Myosin-V is a mechanical ratchet.

Force-induced bidirectional stepping of cytoplasmic dynein. Cell (2007) 3.31

Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell (2008) 3.02

LIS1 and NudE induce a persistent dynein force-producing state. Cell (2010) 2.88

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells. Nat Methods (2013) 2.22

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis. Nat Struct Mol Biol (2009) 2.03

Mechanical modulation of catalytic power on F1-ATPase. Nat Chem Biol (2011) 1.33

Motor number controls cargo switching at actin-microtubule intersections in vitro. Curr Biol (2010) 1.30

Direct observation of the myosin-Va power stroke and its reversal. Nat Struct Mol Biol (2010) 1.28

Load and Pi control flux through the branched kinetic cycle of myosin V. J Biol Chem (2008) 1.24

Robust transport by multiple motors with nonlinear force-velocity relations and stochastic load sharing. Phys Biol (2010) 1.17

Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle. Proc Natl Acad Sci U S A (2010) 1.17

Velocity, processivity, and individual steps of single myosin V molecules in live cells. Biophys J (2009) 1.15

Two modes of microtubule sliding driven by cytoplasmic dynein. Proc Natl Acad Sci U S A (2006) 1.13

Influence of lever structure on myosin 5a walking. Proc Natl Acad Sci U S A (2010) 1.05

Myosin V stepping mechanism. Proc Natl Acad Sci U S A (2007) 1.01

Heat shock protein 90's mechanochemical cycle is dominated by thermal fluctuations. Proc Natl Acad Sci U S A (2011) 1.00

Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI. Biophys J (2011) 1.00

Mechanochemical model for myosin V. Proc Natl Acad Sci U S A (2009) 0.97

Mechanoenzymes under superstall and large assisting loads reveal structural features. Proc Natl Acad Sci U S A (2007) 0.96

Dwell time symmetry in random walks and molecular motors. Biophys J (2007) 0.94

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains. Proc Natl Acad Sci U S A (2015) 0.93

Design principles governing the motility of myosin V. Proc Natl Acad Sci U S A (2013) 0.90

Direct correlation of DNA binding and single protein domain motion via dual illumination fluorescence microscopy. Nano Lett (2014) 0.90

Motor proteins and molecular motors: how to operate machines at the nanoscale. J Phys Condens Matter (2013) 0.87

Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments. Nat Nanotechnol (2015) 0.86

It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry. Commun Integr Biol (2013) 0.85

Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection. Traffic (2012) 0.85

Cytokinesis mechanics and mechanosensing. Cytoskeleton (Hoboken) (2012) 0.85

Insights into the mechanisms of myosin and kinesin molecular motors from the single-molecule unbinding force measurements. J R Soc Interface (2010) 0.84

Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET. EMBO J (2013) 0.84

Chemomechanical coupling and motor cycles of myosin V. Biophys J (2011) 0.84

Tuning myosin-driven sorting on cellular actin networks. Elife (2015) 0.82

Spontaneous detachment of the leading head contributes to myosin VI backward steps. PLoS One (2013) 0.81

The lever arm effects a mechanical asymmetry of the myosin-V-actin bond. Biophys J (2010) 0.81

Coordinated Mechanosensitivity of Membrane Rafts and Focal Adhesions. Cell Mol Bioeng (2012) 0.80

Kinetic Adaptations of Myosins for Their Diverse Cellular Functions. Traffic (2016) 0.79

Myosin V passing over Arp2/3 junctions: branching ratio calculated from the elastic lever arm model. Biophys J (2008) 0.77

Myosin's mechanical ratchet. Proc Natl Acad Sci U S A (2006) 0.76

The path to visualization of walking myosin V by high-speed atomic force microscopy. Biophys Rev (2014) 0.76

Capillary muscle. Proc Natl Acad Sci U S A (2015) 0.75

Embedding dual function into molecular motors through collective motion. Sci Rep (2017) 0.75

Quantifying the Assembly of Multicomponent Molecular Machines by Single-Molecule Total Internal Reflection Fluorescence Microscopy. Methods Enzymol (2016) 0.75

Phenomenological analysis of ATP dependence of motor proteins. PLoS One (2012) 0.75

