Published in Science on October 28, 2011
Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science (2012) 2.98
Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol (2015) 1.66
Hidden dynamics in the unfolding of individual bacteriorhodopsin proteins. Science (2017) 1.39
Markov state models of biomolecular conformational dynamics. Curr Opin Struct Biol (2014) 1.28
Slow unfolded-state structuring in Acyl-CoA binding protein folding revealed by simulation and experiment. J Am Chem Soc (2012) 1.19
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Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism. Nat Commun (2013) 1.15
Reconstructing folding energy landscapes by single-molecule force spectroscopy. Annu Rev Biophys (2014) 1.12
From mechanical folding trajectories to intrinsic energy landscapes of biopolymers. Proc Natl Acad Sci U S A (2013) 1.10
Direct observation of multiple misfolding pathways in a single prion protein molecule. Proc Natl Acad Sci U S A (2012) 1.08
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Calcium-dependent folding of single calmodulin molecules. Proc Natl Acad Sci U S A (2012) 0.98
Single-molecule observation of helix staggering, sliding, and coiled coil misfolding. Proc Natl Acad Sci U S A (2012) 0.98
Complex RNA folding kinetics revealed by single-molecule FRET and hidden Markov models. J Am Chem Soc (2014) 0.97
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Optical trapping of individual human immunodeficiency viruses in culture fluid reveals heterogeneity with single-molecule resolution. Nat Nanotechnol (2014) 0.92
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Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy. Proc Natl Acad Sci U S A (2013) 0.91
Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge. Curr Opin Struct Biol (2014) 0.91
Propensity to form amyloid fibrils is encoded as excitations in the free energy landscape of monomeric proteins. J Mol Biol (2014) 0.90
Shedding light on protein folding landscapes by single-molecule fluorescence. Chem Soc Rev (2014) 0.89
Interrogating biology with force: single molecule high-resolution measurements with optical tweezers. Biophys J (2013) 0.87
Interaction Networks in Protein Folding via Atomic-Resolution Experiments and Long-Time-Scale Molecular Dynamics Simulations. J Am Chem Soc (2015) 0.87
Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape. Proc Natl Acad Sci U S A (2015) 0.87
A transformation for the mechanical fingerprints of complex biomolecular interactions. Proc Natl Acad Sci U S A (2013) 0.86
The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function. Proc Natl Acad Sci U S A (2014) 0.85
Adaptable hydrogel networks with reversible linkages for tissue engineering. Adv Mater (2015) 0.85
Energy landscape views for interplays among folding, binding, and allostery of calmodulin domains. Proc Natl Acad Sci U S A (2014) 0.84
Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition. Proc Natl Acad Sci U S A (2015) 0.84
Protein folding and unfolding under force. Biopolymers (2013) 0.84
Single-Molecule Chemo-Mechanical Spectroscopy Provides Structural Identity of Folding Intermediates. Biophys J (2016) 0.84
Force-induced remodelling of proteins and their complexes. Curr Opin Struct Biol (2015) 0.83
Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments. Proc Natl Acad Sci U S A (2016) 0.83
Calmodulin transduces Ca2+ oscillations into differential regulation of its target proteins. ACS Chem Neurosci (2013) 0.83
Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly. Proc Natl Acad Sci U S A (2012) 0.83
Mapping the energy landscape for second-stage folding of a single membrane protein. Nat Chem Biol (2015) 0.82
Single-molecule force spectroscopy reveals force-enhanced binding of calcium ions by gelsolin. Nat Commun (2014) 0.82
Structure-Based Derivation of Protein Folding Intermediates and Energies from Optical Tweezers. Biophys J (2016) 0.82
Ca2+ binding enhanced mechanical stability of an archaeal crystallin. PLoS One (2014) 0.81
Diverse metastable structures formed by small oligomers of α-synuclein probed by force spectroscopy. PLoS One (2014) 0.81
Mechanisms of cellular proteostasis: insights from single-molecule approaches. Annu Rev Biophys (2014) 0.81
Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1. Proc Natl Acad Sci U S A (2014) 0.80
Atomic force microscopy with sub-picoNewton force stability for biological applications. Methods (2013) 0.80
High-resolution optical tweezers for single-molecule manipulation. Yale J Biol Med (2013) 0.80
Biochemistry. How proteins fold. Science (2011) 0.80
Forced protein unfolding leads to highly elastic and tough protein hydrogels. Nat Commun (2013) 0.80
Optimizing 1-μs-Resolution Single-Molecule Force Spectroscopy on a Commercial Atomic Force Microscope. Nano Lett (2015) 0.79
Tandem Spinach Array for mRNA Imaging in Living Bacterial Cells. Sci Rep (2015) 0.79
Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and Dynamics. PLoS Comput Biol (2016) 0.78
Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin. Proc Natl Acad Sci U S A (2014) 0.78
