Protein structure by mechanical triangulation.

Anisotropic deformation response of single protein molecules. Proc Natl Acad Sci U S A (2006) 2.28

Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Biophys J (2006) 1.82

The folding cooperativity of a protein is controlled by its chain topology. Nature (2010) 1.76

Single-molecule tracking of mRNA exiting from RNA polymerase II. Proc Natl Acad Sci U S A (2007) 1.59

The ribosome modulates nascent protein folding. Science (2011) 1.51

The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A (2009) 1.40

Parallel force assay for protein-protein interactions. PLoS One (2014) 1.39

Mechanical biochemistry of proteins one molecule at a time. J Biol Chem (2008) 1.33

Protein-DNA chimeras for single molecule mechanical folding studies with the optical tweezers. Eur Biophys J (2008) 1.29

Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc Natl Acad Sci U S A (2008) 1.14

Selection of optimal variants of Gō-like models of proteins through studies of stretching. Biophys J (2008) 1.10

Tightening the knot in phytochrome by single-molecule atomic force microscopy. Biophys J (2009) 1.06

Nanoimaging for protein misfolding and related diseases. J Cell Biochem (2006) 1.05

Single-molecule dissection of the high-affinity cohesin-dockerin complex. Proc Natl Acad Sci U S A (2012) 1.04

Mechanical strength of 17,134 model proteins and cysteine slipknots. PLoS Comput Biol (2009) 1.01

Toward a molecular understanding of the anisotropic response of proteins to external forces: insights from elastic network models. Biophys J (2008) 0.99

Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface. Biophys J (2014) 0.99

Axis-dependent anisotropy in protein unfolding from integrated nonequilibrium single-molecule experiments, analysis, and simulation. Proc Natl Acad Sci U S A (2007) 0.98

Protein stabilization in a highly knotted protein polymer. Protein Eng Des Sel (2011) 0.98

Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96

Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions. Nucleic Acids Res (2013) 0.96

Single-molecule detection of structural changes during Per-Arnt-Sim (PAS) domain activation. Proc Natl Acad Sci U S A (2006) 0.93

From genes to protein mechanics on a chip. Nat Methods (2014) 0.87

Mechanical unfolding of acylphosphatase studied by single-molecule force spectroscopy and MD simulations. Biophys J (2010) 0.87

Predicting the order in which contacts are broken during single molecule protein stretching experiments. Proteins (2008) 0.83

Nanomechanical properties of human prion protein amyloid as probed by force spectroscopy. Biophys J (2008) 0.82

The c2 domains of human synaptotagmin 1 have distinct mechanical properties. Biophys J (2009) 0.82

Investigating receptor-ligand systems of the cellulosome with AFM-based single-molecule force spectroscopy. J Vis Exp (2013) 0.81

Tracking unfolding and refolding reactions of single proteins using atomic force microscopy methods. Methods (2013) 0.80

DNA tape measurements of AraC. Nucleic Acids Res (2007) 0.79

pHLIP Peptide Interaction with a Membrane Monitored by SAXS. J Phys Chem B (2016) 0.78

Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy. Nat Commun (2015) 0.78

Sequence-resolved free energy profiles of stress-bearing vimentin intermediate filaments. Proc Natl Acad Sci U S A (2014) 0.77

Knotting and unknotting of a protein in single molecule experiments. Proc Natl Acad Sci U S A (2016) 0.77

Chaperones rescue luciferase folding by separating its domains. J Biol Chem (2014) 0.77

Modular, Nondegenerate Polyprotein Scaffolds for Atomic Force Spectroscopy. Biomacromolecules (2016) 0.76

Self-assembly of the full-length amyloid Aβ42 protein in dimers. Nanoscale (2016) 0.75

Competing Pathways and Multiple Folding Nuclei in a Large Multidomain Protein, Luciferase. Biophys J (2017) 0.75

Kinetic Ductility and Force-Spike Resistance of Proteins from Single-Molecule Force Spectroscopy. Biophys J (2016) 0.75

Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein. J Biol Chem (2016) 0.75

Uncovering the forces between nucleosomes using DNA origami. Sci Adv (2016) 0.75

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science (2000) 28.25

Reversible unfolding of individual titin immunoglobulin domains by AFM. Science (1997) 19.62

Entropic elasticity of lambda-phage DNA. Science (1994) 15.40

Mechanical unfolding intermediates in titin modules. Nature (1999) 6.12

Identifying conformational changes with site-directed spin labeling. Nat Struct Biol (2000) 5.76

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein. Proc Natl Acad Sci U S A (1997) 4.99

The mechanical stability of ubiquitin is linkage dependent. Nat Struct Biol (2003) 4.66

Single-molecule fluorescence resonance energy transfer. Methods (2001) 4.58

Structural insights into a yeast prion illuminate nucleation and strain diversity. Nature (2005) 3.86