Dwell time distributions of the molecular motor myosin V. PLoS One (2013) 0.75

Cargo Transport by Two Coupled Myosin Va Motors on Actin Filaments and Bundles. Biophys J (2016) 0.75

Engineering Circular Gliding of Actin Filaments Along Myosin-Patterned DNA Nanotube Rings To Study Long-Term Actin-Myosin Behaviors. ACS Nano (2016) 0.75

Bounds and phase diagram of efficiency at maximum power for tight-coupling molecular motors. Eur Phys J E Soft Matter (2013) 0.75

Models for the specific adhesion of cells to cells. Science (1978) 28.03

Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization. Science (2003) 20.21

Biological applications of optical forces. Annu Rev Biophys Biomol Struct (1994) 10.00

The way things move: looking under the hood of molecular motor proteins. Science (2000) 7.28

Myosin-V is a processive actin-based motor. Nature (1999) 7.13

Single kinesin molecules studied with a molecular force clamp. Nature (1999) 6.59

Identification of a factor in conventional muscle actin preparations which inhibits actin filament self-association. Biochem Biophys Res Commun (1980) 5.50

The gated gait of the processive molecular motor, myosin V. Nat Cell Biol (2002) 5.34

Brain myosin-V is a two-headed unconventional myosin with motor activity. Cell (1993) 5.24

Mechanics of the kinesin step. Nature (2005) 5.15

Myosin-V stepping kinetics: a molecular model for processivity. Proc Natl Acad Sci U S A (2000) 5.03

Kinesin hydrolyses one ATP per 8-nm step. Nature (1997) 4.57

The kinetic mechanism of myosin V. Proc Natl Acad Sci U S A (1999) 4.56

F1-ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps. Cell (1998) 4.47

Purification of muscle actin. Methods Cell Biol (1982) 3.87

Two-headed binding of a processive myosin to F-actin. Nature (2000) 3.73

Load-dependent kinetics of myosin-V can explain its high processivity. Nat Cell Biol (2005) 3.69

A structural state of the myosin V motor without bound nucleotide. Nature (2003) 3.63

Unconventional myosins in cell movement, membrane traffic, and signal transduction. Science (1998) 3.53

Mechanically driven ATP synthesis by F1-ATPase. Nature (2004) 3.45

Direct interaction of microtubule- and actin-based transport motors. Nature (1999) 3.25

Three myosin V structures delineate essential features of chemo-mechanical transduction. EMBO J (2004) 3.21

Fluctuation driven ratchets: Molecular motors. Phys Rev Lett (1994) 2.85

Direct observation of processive movement by individual myosin V molecules. Biochem Biophys Res Commun (2000) 2.83

Class V myosins. Biochim Biophys Acta (2000) 2.62

Chemomechanical coupling of the forward and backward steps of single kinesin molecules. Nat Cell Biol (2002) 2.56

A model of myosin V processivity. J Biol Chem (2004) 2.49

A force-dependent state controls the coordination of processive myosin V. Proc Natl Acad Sci U S A (2005) 2.39

Highly coupled ATP synthesis by F1-ATPase single molecules. Nature (2005) 2.32

The prepower stroke conformation of myosin V. J Cell Biol (2002) 2.12

Force generation in single conventional actomyosin complexes under high dynamic load. Biophys J (2005) 1.90

The kinetic mechanism of kinesin. Trends Biochem Sci (2004) 1.88

Force-dependent stepping kinetics of myosin-V. Biophys J (2005) 1.88

Rotation of F1-ATPase: how an ATP-driven molecular machine may work. Annu Rev Biophys Biomol Struct (2004) 1.83

Purification and assay of myosin V. Methods Enzymol (1998) 1.72

Myosin learns to walk. J Cell Sci (2001) 1.71

Myosin V motor proteins: marching stepwise towards a mechanism. J Cell Biol (2003) 1.63

Elastic lever-arm model for myosin V. Biophys J (2005) 1.62

Dynamic force spectroscopy of the digoxigenin-antibody complex. FEBS Lett (2005) 1.60

Single-molecule unfolding force distributions reveal a funnel-shaped energy landscape. Biophys J (2005) 1.58

