Published in Cell on February 08, 2002
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
The life and miracles of kinetochores. EMBO J (2009) 4.59
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science (2009) 4.10
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev (2003) 3.51
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol (2010) 3.50
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell (2010) 3.44
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
Chromosomal passengers: the four-dimensional regulation of mitotic events. Chromosoma (2004) 2.94
The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature (2010) 2.90
Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends Cell Biol (2010) 2.88
Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes Dev (2002) 2.77
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J (2003) 2.70
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J Cell Biol (2004) 2.55
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell (2004) 2.51
Kinetochore localization of spindle checkpoint proteins: who controls whom? Mol Biol Cell (2004) 2.50
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal (2011) 2.33
A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J (2005) 2.28
Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles. J Cell Biol (2007) 2.22
Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling. EMBO J (2009) 2.13
Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p. Mol Biol Cell (2003) 2.13
Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast. J Cell Biol (2002) 2.08
Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. Genes Dev (2007) 2.06
Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal. J Cell Sci (2010) 2.05
The enhancement of pericentromeric cohesin association by conserved kinetochore components promotes high-fidelity chromosome segregation and is sensitive to microtubule-based tension. Genes Dev (2007) 2.04
Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex. Cell (2007) 2.00
Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell (2010) 2.00
The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast. EMBO J (2005) 1.99
The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly. J Cell Biol (2003) 1.99
Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B. J Cell Biol (2010) 1.94
Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle. Biophys J (2003) 1.93
Aurora kinase inhibitors--rising stars in cancer therapeutics? Mol Cancer Ther (2010) 1.91
Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol (2008) 1.91
Merotelic kinetochores in mammalian tissue cells. Philos Trans R Soc Lond B Biol Sci (2005) 1.90
Age-associated increase in aneuploidy and changes in gene expression in mouse eggs. Dev Biol (2008) 1.85
Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Curr Opin Cell Biol (2009) 1.83
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep (2006) 1.82
Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset. Curr Biol (2010) 1.82
Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. J Cell Biol (2007) 1.82
Kinetochore geometry defined by cohesion within the centromere. Nature (2009) 1.80
Kinetochore-microtubule interactions: the means to the end. Curr Opin Cell Biol (2008) 1.80
Cell division and cell survival in the absence of survivin. Proc Natl Acad Sci U S A (2004) 1.79
A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Cell (2006) 1.79
Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis. J Cell Sci (2011) 1.79
Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle. Mol Biol Cell (2003) 1.78
Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol (2009) 1.73
Kinetochore microtubule interaction during S phase in Saccharomyces cerevisiae. Genes Dev (2007) 1.72
Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast. EMBO J (2002) 1.70
Mps1 kinase promotes sister-kinetochore bi-orientation by a tension-dependent mechanism. Curr Biol (2007) 1.68
Spindle assembly checkpoint: the third decade. Philos Trans R Soc Lond B Biol Sci (2011) 1.68
An overview of Cdk1-controlled targets and processes. Cell Div (2010) 1.66
The kinetochore. Cold Spring Harb Perspect Biol (2014) 1.64
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. EMBO J (2011) 1.62
Protein phosphatase 1 regulates exit from the spindle checkpoint in budding yeast. Curr Biol (2009) 1.61
Merotelic kinetochore attachment: causes and effects. Trends Cell Biol (2011) 1.60
The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation. Chromosome Res (2004) 1.60
Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B. J Cell Biol (2002) 1.60
Geometry and force behind kinetochore orientation: lessons from meiosis. Nat Rev Mol Cell Biol (2012) 1.55
Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cells. EMBO J (2006) 1.55
CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. J Cell Biol (2003) 1.52
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proc Natl Acad Sci U S A (2004) 1.51
Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol (2006) 1.50
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. PLoS One (2010) 1.50