How soft is a protein? A protein dynamics force constant measured by neutron scattering. Science (2000) 3.62

Green fluorescent protein (GFP): applications, structure, and related photophysical behavior. Chem Rev (2002) 3.46

Pulling geometry defines the mechanical resistance of a beta-sheet protein. Nat Struct Biol (2003) 3.21

Immunoglobulin-like modules from titin I-band: extensible components of muscle elasticity. Structure (1996) 2.97

The mechanical stability of immunoglobulin and fibronectin III domains in the muscle protein titin measured by atomic force microscopy. Biophys J (1998) 2.90

Exploring the energy landscape of GFP by single-molecule mechanical experiments. Proc Natl Acad Sci U S A (2004) 2.65

The state of the prion. Nat Rev Microbiol (2004) 2.60

Protein dynamics from NMR. Nat Struct Biol (2000) 2.52

Changes in biomolecular conformation seen by small angle X-ray scattering. Chem Rev (2001) 2.48

Atomic force microscopy captures length phenotypes in single proteins. Proc Natl Acad Sci U S A (1999) 2.28

Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme. Proc Natl Acad Sci U S A (2000) 2.25

Stretching single molecules into novel conformations using the atomic force microscope. Nat Struct Biol (2000) 2.21

A mechanical unfolding intermediate in an actin-crosslinking protein. Nat Struct Mol Biol (2003) 2.12

Cryo-electron tomography reveals the cytoskeletal structure of Spiroplasma melliferum. Science (2005) 1.72

Temperature softening of a protein in single-molecule experiments. J Mol Biol (2005) 1.59

NMR spectroscopy of large molecules and multimolecular assemblies in solution. Curr Opin Struct Biol (1999) 1.33

Molecular structure of the rod domain of dictyostelium filamin. J Mol Biol (2004) 1.12

Recent developments in structural proteomics for protein structure determination. Proteomics (2005) 1.08

Finding a protein's Achilles heel. Nat Struct Biol (2003) 0.99

Molecular architecture of the rod domain of the Dictyostelium gelation factor (ABP120). J Mol Biol (1999) 0.97

Exploring the energy landscape of GFP by single-molecule mechanical experiments. Proc Natl Acad Sci U S A (2004) 2.65

The myosin coiled-coil is a truly elastic protein structure. Nat Mater (2002) 2.38

The complex folding network of single calmodulin molecules. Science (2011) 2.37

Can tyrosine kinase inhibitors be discontinued in patients with metastatic renal cell carcinoma and a complete response to treatment? A multicentre, retrospective analysis. Eur Urol (2008) 2.29

Single-molecule folding. Curr Opin Struct Biol (2003) 2.28

Anisotropic deformation response of single protein molecules. Proc Natl Acad Sci U S A (2006) 2.28

A mechanical unfolding intermediate in an actin-crosslinking protein. Nat Struct Mol Biol (2003) 2.12

Ligand-dependent equilibrium fluctuations of single calmodulin molecules. Science (2009) 2.05

Force-dependent stepping kinetics of myosin-V. Biophys J (2005) 1.88

Full distance-resolved folding energy landscape of one single protein molecule. Proc Natl Acad Sci U S A (2010) 1.85

Myosin-V is a mechanical ratchet. Proc Natl Acad Sci U S A (2006) 1.83

Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations. Proc Natl Acad Sci U S A (2007) 1.74

Temperature softening of a protein in single-molecule experiments. J Mol Biol (2005) 1.59

Single-molecule unfolding force distributions reveal a funnel-shaped energy landscape. Biophys J (2005) 1.58

Comparison of non-gated vs. electrocardiogram-gated 64-detector-row computed tomography for integrated electroanatomic mapping in patients undergoing pulmonary vein isolation. Europace (2010) 1.50

The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A (2009) 1.40

Direct observation of active protein folding using lock-in force spectroscopy. Biophys J (2007) 1.32

The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments. EMBO Rep (2005) 1.21

Dynamic force sensing of filamin revealed in single-molecule experiments. Proc Natl Acad Sci U S A (2012) 1.17

From mechanical folding trajectories to intrinsic energy landscapes of biopolymers. Proc Natl Acad Sci U S A (2013) 1.10

Mechanical unfoldons as building blocks of maltose-binding protein. J Mol Biol (2008) 1.08

Highly stretched single polymers: atomic-force-microscope experiments versus ab-initio theory. Phys Rev Lett (2005) 1.08

Tightening the knot in phytochrome by single-molecule atomic force microscopy. Biophys J (2009) 1.06

Single-molecule dynamics of mechanical coiled-coil unzipping. Langmuir (2007) 1.04

Elastic bond network model for protein unfolding mechanics. Phys Rev Lett (2008) 1.03