Theory of mitotic spindle oscillations. Phys Rev Lett (2005) 1.55

Magnesium, ADP, and actin binding linkage of myosin V: evidence for multiple myosin V-ADP and actomyosin V-ADP states. Biochemistry (2005) 1.53

Magnesium regulates ADP dissociation from myosin V. J Biol Chem (2004) 1.42

N-ethylmaleimide-modified heavy meromyosin. A probe for actomyosin interactions. J Cell Biol (1979) 1.27

Rotary protein motors. Trends Cell Biol (2003) 1.22

Exploring the energy landscape of GFP by single-molecule mechanical experiments. Proc Natl Acad Sci U S A (2004) 2.65

The myosin coiled-coil is a truly elastic protein structure. Nat Mater (2002) 2.38

The complex folding network of single calmodulin molecules. Science (2011) 2.37

Can tyrosine kinase inhibitors be discontinued in patients with metastatic renal cell carcinoma and a complete response to treatment? A multicentre, retrospective analysis. Eur Urol (2008) 2.29

Single-molecule folding. Curr Opin Struct Biol (2003) 2.28

Anisotropic deformation response of single protein molecules. Proc Natl Acad Sci U S A (2006) 2.28

A mechanical unfolding intermediate in an actin-crosslinking protein. Nat Struct Mol Biol (2003) 2.12

Ligand-dependent equilibrium fluctuations of single calmodulin molecules. Science (2009) 2.05

Force-dependent stepping kinetics of myosin-V. Biophys J (2005) 1.88

Full distance-resolved folding energy landscape of one single protein molecule. Proc Natl Acad Sci U S A (2010) 1.85

Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations. Proc Natl Acad Sci U S A (2007) 1.74

Protein structure by mechanical triangulation. Proc Natl Acad Sci U S A (2006) 1.65

Temperature softening of a protein in single-molecule experiments. J Mol Biol (2005) 1.59

Single-molecule unfolding force distributions reveal a funnel-shaped energy landscape. Biophys J (2005) 1.58

Comparison of non-gated vs. electrocardiogram-gated 64-detector-row computed tomography for integrated electroanatomic mapping in patients undergoing pulmonary vein isolation. Europace (2010) 1.50

The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A (2009) 1.40

Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity. Hum Mol Genet (2008) 1.33

Direct observation of active protein folding using lock-in force spectroscopy. Biophys J (2007) 1.32

The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments. EMBO Rep (2005) 1.21

Dynamic force sensing of filamin revealed in single-molecule experiments. Proc Natl Acad Sci U S A (2012) 1.17

From mechanical folding trajectories to intrinsic energy landscapes of biopolymers. Proc Natl Acad Sci U S A (2013) 1.10

Mechanical unfoldons as building blocks of maltose-binding protein. J Mol Biol (2008) 1.08

Highly stretched single polymers: atomic-force-microscope experiments versus ab-initio theory. Phys Rev Lett (2005) 1.08

Tightening the knot in phytochrome by single-molecule atomic force microscopy. Biophys J (2009) 1.06

Single-molecule dynamics of mechanical coiled-coil unzipping. Langmuir (2007) 1.04

Force as a single molecule probe of multidimensional protein energy landscapes. Curr Opin Struct Biol (2012) 1.03

Elastic bond network model for protein unfolding mechanics. Phys Rev Lett (2008) 1.03

Myosin V stepping mechanism. Proc Natl Acad Sci U S A (2007) 1.01

Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner. Proc Natl Acad Sci U S A (2010) 1.01

Torque generation of kinesin motors is governed by the stability of the neck domain. Mol Cell (2012) 1.01

Single molecule unzipping of coiled coils: sequence resolved stability profiles. Phys Rev Lett (2006) 1.00

Calcium-dependent folding of single calmodulin molecules. Proc Natl Acad Sci U S A (2012) 0.98

Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96

Auto- and cross-power spectral analysis of dual trap optical tweezer experiments using Bayesian inference. Rev Sci Instrum (2012) 0.96

Hidden Markov analysis of trajectories in single-molecule experiments and the effects of missed events. Chemphyschem (2012) 0.96