S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase. Cell (2013) 1.49
Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell (2003) 1.48
MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation. Bioessays (2015) 1.47
Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Genes Dev (2007) 1.45
Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity. Genes Dev (2004) 1.41
Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association. Mol Cell Biol (2005) 1.41
Feedback control in sensing chromosome biorientation by the Aurora B kinase. Curr Biol (2011) 1.40
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation. Chromosoma (2013) 1.39
Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres. Genes Dev (2010) 1.38
Aurora controls sister kinetochore mono-orientation and homolog bi-orientation in meiosis-I. EMBO J (2007) 1.38
The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation? J Cell Biol (2002) 1.38
Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr Biol (2003) 1.37
Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis. PLoS Genet (2007) 1.37
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol (2012) 1.36
Structural organization of the kinetochore-microtubule interface. Curr Opin Cell Biol (2011) 1.36
The kinetochore protein Ndc10p is required for spindle stability and cytokinesis in yeast. Proc Natl Acad Sci U S A (2005) 1.34
Cell division: control of the chromosomal passenger complex in time and space. Chromosoma (2013) 1.34
The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol (2012) 1.33
A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. EMBO J (2006) 1.33
Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres. Mol Biol Cell (2006) 1.33
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores. J Cell Biol (2005) 1.32
Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis. Mol Biol Cell (2007) 1.32
Pericentromeric sister chromatid cohesion promotes kinetochore biorientation. Mol Biol Cell (2009) 1.31
Kinetochore-microtubule interactions: steps towards bi-orientation. EMBO J (2010) 1.30
Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway. Curr Biol (2015) 1.28
Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One (2009) 1.27
Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. EMBO J (2003) 1.27
Biophysics of mitosis. Q Rev Biophys (2012) 1.26
Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Nat Cell Biol (2012) 1.25
The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments. Mol Biol Cell (2008) 1.24
Tension sensing by Aurora B kinase is independent of survivin-based centromere localization. Nature (2013) 1.24
INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol (2009) 1.23
A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes. Yeast (2004) 9.02
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
Molecular architecture of SMC proteins and the yeast cohesin complex. Mol Cell (2002) 5.36
Un ménage à quatre: the molecular biology of chromosome segregation in meiosis. Cell (2003) 4.82
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69
Chromosomal cohesin forms a ring. Cell (2003) 4.38
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature (2006) 3.81
The cohesin ring concatenates sister DNA molecules. Nature (2008) 3.58
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 3.38
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol (2005) 3.33
Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity. Mol Cell (2009) 3.33
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr Biol (2003) 3.31
Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I. Nat Cell Biol (2003) 2.94
Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14. Science (2003) 2.88
Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons. Dev Cell (2008) 2.82
Structure and stability of cohesin's Smc1-kleisin interaction. Mol Cell (2004) 2.81
Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1. Cell (2006) 2.70
ATP hydrolysis is required for cohesin's association with chromosomes. Curr Biol (2003) 2.69
Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation. EMBO J (2002) 2.68
Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle. Nature (2004) 2.64
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains. Mol Cell (2006) 2.61
Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge. Cell (2006) 2.58
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58
A topological interaction between cohesin rings and a circular minichromosome. Cell (2005) 2.35
CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites. J Cell Biol (2008) 2.31
Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II. Curr Biol (2004) 2.28
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
An Smc3 acetylation cycle is essential for establishment of sister chromatid cohesion. Mol Cell (2010) 2.23
Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell (2003) 2.17
Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science (2004) 2.14
Cdc14-regulated midzone assembly controls anaphase B. J Cell Biol (2007) 2.09
Directional switching of the kinesin Cin8 through motor coupling. Science (2011) 2.06