Weak temporal signals can synchronize and accelerate the transition dynamics of biopolymers under tension. Proc Natl Acad Sci U S A (2012) 0.78
Chaperones rescue luciferase folding by separating its domains. J Biol Chem (2014) 0.77
Alternative pathways for association and dissociation of the calmodulin-binding domain of plasma membrane Ca(2+)-ATPase isoform 4b (PMCA4b). J Biol Chem (2012) 0.77
Spectral Rate Theory for Two-State Kinetics. Phys Rev X (2014) 0.77
Hidden Markov Modeling with Detailed Balance and Its Application to Single Protein Folding. Biophys J (2016) 0.77
Knotting and unknotting of a protein in single molecule experiments. Proc Natl Acad Sci U S A (2016) 0.77
Meandering Down the Energy Landscape of Protein Folding: Are We There Yet? Biophys J (2016) 0.76
Subnanometre enzyme mechanics probed by single-molecule force spectroscopy. Nat Commun (2016) 0.76
α-Actinin/titin interaction: A dynamic and mechanically stable cluster of bonds in the muscle Z-disk. Proc Natl Acad Sci U S A (2017) 0.75
Understanding the physics of DNA using nanoscale single-molecule manipulation. Front Phys (2012) 0.75
When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches. Biochem J (2016) 0.75
How cooperative are protein folding and unfolding transitions? Protein Sci (2016) 0.75
Ligand-induced changes of the apparent transition-state position in mechanical protein unfolding. Biophys J (2015) 0.75
Decoding Single Molecule Time Traces with Dynamic Disorder. PLoS Comput Biol (2016) 0.75
Variation in the mechanical unfolding pathway of p53DBD induced by interaction with p53 N-terminal region or DNA. PLoS One (2012) 0.75
Exact solution of the Zwanzig-Lauritzen model of polymer crystallization under tension. J Chem Phys (2013) 0.75
Arabidopsis CaM1 and CaM4 Promote Nitric Oxide Production and Salt Resistance by Inhibiting S-Nitrosoglutathione Reductase via Direct Binding. PLoS Genet (2016) 0.75
Single-molecule folding mechanisms of the apo- and Mg(2+)-bound states of human neuronal calcium sensor-1. Biophys J (2015) 0.75
Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein. Nat Commun (2016) 0.75
A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions. Biophys J (2016) 0.75
Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains? Curr Opin Struct Biol (2016) 0.75
Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein. J Biol Chem (2016) 0.75
Opposing Intermolecular Tuning of Ca(2+) Affinity for Calmodulin by Neurogranin and CaMKII Peptides. Biophys J (2017) 0.75
Conformational dynamics of the frameshift stimulatory structure in HIV-1. RNA (2017) 0.75
Exploring the energy landscape of GFP by single-molecule mechanical experiments. Proc Natl Acad Sci U S A (2004) 2.65
The myosin coiled-coil is a truly elastic protein structure. Nat Mater (2002) 2.38
Can tyrosine kinase inhibitors be discontinued in patients with metastatic renal cell carcinoma and a complete response to treatment? A multicentre, retrospective analysis. Eur Urol (2008) 2.29
Single-molecule folding. Curr Opin Struct Biol (2003) 2.28
Anisotropic deformation response of single protein molecules. Proc Natl Acad Sci U S A (2006) 2.28
A mechanical unfolding intermediate in an actin-crosslinking protein. Nat Struct Mol Biol (2003) 2.12
Ligand-dependent equilibrium fluctuations of single calmodulin molecules. Science (2009) 2.05
Force-dependent stepping kinetics of myosin-V. Biophys J (2005) 1.88
Full distance-resolved folding energy landscape of one single protein molecule. Proc Natl Acad Sci U S A (2010) 1.85
Myosin-V is a mechanical ratchet. Proc Natl Acad Sci U S A (2006) 1.83
Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations. Proc Natl Acad Sci U S A (2007) 1.74
Protein structure by mechanical triangulation. Proc Natl Acad Sci U S A (2006) 1.65
Temperature softening of a protein in single-molecule experiments. J Mol Biol (2005) 1.59
Single-molecule unfolding force distributions reveal a funnel-shaped energy landscape. Biophys J (2005) 1.58
Comparison of non-gated vs. electrocardiogram-gated 64-detector-row computed tomography for integrated electroanatomic mapping in patients undergoing pulmonary vein isolation. Europace (2010) 1.50
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A (2009) 1.40
Direct observation of active protein folding using lock-in force spectroscopy. Biophys J (2007) 1.32
The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments. EMBO Rep (2005) 1.21
Dynamic force sensing of filamin revealed in single-molecule experiments. Proc Natl Acad Sci U S A (2012) 1.17
From mechanical folding trajectories to intrinsic energy landscapes of biopolymers. Proc Natl Acad Sci U S A (2013) 1.10
Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy. Proc Natl Acad Sci U S A (2013) 1.09
Highly stretched single polymers: atomic-force-microscope experiments versus ab-initio theory. Phys Rev Lett (2005) 1.08
Mechanical unfoldons as building blocks of maltose-binding protein. J Mol Biol (2008) 1.08
Tightening the knot in phytochrome by single-molecule atomic force microscopy. Biophys J (2009) 1.06
