Published in Proc Natl Acad Sci U S A on December 12, 2011
RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol (2013) 15.51
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A ruler protein in a complex for antiviral defense determines the length of small interfering CRISPR RNAs. J Biol Chem (2013) 1.35
RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus. Mol Cell (2014) 1.32
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The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae. MBio (2013) 1.18
Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases. RNA (2012) 1.18
CRISPRmap: an automated classification of repeat conservation in prokaryotic adaptive immune systems. Nucleic Acids Res (2013) 1.16
Molecular mechanisms of CRISPR-mediated microbial immunity. Cell Mol Life Sci (2014) 1.13
CRISPR-Cas systems in the cyanobacterium Synechocystis sp. PCC6803 exhibit distinct processing pathways involving at least two Cas6 and a Cmr2 protein. PLoS One (2013) 1.13
GraphProt: modeling binding preferences of RNA-binding proteins. Genome Biol (2014) 1.12
In vivo protein interactions and complex formation in the Pectobacterium atrosepticum subtype I-F CRISPR/Cas System. PLoS One (2012) 1.07
Adaptation and modification of three CRISPR loci in two closely related cyanobacteria. RNA Biol (2013) 1.06
The three major types of CRISPR-Cas systems function independently in CRISPR RNA biogenesis in Streptococcus thermophilus. Mol Microbiol (2014) 1.02
A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas) in Haloferax volcanii. J Biol Chem (2014) 1.02
Essential requirements for the detection and degradation of invaders by the Haloferax volcanii CRISPR/Cas system I-B. RNA Biol (2013) 1.01
Small RNAs for defence and regulation in archaea. Extremophiles (2012) 0.99
In vitro assembly and activity of an archaeal CRISPR-Cas type I-A Cascade interference complex. Nucleic Acids Res (2014) 0.98
Genetic determinants of PAM-dependent DNA targeting and pre-crRNA processing in Sulfolobus islandicus. RNA Biol (2013) 0.96
Staphylococcus epidermidis Csm1 is a 3'-5' exonuclease. Nucleic Acids Res (2013) 0.96
Programmable plasmid interference by the CRISPR-Cas system in Thermococcus kodakarensis. RNA Biol (2013) 0.96
Structure and RNA-binding properties of the type III-A CRISPR-associated protein Csm3. RNA Biol (2013) 0.95
Comparative genomic and transcriptional analyses of CRISPR systems across the genus Pyrobaculum. Front Microbiol (2012) 0.93
CRISPR-Cas: biology, mechanisms and relevance. Philos Trans R Soc Lond B Biol Sci (2016) 0.93
Targeted DNA degradation using a CRISPR device stably carried in the host genome. Nat Commun (2015) 0.91
Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch. BMC Genomics (2013) 0.90
Mobile CRISPR/Cas-mediated bacteriophage resistance in Lactococcus lactis. PLoS One (2012) 0.89
Control of gene expression by CRISPR-Cas systems. F1000Prime Rep (2013) 0.88
Impact of CRISPR immunity on the emergence and virulence of bacterial pathogens. Curr Opin Microbiol (2013) 0.87
Three CRISPR-Cas immune effector complexes coexist in Pyrococcus furiosus. RNA (2015) 0.86
CRISPR-Cas systems preferentially target the leading regions of MOBF conjugative plasmids. RNA Biol (2013) 0.86
Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system. Nucleic Acids Res (2014) 0.84
Comparative analysis ofCas6b processing and CRISPR RNA stability. RNA Biol (2013) 0.83
Precision genetic modifications: a new era in molecular biology and crop improvement. Planta (2014) 0.83
CRISPRstrand: predicting repeat orientations to determine the crRNA-encoding strand at CRISPR loci. Bioinformatics (2014) 0.83
DNA targeting by the type I-G and type I-A CRISPR-Cas systems of Pyrococcus furiosus. Nucleic Acids Res (2015) 0.82
An active immune defense with a minimal CRISPR (clustered regularly interspaced short palindromic repeats) RNA and without the Cas6 protein. J Biol Chem (2014) 0.82
Impact of Different Target Sequences on Type III CRISPR-Cas Immunity. J Bacteriol (2016) 0.80
CRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli. Nucleic Acids Res (2014) 0.80
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annu Rev Biophys (2015) 0.80
Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2. Nucleic Acids Res (2013) 0.79
Functional Analysis of Porphyromonas gingivalis W83 CRISPR-Cas Systems. J Bacteriol (2015) 0.76
Global transcription of CRISPR loci in the human oral cavity. BMC Genomics (2015) 0.76
CRISPR decoys: competitive inhibitors of CRISPR immunity. RNA Biol (2013) 0.76
Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis. FEBS Lett (2015) 0.75