Cysteine engineering of polyproteins for single-molecule force spectroscopy. Nat Protoc (2006) 0.96

Ligand binding mechanics of maltose binding protein. J Mol Biol (2009) 0.95

Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex. Proc Natl Acad Sci U S A (2010) 0.95

Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice. Diabetes (2002) 0.95

Rigid DNA beams for high-resolution single-molecule mechanics. Angew Chem Int Ed Engl (2013) 0.94

Reduction of claustrophobia during magnetic resonance imaging: methods and design of the "CLAUSTRO" randomized controlled trial. BMC Med Imaging (2011) 0.94

Complex unfolding kinetics of single-domain proteins in the presence of force. Biophys J (2010) 0.94

Single molecule mechanics of the kinesin neck. Proc Natl Acad Sci U S A (2009) 0.94

Covalent immobilization of recombinant fusion proteins with hAGT for single molecule force spectroscopy. Eur Biophys J (2005) 0.93

Gadofosveset trisodium-enhanced magnetic resonance angiography of the left atrium--a feasibility study. Eur J Radiol (2009) 0.93

Measuring forces between two single actin filaments during bundle formation. Nano Lett (2011) 0.92

Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy. Proc Natl Acad Sci U S A (2013) 0.91

Flexibility of the neck domain enhances Kinesin-1 motility under load. Biophys J (2006) 0.90

Reduction of claustrophobia with short-bore versus open magnetic resonance imaging: a randomized controlled trial. PLoS One (2011) 0.89

Structural and mechanical hierarchies in the alpha-crystallin domain dimer of the hyperthermophilic small heat shock protein Hsp16.5. J Mol Biol (2010) 0.89

Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin. Proc Natl Acad Sci U S A (2011) 0.89

High spatial resolution T1-weighted MR imaging of liver and biliary tract during uptake phase of a hepatocyte-specific contrast medium. Invest Radiol (2008) 0.88

Single-molecule protein unfolding and refolding using atomic force microscopy. Methods Mol Biol (2011) 0.87

Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium. J Biol Chem (2006) 0.87

Direct evidence of the multidimensionality of the free-energy landscapes of proteins revealed by mechanical probes. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.85

Surprising simplicity in the single-molecule folding mechanics of proteins. Angew Chem Int Ed Engl (2009) 0.85

Biochemistry. Force signaling in biology. Science (2009) 0.85

DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study. Eur Radiol (2012) 0.84

Navigating the folding energy landscape of green fluorescent protein. Angew Chem Int Ed Engl (2008) 0.84

Single-molecule force spectroscopy distinguishes target binding modes of calmodulin. Proc Natl Acad Sci U S A (2009) 0.83

Evidence for a broad transition-state ensemble in calmodulin folding from single-molecule force spectroscopy. Angew Chem Int Ed Engl (2010) 0.81

Whole-heart coronary magnetic resonance angiography at 1.5 Tesla: does a blood-pool contrast agent improve diagnostic accuracy? Invest Radiol (2011) 0.81

The lever arm effects a mechanical asymmetry of the myosin-V-actin bond. Biophys J (2010) 0.81

Designing the folding mechanics of coiled coils. Chemphyschem (2009) 0.80

Dissection of kinesin's processivity. PLoS One (2009) 0.80

Whole-body MRI with assessment of hepatic and extraabdominal enhancement after administration of gadoxetic acid for staging of rectal carcinoma. Acta Radiol (2010) 0.80

Intra-arterial ultra low iodine CT angiography of renal transplant arteries. Cardiovasc Intervent Radiol (2014) 0.79

Biomimetic F-actin cortex models. Chemphyschem (2009) 0.79

Mechanical stability of the antibody domain CH3 homodimer in different oxidation states. J Am Chem Soc (2013) 0.78

Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin. Proc Natl Acad Sci U S A (2014) 0.78

Optical force sensor array in a microfluidic device based on holographic optical tweezers. Lab Chip (2009) 0.76

A new manganese-based oral contrast agent (CMC-001) for liver MRI: pharmacological and pharmaceutical aspects. Acta Radiol (2012) 0.75

Contrast agent bolus tracking with a fixed threshold or a manual fast start for coronary CT angiography. Eur Radiol (2014) 0.75