Single-molecule dynamics of mechanical coiled-coil unzipping. Langmuir (2007) 1.04
Elastic bond network model for protein unfolding mechanics. Phys Rev Lett (2008) 1.03
Force as a single molecule probe of multidimensional protein energy landscapes. Curr Opin Struct Biol (2012) 1.03
Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner. Proc Natl Acad Sci U S A (2010) 1.01
Torque generation of kinesin motors is governed by the stability of the neck domain. Mol Cell (2012) 1.01
Myosin V stepping mechanism. Proc Natl Acad Sci U S A (2007) 1.01
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Calcium-dependent folding of single calmodulin molecules. Proc Natl Acad Sci U S A (2012) 0.98
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96
Auto- and cross-power spectral analysis of dual trap optical tweezer experiments using Bayesian inference. Rev Sci Instrum (2012) 0.96
Hidden Markov analysis of trajectories in single-molecule experiments and the effects of missed events. Chemphyschem (2012) 0.96
Cysteine engineering of polyproteins for single-molecule force spectroscopy. Nat Protoc (2006) 0.96
Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex. Proc Natl Acad Sci U S A (2010) 0.95
Ligand binding mechanics of maltose binding protein. J Mol Biol (2009) 0.95
Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice. Diabetes (2002) 0.95
Rigid DNA beams for high-resolution single-molecule mechanics. Angew Chem Int Ed Engl (2013) 0.94
Reduction of claustrophobia during magnetic resonance imaging: methods and design of the "CLAUSTRO" randomized controlled trial. BMC Med Imaging (2011) 0.94
Single molecule mechanics of the kinesin neck. Proc Natl Acad Sci U S A (2009) 0.94
Complex unfolding kinetics of single-domain proteins in the presence of force. Biophys J (2010) 0.94
Covalent immobilization of recombinant fusion proteins with hAGT for single molecule force spectroscopy. Eur Biophys J (2005) 0.93
Gadofosveset trisodium-enhanced magnetic resonance angiography of the left atrium--a feasibility study. Eur J Radiol (2009) 0.93
Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy. Proc Natl Acad Sci U S A (2013) 0.91
Flexibility of the neck domain enhances Kinesin-1 motility under load. Biophys J (2006) 0.90
Reduction of claustrophobia with short-bore versus open magnetic resonance imaging: a randomized controlled trial. PLoS One (2011) 0.89
Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin. Proc Natl Acad Sci U S A (2011) 0.89
Structural and mechanical hierarchies in the alpha-crystallin domain dimer of the hyperthermophilic small heat shock protein Hsp16.5. J Mol Biol (2010) 0.89
High spatial resolution T1-weighted MR imaging of liver and biliary tract during uptake phase of a hepatocyte-specific contrast medium. Invest Radiol (2008) 0.88
Single-molecule protein unfolding and refolding using atomic force microscopy. Methods Mol Biol (2011) 0.87
Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium. J Biol Chem (2006) 0.87
Biochemistry. Force signaling in biology. Science (2009) 0.85
Surprising simplicity in the single-molecule folding mechanics of proteins. Angew Chem Int Ed Engl (2009) 0.85
Direct evidence of the multidimensionality of the free-energy landscapes of proteins revealed by mechanical probes. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.85
DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study. Eur Radiol (2012) 0.84
Navigating the folding energy landscape of green fluorescent protein. Angew Chem Int Ed Engl (2008) 0.84
Single-molecule force spectroscopy distinguishes target binding modes of calmodulin. Proc Natl Acad Sci U S A (2009) 0.83
Subunit Interactions and cooperativity in the microtubule-severing AAA ATPase spastin. J Biol Chem (2012) 0.82
Whole-heart coronary magnetic resonance angiography at 1.5 Tesla: does a blood-pool contrast agent improve diagnostic accuracy? Invest Radiol (2011) 0.81
Evidence for a broad transition-state ensemble in calmodulin folding from single-molecule force spectroscopy. Angew Chem Int Ed Engl (2010) 0.81
The lever arm effects a mechanical asymmetry of the myosin-V-actin bond. Biophys J (2010) 0.81
Whole-body MRI with assessment of hepatic and extraabdominal enhancement after administration of gadoxetic acid for staging of rectal carcinoma. Acta Radiol (2010) 0.80
Dissection of kinesin's processivity. PLoS One (2009) 0.80
Designing the folding mechanics of coiled coils. Chemphyschem (2009) 0.80
Intra-arterial ultra low iodine CT angiography of renal transplant arteries. Cardiovasc Intervent Radiol (2014) 0.79
Mechanical stability of the antibody domain CH3 homodimer in different oxidation states. J Am Chem Soc (2013) 0.78
Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin. Proc Natl Acad Sci U S A (2014) 0.78
Reply to "Convergence of chromatin binding estimates in live cells". Nat Methods (2013) 0.76
A new manganese-based oral contrast agent (CMC-001) for liver MRI: pharmacological and pharmaceutical aspects. Acta Radiol (2012) 0.75
Contrast agent bolus tracking with a fixed threshold or a manual fast start for coronary CT angiography. Eur Radiol (2014) 0.75