversity and plasticity. Trends Immunol (2013) 1.14
Deviation from a strong Th1-dominated to a modest Th17-dominated CD4 T cell response in the absence of IL-12p40 and type I IFNs sustains protective CD8 T cells. J Immunol (2008) 1.14
Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish. Immunogenetics (2008) 1.13
Quantitative events determine the differentiation and function of helper T cells. Nat Immunol (2011) 1.13
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis? Immunol Rev (2010) 1.12
Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells. Proc Natl Acad Sci U S A (2008) 1.12
Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J Immunol (2009) 1.12
Epigenomics of T cell activation, differentiation, and memory. Curr Opin Immunol (2010) 1.10
Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med (2009) 1.08
Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev (2010) 1.07
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression. PLoS One (2011) 1.06
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. J Immunol (2007) 1.06
TCF1 and beta-catenin regulate T cell development and function. Immunol Res (2010) 1.06
Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells. J Orthop Res (2011) 1.05
Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation. J Biol Chem (2009) 1.05
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87
Orai1 is an essential pore subunit of the CRAC channel. Nature (2006) 8.60
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 8.10
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol (2006) 4.81
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity (2010) 4.52
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 4.21
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14
Transcriptional mechanisms underlying lymphocyte tolerance. Cell (2002) 4.04
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) 3.93
An epigenetic view of helper T cell differentiation. Nat Immunol (2003) 3.87
Biochemical and functional characterization of Orai proteins. J Biol Chem (2007) 3.87
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature (2006) 3.61
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47
Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol (2006) 3.19
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18
Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (2008) 3.17
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol (2002) 3.05
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med (2009) 3.01
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature (2013) 2.76
STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N Engl J Med (2009) 2.72
A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem (2003) 2.59
Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol (2008) 2.50
Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity (2002) 2.47
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood (2011) 2.47
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
Calcium signaling in lymphocytes. Curr Opin Immunol (2008) 2.38
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest (2004) 2.31
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature (2013) 2.31
Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium (2007) 2.23
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. J Exp Med (2005) 2.20
STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol (2009) 2.15
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev (2012) 2.10
ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia. J Allergy Clin Immunol (2009) 2.09
Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol (2010) 1.84
Dissecting ICRAC, a store-operated calcium current. Trends Biochem Sci (2007) 1.82
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol (2004) 1.78
Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling. Mol Cells (2004) 1.75
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity (2002) 1.74
Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol (2004) 1.72
NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription. Eur J Immunol (2002) 1.68
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature (2013) 1.65
Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell (2008) 1.63
Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction. J Mol Biol (2007) 1.60
Pore architecture of the ORAI1 store-operated calcium channel. Proc Natl Acad Sci U S A (2010) 1.52
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2014) 1.50
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A (2011) 1.47
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol (2012) 1.46
Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor. Nat Struct Biol (2002) 1.45
Ca2+/calcineurin signalling in cells of the immune system. Biochem Biophys Res Commun (2003) 1.44
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell (2013) 1.40
Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A (2012) 1.39
Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol (2005) 1.37
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A (2004) 1.37
Chromatin-level regulation of the IL10 gene in T cells. J Biol Chem (2004) 1.36
Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U S A (2004) 1.34
Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA. Nat Immunol (2004) 1.34
The transcription factor NFAT3 mediates neuronal survival. J Biol Chem (2004) 1.27
Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol (2008) 1.26
DNA methylation and methylcytosine oxidation in cell fate decisions. Curr Opin Cell Biol (2013) 1.24
T-cell anergy. Curr Opin Immunol (2004) 1.24
Initial activation of STIM1, the regulator of store-operated calcium entry. Nat Struct Mol Biol (2013) 1.24
The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine. Nat Protoc (2012) 1.24
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. J Exp Med (2009) 1.24
Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity (2011) 1.23
Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity (2012) 1.19
TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunol Rev (2015) 1.18
Chromosome transfer activates and delineates a locus control region for perforin. Immunity (2007) 1.16
The transcriptional control of the perforin locus. Immunol Rev (2010) 1.15
The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS One (2009) 1.15
MicroRNA-221-222 regulate the cell cycle in mast cells. J Immunol (2009) 1.14
New twists of T cell fate: control of T cell activation and tolerance by TGF-beta and NFAT. Curr Opin Immunol (2007) 1.12
Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells. Immunity (2008) 1.12
Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions. J Mol Biol (2004) 1.12
Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT. Trends Immunol (2007) 1.10
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proc Natl Acad Sci U S A (2009) 1.09
NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone. Nucleic Acids Res (2005) 1.06
Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules. Proc Natl Acad Sci U S A (2013) 1.05