Characterization of CRISPR RNA transcription by exploiting stranded metatranscriptomic data. RNA (2016) 0.75
Molecular determinants for CRISPR RNA maturation in the Cas10-Csm complex and roles for non-Cas nucleases. Nucleic Acids Res (2017) 0.75
Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer. Oncotarget (2016) 0.75
crRNAs in Porphyromonas gingivalis CRISPR-Cas I-C system. J Bacteriol (2017) 0.75
Conjugation Assay for Testing CRISPR-Cas Anti-plasmid Immunity in Staphylococci. Bio Protoc (2017) 0.75
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
CRISPR provides acquired resistance against viruses in prokaryotes. Science (2007) 29.74
The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature (1983) 19.44
CRISPR/Cas, the immune system of bacteria and archaea. Science (2010) 18.72
Small CRISPR RNAs guide antiviral defense in prokaryotes. Science (2008) 17.79
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature (2011) 17.38
Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol (2011) 17.11
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature (2010) 14.21
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell (2006) 11.98
CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science (2008) 11.82
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex. Cell (2009) 11.12
CRISPR-based adaptive immune systems. Curr Opin Microbiol (2011) 8.07
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nat Rev Genet (2010) 7.47
CRISPR/Cas system and its role in phage-bacteria interactions. Annu Rev Microbiol (2010) 7.15
Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes. Genes Dev (2008) 7.09
Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence. Proc Natl Acad Sci U S A (2011) 6.89
Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science (2010) 6.79
Sorting of protein A to the staphylococcal cell wall. Cell (1992) 6.48
Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nat Struct Mol Biol (2011) 6.02
Self versus non-self discrimination during CRISPR RNA-directed immunity. Nature (2010) 5.89
Structural basis for double-stranded RNA processing by Dicer. Science (2006) 5.86
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc Natl Acad Sci U S A (2011) 4.58
Prokaryotic silencing (psi)RNAs in Pyrococcus furiosus. RNA (2008) 4.46
Construction of single-copy integration vectors for Staphylococcus aureus. Gene (1991) 4.43
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol Direct (2011) 3.92
Interaction of the Cas6 riboendonuclease with CRISPR RNAs: recognition and cleavage. Structure (2011) 3.58
Transcription, processing and function of CRISPR cassettes in Escherichia coli. Mol Microbiol (2010) 3.05
An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Mol Biol (2011) 2.49
Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat Struct Mol Biol (2011) 2.47
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol (2013) 19.99
RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol (2013) 15.51
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res (2013) 3.51
Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae. Mol Microbiol (2004) 2.80
Protein sorting to the cell wall envelope of Gram-positive bacteria. Biochim Biophys Acta (2004) 2.42
CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection. Cell Host Microbe (2012) 2.15
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Assembly of pili on the surface of Bacillus cereus vegetative cells. Mol Microbiol (2007) 1.67
Amide bonds assemble pili on the surface of bacilli. Proc Natl Acad Sci U S A (2008) 1.53
Bacillus anthracis sortase A (SrtA) anchors LPXTG motif-containing surface proteins to the cell wall envelope. J Bacteriol (2005) 1.46
A ruler protein in a complex for antiviral defense determines the length of small interfering CRISPR RNAs. J Biol Chem (2013) 1.35
Innate and adaptive immunity in bacteria: mechanisms of programmed genetic variation to fight bacteriophages. Curr Opin Immunol (2011) 1.31
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Genetic characterization of antiplasmid immunity through a type III-A CRISPR-Cas system. J Bacteriol (2013) 1.22
Microbiology: slicer for DNA. Nature (2010) 1.10
Control of gene expression by CRISPR-Cas systems. F1000Prime Rep (2013) 0.88
Impact of CRIPSR immunity on the emergence of bacterial pathogens. Future Microbiol (2010) 0.84
Peptides mimicking the unique ARTS-XIAP binding site promote apoptotic cell death in cultured cancer cells. Clin Cancer Res (2012) 0.77
CRISPR decoys: competitive inhibitors of CRISPR immunity. RNA Biol (2013) 0.76