Tandem fluorescent protein timers for in vivo analysis of protein dynamics. Nat Biotechnol (2012) 2.06
Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol (2006) 2.04
Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr Biol (2002) 2.04
Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc Natl Acad Sci U S A (2007) 2.04
Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev (2010) 2.04
Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Cell (2006) 1.96
Maintenance of cohesin at centromeres after meiosis I in budding yeast requires a kinetochore-associated protein related to MEI-S332. Curr Biol (2004) 1.93
Cohesin's concatenation of sister DNAs maintains their intertwining. Mol Cell (2011) 1.91
A targeted multienzyme mechanism for selective microtubule polyglutamylation. Mol Cell (2007) 1.90
A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. Curr Biol (2010) 1.86
Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. Mol Cell (2003) 1.85
Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions. EMBO J (2003) 1.83
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol (2006) 1.80
A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell (2010) 1.77
Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast. Curr Biol (2005) 1.76
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint. Curr Biol (2009) 1.76
Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation. Cell (2012) 1.75
Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. Nat Cell Biol (2010) 1.74
Structure and function of the PP2A-shugoshin interaction. Mol Cell (2009) 1.66
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat Cell Biol (2010) 1.64
Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery. Nat Cell Biol (2004) 1.63
Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis. Dev Cell (2010) 1.61
Building and breaking bridges between sister chromatids. Bioessays (2003) 1.61
Phosphorylation-dependent protein interactions at the spindle midzone mediate cell cycle regulation of spindle elongation. Dev Cell (2009) 1.58
Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci (2010) 1.58
Regulation of the Bfa1p-Bub2p complex at spindle pole bodies by the cell cycle phosphatase Cdc14p. J Cell Biol (2002) 1.58
The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network. PLoS Genet (2013) 1.56
Kinetochore capture and bi-orientation on the mitotic spindle. Nat Rev Mol Cell Biol (2005) 1.56
Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. J Cell Sci (2004) 1.51
Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis. J Cell Biol (2012) 1.51
A role for cell polarity proteins in mitotic exit. EMBO J (2002) 1.51
Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification. Mol Microbiol (2003) 1.50
Kin4 kinase delays mitotic exit in response to spindle alignment defects. Mol Cell (2005) 1.49
Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. J Cell Biol (2010) 1.49
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19. Dev Cell (2003) 1.48
The CENP-A chaperone Scm3 becomes enriched at kinetochores in anaphase independently of CENP-A incorporation. Cell Cycle (2011) 1.47
Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Genes Dev (2007) 1.45
Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J Cell Biol (2010) 1.44
Breaking the ties that bind: new advances in centrosome biology. J Cell Biol (2012) 1.41
The XMAP215 homologue Stu2 at yeast spindle pole bodies regulates microtubule dynamics and anchorage. EMBO J (2003) 1.39
The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal. J Cell Biol (2007) 1.39
A physical assay for sister chromatid cohesion in vitro. Mol Cell (2007) 1.35
Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev (2004) 1.34
The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation. Curr Biol (2007) 1.33
Spo13 facilitates monopolin recruitment to kinetochores and regulates maintenance of centromeric cohesion during yeast meiosis. Curr Biol (2004) 1.33
TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia. Dev Cell (2009) 1.32
Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit. Curr Biol (2006) 1.32
Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nat Protoc (2007) 1.32
Control of Shugoshin function during fission-yeast meiosis. Curr Biol (2005) 1.31
High-throughput knockout screen in fission yeast. Nat Protoc (2006) 1.30
Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell (2009) 1.28
Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. EMBO J (2003) 1.27
Polyglutamylation is a post-translational modification with a broad range of substrates. J Biol Chem (2007) 1.26
Mutual regulation of cyclin-dependent kinase and the mitotic exit network. J Cell Biol (2010) 1.25
Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I. J Cell Sci (2009) 1.24
Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction. Curr Biol (2011) 1.22
Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Nat Cell Biol (2008) 1.21
Structural basis of tubulin tyrosination by tubulin tyrosine ligase. J Cell Biol (2013) 1.21
Cohesin cleavage is insufficient for centriole disengagement in Drosophila. Curr Biol (2013) 1.21