Force as a single molecule probe of multidimensional protein energy landscapes. Curr Opin Struct Biol (2012) 1.03

Myosin V stepping mechanism. Proc Natl Acad Sci U S A (2007) 1.01

Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner. Proc Natl Acad Sci U S A (2010) 1.01

Torque generation of kinesin motors is governed by the stability of the neck domain. Mol Cell (2012) 1.01

Single molecule unzipping of coiled coils: sequence resolved stability profiles. Phys Rev Lett (2006) 1.00

Calcium-dependent folding of single calmodulin molecules. Proc Natl Acad Sci U S A (2012) 0.98

Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96

Cysteine engineering of polyproteins for single-molecule force spectroscopy. Nat Protoc (2006) 0.96

Hidden Markov analysis of trajectories in single-molecule experiments and the effects of missed events. Chemphyschem (2012) 0.96

Auto- and cross-power spectral analysis of dual trap optical tweezer experiments using Bayesian inference. Rev Sci Instrum (2012) 0.96

Ligand binding mechanics of maltose binding protein. J Mol Biol (2009) 0.95

Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex. Proc Natl Acad Sci U S A (2010) 0.95

Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice. Diabetes (2002) 0.95

Rigid DNA beams for high-resolution single-molecule mechanics. Angew Chem Int Ed Engl (2013) 0.94

Reduction of claustrophobia during magnetic resonance imaging: methods and design of the "CLAUSTRO" randomized controlled trial. BMC Med Imaging (2011) 0.94

Complex unfolding kinetics of single-domain proteins in the presence of force. Biophys J (2010) 0.94

Single molecule mechanics of the kinesin neck. Proc Natl Acad Sci U S A (2009) 0.94

Covalent immobilization of recombinant fusion proteins with hAGT for single molecule force spectroscopy. Eur Biophys J (2005) 0.93

Gadofosveset trisodium-enhanced magnetic resonance angiography of the left atrium--a feasibility study. Eur J Radiol (2009) 0.93

Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy. Proc Natl Acad Sci U S A (2013) 0.91

Flexibility of the neck domain enhances Kinesin-1 motility under load. Biophys J (2006) 0.90

Reduction of claustrophobia with short-bore versus open magnetic resonance imaging: a randomized controlled trial. PLoS One (2011) 0.89

Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin. Proc Natl Acad Sci U S A (2011) 0.89

Structural and mechanical hierarchies in the alpha-crystallin domain dimer of the hyperthermophilic small heat shock protein Hsp16.5. J Mol Biol (2010) 0.89

High spatial resolution T1-weighted MR imaging of liver and biliary tract during uptake phase of a hepatocyte-specific contrast medium. Invest Radiol (2008) 0.88

Single-molecule protein unfolding and refolding using atomic force microscopy. Methods Mol Biol (2011) 0.87

Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium. J Biol Chem (2006) 0.87

Biochemistry. Force signaling in biology. Science (2009) 0.85

Direct evidence of the multidimensionality of the free-energy landscapes of proteins revealed by mechanical probes. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.85

Surprising simplicity in the single-molecule folding mechanics of proteins. Angew Chem Int Ed Engl (2009) 0.85

DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study. Eur Radiol (2012) 0.84

Navigating the folding energy landscape of green fluorescent protein. Angew Chem Int Ed Engl (2008) 0.84

Single-molecule force spectroscopy distinguishes target binding modes of calmodulin. Proc Natl Acad Sci U S A (2009) 0.83

The lever arm effects a mechanical asymmetry of the myosin-V-actin bond. Biophys J (2010) 0.81

Evidence for a broad transition-state ensemble in calmodulin folding from single-molecule force spectroscopy. Angew Chem Int Ed Engl (2010) 0.81

Whole-heart coronary magnetic resonance angiography at 1.5 Tesla: does a blood-pool contrast agent improve diagnostic accuracy? Invest Radiol (2011) 0.81

Dissection of kinesin's processivity. PLoS One (2009) 0.80

Whole-body MRI with assessment of hepatic and extraabdominal enhancement after administration of gadoxetic acid for staging of rectal carcinoma. Acta Radiol (2010) 0.80

Designing the folding mechanics of coiled coils. Chemphyschem (2009) 0.80

Intra-arterial ultra low iodine CT angiography of renal transplant arteries. Cardiovasc Intervent Radiol (2014) 0.79

Mechanical stability of the antibody domain CH3 homodimer in different oxidation states. J Am Chem Soc (2013) 0.78

Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin. Proc Natl Acad Sci U S A (2014) 0.78

A new manganese-based oral contrast agent (CMC-001) for liver MRI: pharmacological and pharmaceutical aspects. Acta Radiol (2012) 0.75

Contrast agent bolus tracking with a fixed threshold or a manual fast start for coronary CT angiography. Eur Radiol (2014) 0.75